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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | N_2O emissions from agricultural soils in the North China Plain: the effect of chemical nitrogen fertilizer and organic manure显示文摘An enclosed chamber technique was used to measure N 2O emissions from intensively agricultural soils of the North China Plain during the periods of 1995—1996 and 1997—1998, to reflect distinct components of winter wheat and summer maize growing seasons. The results showed that the continuous application of fertilizer in agricultural soils increased N\-2O emissions by a factor of 24.1—28.1, the calculated annual chemical N fertilizer\|transformed N\-2O\|N emissions was 0.67%. Our results indicated that the application of organic manure also had a significant influence on soil N 2O emissions, which combined with the use of chemical N increased about 20% in a year. It was calculated that there were about 0.11% N of organic manure transformed as N 2O N. Annual mean N 2O emission from our study area of fertilized soils was estimated to be 57.1 μgN 2O/(m 2·h). A weak correlation was also found between N 2O emissions and soil available nitrogen content NH + 4. | DONG Yun\|she 1,2,3 , Dieter Scharffe 2, Manfred Domroes 3, QI Yu chun 1, ZHANG Shen 1 (1. Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China E\|mail: dongys@dls.iog.ac.cn 2. M | 2000 | Journal of Environmental Sciences2000，12，4： | 6 |
| 3 | Braind erived proteins as markers of acute stroke: their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring显示文摘 | MANFRED H HANNELORE E | 2003 | Restor Neurol Neurosci2003，21，34： | 1 |
| 4 | Experimental study of multiple steady states in homogeneous azeotropic distillation显示文摘 | Thomas E Gu1ttinger Cornelius Dorn Manfred Morari | 1997 | Ind Eng Chem Res1997，36，： | 1 |
| 5 | Image fusion using thee hlers spectral characteristics preservation algorithm显示文摘 | Sascha K Manfred E | | 0，，02： | 1 |
| 6 | Phytoene desaturase is localized exclusively in the chlorplast and up-regulated at the mRNA level during accumulation of secondary carotenoids in Haematococcus pluvialis (Volvocales,Chlorophyceae)显示文摘 | Manfred E Joseph H | 2000 | Plant Physiol2000，122，4： | 1 |
| 7 | Vibration control for plate-like structures using strategic cut-outs 显示文摘 | Manfred H U Semercigil S E | 2008 | Journal of Sound and Vibration2008，309，12： | 1 |
| 8 | Vibration control for plate-like structures using strategic cut-outs 显示文摘 | Manfred H U Semercigil S E | 2008 | Journal of Sound and Vibration2008，309，12： | 1 |
| 9 | Methods for the Immobilization of Lipase and Their Use for Ester Synthesis显示文摘 | Manfred P S | 1997 | Journal of Molecular Catalysis B:Enzymatic1997，3，6： | 1 |
| 10 | Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis显示文摘 | Manfred W Lyle L M Schneider E M | 1999 | Blood1999，93，2： | 1 |
| 11 | MR dacryocystography:comparison with dacryocystography and CT dacryocystography显示文摘 | Manfrè L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | | 0，，06： | 1 |
| 12 | Radical reactions on PP in the solid state显示文摘 | Manfred Ra e tzscha Manfred Arnoldb Eberhard Borsigc | 2002 | Prog Polym Sci2002，27，7： | 1 |
| 13 | Mercury sun- synchronous polar orbits using solar sail propulsion显示文摘 | Manfred E Leipold Otto Wagner | 1996 | J of Guidance Control and Dynamics1996，19，6： | 1 |
| 14 | Increased sediment ac- cumulation rates and climatic forcing in the central Andes dur- ing the late Miocene 显示文摘 | Cornelius E U Manfred R S Axel K S | 2007 | Geology2007，35，11： | 1 |
| 15 | Mixtures of hydrogen and methane in the internal combustion engine-synergies, potential and regulations显示文摘 | MANFRED K HELMUT E MARKUS S | 2012 | International journal of hydrogen energy2012，37，11： | 1 |
| 16 | Induction of mycosporine-like amino acids (MAAs) in cyanobacteria by solar ultraviolet-B radiation显示文摘 | Rajeshwar P Sinha Manfred Klisch E Walter Helbling | 2001 | Journal of Photochemistry and Photobiology B:Biology2001，60，： | 1 |
| 17 | Variable mixtures of hydrogen and methane in the internal combustion engine of a prototype vehicle : regulations, safety and potential显示文摘 | MANFRED K HELMUT E MARKUS S | 2010 | International journal of vehicle design2010，54，2： | 1 |
| 18 | Valuation of Customers in Growth Companies2a Scenario Based Model显示文摘 | Manfred K Rudolf M Sipotz E | 2011 | Schmalenbach Business Re- view2011，，57： | 1 |
| 19 | MR dacryocystography: comparison with dacryocystography and CT dacryocystography显示文摘 | Manfr L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | 2000 | AJNR Am J Neuroradiol2000，21，： | 1 |
| 20 | Estrogen receptors in the avian brain :survey reveals general distribution and forebrain areas unique to songbirds显示文摘 | Guttinger H Kroodsma E | 1993 | J Comp Neurol1993，327，： | 1 |
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