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| 1 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 2 | Controlling self-assembling and tumor cell-targeting of protein-only nanoparticles through modular protein engineering显示文摘Modular protein engineering is suited to recruit complex and multiple functionalities in single-chain polypeptides. Although still unexplored in a systematic way, it is anticipated that the positioning of functional domains would impact and refine these activities, including the ability to organize as supramolecular entities and to generate multifunctional protein materials. To explore this concept, we have repositioned functional segments in the modular protein T22-GFP-H6 and characterized the resulting alternative fusions. In T22-GFP-H6, the combination of T22 and H6 promotes selfassembling as regular nanoparticles and selective binding and internalization of this material in CXCR4-overexpressing tumor cells, making them appealing as vehicles for selective drug delivery. The results show that the pleiotropic activities are dramatically affected in module-swapped constructs, proving the need of a carboxy terminal positioning of H6 for protein self-assembling, and the accommodation of T22 at the amino terminus as a requisite for CXCR4^+ cell binding and internalization. Furthermore, the failure of self-assembling as regular oligomers reduces cellular penetrability of the fusions while keeping the specificity of the T22-CXCR4 interaction.All these data instruct how multifunctional nanoscale protein carriers can be designed for smart, protein-driven drug delivery, not only for the treatment of CXCR4^+ human neoplasias, but also for the development of anti-HIV drugs and other pathologies in which CXCR4 is a relevant homing marker. | Eric Volta-Duran Olivia Cano-Garrido Naroa Serna Hector Lopez-Laguna Laura Sanchez-Garcia Mireia Pesarrodona Alejandro Sanchez-Chardi Ramon Mangues Antonio Villaverde Esther Vazquez Ugutz Unzueta | 2020 | Science China Materials2020，63，1： | 2 |
| 3 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 4 | American Society of Clinical Oncology 2009 clinical evidence review on radiofre- quency ablation of hepatic metastases from colorectal cancer 显示文摘 | Wong SL Mangu PB Choti MA et at | 2010 | J Clin Oncol2010，28，3： | 1 |
| 5 | Appropriate chemotherapy dosing for obese adult patients with cancer:American Society of Clinical Oncology clinical practice guideline显示文摘 | Griggs JJ Mangu PB Anderson H | 2012 | Journal of Clinical Oncology2012，30，13： | 1 |
| 6 | Fertility Preservation for Pa- tients With Cancer:American Society of Clinical Oncology Clinical Practice Guideline Update显示文摘 | Loren AW Mangu PB Beck LN | 2013 | J Clin Oncol2013，31，19： | 1 |
| 7 | Finding consensus in speech recognition: word error minimization and other applications of confusion networks显示文摘 | Mangu L Brill E and Stolcke A | 2000 | Computer Speech & Language2000，14，4： | 1 |
| 8 | Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene显示文摘 | Seidman I Pellicer A | 1990 | Oncogene1990，5，10： | 1 |
| 9 | Severe hypernatremia in deceased liver donors does not impact early transplant outcome显示文摘 | Mangus RS Fridell JA Vianna RM | 2010 | Transplantation2010，90，4： | 1 |
| 10 | American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation'of hepatic metastases from colorectal cancer显示文摘 | Wong SL Mangu PB Choti MA | 2010 | J Clin Oncol2010，28，： | 1 |
| 11 | Translation factors promote the formation of two states of the closed-loop mRNP 显示文摘 | Amrani N Ghosh S Mangus D A | 2008 | Nature2008，453，7199： | 1 |
| 12 | The PDL1- PD1 axis converts human Thl cells into regulatory T cells 显示文摘 | Amamath S Mangus CW Wang JC | 2011 | Sci Transl Meal2011，30，111： | 1 |
| 13 | Modular protein engineering in emerging cancer therapies显示文摘 | Vázquez E Ferrer-Miralles N Mangues R | 2009 | Curr Pharm Des2009，15，8： | 1 |
| 14 | Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival显示文摘 | Tector AJ Mangus RS Chestovich P | 2006 | Ann Surg2006，244，3： | 1 |
| 15 | Multivisceral Transplantation for Diffuse Portomesenteric Thrombosis显示文摘 | Rodrigo M. Vianna Richard S. Mangus Chandrashekhar Kubal Jonathan A. Fridell Thiago Beduschi A. Joseph Tector | 2012 | Annals of Surgery2012，，6： | 1 |
| 16 | Induction immunosuppression with thymoglobulin and rituximab in intestinal and multivisceral transplantation显示文摘 | Vianna RM Mangus RS Fridell JA | | 0，，09： | 1 |
| 17 | Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update显示文摘 | Antonio C. Wolff M. Elizabeth H. Hammond David G. Hicks Mitch Dowsett Lisa M. McShane Kimberly H. Allison Donald C. Allred John M.S. Bartlett Michael Bilous Patrick Fitzgibbons Wedad Hanna Robert B. Jenkins Pamela B. Mangu Soonmyung Paik Edith A. Perez Mi | 2013 | Journal of Clinical Oncology2013，，： | 1 |
| 18 | Appropriate chemotherapy dosing for obese adult patients with Cancer: American Society of Clinical Oncology clinical practice guideline显示文摘 | Griggs JJ Mangu PB Anderson H | 2012 | J Clin Oncol2012，30，13： | 1 |
| 19 | Translation factors promote the formation of two states of the closed-loop mRNP显示文摘 | Amrani N Ghosh S Mangus D A | 2008 | Nature2008，453，7199： | 1 |
| 20 | Follow-up care,surveillance protocol, and secondary prevention measures forsurvivors of colorectal cancer: American Society of ClinicalOncology clinical practice guideline endorsement 显示文摘 | Meyerhardt JA Mangu PB Flynn PJ | 2013 | J ClinOncol2013，31，： | 1 |
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