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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | A Multicentric Western Analysis of Prognostic Factors in Advanced, Node-Negative Gastric Cancer Patients显示文摘 | Gian Luca Baiocchi Guido A. Tiberio Anna Maria Minicozzi Paolo Morgagni Daniele Marrelli Lorenzo Bruno Fausto Rosa Alberto Marchet Arianna Coniglio Luca Saragoni Marco Veltri Fabio Pacelli Franco Roviello Donato Nitti Stefano M. Giulini Giovanni De Manzon | 2010 | Annals of Surgery2010，，1： | 2 |
| 3 | Impact of diabetes on overall and cancer- specific mortality in colorectal cancer patients显示文摘 | Bella F Minicozzi P Giacomin A | 2013 | J Cancer Res Clin Oncol2013，139，8： | 1 |
| 4 | Survival for ovar-ian cancer in Europe: the across-country variation did not shrink inthe past decade显示文摘 | Oberaigner W Minicozzi P Bielska-Lasota M | 2012 | Aeta Oncol2012，51，4： | 1 |
| 5 | Lymph Node Involvement in Gastric Cancer for Different Tumor Sites and T Stage显示文摘 | Alberto Leo Daniele Marrelli Franco Roviello Marco Bernini AnnaMaria Minicozzi Simone Giacopuzzi Corrado Pedrazzani Luca Gian Baiocchi Giovanni Manzoni | 2007 | Journal of Gastrointestinal Surgery2007，，9： | 1 |
| 6 | One stage or two stage treatment of colorectal cancer associated to abdominal aortic aneurysm:morbidity and mortality显示文摘 | Minicozzi A Veraldi GF Sboarina A | 2012 | Minerva Chir2012，67，5： | 1 |
| 7 | Validation of the new AJCC TNM staging system for gastric cancer in a large cohort of patients ( n = 2,155): Focus on the T category显示文摘 | A. Marchet S. Mocellin A. Ambrosi P. Morgagni G. Vittimberga F. Roviello D. Marrelli G. de Manzoni A. Minicozzi A. Coniglio G. Tiberio F. Pacelli F. Rosa D. Nitti | 2011 | European Journal of Surgical Oncology2011，，9： | 1 |
| 8 | The short term effect of educational debt on job decisions显示文摘 | Minicozzi Alexandra | 2005 | Economics of Education Review2005，24，4： | 1 |
| 9 | F-18 FDG PET/CT in Rectal Carcinoma: Where Are We Now?显示文摘 | Gaia Grassetto Maria Cristina Marzola Annamaria Minicozzi Adil Al-Nahhas Domenico Rubello | 2011 | Clinical Nuclear Medicine2011，，10： | 1 |
| 10 | The Ratio Between Metastatic and Examined Lymph Nodes (N Ratio) Is an Independent Prognostic Factor in Gastric Cancer Regardless of the Type of Lymphadenectomy: Results From an Italian Multicentric Study in 1853 Patients显示文摘 | Alberto Marchet Simone Mocellin Alessandro Ambrosi Paolo Morgagni Domenico Garcea Daniele Marrelli Franco Roviello Giovanni de Manzoni Annamaria Minicozzi Giovanni Natalini Francesco De Santis Luca Baiocchi Arianna Coniglio Donato Nitti | 2007 | Annals of Surgery2007，，4： | 1 |
| 11 | Epigenetic al- teration: new insights moving from tissue to plasma: the ex- ample of PCDH10 promoter methylation in colorectal cancer 显示文摘 | Danese E Minicozzi A M Benati M | 2013 | Br J Cancer2013，109，3： | 1 |
| 12 | The Short Term Effect of Education-al Debt on Job Decisions 显示文摘 | Minicozzi Alexandra | 2005 | Economics of EducationReview2005，24，4： | 1 |
| 13 | Surviv- al for ovarian cancer in Europe:the across-country variation did not shrink in the past decade显示文摘 | Oberaigner W Minicozzi P Bielska-Lasota M | 2012 | Acta Oncol2012，51，4： | 1 |
| 14 | Perianal Paget's disease: presentation of six cases and literature review 显示文摘 | Minicozzi A Borzellino G Momo R | 2010 | Int J Colorectal Dis2010，25，1： | 1 |
| 15 | Perianal Paget's disease:presentation of six cases and literature review显示文摘 | Annamaria Minicozzi Giuseppe Borzellino Rostand Momo | 2009 | Int J Colorectal Dis2009，8，： | 1 |
| 16 | Treatment of abdominal static aneurysm associated with colorectal cancer:presentation of 14 cases and literature review显示文摘 | Veraldi GF Minicozzi AM Leopardi F | 2008 | Int J Colorectal Dis2008，23，4： | 1 |
| 17 | One stage or two stage treatment of colorectal cancer associated to abdominal aortic aneurysm: morbidity and mortality 显示文摘 | Minicozzi A Veraldi GF Sboarina A | 2012 | Minerva Chit2012，67，5： | 1 |
| 18 | Laparoscopic hepatic resection 显示文摘 | Borzellino G Ruzzenente A Minicozzi AM | 2006 | Surg Endosc2006，20，5： | 1 |
| 19 | A multicentric Western analysis of prognostic factors in advanced, node-negativegas|rio cancer patients显示文摘 | Baiocchi GL Tiberio GA Minicozzi AM | 2010 | Ann Surg2010，252，1： | 1 |
| 20 | Survival for ovarian cancer in Europe:the across-country variation did not shrink in the past decade显示文摘 | Oberaigner W Minicozzi P Bielska-Lasota M | 2012 | Acta Oncol2012，51，4： | 1 |
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