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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Delimitation of New Zealand hydrological regions显示文摘 | | 1981 | Journal of Hydrology1981，49，： | 1 |
| 3 | Time course of diffusion imaging abnormalities in human stroke 显示文摘 | WARACH S MOSLEY M SORENSEN A G | 1996 | Stroke1996，27，7： | 1 |
| 4 | Hydrogen peroxide concentrations in relation to optical properties in a fiord ( Doubtful Sound, New Zealand) 显示文摘 | Peake B M Mosley L M | 2004 | New Zealand Journal of Marine and Freshwater Research2004，38，4： | 1 |
| 5 | Flow requirements for recreation and wildlife in New Zealand rivers-a review显示文摘 | MOSLEY M P | 1983 | Journal of Hydrology1983，22，2： | 1 |
| 6 | Charge measurements on individua individual particles exiting laboratory precipiators with positive and negative corona at various temperatures显示文摘 | McDonald J R Anderson M H Mosley R B | 1980 | J Appl Phy1980，51，： | 1 |
| 7 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | J Lipid Res2002，43，： | 1 |
| 8 | Isomerization of stable isotopically labeled elaidic acid to cis and trails monoenes by ruminal microbes显示文摘 | PROELL J M MOSLEY E E POWELL G L | 2002 | J Lipid Res2002，43，12： | 1 |
| 9 | Partnering guidelines for winwin project management显示文摘 | Moore C Mosley D Slagle M | | 0，，01： | 1 |
| 10 | Treatment of leukoaraiosis 显示文摘 | Schwartz GL Fornage M Mosley T | 2005 | Curr Treat Options Cardiovasc Med2005，7，： | 1 |
| 11 | The impact of ambulance practice on acute stroke care 显示文摘 | Mosley I Nicol M Donnan G | 2007 | Stroke2007，38，10： | 1 |
| 12 | Maitenance Scheduling and Staffing Policies in A Wafer Fabrication Facility显示文摘 | Mosley S A Teyner T Uzsoy R M | 1998 | IEEE Transactions Semiconductor Manufactory1998，11，： | 1 |
| 13 | Pollutant Loads Returned to the Lower Murray River from Flood-Irrigated Agriculture显示文摘 | Mosley L M Fleming N | 2010 | Water Air & Soil Pollution2010，211，14： | 1 |
| 14 | Microbial biohydrogenation of oleic acid to trans isomers in vitro 显示文摘 | E E Mosley G L Powell M B Riley | 2002 | Lipid Research2002，43，： | 1 |
| 15 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | Journal of Lipid Research2002，43，： | 1 |
| 16 | Isomerization of stable isotopically labeled elaidic acid to cis andtrans monoenes by ruminal microbes显示文摘 | Proell J M Mosley E E Powell G L | 2002 | J Lipid Res2002，43，： | 1 |
| 17 | Isomerization of stable isotopically labeled elaidic acid to cis and trans monoenes by ruminal microbes 显示文摘 | PROELL J M MOSLEY E E POWELL G L | 2002 | J Lip Res2002，43，： | 1 |
| 18 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | MOSLEY E E POWELL G L RILEY M B | 2002 | J Lip Res2002，43，： | 1 |
| 19 | Experimental Non-linear Dynamics of a Shape Memory Alloy Wire Bundle Actuator显示文摘 | Mosley M J Mavroidis C | 2001 | Journal of Dynamic Systems Meas- urement and Control(Transactions of the ASME)2001，123，1： | 1 |
| 20 | Stroke symptoms and the deci- sion to call for an ambulance显示文摘 | Mosley l Nicol M Donnan G | 2007 | Stroke2007，38，2： | 1 |
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