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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Parameters affecting the yield of DNA from human blood显示文摘 | Gustafson S Proper J A Bowie E J | 1987 | Anal Biochem1987，165，2： | 2 |
| 3 | Population pharmacokinetic model of PI-88, a heparanase inhibitor显示文摘 | Susan F. Hudachek S. Gail Eckhardt Barbara Hicks Daniel L. Gustafson | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 4 | Cardiac implications of thrombotic thrombocytopenic purpura显示文摘Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular thrombosis.Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac involvement would also benefit from routine cardiology follow up during remission. | Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai | 2018 | World Journal of Cardiology2018，10，12： | 2 |
| 5 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 6 | Use of satellite information in observing and forecasting fog dissipation and cloud formation显示文摘 | Gustafson A V Wasserman S E | 1976 | Mon Wea Rev1976，104，3： | 2 |
| 7 | 钢水脱气用真空泵系统的选择显示文摘干式机械真空泵(MVP)在钢水脱气工艺中的应用在过去10年间取得了巨大进展,但主要局限在150 T炉容以下;推广到更大炉容的工作正在进行中。因为有蒸汽来源,蒸汽喷射真空泵(SVP )主要用于联合钢厂150~350 T的大炉容。除了投资和运行成本方面的考虑,所有真空工艺和设备类型都能够不受限制地使用任何类型的现代真空泵系统。这两种系统都能够满足全部的冶金要求。由于 MVP 系统的运行成本明显降低,所以有必要重新审视在减少漏气、使用保护气体和降低泵组与冶金反应罐间压力损失等方面的努力。这两种系统的能效都得到了提高,但 MVP的能源优势更为明显。在对真空泵系统进行比较时,应当只考虑总成本,包括为满足排放限制和安全标准的要求而必须付出的成本以及反应罐内的压力。此外,还应当重新考虑除尘系统的类型和使用,因为它们能够通过减少清理次数、节省用水、减少淤泥处理、降低 SVP 系统的设计抽气能力来显著降低成本。在同基于体积流量的 MVP比较前,需要利用一个特殊的系数对 SVP 的质量流进行修正。根据所选泵需要的工作压力, MVP系统能够以大大低于SVP系统的质量流在反应罐达到同样的性能。 | BURGMANN Wilhelm GUSTAFSON Thoret DAVENE Jean | 2014 | 中国冶金2014，24，8： | 2 |
| 8 | microRNA-Directed Phasing during Trans -Acting siRNA Biogenesis in Plants显示文摘 | Edwards Allen Zhixin Xie Adam M. Gustafson James C. Carrington | 2005 | Cell2005，，2： | 2 |
| 9 | Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis 显示文摘 | Nilsson K Gustafson L Hultberg B | 2007 | Dement Geriatr Cngn Disord2007，24，3： | 1 |
| 10 | Sub-Hertz relative frequency stabilization of two-diode laser-pumped Nd: YAG lasers locked to a Fabry-Perot interferometer 显示文摘 | Eric K Gustafson Robert L Byer | 1992 | IEEE Journal of Quantum Electronics1992，28，4： | 1 |
| 11 | Microstructure of model cermets with high Mo or W content显示文摘 | Gustafson P Rolander U | 1999 | International Journal of RM&HM1999，17，6： | 1 |
| 12 | The complete nucleotide sequence of RNA beta from the type strain of Barley stripe mosaic virus显示文摘 | Gustafson G Armour S L | 1986 | Nucleic Acids Research1986，14，9： | 1 |
| 13 | A new cellular target for mitomycin C: a case for mitochondriat DNA显示文摘 | Pritsos CA Briggs LA Gustafson DL | 1997 | Oncol Res1997，9，67： | 1 |
| 14 | Microstructure of model cermets with high Mo or W content显示文摘 | LINDAHL P GUSTAFSON P ROLANDER U STALS L ANDREN H O | 1999 | International Journal of Refractory Metals & Hard Materials1999，17，6： | 1 |
| 15 | Isoform-and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase显示文摘 | Grim JE Gustafson MP Hirata R K | 2008 | Cell Biol2008，181，6： | 1 |
| 16 | Impact of a pa- tient - centered, computer - based health information/sup- port system显示文摘 | Gustafson DH Hawkins R Boberg E | 1999 | Am J Prey Med1999，16，1： | 1 |
| 17 | Elevated plasma homo- cysteine level is not primarily related to alzheimer's disease 显示文摘 | Nilsson K Gustafson L Hultberg B | 2012 | Dement Geriatr Cogn Disord2012，34，2： | 1 |
| 18 | Reevaluating amdahl's law 显示文摘 | Gustafson J L | 1988 | Communications of the ACM1988，31，5： | 1 |
| 19 | Post-Kombolgie metasomatism at Jabiluka,Northern Territory,Australia,and its significance in the formation of high-grade uranium mineralization in lower proterozoic rocks显示文摘 | Gustafson L B Curtis L W | | 0，，1： | 1 |
| 20 | Adipose tissue,inflammation and atherosclerosis显示文摘 | Gustafson B | | 0，，04： | 1 |
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