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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine 显示文摘 | Pisarev VM Parajuli P Mosley RL | 2000 | Int J Immunopharmacol2000，22，11： | 2 |
| 3 | LPA Receptors: Subtypes and Biological Actions显示文摘 | Ji Woong Choi Deron R. Herr Kyoko Noguchi Yun C. Yung Chang-Wook Lee Tetsuji Mutoh Mu-En Lin Siew T. Teo Kristine E. Park Alycia N. Mosley Jerold Chun | 2010 | Annual Review of Pharmacology and Toxicology2010，，： | 2 |
| 4 | Delimitation of New Zealand hydrological regions显示文摘 | | 1981 | Journal of Hydrology1981，49，： | 1 |
| 5 | Molecu- lar-cloning of the interleukin-l-Beta converting znzyme显示文摘 | Cerretti D P Kozlosky C J Mosley B | 1992 | Science1992，256，： | 1 |
| 6 | The cardiovascular dose-response efects of isoflurane alone and combined with butorphanol in the green iguana( Iguana iguana)显示文摘 | Mosley CA Dyson D Smith DA | 2004 | Vet Anaesth Analg2004，31，1： | 1 |
| 7 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R B GREENWELL D J SPARKS L E | | 0，，01： | 1 |
| 8 | HCV viral load in anti- HCV- positive donors and ter outcome in their recipients显示文摘 | Operskalski EA Mosley JW | 2001 | Transfusion2001，41，9： | 1 |
| 9 | Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes 显示文摘 | Mosley WJ Greenland P Garside DB | 2007 | Hypertension2007，49，6： | 1 |
| 10 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 11 | Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes显示文摘 | Mosley WJ Greenland P Garside DB | 2007 | Hypertension2007，49，6： | 1 |
| 12 | Cardiovascular risk factors and cognitive decline in middle-aged adults 显示文摘 | Knopman D Boland LL Mosley T | 2001 | Neurology2001，56，1： | 1 |
| 13 | Fourteen-year longitudi- nal study of vascular risk factors, APOE genotype, and cognition : the ARIC MRI Study显示文摘 | Knopman DS Mosley TH Catellier DJ | 2009 | Alzheimers Dement2009，5，3： | 1 |
| 14 | Heme oxygenase is induced in nephrotoxic nephritis and hemin,a stimulator of heme oxygenase synthesis,ameliorates disease显示文摘 | Mosley K Wembridge DE Cattell V | 1998 | Kidney Int1998，53，3： | 1 |
| 15 | Predictive u-tility of pulse pressure and other blood pressure measures forcardiovascular outcomes 显示文摘 | Mosley WJ Greenland P Garside DB | 2007 | Hypertension2007，49，6： | 1 |
| 16 | Folic acid and the decline in neural tube defects in Arkansas显示文摘 | Mosley BS Hobbs CA Flowers BS | | 0，，： | 1 |
| 17 | Effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosley A R Shock C C Stieber T D | | 0，，： | 1 |
| 18 | Cardiovascular risk factors and cerebral atrophy in a middle- aged cohort 显示文摘 | Knopman DS Mosley TH Catellier DJ | 2005 | Neurology2005，65，6： | 1 |
| 19 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R GREENWELL D SPARKSL L | 2001 | Aerosol Science&Technology2001，34，1： | 1 |
| 20 | Time course of diffusion imaging abnormalities in human stroke 显示文摘 | WARACH S MOSLEY M SORENSEN A G | 1996 | Stroke1996，27，7： | 1 |
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