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| 1 | Optimized management of advanced hepatocellular carcinoma:Four long-lasting responses to sorafenib显示文摘The therapeutic options for hepatocellular carcinoma (HCC) have been so far rather inadequate.Sorafenib has shown an overall survival benefit and has become the new standard of care for advanced HCC.Nevertheless,in clinical practice,some patients are discontinuing this drug because of side effects,and misinterpretation of radiographic response may contribute to this.We highlight the importance of prolonged sorafenib ad-ministration,even at reduced dose,and of qualitative and careful radiographic evaluation.We observed two partial and two complete responses,one histologically confirmed,with progression-free survival ranging from 12 to 62 mo.Three of the responses were achieved following substantial dose reductions,and a gradual change in lesion density preceded or paralleled tumor shrinkage,as seen by computed tomography.This report supports the feasibility of dose adjustments to allow prolonged administration of sorafenib,and highlights the need for new imaging criteria for a more appropriate characterization of response in HCC. | Giovanni Abbadessa Lorenza Rimassa Tiziana Pressiani Cynthia Carrillo-Infante Emanuele Cucchi Armando Santoro | 2011 | World Journal of Gastroenterology2011，17，19： | 2 |
| 2 | 肩关节不稳手术的历史显示文摘肩关节不稳定对于骨科医生具有一定的挑战性,导致肩关节不稳的原因很多,历经百余年才逐渐获得了比较充分地认识。我们现在掌握的有关肩关节不稳的知识,都是以前众多患者对医学的无私奉献和历代医生的不断探索汇集而来。当我们从容地给患者做手术时,真的应该好好地感谢患者和医学前辈。本文以时间顺序介绍了历代前辈对肩关节不稳的认识过程,以及各个时期主要肩关节大师的贡献。 | 陈建海(编译) randelli p cucchi d butt u | 2016 | 中华肩肘外科电子杂志2016，4，2： | 2 |
| 3 | Thiol-peptide level and proteomic changes in response to cadmium toxicity in Oryza sativa L. roots显示文摘 | Roberta Aina Massimo Labra Pietro Fumagalli Candida Vannini Milena Marsoni Ulisse Cucchi Marcella Bracale Sergio Sgorbati Sandra Citterio | 2006 | Environmental and Experimental Botany2006，，3： | 2 |
| 4 | Spotlight on measles 2010: In- creased measles transmission in Ferrara, Italy, despite high vacci- nation coverage, March to May 2010 显示文摘 | Cova M Cucchi A Turla G | 2010 | Euro Surveill2010，15，19： | 1 |
| 5 | Higher plasma cate- cholamine and metabolite levels in the early phase of nonsegental vitiligo显示文摘 | Cucchi ML Frattini P Santagostino G | 2000 | Pigment Cell Res2000，13，： | 1 |
| 6 | Proposal for a urodynamic redefinition of detrusor underactivity显示文摘 | Cucchi A Quaglini S Rovereto B | 2009 | J Urol2009，181，1： | 1 |
| 7 | The development of detrusor instability in prostatic obstruction in relation to sequential changes in voiding dynamics 显示文摘 | Cucchi A | 1994 | Jurol1994，51，： | 1 |
| 8 | Proposal of a step-wise follow-up for hepatitis C seropositive mothers and their infants显示文摘 | Cucchi C Torcoletti M | 2003 | Pediatr Med Chir2003，25，： | 1 |
| 9 | Proposal for a urodynamic redefini- tion of detrusor underact ivity显示文摘 | Cucchi A Quaglini S Rovereto B | 2009 | J Uro12009，181，1： | 1 |
| 10 | Detrusor instability as an energysaving device in prostatic obstruction显示文摘 | Cucchi A Achilli MP Ravasi S | 1997 | J Urol1997，157，： | 1 |
| 11 | Higher plasma cate-cholamine and metabolite levels in the early phase of nonsegmental vitiligo显示文摘 | Cucchi M L Frattini P Santagostino G | 2000 | Pigment Cell Res2000，13，1： | 1 |
| 12 | Influence of the exhaust gas turbocharger on nano-scale particulate matter emissions from a GDI spark ignition engine显示文摘 | CUCCHI M SAMUEL S | 2015 | Applied Thermal Engineering2015，76，2： | 1 |
| 13 | Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes 显示文摘 | S Meini P Cucchi C Catalani | 2011 | British Journal of Pharmacology2011，162，3： | 1 |
| 14 | The expression of the mi-crosomal/peroxidase autoantigen in human thyroid cells isthyrotrophin-dependent显示文摘 | Chiovato L Vitti P Cucchi P | 1989 | Clin Exp Immunol1989，76，1： | 1 |
| 15 | Detrusor instability as an energy-saving device in prostatic obstruction显示文摘 | Cucchi A Achilli MP Ravasi S | 1997 | J Urol1997，157，3： | 1 |
| 16 | Some observations on a condition of relatively lower detrusor contractility in stable versus unstable unobstr- ucted bladders显示文摘 | Cucchi A | 1995 | Neurourol Urodyn1995，14，4： | 1 |
| 17 | Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts显示文摘 | F Bellucci P Cucchi C Catalani | 2009 | British Journal of Pharmacology2009，158，8： | 1 |
| 18 | Urinary lev- els of glycosaminoglycans in patients with idiopathic detrusor overactivity显示文摘 | Siracusano S Cucchi A Ciciliato S | 2009 | Int Urogynecol J2009，20，12： | 1 |
| 19 | The development of detrusor instability in prostatic obstructionin relation to sequential changes in voiding dynamics显示文摘 | Cucchi A | 1994 | J Urol1994，151，： | 1 |
| 20 | Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-κB pathway activation 显示文摘 | Terzuoli E Meini S Cucchi P | 2014 | PLoS One2014，9，84： | 1 |
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