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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells显示文摘 | An LJ Guan S Shi GF Bao YM Duan YL Jiang B | 2006 | 中国生物学文摘2006，20，10： | 30 |
| 3 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 4 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 5 | Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma显示文摘AIM To explore the effect and mechanism ofgastrin and its antagonists proglumide and somatostatin on coIorectal carcinoma and their clinical significance.METHODS A model of transplanted human colonic carcinoma was established from SW480cell line in gymnomouse body. The volume andweight of transplanted carcinoma was observedunder the effect of pentagatrin (PG), proglumide (PGL) and octapeptide somotostatin (SMS201-995, SMS). The cAMP content ot carcinoma cell was determined by redioimmunoassay and the DNA, protein content and cell cycle were determined by flow-cytometry. The amount of viabIe cells was determined by MTT colorimetric analysis, lP3 content was determined by radioimmunoassay, Ca2+ concentration in cell by fluorometry and PKC activity by isotopic enzymolysis. The expression of gastrin, c-myc,C-fos and rasP21 in 48 cases of colorectal carcinoma tissue was detected by the immunocytochemistry SP method. Argyrophilianucleolar organizer regions was determined withargyrophilia stain.RESULTS The volume, weight, cAMP, DNAand protein content in carcinoma cell, cellamount and proliferation index of S and G2Mphase in PG group were all significantly higher than those of control group. When PG was at theconcentration of 25 mg/ L, the amount of viablecells, lP3 content and Ca2+ concentration in celland membrane PKC activity in PG group weresigniticantly higher than those in control group;when PGL was at a concentration ot 32 mg/L,they dropped to the lowest level in PG (25 mg/L)+ PGL group, but without significant differencefrom the control group. The positive expression rate of gastrin, c-myc, c-fos and rasp21 in carcinoma tissue was 39 .6%, 54 .2%, 47. 9% and54 .2% resPectively and significantly higher than that in mucosa 3 cm and 6 cm adjacent tocarcinoma tissue and normal colorectal mucosa.The positive expression rate of gastrin of highlydifferentiated adenocarcinoma group was significantly higher than that of poorly differentiated and mucinous adenocarcinoma groups. The AgNORs count of carcinoma tissue was significantly higher than that in mucosa 3 cm and 6 cm adjacent to carcinoma tissue and normal colorectal mucosa; and the positive expression of c-myc and c-fos and the AgNORs count in gastrin-positive group was significantly higher than those in gastrin-negative group.CONCLUSION Pentagastrin has a promoting effect on the growth of transplanted human colonic carcinoma from SW480 cell line. PGL hasno obvious effect on the growth of human colonic carcinoma SW480 cell line, but couldinhibit the growth-promoting effect of PG on transplanted carcinoma. Somatostatin can not only inhibit the growth of transplanted human colonic carcinoma from SW480 cell line directlybut also depress the growth-promoting effect ofgastrin on the transplanted carcinoma. Somecolorectal carcinoma cells can produce and secrete gastrin through autocrine, highly-differentiated adenocarcinoma express the highest level gastrin. Endogenous gastrin can stimulate the cell division and proliferation of carcinoma cell and promote the growth of colorectal carcinoma regulating the expression of oncogene omyc, c-fos. Our study has provided experimental basis for the adjuvant treatment using gastrin antagonist such as PGL,somatostatin of patients with colorectalcarcinoma. | He SW Shen KQ He YJ Xie B Zhao YM | 1999 | World Journal of Gastroenterology1999，5，5： | 20 |
| 6 | Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer显示文摘 | Ji F Wang WL Yang ZL Li YM Huang HD Chen WD | 1999 | World Journal of Gastroenterology1999，5，5： | 19 |
| 7 | Protocatechuic acid suppresses MPP(+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells.显示文摘 | Guan S Jiang B Bao YM An LJ | 2006 | 中国生物学文摘2006，20，10： | 17 |
| 8 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 9 | Localization of HCV RNA and capsid protein in human hepatocellular carcinoma显示文摘INTRODUCTIONThe relation of HCV to hepatocytic carcinoma(HCC) has been emphasized recently in low HBVinfection countries and regions.The distributionpatterns of HCV in liver tissues are not wellunderstood although studies on HCV infection inblood and hepatocytes have been conducted byPCR.In this study,42 liver cancers | Dai YM Shou ZP Ni CR Wang NJ Zhang SP | 2000 | World Journal of Gastroenterology2000，6，1： | 15 |
| 10 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 11 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 12 | ON NUMEROV SCHEME FOR NONLINEAR TWO-POINTS BOUNDARY VALUE PROBLEM显示文摘Nonlinear Jacobi iteration and nonlinear Gauss-Seidel iteration are proposed to solve the famous Numerov finite difference scheme for nonlinear two-points boundary value problem. The concept of supersolutions and subsolutions for nonlinear algebraic systems are introduced. By taking such solutions as initial values, the above two iterations provide monotone sequences, which tend to the solutions of Numerov scheme at geometric convergence rates. The global existence and uniqueness of solution of Numerov scheme are discussed also. The numerical results show the advantages of these two iterations. | Wang, YM Guo, BY | 1998 | Journal of Computational Mathematics1998，16，4： | 9 |
| 13 | Isotopic compositions of chlorine in brine and saline minerals显示文摘CHLORINE in the nature has two stable isotopes, 35Cl and 37Cl. Two methods of determining isotopic ratios of chlorine were once developed. Owen, Kaufmann and Long determined 37Cl/35Cl ratios based on the measurement of CH3Cl+ ion produced by ionization of methyl chlorine. The precision of the measurement of Cl-(NTIMS) was reported by Shields and Vengosh. The NTIMS has less precision. | Xiao, YK Liu, WG Zhou, YM Sun, DP | 1997 | Chinese Science Bulletin1997，42，5： | 7 |
| 14 | A clinical evaluation of serological diagnosis for pancreatic cancer显示文摘AclinicalevaluationofserologicaldiagnosisforpancreaticcancerZHAOXiaoYan,YUShiYuan,DAShiPing,BAILi,GUOXiaoZhong,DAIXiaoJ... | Zhao, XY Yu, SY Da, SP Bai, L Guo, XZ Dai, XJ Wang, YM | 1998 | World Journal of Gastroenterology1998，4，2： | 6 |
| 15 | FREE VIBRATION OF PIEZOELECTRIC CYLINDRICAL SHELLS显示文摘Three displacement functions are introduced to represent each mechanical displacementaccording to the 3-D theory in this paper,By expanding the displacement functions and the electric po-tential in orthogonal series,the free vibration equation of piezoelectric cylindrical shells satisfying SS3boundary conditions can be obtained.The equation was solved by utilizing Bessel functions with com-plex arguments.Results are presented graphically as well as in table,and compared with those of otherreferences.Some frequencies that were missing in Ref.[9]are discovered. | Ding, HJ Guo, YM Yang, QD Chen, WQ | 1997 | Acta Mechanica Solida Sinica1997，10，1： | 5 |
| 16 | Topologic configuration of a graphoglyptid and its functional morphologic analysis显示文摘IN the course of investigating the electric current and voltage efficiency of a circuit, it is more important to study its topologic configuration than to Study its Euclidean geometric morphology. If two kinds of partial topologic variations take place in the tree-network circuit, its electric current and voltage efficiency will synchronously change, but the electric current and | Gong, YM Huang, DH | 1997 | Chinese Science Bulletin1997，42，16： | 4 |
| 17 | Crohn's disease in adults: Observations in a multiracial Asian population显示文摘瞄准:决定人口统计学和 CD 并且第二的临床的表示在一张多种族的亚洲人口在在不同的种族组之间的流行决定任何差别。方法:在马来亚医学中心(UMMC ) 的大学里在 2001-2003 被看见的有 CD 的病人在这研究被注册。疾病的流行作为分母每种族组与医院录取总体上并且由种族为这个组被计算。结果:34 个病人被诊断有 CD。病人的基本人口统计的数据;male:female 17:17;意味着年龄 29.1 年(+/-13.5 年) ;种族组:马来语 5 (14.7%) ,汉语 12 (35.3%) 并且印第安人 17 (50%) 。(76.5%) 26 不到 40 和 8 岁被诊断(23.5%) 超过 40 岁被诊断。疾病的地点作为 follows:ileocolonic 13 (38.2%) ,终端回肠仅仅 9 (26.5%) ,结肠仅仅 8 (23.5%) ,并且上面胃肠 4 (11.8%) 。(47.1%) 十六让了渗透疾病,(26.5%) 9 有 stricturing 疾病,(26.5%) 9 有非渗透、苛评得非的疾病。CD 的医院承认流行总的来说是 26.0,印第安人 52.6,汉语 6.9,并且马来语 9.3 每 10 (5 ) 录取每种族组。印第安人和马来语之间的差别:[或 5.67 (1.97, 17.53 ) P<0.001 ] 是统计上重要的然而并非在印第安人和汉语之间[或 1.95 (0.89, 4.35 ) P=0.700 ] 汉语之间的 .The 差别和马来语也不是统计上重要的。[或 2.90 (0.95, 9.42 ) P=0.063 ] 。结论:CD 的临床的演讲类似于西方的经验。尽管全面流行是低的,看起来是在印第安人之中的清楚的种族优势。 | Ida Hilmi YM Tan KL Goh | 2006 | World Journal of Gastroenterology2006，12，9： | 4 |
| 18 | SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS显示文摘SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS￥TaiBaoWEI;JiChouCHEN;YouMing... | Wei, TB Chen, JC Zhang, YM Wang, LL | 1995 | Chinese Chemical Letters1995，6，3： | 4 |
| 19 | P-wave velocities of alkaline olivine basalt at high pressure and temperature and its controlling factors显示文摘SEISMIC wave inversion is one of the most important means for us to recognize the compositionand structure of the Earth’s interior.Although the experimental techniques of elastic wave ve-locity measurement at in situ high pressure and temperature develop very fast in recent | Song, MS Xie, HS Zhang, YM Hou, W Xu, J Xu, YS | 1997 | Chinese Science Bulletin1997，42，9： | 3 |
| 20 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
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