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| 1 | 老年结直肠癌的临床病理特征和预后显示文摘目的分析老年结直肠癌的临床病理特征和预后。方法回顾性分析经术后病理确诊为结直肠腺癌的2 460例患者的临床资料。比较老年组(≥70岁)和年轻组(<70岁)的临床病理特征和术后生存情况。结果2 460例患者中位年龄59岁,老年组544例(22.1%),年轻组1 916例(77.9%)。老年结直肠癌患者以男性、结肠部位和管状腺癌多见(均P<0.05),远处转移较少(P=0.008),但接受姑息术治疗的比例高(P=0.005)。老年组和年轻组的术后10年总生存比较,差异无统计学意义(P=0.601)。Ⅱ期疾病患者中,老年组术后5年总生存率较年轻组差(P=0.008)。结论老年结直肠癌患者的术后总生存不差于年轻患者。Ⅱ期患者中,老年患者预后较差。 | 杨姣 傅健飞 谭伊诺 蒋梦婕 文飞 袁瑛 | 2018 | 实用肿瘤杂志2018，33，3： | 13 |
| 2 | Clinical characteristics and prognosis of young patients with colorectal cancer in Eastern China显示文摘AIM:To explore the clinical characteristics and prognosis of young patients with colorectal cancer patients in Eastern China.METHODS:A total of 1335 patients with colorectal cancer treated from December 1985 to December 2005at the Second Affiliated Hospital of Zhejiang University School of Medicine were studied retrospectively.The patients were divided into two groups,a younger group(aged≤30 years)and an older group(aged>30 years),and comparison was made in the clinical characteristics and prognosis between the two groups.Chisquare test was used for data analysis of all categorical variables,and overall survival(OS)was calculated by the Kaplan-Meier method.A multivariate analysis was performed using the Cox model.RESULTS:There were 42(3.1%)and 1293(96.9%)cases in the younger group and older group,respectively.Univariate analysis showed that the 5-and10-year OS in the younger group were 33.9%and26.1%,respectively,and those in the older group were60.1%and 52.2%,respectively.Younger group had poor survival(χ2=14.146,P=0.000).Multivariate analysis revealed that age was not a dependent factor for prognosis(OR=0.866,95%CI:0.592-1.269,P=0.461).Stratified analysis indicated that in stageⅢandⅣdisease,the 5-and 10-year OS were 24.6%and14.8%in the younger group,and 40.4%and 33.3%in the older group,respectively,with a significant difference between the two groups(χ2=5.101,P=0.024).In the subgroup of radical surgery,the 5-and 10-year OS were 44.3%and 34.2%in the younger group,and69.6%and 60.5%in the older group,with a difference being significant between the two groups(χ2=7.830,P=0.005).CONCLUSION:Compared with older patients,the younger patients have lower survival,especially in the subgroups of stageⅢandⅣdisease and radical surgery. | Jian-Fei Fu Yan-Qin Huang Jiao Yang Cheng-Hao Yi Hai-Long Chen Shu Zheng | 2013 | World Journal of Gastroenterology2013，19，44： | 11 |
| 3 | 老年结直肠癌的治疗显示文摘老年患者占结直肠癌患者的70%,因此老年人是结直肠癌的主要患病人群。为了提高结直肠癌治疗的总体疗效,我们应当特别关注老年性结直肠癌的治疗。以往,手术治疗和化疗的应用随着年龄的增高而明显减少。我们一直以为老年人手术和化疗的效果不令人满意。近期的研究改变了这一认识。证据表明辅助化疗和姑息性化疗对一般情况良好的老年人是有效而安全的。即使存在一些与年龄相关的基础疾病的老年结直肠癌患者仍然能从合理的治疗方案中获益。所以我们尚有许多工作需做,以提高老年性结直肠癌患者的疗效。腹腔镜下结肠癌根治术是对老年人安全有效的手术技术。我们期待随着经腔道的内窥镜手术技术的发展,将来会使老年性结直肠癌患者受益。 | 蒋蔚茹 刘杰 | 2010 | 医学与哲学(B)2010，31，4： | 4 |
| 4 | Comparison between surgical outcomes of colorectal cancer in younger and elderly patients显示文摘AIM:To compare the outcome of surgical treatment of colorectal adenocarcinoma in elderly and younger patients.METHODS:The outcomes of 122 patients with colorectal adenocarcinoma who underwent surgical treatment between January 2004 and June 2009 were analyzed.The clinicopathological and blood biochemistry data of the younger group(<75 years) and the elderly group (≥75 years) were compared.RESULTS:There were no significant differences between the two groups in operation time,intraoperative blood loss,hospital stay,time to resumption of oral intake,or morbidity.The elderly group had a significantly higher rate of hypertension and cardiovascular disease.The perioperative serum total protein and albumin levels were significantly lower in the elderly than in the younger group.The serum carcinoembryonic antigen level was lower in the elderly than in the younger group,and there was a significant decreasing trend after the operation in the elderly group.CONCLUSION:The short-term outcomes of surgical treatment in elderly patients with colorectal adenocarcinoma were acceptable.Surgical treatment in elderly patients was considered a selectively effective approach. | Longxue Jin Norio Inoue Naoki Sato Susumu Matsumoto Hitoshi Kanno Yuko Hashimoto Kazuhiro Tasaki Kinya Sato Shun Sato Katsutoshi Kaneko | 2011 | World Journal of Gastroenterology2011，17，12： | 3 |
| 5 | 培美曲塞单药治疗老年晚期结直肠癌患者的临床疗效观察显示文摘目的观察单药二线培美曲塞治疗老年晚期结直肠癌患者的近期疗效与不良反应。方法对34例接受单药培美曲塞化疗的老年复发晚期结直肠癌患者的临床疗效进行回顾性分析。结果全组34例患者,总有效率(CR+PR)38.24%,不良反应均尚可耐受,发生Ⅲ度和Ⅳ度血液学不良反应者较少。结论老年晚期结直肠癌患者可从单药培美曲塞化疗中获益:培美曲塞不良反应轻。 | 赵梅 刘峰 | 2011 | 医学信息2011，24，20： | 2 |
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