|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R B GREENWELL D J SPARKS L E | | 0，，01： | 1 |
| 3 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 4 | Effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosley A R Shock C C Stieber T D | | 0，，： | 1 |
| 5 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R GREENWELL D SPARKSL L | 2001 | Aerosol Science&Technology2001，34，1： | 1 |
| 6 | Charge measurements on individua individual particles exiting laboratory precipiators with positive and negative corona at various temperatures显示文摘 | McDonald J R Anderson M H Mosley R B | 1980 | J Appl Phy1980，51，： | 1 |
| 7 | Constraints to the potential impact of child survival in developing countries显示文摘 | Gadomski A Black R Mosley H | 1990 | Health Policy Plan1990，5，3： | 1 |
| 8 | Neuroinflammation,oxidative stress,and the pathogenesis of Parkinson's disease显示文摘 | Mosley R L Benner E J Kadiu I | 2006 | Clin Neurosci Res2006，6，： | 1 |
| 9 | Ivory Crisp: a potato variety with high tuber solids and cold chipping ability 显示文摘 | Love S L Mosley A R Novy R | 2003 | American Journal of Potato Research2003，80，： | 1 |
| 10 | Innate and adaptive immunity for the pathobiology of Parkinson's disease显示文摘 | Stone D K Reynolds A D Mosley R L | 2009 | Antioxid Redox Signal2009，11，： | 1 |
| 11 | Maitenance Scheduling and Staffing Policies in A Wafer Fabrication Facility显示文摘 | Mosley S A Teyner T Uzsoy R M | 1998 | IEEE Transactions Semiconductor Manufactory1998，11，： | 1 |
| 12 | Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease显示文摘 | Benner E J Mosley R L Destache C J | 2004 | Pro Natl Acad Sci USA2004，101，： | 1 |
| 13 | Retinal microvascular signs and 10-year risk of cerebral atrophy:the Atherosclerosis Risk in Communities(ARIC)study显示文摘 | Kawasaki R Cheung N Mosley T | 2010 | Stroke2010，41，8： | 1 |
| 14 | Can Crop Insurance Work? The Case of India显示文摘 | MOSLEY PAULKRISHNAMURTHY R | 1995 | The Journal of Development Studies1995，，3： | 1 |
| 15 | The effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | ELDREDGE E P HOLMES Z A MOSLEY A R | 1996 | Am Potato J1996，73，： | 1 |
| 16 | Urinary proteomic profiles distinguish between active and inactive lupus nephritis显示文摘 | Mosley K Tam F W Edwards R J | 2006 | Rheumatology(Oxford)2006，45，12： | 1 |
| 17 | Penetration of ambient fine particles into the indoor environment 显示文摘 | Mosley R B Greenwell L E Sparks L E | 2001 | Aerosol Science and Technology2001，34，： | 1 |
| 18 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R B GREENWELL D J SPARKS L E | 2001 | Aerosol Science and Technology2001，34，1： | 1 |
| 19 | Association of Ambulatory Blood Pressure With Ischemic Brain Injury显示文摘 | Schwartz G L Bailey K R Mosley T | 2007 | Hypertension2007，49，6： | 1 |
| 20 | Penetration of Ambient Fine Particles into the Indoor Environment显示文摘 | Mosley R B Greenwell D J Sparks L E | 2001 | Aerosol Science & Technology2001，34，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员