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| 1 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 2 | The cardiovascular dose-response efects of isoflurane alone and combined with butorphanol in the green iguana( Iguana iguana)显示文摘 | Mosley CA Dyson D Smith DA | 2004 | Vet Anaesth Analg2004，31，1： | 1 |
| 3 | 1 -Butyl- 3 - methylimidazolium cobalt tetracarbonyl :a catalytically active organometallic ionic liquid 显示文摘 | Brown R J C Dyson P J Ellis D J | 2001 | Chem Commun2001，，18： | 1 |
| 4 | High rates of child hypertension associated with obesity: a community survey in China,India and Mexico 显示文摘 | Dyson PA Anthony D Fenton B | 2014 | Paediatr Int Child Health2014，34，1： | 1 |
| 5 | Ham- string tendon grafts for reconstruction of the anterior cruciate ligament: Biomechanical evaluation of the use of multiple strands and tensioning techniques 显示文摘 | DYSON L HAMNER M D CHARLES H | 1999 | The Journal of Bone and Joint Surgery1999，81，4： | 1 |
| 6 | Breast feeding promotionfor infants in neonatal units:a systematic review and economicanalysis显示文摘 | Renfrew MJ Craig D Dyson L | 2009 | Health Technol Assess2009，13，40： | 1 |
| 7 | Liquid bridges between cylinders, in a torus and between spheres 显示文摘 | Erie M A Dyson D C Morrow N R | 1971 | AICHE Journal1971，17，： | 1 |
| 8 | Arene hydrogenation in a room - temperature ionic liquid using a ruthenium cluster catalyst显示文摘 | DYSON P J ELLIS D J PARKER D G | 1999 | Chem Commun1999，1，： | 1 |
| 9 | Foot pain and the elusive diagnosis 显示文摘 | Dyson S Marks D | 2003 | Vet Clin Noah Am Equine Pract2003，19，2： | 1 |
| 10 | Analysis of oocyst wall and sporozoite antigens from three Cryptosporidium species显示文摘 | NINA J M MCDONALD V DYSON D A | 1992 | Infect Immun1992，60，4： | 1 |
| 11 | The application of acoustic emission for detecting incipient cavitation and the best efficiency of a 60 kW centrifugal pump: case study显示文摘 | ALFAYEZ L MBA D DYSON G | 2005 | NDT&E International2005，，38： | 1 |
| 12 | 显示文摘 | Ellis D J Papker D G | 1999 | Chem Commun1999，64，1： | 1 |
| 13 | An analysis of the effects of nutrient supply on the growth of potato crops显示文摘 | Dyson P W D J Watson | 1971 | Annals of Botany1971，69，： | 1 |
| 14 | The application of acoustic emission for detecting incipient cavitation and the best efficiency of a 60 kW centrifugal pump: ease study显示文摘 | Alfayez I Mba D Dyson D | 2005 | NDT & E International2005，38，： | 1 |
| 15 | The applica- tion of acoustic emission for detection incipient cavi- tation and the best efficiency point of a 60 kW cen- trifugal: Case study显示文摘 | ALFAYEZ L MBA D DYSON G | 2005 | NDT and E International2005，38，5： | 1 |
| 16 | Arene hydrogenation in a room- temperature ionic liquid using a ruthenium cluster catalyst 显示文摘 | DYSON P J ELLIS D J PARKER D G | 1999 | Chem Commun1999，，1： | 1 |
| 17 | Arene hydrogenation in a room-temperature ionic liquid using a ruthenium cluster catalyst 显示文摘 | Dyson P J Ellis D J Parker D G | 1999 | Chem Commun1999，64，1： | 1 |
| 18 | Circulating fibroblast growth factor 21 is induced by peroxisome pro- liferator-activated receptor agonists but not ketosis in man 显示文摘 | Christodoulides C Dyson P Sprecher D | 2009 | J Clin Endocrinol Metab2009，94，9： | 1 |
| 19 | The E2F transcriptional network:old acquaintances with new faces显示文摘 | Dimova D K Dyson N J | 2005 | Oncogene2005，24，17： | 1 |
| 20 | 1 - Butyl - 3 -methylimidazolium cobalt tetracarbonyl : a catalytically active organometallic ionic liquid 显示文摘 | BROWN R J C DYSON P J ELLIS D J | 2001 | Chem Commun2001，，18： | 1 |
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