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| 1 | Implant retention after acute and hematogenous periprosthetic hip and knee infections: Whom, when and how?显示文摘Periprosthetic joint infections(PJI) of the hip and the knee are grossly classified as early post-operative, acute hematogenous and late chronic infections. Whereas two-stage exchange arthroplasty is the standard of care in North America for treating chronic infections, irrigation and debridement(I and D) with retention of implants has been used in an attempt to treat the other two types of PJIs. The rationale of this approach is that a PJI may be eradicated without the need of explanting the prostheses, as long as it has not transitioned into a chronic state. With the present paper, we review current evidence regarding the role of I and D with implant retention for treating PJIs of the hip and the knee. While a very wide range of success rates is reported in different studies, a short period of time between initiation of symptoms and intervention seems to play a prominent role with regards to a successful outcome. Moreover, pathogens of higher virulence and resistance to antibiotics are associated with a poorer result. Specific comorbidities have been also correlated with a less favorable outcome. Finally, one should proceed with serial I and Ds only under the condition that a predefined,aggressive protocol is applied. In conclusion,when treating a PJI of the hip or the knee, all the above factors should be considered in order to decide whether the patient is likely to benefit from this approach. | Georgios K Triantafyllopoulos Vasileios Soranoglou Stavros G Memtsoudis Lazaros A Poultsides | 2016 | World Journal of Orthopedics2016，7，9： | 7 |
| 2 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 3 | Erythrocyte Duffy antigen receptor for chemokines (DARC): diagnostic and therapeutic implications in atherosclerotic cardiovascular disease显示文摘动脉粥样硬化是煽动性的疾病。最后三个十年努力被作了阐明在 atherogenesis 和匾开发的过程被含有的生物化学的小径。Chemokines 是在这个过程的每步的关键调停人。另外,外部血的细胞的部件在动脉粥样硬化患者损害的形成和前进被证明调停人重要。然而,直到最近,数据主要正在集中于白血球和血小板。红血球被考虑 unreceptive 旁观者和有限数据在动脉粥样硬化患者匾的前进和 destabilization 支持了他们的重要性。通过他们为 chemokines (DARC ) 的 Duffy 抗原受体,最近,红血球作为导致 chemokine 的小径的呼吁的管理者被建议了。对每隔一 chemokine 受体 DARC 不一样从 CC 和 CXC chemokine 亚科为几 ligands 拥有高亲密关系。而且, DARC 没被联合到 G 蛋白质或任何另外的细胞内部的发信号系统;因此产生第二条消息不能。红血球 DARC 的准确生物化学的角色尚待坚定。它然而正在质问 DARC 是一个管理者的事实几乎每 CC 和 CXC chemokine ligand 并且因此, DARC 对抗能有效地堵住复杂 pre 煽动性的 chemokine 网络。在现在的评论我们提供在动脉粥样硬化通过 Duffy 抗原系统集中于 erythrocyte-chemokine 相互作用支持红血球的角色的最近的证据的目的。 | Stavros APOSTOLAKIS Georgios K CHALIKIAS Dimitrios N TZIAKAS Stavros KONSTANTINIDES | 2011 | Acta Pharmacologica Sinica2011，32，4： | 2 |
| 4 | Guidelines on the diagnosis and management of acute pulmonary embolism显示文摘 | Torbicki A Perrier A Stavros K | 2009 | G Ital Cardiol(Rome)2009，10，5： | 1 |
| 5 | Dynamics of low(1-4 cells)vs high populations of Listeria monocytogenes and Salmonella Typhimurium in fresh-cut salads and their sterile liquid or solidified extracts显示文摘 | STAVROS G M NIKOLAOS K ANTONIA S G | 2013 | Food Control2013，29，2： | 1 |
| 6 | Widespread and sustained cognitive deficits in alcoholism: a meta-analysis显示文摘 | Stavro K Pelletier J Potvin S | 2013 | Addict Biol2013，18，2： | 1 |
| 7 | Guidelines on the diagnosis and management of acute pulmonary em- bolism 显示文摘 | Torbicki A Perrier A Stavros K | 2009 | G Ital Cardiol ( Rome )2009，10，5： | 1 |
| 8 | Guidelines on the diag- nosis and management of acute pulmonary embolism显示文摘 | Adam T C Arnaud P Stavros K | 2008 | Eur Heart J2008，29，18： | 1 |
| 9 | Guidelines on the diagnosis and management of acute pulmonary embolism 显示文摘 | Torbicki A Perrier A Stavros K | 2009 | G Ital Cardiol (Rome)2009，10，5： | 1 |
| 10 | A unified classification of two-stage DEA models显示文摘 | George E H Nickolaos G T Stavros A K | 2014 | Surveys in Operations Research and Management Science2014，19，： | 1 |
| 11 | Overexpression of the Replication Licensing Regulators hCdtl and hCdc6 Characterizes a Subset of Non - Small - Cell Lung Carcinomas 显示文摘 | Panagiotis K Stavros T Leandros VV | 2004 | Am J Pathal2004，165，4： | 1 |
| 12 | Esomeprazole versus omeprazole for the eradication of helicobacter pylori Infection results of a randomized controlled study显示文摘 | George K Anagnostopoulos MD Stavros T | 2004 | J Clin Gastroentero2004，38，： | 1 |
| 13 | Estimating Power of the Scale Parameter of an Exponential Distribution with Unknown Location under Pitman's Mea,sure of Closeness显示文摘 | Stavros K | 1995 | Journal of Statistical Planning and Inference1995，，11： | 1 |
| 14 | Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism显示文摘 | STAVROS K ANNETTE G MANFRED O | 2002 | Circulation2002，106，3： | 1 |
| 15 | Decreased placental expression of hPGH, IGF - I and IGFBP - 1 in pregnancies complicated by fetal growth restriction 显示文摘 | Maria K Stavros S Apostalos Z | 2011 | Growth Horm IGF Res2011，21，1： | 1 |
| 16 | Radio frequency vacuum drying of wood (Ⅰ):Mathematical model显示文摘 | ANASTASIOS K STAVROS A SAVVAS G H | 2001 | Drying Technology2001，19，1： | 1 |
| 17 | Radio frequency vacuum drying of wood (Ⅱ):Experimental model evaluation显示文摘 | ANASTASIOS K STAVROS A SAVVAS G H | 2001 | Drying Technology2001，19，1： | 1 |
| 18 | Antiphospholipid syndrome; its implication in cardiovascular diseases; a review显示文摘 | Ioanna K Stavros NS Nikolaos GB | 2010 | Journal of Cardiothoracic Surgery2010，5，1： | 1 |
| 19 | Dccurence of semicircular canal involvement in benign paroxysmal positional Vertigo显示文摘 | Stavros K Dimitrios G | 2002 | Otoi Neurotol2002，23，6： | 1 |
| 20 | The effect of korean red ginseng extracts with escalating levels of ginsen- oside Rg3 on blood pressure in individuals with high normal blood pressure or hypertension显示文摘 | STAVRO P M HANA A K VUKSAN V | 2002 | American Journal of Hypertension2002，15，3： | 1 |
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