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1Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome显示文摘AIM: To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS: Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS: Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%.CONCLUSION: Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.Milena Todorovic Bela Balint Miodrag Jevtic Nada Suvajdzic Amela Ceric Dragana Stamatovic Olivera Markovic Maja Perunicic Slobodan Marjanovic Miodrag Krstic 2008World Journal of Gastroenterology2008,14,15:10
2Galectin-3 and IL-33/ST2 axis roles and interplay in dietinduced steatohepatitis显示文摘Immune reactivity and chronic low-grade inflammation(metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease(NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis(NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death. Experimental models of dietary-induced NAFLD/NASH in mice on different genetic backgrounds or knockout mice with different immune reactivity are used for elucidating the pathogenesis of NASH and liver fibrosis. Galectin-3(Gal-3), a unique chimera-type β-galactoside-binding protein of the galectin family has a regulatory role in immunometabolism and fibrogenesis. Mice deficient in Gal-3 develop pronounced adiposity, hyperglycemia and hepatic steatosis, as well as attenuated liver inflammation and fibrosis when fed an obesogenic high-fat diet. Interleukin(IL)-33, a member of the IL-1 cytokine family, mediates its effects through the ST receptor, which is present on immune and nonimmune cells and participates in immunometabolic and fibrotic disorders. Recent evidence, including our own data, suggests a protective role for the IL-33/IL-33R(ST2) signaling pathway in obesity, adipose tissue inflammation and atherosclerosis, but a profibrotic role in NASH development. The link between Gal-3 and soluble ST2 in myocardial fibrosis and heart failure progression has been demonstrated and we have recently shown that Gal-3 and the IL-33/ST2 pathway interact and both have a profibrotic role in diet-induced NASH. This review discusses the current evidence on the roles of Gal-3 and the IL-33/ST2 pathway and their interplay in obesity-associated hepatic inflammation and fibrogenesis that may be of interest in the development of therapeutic interventions to prevent and/or reverse obesity-associated hepatic inflammation and fibrosis.Nada Pejnovic Ilija Jeftic Nemanja Jovicic Nebojsa Arsenijevic Miodrag L Lukic 2016World Journal of Gastroenterology2016,22,44:9
3EUS mini probes in diagnosis of cystic dystrophy of duodenal wall in heterotopic pancreas:A case report显示文摘Cystic dystrophy of the duodenal wall is a rare condition characterized by the development of cysts in heterotopic pancreatic tissue localized in the duodenal wall. A 38-year-old man was admitted to the hospital for abdominal pain and vomiting after food intake. The diagnosis of acute pancreatitis was initially suspected. Abdominal ultrasound examination revealed thickening of the second portion of duodenal wall within which, small cysts (diameter, less than 1 cm) were present in the vicinity of pancreatic head.The head of pancreas appeared enlarged (63 mm×42 mm)and hypoechoic. Upper endoscopy and barium X-ray series were performed revealing a severe circumferential deformation, as well as 4 cm long stenosis of the second portion of the duodenum. CT examination revealed multiple cysts located in an enlarged, thickened duodenal wall with moderate to strong post-contrast enhancement. We suspected that patient had cystic dystrophy of duodenal wall developed in the heterotopic pancreas and diagnosis was confirmed by endoscopic ultrasound (EUS). Endoscopi cutrasound (EUS) revealed drcular stenosis from the duodenal bulb onwards. A twenty megaHertz mini-probe examination further showed diffuse (intramural) infiltration of duodenal wall limited to the submucosa and muscularis propria of the second portion of duodenum with multiple microcysts within the thickened mucosa and submucosa, a. Patient was successfully surgically treated and pancreatoduodenectomy was performed. The pathological examination confirmed a diagnosis of cystic dystrophy of a heterotopic pancreas.Endoscopic ultrasonography features allow preoperative diagnosis of cystic dystrophy of a heterotopic pancreas in duodenal wall, with inb'alumina120 MHz mini probe sonography being more efficient in cases of luminal stenosis.Ivan Jovanovic Srbislav Knezevic Miodrag Krstic Marjan Micev 2004World Journal of Gastroenterology2004,10,17:8
4Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness.Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic 2012Hepatobiliary & Pancreatic Diseases International2012,11,2:8
5Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content.■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi 2007World Journal of Gastroenterology2007,13,43:5
6Mechanism of diarrhea in microscopic colitis显示文摘AIM: To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes,osmotic gap and pH.METHODS: Seventy-six patients were included: 51 with microscopic colitis (MC) [40 with lymphocytic colitis (LC);11 with collagenous colitis (CC)]; 7 with MC without diarrhea and 18 as a control group (CG). They collected stool for 3 d. Sodium and potassium concentration were determined by flame photometry and chloride concentration by titration method of Schales. Fecal osmotic gap was calculated from the difference of osmolarity of fecal fluid and double sum of sodium and potassium concentration.RESULTS: Fecal fluid sodium concentration was significantly increased in LC 58.11±5.38 mmol/L (P<0.01)and CC 54.14±8.42 mmol/L (P<0.05) than in CG 34.28±2.98 mmol/L. Potassium concentration in LC 74.65±5.29 mmol/L (P<0.01) and CC 75.53±8.78 mmol/L (P<0.05) was significantly less compared to CG 92.67±2.99 mmol/L.Chloride concentration in CC 36.07±7.29 mmol/L was significantly higher than in CG 24.11±2.05 mmol/L (P<0.05).Forty-four (86.7%) patients had a secretory diarrhea compared to fecal osmotic gap. Seven (13.3%) patients had osmotic diarrhea.CONCLUSION: Diarrhea in MC mostly belongs to the secretory type. The major pathophysiological mechanism in LC could be explained by a decrease of active sodium absorption. In CC, decreased Cl/HCO3 exchange rate and increased chloride secretion are coexistent pathways.Marijana Protic Njegica Jojic Daniela Bojic Svetlana Milutinovic Dusanka Necic Bozidar Bojic Petar Svorcan Miodrag Krstic Obren Popovic 2005World Journal of Gastroenterology2005,11,35:5
7Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis显示文摘AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy.Tamara Alempijevic Miodrag Krstic Rada Jesic Ivan Jovanovic Aleksandra Sokic Milutinovic Nada Kovacevic Slobodan Krstic Dragan Popovic 2009World Journal of Gastroenterology2009,15,5:4
8EUS diagnosis of ectopic opening of the common bile duct in the duodenal bulb: A case report显示文摘Among the various congenital anomalies of the biliary system,an ectopic opening of the common bile duct (CBD) in the duodenal bulb is extremely rare. ERCP is essential for diagnosing the anomaly. A 55-year-old male was admitted to hospital for severe right upper quadrant abdominal pain,followed by fever, chills, elevated body temperature and mild icterus. The diagnosis of ectopic opening of CBD in the duodenal bulb was established on endoscopic ultraso-nography (EUS),which clearly demonstrated dilated CBD, with multiple stones and air in the lumen, draining into the bulb. A normal pancreatic duct, which did not drain into the bulb, was also observed. This finding was confirmed on ERCP and surgery.As far as we know, this is the first case of this anomaly diagnosed by EUS. Ectopic opening of the CBD in the duodenal bulb is not an incidental finding, but a pathologic condition which can be associated with clinical entities such as recurrent or intractable duodenal ulcer, recurrent biliary pain,choledocholithiasis or acute cholangitis. Endoscopic ultrasonography features allow preoperative diagnosis of this anomaly and can replace ERCP as a first diagnostic tool in such clinical circumstances. Embryology of the anomalies of the extrahepatic biliary tree has been also reviewed.Miodrag Krstic Bojan Stimec Radmilo Krstic Milenko Ugljesic Srbislav Knezevic Ivan Jovanovic 2005World Journal of Gastroenterology2005,11,32:4
9Right liver lobe/albumin ratio:Contribution to non-invasive assessment of portal hypertension显示文摘瞄准:学习价值生物化学并且在存在的预言和食道的静脉曲张的尺寸的 ultraso-nographic 参数。方法:学习包括经历了一个完全的生物化学的工作在上面的选择肝脏硬化症的病人,上面内视镜的 digestive 和 ultrasonographic 考试。白朊 / 权利肝脑叶直径和血小板计数 / 脾直径比率是计算的。在食道的静脉曲张的计算比率和存在和度之间的关联被评估。结果:94 个题目(62 男性, 32 女性) ,与 52.32 +/- 的吝啬的年龄 13.60 年,被学习。孩子呸班 A 占了 42.6% ,班 B 37.2% ,而班 C 20.2% 。,食道的静脉曲张(OE ) 没被上面的消化内视镜检查法在 24.5% 表明我在 22.3% 病人,被发现的 OE 等级在 33.0% 分级 II,在 16.0% 分级 III,并且分级在 4.3% 的 IV。正确的肝脑叶直径 / 白朊比率的吝啬的价值是 5.51 +/- 1.82 (从 2.76 ~ 11.44 的范围) 当吝啬的血小板计数 / 脾直径比率是 1017.75 +/- 时 729.36 (从 117.39 ~ 3362.50 的范围) 分别地。统计上重要的关联被枪兵在 OE 等级和计算比率之间的测试证明。P 价值是 0.481 并且 -0.686, 分别地。结论:正确的肝脑叶直径 / 白朊和血小板计数 / 脾直径比率是提供对食道的静脉曲张,并且他们与肝肝硬化在病人分级的存在的决心恰当的精确信息的非侵略的参数。Tamara Alempijevic Vladislava Bulat Srdjan Djuranovic Nada Kovacevic Rada Jesic Dragan Tomic Slobodan Krstic Miodrag Krstic 2007World Journal of Gastroenterology2007,13,40:4
10An aortoduodenal fistula as a complication of immunoglobulin G4-related disease显示文摘Most primary aortoduodenal fistulas occur in the presence of an aortic aneurysm,which can be part of immunoglobulin G4(IgG4)-related sclerosing disease.We present a case who underwent endovascular grafting of an aortoduodenal fistula associated with a high serum IgG4 level.A 56-year-old male underwent urgent endovascular reconstruction of an aortoduodenal fistula.The patient received antibiotics and other supportive therapy,and the postoperative course was uneventful,however,elevated levels of serum IgG,IgG4 and C-reactive protein were noted,which normalized after the introduction of steroid therapy.Control computed tomography angiography showed no endoleaks.The primary aortoduodenal fistula may have been associated with IgG4-related sclerosing disease as a possible complication of IgG4-related inflammatory aortic aneurysm.Endovascular grafting of a primary aortoduodenal fistula is an effective and minimally invasive alternative to standard surgical repair.Momir Sarac Ivan Marjanovic Mihailo Bezmarevic Uros Zoranovic Stanko Petrovic Miodrag Mihajlovic 2012World Journal of Gastroenterology2012,18,42:3
11Recent advances in assessment of soil erosion vulnerability in a watershed显示文摘Soil erosion is one of the most critical hazards adversely affecting both environment and economy.Assessment of the annual soil erosion rate provides information on soil erosion risk zones indicating the areas with high,severe and low risks.Modelling and prediction of soil erosion has a long history of more than seven decades.It becomes imperative to be familiar with the quantum of studies conducted and methods employed across the world to assess vulnerability of ecosystems to soil erosion to plan strategies for their conservation.There are several methods based on various factors like land use,soil quality,topography etc.available to assess the susceptibility of a region to soil loss.With time the gap in understanding of such models and their use around the world has increased.Numerous models for assessing soil erosion exist but there is a lack of knowledge on spatial distribution of the methods being used.Academic papers related to assessment of soil erosion vulnerability published during the past three decades(1991—2019)were reviewed.Total 160 studies were reviewed to understand advances in the methods used to assess soil erosion vulnerability worldwide,identification of the most popular methods and proportion of studies conducted in the fragile region of Himalayas.The results show that 18 different methods have mainly been used to assess soil erosion risk in different regions.These methods include statistical,physical,process based and empirical models.The use of few physical methods like ANSWERS and SHE has decreased with time while that of physical and process methods like RUSLE,SWAT,WEPP and PESERA has increased with time.The review highlighted that various models being used worldwide are based on their suitability to the region.It also brings to attention that few models like PESERA,EUROSEM and WEPP are mostly being used concentrated in a particular region.Models like PESERA and EPM are mostly used in European region and may be encouraged to estimate soil erosion in Himalayan region.The review also highlights lack of studies with inclusion of water quality as an important parameter while assessing soil erosion vulnerability in the region.The review suggests that in case of lack of data,various statistical methods like PCA,CF,FUZZY etc can be preferred for qualitative assessment over quantitative assessment Considering availability of accurate input,researchers need to attempt more methods and perform comparative studies to attain accurate results for assessing soil erosion vulnerability leading to strategizing soil conservation in fragile regions.Shachi Pandey Parmanand Kumar Miodrag Zlatic Raman Nautiyal Vijender Pal Panwar 2021International Soil and Water Conservation Research2021,9,3:2
12用传统和超声提取的松果菊(紫锥菊属)的抗氧化和抗菌活性(英文)显示文摘Antioxidant and antimicrobial activities of Echinacea purpurea L. (Asteraceae) extracts obtained by classical and ultrasound solvent extraction were compared. The dry aerial part of plant was extracted by 70% etha-nol at a solid-to-liquid ratio of 1︰10 (m/v) and 25°C. The extract obtained by classical solvent extraction contained 29% larger amounts of phenolic compounds and 20% higher content of flavonoids. 2,2-diphenyl-1-picril hydrazyl radical (DPPH) scavenging reached 93.6% and the values of EC50 were (34.16±0.65) μg·ml-1 and (65.48±1.12) μg·ml-1 for the extracts obtained by the classical and ultrasound extractions, respectively. The extracts, independent of the extraction technique applied, showed a considerable growth inhibition on Candida albicans and Saccharo-myces cerevisiae, while no growth inhibition zones were observed for Aspergillus niger. The diameters of inhibition zone observed for all the microorganisms were larger for extracts obtained by classical extraction than those by ul-trasound extraction.Ivana Stanisavljevi Sаa Stojievi Dragan Velikovi Vlada Veljkovi Miodrag Lazi 2009Chinese Journal of Chemical Engineering2009,17,3:2
13Interleukin‐33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells显示文摘Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Jelena M. Pantic Marija Z. Milovanovic Nebojsa N. Arsenijevic Miodrag L. Lukic 2014Int. J. Cancer2014,,:2
14Meta-analysis of stent thrombosis after drug-eluting stent implantation: 4-year follow-up显示文摘背景 Drug-eluting stents (DES ) 是在冠的动脉疾病的经皮的治疗使用的最普通的设备。最近,关于他们的安全侧面有一颗增加的担心,与赤裸的金属 stents (BMS ) 相比的特别地晚并且很迟了的 stent 血栓率。学习的目的是近来并且很晚比较报导发生在从有到四 years.Methods 的一个扩大后续时期的出版临床的研究的病人的 DES 和 BMS 的 stent 血栓搜索策略被开发识别在 BMS 和可得到的 DES 的晚或很迟了的血栓上报导的出版物通过 MEDLINE 和 Cochrane 图书馆数据库。二个独立评论家估价了合格研究并且提取了数据。机会比率(或) 为每结果被计算并且与 95% 信心间隔(CI ) 介绍了 .Results 十四使随机化控制试用,是使失明的至少单身者,被识别。近来在发生没有差别,在病人的很迟了的 stent 血栓与与 BMS 对待的病人相比与 DES 对待(迟了或 0.55, 95%Cl 0.23-1.31 和晚 / 很迟了的 OR=1.08, 95%CI 0.61-1.91 ).Conclusions 安全侧面 DES 以 stent 血栓类似于 BMS。我们没近来并且很晚发现增加的风险的证据为 DES 的血栓。Natasa M Milic Biljana J Parapid Miodrag C Ostojic Milan A Nedeljkovic Jelena M Marinkovic 2010Chinese Medical Journal2010,,24:2
15Numerical algorithm for rigid body position estimation using the quaternion approach显示文摘This paper deals with rigid body attitude estimation on the basis of the data obtained from an inertial measurement unit mounted on the body. The aim of this work is to present the numerical algorithm, which can be easily applied to the wide class of problems concerning rigid body positioning, arising in aerospace and marine engineering, or in increasingly popular robotic systems and unmanned aerial vehicles. Following the considerations of kinematics of rigid bodies, the relations between accelerations of different points of the body are given. A rotation matrix is formed using the quaternion approach to avoid singularities. We present numerical procedures for determination of the absolute accelerations of the center of mass and of an arbitrary point of the body expressed in the inertial reference frame, as well as its attitude. An application of the algorithm to the example of a heavy symmetrical gyroscope is presented, where input data for the numerical procedure are obtained from the solution of differential equations of motion, instead of using sensor measurements.Miodrag Zigic Nenad Grahovac 2018Acta Mechanica Sinica2018,34,2:2
16Adenosquamous carcinoma arising within a retrorectal tailgut cyst: Report of a case显示文摘Retrorectal, developmental tail gut cysts, include dermoid cysts, rectal duplication cysts and retrorectal cyst-hamartomas. Retrorectal cyst-hamartomas (RCH) are derived from remnants of the tail gut, the most caudal part of the embryonic hind gut, which normally involutes by the 8th wk of embryonic development (3-8 mm stage). They have specific radiological and histopathological features that distinguish them from other similar formations (dermoid cysts, enteric duplication cysts and teratomas). We report a patient with adenosquamous carcinoma arising within RCH, who underwent complete resection of the cyst through anterior laparotomy, and reached complete (recurrencefree for 14 mo, so far) functional recovery. The cyst was incidentally discovered during hysterectomy 12 years ago.Diagnostic, therapeutic and histopathological aspects of this rare case are discussed. The mentioned period between diagnosis and surgical treatment suggests that RCH, given enough time, can develop malignant degeneration, and should be resected at the time of diagnosis.Zoran Krivokapic Ivan Dimitrijevic Goran Barisic Velimir Markovic Miodrag Krstic 2005World Journal of Gastroenterology2005,11,39:2
17Integration of RFID and Wireless Sensor Networks显示文摘Radio Frequency Identification (RFID) and Wireless Sensor Network (WSN) are two important wireless technologies that have wide variety of applications and provide limitless future potentials. However,RFID and sensor networks almost are under development in parallel way. Integration of RFID and wireless sensor networks attracts little attention from research community. This paper first presents a brief introduction on RFID,and then investigates recent research works,new products/patents and applications that integrate RFID with sensor networks. Four types of integration are discussed. They are integrating tags with sensors,integrating tags with wireless sensor nodes,integrating readers with wireless sensor nodes and wire-less devices,and mix of RFID and sensors. New challenges and future works are discussed in the end.Miodrag Bolic Amiya Nayak Ivan Stojmenovi. 2007射频世界2007,,6:2
18ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma显示文摘Ivan Jovanovic Gordana Radosavljevic Maja Mitrovic Vanda Lisnic Juranic Andrew N. J. McKenzie Nebojsa Arsenijevic Stipan Jonjic Miodrag L. Lukic 2011Eur. J. Immunol2011,,:2
19Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma显示文摘AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed.RESULTS: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P<0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P>0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings.Rajko Milosevic Milena Todorovic Bela Balint Miodrag Jevtic Miodrag Krstic Elizabeta Ristanovic Nebojsa Antonijevic Mirjana Pavlovic Maja Perunicic Milan Petrovic Biljana Mihaljevic 2009World Journal of Gastroenterology2009,15,32:2
20IL-33/ST2 axis in innate and acquired immunity to tumors显示文摘Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Nebojsa N. Arsenijevic Miodrag L. Lukic 2012OncoImmunology2012,,:2
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