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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans显示文摘 | Alyson Ashe Alexandra Sapetschnig Eva-Maria Weick Jacinth Mitchell Marloes P. Bagijn Amy C. Cording Anna-Lisa Doebley Leonard D. Goldstein Nicolas J. Lehrbach Jérémie Le Pen Greta Pintacuda Aisa Sakaguchi Peter Sarkies Shawn Ahmed Eric A. Miska | 2012 | Cell2012，，1： | 2 |
| 3 | Input, Interaction, and Second Language Production显示文摘 | Susan M. Gass Evangeline Marlos Varonis | 1994 | Studies in Second Language Acquisition1994，，3： | 2 |
| 4 | Diagnosis and management of splanchnic ischemia显示文摘Splanchnic or gastrointestinal ischemia is rare and randomized studies are absent. This review focuses on new developments in clinical presentation, diagnostic approaches, and treatments. Splanchnic ischemia can be caused by occlusions of arteries or veins and by physiological vasoconstriction during low-flow states. The prevalence of significant splanchnic arterial stenoses is high, but it remains mostly asymptomatic due to abundant collateral circulation. This is known as chronic splanchnic disease (CSD). Chronic splanchnic syndrome (CSS) occurs when ischemic symptoms develop. Ischemic symptoms are characterized by postprandial pain, fear of eating and weight loss. CSS is diagnosed by a test for actual ischemia. Recently, gastro-intestinal tonometry has been validated as a diagnostic test to detect splanchnic ischemia and to guide treatment. In single- vessel CSD, the complication rate is very low, but some patients have ischemic complaints, and can be treated successfully. In multi-vessel stenoses, the complication rate is considerable, while most have CSS and treatment should be strongly considered. CT and MR-based angiographic reconstruction techniques have emerged as alternatives for digital subtraction angiography for imaging of splanchnic vessels. Duplex ultrasound is still the first choice for screening purposes. The strengths and weaknesses of each modality will be discussed. CSS may be treated by minimally invasive endoscopic treatment of the celiac axis compression syndrome, endovascular antegrade stenting, or laparotomy-assisted retrograde endovascular recanalization and stenting.The treatment plan is highly individualized and is mainly based on precise vessel anatomy, body weight, co- morbidity and severity of ischemia. | Jeroen J Kolkman Marloes Bargeman Ad B Huisman Robert H Geelkerken | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 5 | Novel peptides with tyrosinase inhibitory activity 显示文摘 | Marloes S Willem J H van Berkel Harry J W | 2007 | Peptides2007，28，3： | 1 |
| 6 | Density-functional study of bulk and surface properties of titanium nitride using different exchange-correlation functionals 显示文摘 | Marlo M Milman V | 2000 | Phys Rev B(S0163-1829)2000，62，4： | 1 |
| 7 | Density functional study of bulk and surface properties of titanium nitride using different exchange correlation function 显示文摘 | MARLO M MILMAN V | 2000 | Phys Rev B2000，62，4： | 1 |
| 8 | Hydrolyzed Casein Decreases Postprandial Glucose Concentrations in T2DM Patients Irrespective of Leucine Content显示文摘 | Bart F. Geerts Marloes G.J. van Dongen Baukje Flameling Matthijs M. Moerland Marieke L. de Kam Adam F. Cohen Johannes A. Romijn Cindy C. Gerhardt Joris Kloek Jacobus Burggraaf | 2011 | Journal of Dietary Supplements2011，，3： | 1 |
| 9 | Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer显示文摘 | Ninke Leffers Marloes J. M. Gooden Renske A. Jong Baukje-Nynke Hoogeboom Klaske A. Hoor Harry Hollema H. Marieke Boezen Ate G. J. Zee Toos Daemen Hans W. Nijman | 2009 | Cancer Immunology Immunotherapy2009，，3： | 1 |
| 10 | Novel peptides with tyrosinase inhibitory activity显示文摘 | Schurink Marloes Berkel Willem J H van Wichers Harry J | 2007 | Peptides2007，28，： | 1 |
| 11 | Hydrograph separation using hydrochemical tracers in the Makanya catchment, Tanzania显示文摘 | Marloes L. Mul Robert K. Mutiibwa Stefan Uhlenbrook Hubert H.G. Savenije | 2007 | Physics and Chemistry of the Earth2007，，1： | 1 |
| 12 | Three-dimensional reconstruction of intracoronary ultrasound images; rational, approaches, problems, and directions 显示文摘 | Roelandt JRTC Marlo CD Pandian NG | 1994 | Circulation1994，90，2： | 1 |
| 13 | Density-functional study of bulk and surface properties of titanium nitride using different exchange-correlation functionals显示文摘 | MARLO M MILMAN V | 2000 | Physical Review B2000，62，4： | 1 |
| 14 | International law of outer space and the protection of intellectual property rights显示文摘 | Leo B Malagar Marlo Apalisok Magdoza-Malagar | | 0，，： | 1 |
| 15 | Density-functional study of bulk and surface properties of titanium nitride using different exchange?correlation functionals显示文摘 | MARLO M MILMAN V | 2000 | Physical Review B2000，62，4： | 1 |
| 16 | Susceptibility testing of fluconazole by the NCCLS brth macrodilution method,E-test,and disk diffusion for application in roution laboratory显示文摘 | INGE B MARLO V MARLEEN V | 2002 | J Clin Microbiol2002，40，： | 1 |
| 17 | Investiga- tion of chromosome 17 candidate genes in susceptibility to TB in a South African population 显示文摘 | Marlo Moiler Almut Nebel Ruta Valentonyte | 2009 | Tuberculosis2009，89，2： | 1 |
| 18 | Density-functional study of bulk and surface properties of titanium nitride using different exchange-correlation functionals显示文摘 | MARLO M MILMAAN V | 2000 | Phys Rev B2000，62，： | 1 |
| 19 | 显示文摘 | Marlo M | 2000 | Phys Rev B2000，62，4： | 1 |
| 20 | Small firm membership in national trade associations显示文摘 | Wilts Arnold Meyer Marloes | | 0，，1472： | 1 |
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