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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt显示文摘We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved. | Hiromichi Ishii Teruhisa Sonoyama Shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Toshiya Ochiai Yukihito Kokuba Chohei Sakakura Eigo Otsuji | 2010 | World Journal of Gastroenterology2010，16，25： | 11 |
| 3 | Quantitative investigation on collapse margin of steel high-rise buildings subjected to extremely severe earthquakes显示文摘Reponses of structures subjected to severe earthquakes sometimes significantly surpass what was considered in the design.It is important to investigate the failure mechanism and collapse margin of structures beyond design,especially for high-rise buildings.In this study,steel high-rise buildings using either square concrete-filled-tube(CFT) columns or steel tube columns are designed.A detailed three-dimensional(3 D) structural model is developed to analyze the seismic behavior of a steel high-rise towards a complete collapse.The effectiveness is verified by both component tests and a full-scale shaking table test.The collapse margin,which is defined as the ratio of PGA between the collapse level to the design major earthquake level(Level 2),is quantified by a series of numerical simulations using incremental dynamic analyses(IDA).The baseline building using CFT columns collapsed with a weak first story mechanism and presented a collapse margin ranging from 10 to 20.The significant variation in the collapse margin was caused by the different characteristics of the input ground motions.The building using equivalent steel columns collapsed earlier due to the significant shortening of the locally buckled columns,exhibiting only 57% of the collapse margin of the baseline building.The influence of reducing the height of the first story was quite significant.The shortened first story not only enlarged the collapse margin by 20%,but also changed the collapse mode. | Lin Xuchuan Mikiko Kato Zhang Lingxin Masayoshi Nakashima | 2018 | Earthquake Engineering and Engineering Vibration2018，17，3： | 9 |
| 4 | Earthquake engineering research needs in light of lessons learned from the 2011 Tohoku earthquake显示文摘Earthquake engineering research and development have received much attention since the first half of the twentieth century. This valuable research presented a huge step forward in understanding earthquake hazard mitigation,which resulted in appreciable reduction of the effects of past earthquakes. Nevertheless,the 2011 Tohoku earthquake and the subsequent tsunami resulted in major damage. This paper presents the timeline of earthquake mitigation and recovery,as seen by the authors. Possible research directions where the authors think that many open questions still remain are identified. These are primarily based on the important lessons learned from the 2011 Tohoku earthquake. | Masayoshi Nakashima Oren Lavan Masahiro Kurata Yunbiao Luo | 2014 | Earthquake Engineering and Engineering Vibration2014，13，S1： | 4 |
| 5 | Flexible substructure online hybrid test system using conventional testing devices显示文摘This paper presents a substructure online hybrid test system that is extensible for geographically distributed tests.This system consists of a set of devices conventionally used for cyclic tests to load the tested substructures onto the target displacement or the target force.Due to their robustness and portability,individual sets of conventional loading devices can be transported and reconfigured to realize physical loading in geographically remote laboratories.Another appealing feature is the flexible displacement-force mixed control that is particularly suitable for specimens having large disparities in stiffness during various performance stages.To conduct a substructure online hybrid test,an extensible framework is developed,which is equipped with a generalized interface to encapsulate each substructure.Multiple tested substructures and analyzed substructures using various structural program codes can be accommodated within the single framework,simply interfaced with the boundary displacements and forces.A coordinator program is developed to keep the boundaries among all substructures compatible and equilibrated.An Internet-based data exchange scheme is also devised to transfer data among computers equipped with different software environments.A series of online hybrid tests are introduced,and the portability,flexibility,and extensibility of the online hybrid test system are demonstrated. | Wang Tao Masayoshi Nakashima | 2013 | Earthquake Engineering and Engineering Vibration2013，12，3： | 2 |
| 6 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | Virol2012，，2： | 1 |
| 7 | Lateral Instabil ity and Lateral Bracing of Steel Beams Subjected to Cyclic Loading 显示文摘 | Masayoshi Nakashima lori Kanao Liu Dawei | 2002 | Journal of Structural Engineering2002，128，10： | 1 |
| 8 | Research and application of buckling- restrained braced frames 显示文摘 | Uang Chic-Ming Nakashima Masayoshi Tsai KehChyuan | 2004 | Steel Structures2004，82，4： | 1 |
| 9 | Online test using displacement-force mixed control 显示文摘 | Pan Peng Nakashima Masayoshi Tomofuji Hiroshi | 2005 | Earthquake Engineering and Structural Dynamics2005，34，8： | 1 |
| 10 | Steel Moment Frame for Earthquake in United and Japan显示文摘 | Masayoshi Nakashima Charles W Roeder | 2000 | Journal of Structural2000，126，8： | 1 |
| 11 | Seismic resistance capacity of high-rise buildings subjected to long-period ground motions: E-defense shaking table test 显示文摘 | Chung Yu-lin Nagae Takuya Hitaka Toko Nakashima Masayoshi | 2010 | Journal of Structural Engineering2010，136，6： | 1 |
| 12 | Seismic resistance capacity of high-rise buildings subjected to long-period ground motions: E-Defense shaking table test 显示文摘 | Chung Yu-Lin Nagae Takuya Hitaka Toko Nakashima Masayoshi | 2010 | Journal of Structural Engineering2010，136，6： | 1 |
| 13 | Steel moment frame for earthquake in united and japan显示文摘 | Masayoshi Nakashima Charles W Roeder | 2000 | Journal of Structural2000，126，8： | 1 |
| 14 | Comparison of European and Japanese seismic design of steel building structures 显示文摘 | EDOARDO M MARINO MASAYOSHI NAKASHIMA KHALID M MOSALAM | 2005 | Engineering Structures2005，，27： | 1 |
| 15 | Online test using displacement-force mixed control 显示文摘 | Pan Peng Masayoshi Nakashima Hiroshi Tomofuji | 2005 | Earthquake Engineering and Structural Dynamics2005，34，8： | 1 |
| 16 | Instabilityand complete failure of steel columns subjected to cyclicloading显示文摘 | Nakashima Masayoshi ASCE M Liu Dawei | 2005 | Journal of Engineering Mechanics2005，131，6： | 1 |
| 17 | Damping identification of a full‐scale passively controlled five‐story steel building structure显示文摘 | Xiaodong Ji Tsuyoshi Hikino Kazuhiko Kasai Masayoshi Nakashima | 2012 | Earthquake Engng Struct Dyn2012，，2： | 1 |
| 18 | Online test using displacement-force mixed control显示文摘 | PAN Peng Masayoshi Nakashima Hiroshi Tomofuji | 2005 | Earthquake Engineering and Structural Dynamics2005，34，： | 1 |
| 19 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | J. Med. Virol2012，，2： | 1 |
| 20 | Identification of non-small-cell lung cancer with activating EGFR mutations in malignant effusion and cerebrospinal fluid: Rapid and sensitive detection of exon 19 deletion E746-A750 and exon 21 L858R mutation by immunocytochemistry显示文摘 | Akihiko Kawahara Koichi Azuma Akiko Sumi Tomoki Taira Kazutaka Nakashima Emiko Aikawa Hideyuki Abe Tomohiko Yamaguchi Shinzo Takamori Jun Akiba Masayoshi Kage | 2011 | Lung Cancer2011，，1： | 1 |
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