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| 1 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 2 | Total inhibin is a potential serum marker for epithelial ovarian cancer显示文摘 | Tsigkou A Marrelli D Reis FM | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 3 | Numberof lymph nodemetastases and its prognostic significance in early gastric cancer: multicenter Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg Oncol2006，94，4： | 1 |
| 4 | Preoperative positivity of serum tumor markers in a stron predictor of hem atogenous recurrence of gastric cancer显示文摘 | Marrelli D Pinto E De Stefano A | 2001 | J Surg Oncol2001，78，4： | 1 |
| 5 | Number of lymph node metasta- ses and its prognostic significance in early gastric cancer: a multi- center Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg Oncol2006，94，： | 1 |
| 6 | Number of lymph node metastases and its prognosticsignificance in early gastric cancer: amulti- center Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg 0nco2006，94，4： | 1 |
| 7 | Number of lymph node metastases and its prognostic significance in early gastric cancer:a multicenter Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg Oncol2006，94，4： | 1 |
| 8 | Lymph node involvement in advanced gastroesophageal junction adenocarcinoma显示文摘 | Pedrazzani C de Manzoni G Marrelli D | | 0，，02： | 1 |
| 9 | P53 accumulation is a prognostic factor in intestinaltype gastric carcinoma but not in the diffuse type显示文摘 | Roviello F Marrelli D Vindigni C De Stefano A Spina D Pinto E | 1999 | Ann Surg Oncol1999，6，： | 1 |
| 10 | P2u receptor-mediated release of endothelium derived relaxing factor/nitric oxide and endothelium derived hyperpolarizing factor from cerebrovascular endothelium in rats 显示文摘 | You J Johnson T D Marrelli S P Mombouli J V Bryan R M Jr | 1999 | Stroke1999，30，： | 1 |
| 11 | P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia reperfusion显示文摘 | Marrelli S P Khorovets A Johnson T D Childres W F Bryan R M Jr | 1999 | Am J Physiol1999，276，12： | 1 |
| 12 | CA19-9 serum levels in obstructive jaundice:clinical value in benign and malignant conditions显示文摘 | Marrelli D Caruso S Pedrazzani C | | 0，，03： | 1 |
| 13 | Lymph node in- volvement in advanced gastroesophageal junction adenoearcino- ma 显示文摘 | Pedrazzani C de Manzoni G Marrelli D et at | 2007 | J Thorac Cardiovasc Surg2007，134，2： | 1 |
| 14 | Prospective study of peritoneal recurrence after curative surgery for gastric cancer: Italian Research Group for Gastric Cancer显示文摘 | Roviello F Marrelli D de Manzoni G | 2003 | BrJ Surg2003，90，9： | 1 |
| 15 | preoperative positivity of serum tumormarkers in a strong predictor of hematogenous recurrence of gastric cancer 显示文摘 | Marrelli D Pinto E de Stafano A | 2001 | J Surg Oncol2001，78，4： | 1 |
| 16 | Prognostic significance of CEA, CA19-9 and CA72-4 preoperative serum levels in gastric carcinoma显示文摘 | Marrelli D RovieUo F De Stefano A | 1999 | Ontology1999，57，1： | 1 |
| 17 | Surgical treatment of gastric cancer 显示文摘 | Reveille F Pedrazzani C Marrelli D | 2008 | Chir Ital2008，60，3： | 1 |
| 18 | Clinical utility of CEA,CA199 and CA724 in the follow -up of patientswith respectable gastric cancer 显示文摘 | Marrelli D Pinto E De Stefano A | 2001 | Am J Surg2001，181，1： | 1 |
| 19 | Risk factorsfor liver metastases after curative surgical procedures forgastric cancer: a prospective study of 208 patients treatedwith surgical resection 显示文摘 | Marrelli D Roviello F De Stefano A | 2004 | J Am Coll Surg2004，198，1： | 1 |
| 20 | Prospective study of peritoneal recurrence after curative surgery for gastric cancer显示文摘 | Roviello F Marrelli D Manzoni G | 2003 | Br J Surg2003，90，9： | 1 |
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