|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | The penumbra pivotal stroke trial : safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease 显示文摘 | Penumbra Pivotal Stroke Trial Investigators | 2009 | Stroke2009，40，8： | 1 |
| 3 | The penumbra pivocal stroke trial:safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease显示文摘 | Penumbra Pivotal Stroke Trial Investigators | 2009 | Stroke2009，40，8： | 1 |
| 4 | Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer显示文摘 | JOHNSTON S P1PPEN J J R PIVOT X | | 0，，33： | 1 |
| 5 | Once-yearly zoledronic acid for treatment of post-menopausal osteoporosis显示文摘 | Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Krasnow J Hue TF Sellmeyer D Eriksen EF Cummings SR HORIZON Pivotal Fracture Trial | | 0，，： | 1 |
| 6 | Clinical staging for male breast cancer:an adaptation of the international classification (TNM)显示文摘 | Pivot X Llombart CA Rhor AA | | 0，，： | 1 |
| 7 | Ixabepilone, a novel epothilone analog in the treatment of breast cancer 显示文摘 | Pivot X Villanueva C Chaigneau L | 2008 | Expert Opin Investig Drugs2008，17，4： | 1 |
| 8 | Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams显示文摘 | Reid IR Black DM Eastell R Bucci-Rechtweg C Su G Hue TF Mesenbrink P Lyles KW Boonen S HORIZON Pivotal Fracture Trial and HORIZON Recurrent Fracture Trial Steering Commi-ttees | | 0，，： | 1 |
| 9 | Randomized phase II study of sunitinib versus standard of care for patients with pre- viously treated advanced triple-negative breast cancer 显示文摘 | Curigliano G Pivot X Cortrs J | 2013 | Breast2013，22，5： | 1 |
| 10 | Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue 显示文摘 | Villanueva C Dufresne A Pivot X | 2008 | Bull Cancer2008，95，2： | 1 |
| 11 | Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer显示文摘 | Johnston S Pippen J Jr Pivot X | 2009 | J Clin Oncol2009，27，33： | 1 |
| 12 | The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapy显示文摘 | Magen N Pivot X Bensadoun RJ | 2001 | EurJ Cancer2001，37，17： | 1 |
| 13 | CEREBEL (EGF111438): A Phase ]1I, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer显示文摘 | Pivot X Manikhas A Zurawski B | 2015 | J Clin Oncol2015，33，14： | 1 |
| 14 | Efficacy and safety of ixa-- 5epilone(BMS- 247550)in a phase IIs tudy of patients with ad- zanced breast cancer resistant to an anthraeyeline, a tslxane, and apecitabine 显示文摘 | PEREZ EA LERZO G PIVOT X et a/ | 2007 | J Clin Oncology2007，25，23： | 1 |
| 15 | Safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease显示文摘 | The Penumbra Pivotal Stroke Trial Investigators The Penumbra Pivotal Stroke Trial | 2009 | Stroke2009，40，： | 1 |
| 16 | A retrospective study of first indicators of breast cancer recurrence显示文摘 | Pivot X Asmar L Hortobaqyi GN | 2000 | Oncology2000，58，3： | 1 |
| 17 | Adjuvant chemotherapy for local relapse breast cancer显示文摘 | PIVOT X | 2014 | Lancet Oncol2014，15，2： | 1 |
| 18 | Co-variables influencing 5-fluorouracil clearance during continuous venous infusion显示文摘 | Etienne MC Chatelut E Pivot X | 1998 | Eur J Cancer1998，34，1： | 1 |
| 19 | Pharmacokinetics of low - dose carboplatin and applicability of a method of ealculation for estimating individual drug clearance显示文摘 | MC Etienne F Leger X Pivot | 2003 | Ann Oncol2003，14，： | 1 |
| 20 | The penumbrapivotal stroke trial: safety and effectiveness of a new gener- ation of mechanical devices for clot removal in intracranial large vessel occlusive disease 显示文摘 | Penumbra Pivotal Stroke Trial Investigators | 2009 | Stroke2009，40，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员