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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | Proteomic changes in mammalian spermatozoa during epididymal maturation显示文摘附睾成熟与 cAMP-inducedtyrosine 磷酸化串联的激活被联系,它最终与表达式被联系 ofcapacitation 依赖的精子工作,例如亢奋的激活的运动和 acrosomal exocytosis。通过附睾的 Asspermatozoa 进步他们首先在主要的片上在目标上获得能力到 phosphorylatetyrosine,由中间的片列在后面。等到这些房间 haver eached 附睾尾他们装 phosphorylate 从颈的全部尾巴到结束片。磷酸化的 Thisparticular 模式与能够使肥沃的充分功能的精子的个体发生被联系卵母细胞。这改变的 Proteomic 分析 indicate 与几 mitochondrial 蛋白质的磷酸化被联系, amitochondrial 膜电位的创造和 mitochondrial 自由基产生的激活。至少在啮齿类动物种类,精子线粒体的激活看起来是特别地重要的部分 ofepididymal 成熟。 | R. John Aitken Brett Nixon Minjie Lin Adam J. Koppers Yun H. Lee Mark A. Baker | 2007 | Asian Journal of Andrology2007，9，4： | 14 |
| 3 | 发展区域机构能力——英格兰西北区沿海论坛的发展显示文摘20世纪90年代,英国重新加强了对区域政策的关注和区域机构的建设。本文主要介绍英格兰西北沿海论坛的创建发展过程,进一步分析了区域相关机构之间的联系和作用,以及西北区政府办公室(GONW)在此过程中的作用和影响;作者还探讨了一种新型的区域合作关系机制所面临的挑战。 | Mark Baker 杜潇芳 | 2002 | 国外城市规划2002，17，1： | 7 |
| 4 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 5 | Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?显示文摘这章探索 capacitation 和 apoptosis 是他们的普通依赖在反应的氧种类(ROS ) 的继续的产生上加入的连接过程的可能性。根据这个模型的意见, capacitation 在当细胞内部的 ROS 产生的后果,刺激细胞内部的营地产生,禁止酷氨酸磷酸酶活动并且由白朊从精子表面在他们的移动以前提高 oxysterols 的形成,跟随他们的版本进女繁殖的道的 spematozoa 被开始。由使能够的 ROS 的继续的产生精子的人口最后压到这些房间的有限能力保护自己免受氧化应力的伤害。作为精子的 over-capacitation 导致的结果,老朽的一个状态和截断的内在的 apoptotic 串联的激活由提高的 mitochondrial ROS 产生,类脂化合物 peroxidation,活动性损失, caspase 激活和 phosphatidylserine 外表表现描绘了。后者可能在指示吞噬细胞的白血球衰老的、垂死的精子的移动应该是由 proinflammatory cytokines 的产生无伴侣的一个沉默过程是特别地重要的。这些观察表明中央角色在定义精子的生活和死亡由氧化还原作用化学玩了。这些机制的知识可以帮助我们设计新奇答案专业化房间高度支持并且保存这些的功能。 | Robert J Aitken Mark A Baker Brett Nixon | 2015 | Asian Journal of Andrology2015，17，4： | 7 |
| 6 | The 'omics revolution and our understanding of sperm cell biology显示文摘 | Mark A Baker | 2011 | Asian Journal of Andrology2011，13，1： | 4 |
| 7 | The test of functional health literacy in adults显示文摘 | Dr. Ruth M. Parker MD David W. Baker MD MPH Mark V. Williams MD Joanne R. Nurss PhD | 1995 | Journal of General Internal Medicine1995，，10： | 2 |
| 8 | Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice显示文摘 | Bo Xiao Hamed Laroui Emilie Viennois Saravanan Ayyadurai Moiz A. Charania Yuchen Zhang Zhan Zhang Mark T. Baker Benyue Zhang Andrew T. Gewirtz Didier Merlin | 2014 | Gastroenterology2014，，： | 2 |
| 9 | Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics显示文摘 | Richard G. Lee Jeff Crosby Brenda F. Baker Mark J. Graham Rosanne M. Crooke | 2013 | Journal of Cardiovascular Translational Research2013，，6： | 2 |
| 10 | Localized corrosion of a 2219 aluminium alloy exposed to a 3.5% NaCl solution显示文摘 | Rossana Grilli Mark A. Baker James E. Castle Barrie Dunn John F. Watts | 2010 | Corrosion Science2010，，9： | 2 |
| 11 | Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans显示文摘 | Mark J. Graham Richard G. Lee Thomas A. Bell Wuxia Fu Adam E. Mullick Veronica J. Alexander Walter Singleton Nick Viney Richard Geary John Su Brenda F. Baker Jennifer Burkey Stanley T. Crooke Rosanne M. Crooke | 2013 | Circulation Research2013，，11： | 1 |
| 12 | Distribution and Generation of the Overpressure System, Eastern Delaware Basin, Western Texas and Southern New Mexico 显示文摘 | Ming Luo Mark R Baker David V Le Mon | 1994 | AAPG Bulletin1994，78，9： | 1 |
| 13 | Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles显示文摘 | Bo Xiao Mingzhen Zhang Emilie Viennois Yuchen Zhang Na Wei Mark T. Baker Yunjin Jung Didier Merlin | 2015 | Biomaterials2015，，： | 1 |
| 14 | The evolution of the grid显示文摘 | David De Roure Mark A Baker Nicholas R Jennings | 2003 | Grid Computingmaking the Global Infrastructure a Reality2003，12，3： | 1 |
| 15 | Imaging of chronic pancreatitis显示文摘 | Erick M Remer Mark E Baker | 2002 | Radiologic Clinics of North America2002，，6： | 1 |
| 16 | Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster显示文摘 | Mark L. Siegal Bruce S. Baker | 2005 | Development Genes and Evolution2005，，1： | 1 |
| 17 | Effects of untreated syphilis in the aegro male, 1932 to 1972:a closure comes to the Tuskegee study, 2004显示文摘 | Baker SM Brawley OW Marks LS | 2005 | Urology2005，65，6： | 1 |
| 18 | The Mirror Principle and morphosyntactic explanation 显示文摘 | Baker Mark | 1985 | L/ngu/st/c lnqu/ry1985，16，： | 1 |
| 19 | Physiological and molecular effects of brassinosteroids on Arabidopsis thaliana显示文摘 | Steven D. Clouse Allen F. Hall Mark Langford Trevor C. McMorris Michael E. Baker | 1993 | Journal of Plant Growth Regulation1993，，2： | 1 |
| 20 | Health literacy and knowledge of chronic disease显示文摘 | Julie A Gazmararian Mark V Williams Jennifer Peel David W Baker | 2002 | Patient Education and Counseling2002，，3： | 1 |
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