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| 1 | Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor显示文摘AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPI), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. RESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPI (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPI were shown to be significantly higher (P<0.001) in the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSION: In patients with HCC treated with TACE, CT-p provides measurement of flow parameters related to residual arterial structures in viable tumor, thus helping in the assessment of therapeutic response. | Davide Ippolito Pietro Andrea Bonaff ini Laura Ratti Laura Antolini Rocco Corso Ferruccio Fazio Sandro Sironi | 2010 | World Journal of Gastroenterology2010，16，47： | 15 |
| 2 | Diffusion-weighted imaging of pancreatic cancer显示文摘Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Radiology2015，7，10： | 14 |
| 3 | γ-Glutamyltransferase activity in human atherosclerotic plaques—Biochemical similarities with the circulating enzyme显示文摘 | Maria Franzini Alessandro Corti Barbara Martinelli Antonella Del Corso Michele Emdin Giuliano F. Parenti Mattia Glauber Alfonso Pompella Aldo Paolicchi | 2008 | Atherosclerosis2008，，1： | 2 |
| 4 | liver and the defects of cholesterol and bile acids biosynthesis: rare disorders many diagnostic pitfalls显示文摘In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects. | Gaetano Corso Antonio Dello Russo Monica Gelzo | 2017 | World Journal of Gastroenterology2017，23，29： | 2 |
| 5 | Super-extended (D3) lymphadenectomy in advanced gastric cancer显示文摘 | F. Roviello C. Pedrazzani D. Marrelli A. Di Leo S. Caruso S. Giacopuzzi G. Corso G. de Manzoni | 2010 | European Journal of Surgical Oncology2010，，： | 2 |
| 6 | Develo- ping National Performance Standards for Local Public Health Systems 显示文摘 | Bakes-Martin R Corso L C Landrum L B | 2005 | J Public Health Management Practice2005，11，5： | 1 |
| 7 | Assessment of renal function in patients with multiple myeloma:the role of urinary proteins显示文摘 | Corso A Serricehio G Zappasodi P | 1999 | Ann Hematol1999，78，8： | 1 |
| 8 | Occlusion of postcatheterization femoral pseudoaneurysms with percutaneous thrombin injection under ultrasound guidance显示文摘 | Corso R Rampoldi A Riolo F | 2004 | Radiol Med(Torino)2004，108，4： | 1 |
| 9 | Oncogenic mutations in gastric cancer with microsatellite instability显示文摘 | Corso G Velho S Paredes J | | European Journal of Cancer0，47，3： | 1 |
| 10 | Fostering Innovation and Knowledge Transfer in Product Development through Information Technology 显示文摘 | Corso M Paolucei E | 2001 | International Journal of Technology Management2001，22，1： | 1 |
| 11 | Corrosion evaluation of gold based dental alloys显示文摘 | Corso PP Jr German RM Simmons HD Jr | 1985 | J Dent Res1985，64，5： | 1 |
| 12 | Tortuosity,kinking,and coiling of the carotid artery:expression of atherosclerosis or aging显示文摘 | Del Corso L Moruzzo D Conte B | | 0，，05： | 1 |
| 13 | Precursor ion scan profiles of acylcarnitines by atmospheric pressure thermal desorption chemical ionization tandem mass spectrometry 显示文摘 | Paglia G D'Apolito O Corso G | 2008 | Rapid Commun Mass Spectrom2008，22，23： | 1 |
| 14 | preparation condition of pure and stoichiometric NixFe3-xO4 bulk cermics 显示文摘 | STIPHANIE CORSO | 2004 | Solid State Sciences2004，6，： | 1 |
| 15 | Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma:a possible mechanism for its antitumor effect显示文摘 | Corso A Ferretti E Lunghi M | 2005 | Cancer2005，104，1： | 1 |
| 16 | Comparative study of toxicity of azo dye Procion Red MX-5B following biosorption and biodegradation treatments with the fungi Aspergillus niger and Aspergillus terreus显示文摘 | E.J.R. Almeida C.R. Corso | 2014 | Chemosphere2014，，： | 1 |
| 17 | Assessment of renal function in patients with multiple myeloma:the role of urinary proteins显示文摘 | Corso A Serricchio G Zappasodi P | 1999 | Ann Hematol1999，78，8： | 1 |
| 18 | Neutral loss analysis of amino acids by desorption electrospray ionization using an unmodified tandem quadrupole mass spectrometer 显示文摘 | Corso G Paglia G Garofalo D | 2007 | Rapid Commun Mass Spectrom2007，21，23： | 1 |
| 19 | The costs of fatal and non-fatal falls among older adults显示文摘 | Stevens JA Corso PS Finkelstein EA | 2006 | Inj Prev2006，12，5： | 1 |
| 20 | Real-time detection of mesothelin in pancreatic cancer cell line supernatant using an acoustic wave immunosensor显示文摘 | Christopher D Corso Desmond D Stubbs Lee Sang-Hun | 2006 | Cancer Detection and Prevention2006，30，2： | 1 |
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