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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | The long-term pathological evolution of chronic hepatitis C显示文摘 | M Yano H Kumada M Kage K Ikeda K Shimamatsu O Inoue E Hashimoto JH Lefkowitch J Ludwig K Okuda | 1996 | Hepatology1996，，6： | 2 |
| 3 | C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance显示文摘 | Imai Y Nakane M Kage K | 2002 | Mol Cancer Ther2002，1，8： | 1 |
| 4 | Propsal of a new nomencla ture for Budd- Chiari syndrome: hepatic vein thrombosis versus thrombsis of the inferior vena cava at its hepatic portion 显示文摘 | Okuda K Kage M Shrstha SM | 1998 | Hepatlogy1998，28，5： | 1 |
| 5 | Numerical study of compression waves produced by high-speed train entering a tunnel 显示文摘 | Kage K | 1993 | Transactions of Japan Society of Mechanical Engineers(B)1993，59，： | 1 |
| 6 | Dominant-negative inhibition of breast cancer resistance protein as drug efllux pump through the inhibition of S-S dependent homodimerization 显示文摘 | Kage K Tsukahara S Sugiyama T | 2002 | Int J Cancer2002，97，5： | 1 |
| 7 | Dominant-negative inhibi- tion of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization显示文摘 | Kage K Tsukahara S Sugiyama T | 2002 | IntJ Cancer2002，97，5： | 1 |
| 8 | The long -term pathological evolution of chronic hepatitis C显示文摘 | YANO M KUMADA H KAGE M | 1996 | Hepatology1996，23，： | 1 |
| 9 | Efficiencies of CaO/H20/Ca(OH)2 chemical heat pump for heat storing and heating/cooling显示文摘 | Ogura H Yamamoto T Kage H | 2003 | Energy2003，28，14： | 1 |
| 10 | HIV-related stigma and symptoms of post-traumatic stress disorder and depression in HIV-infected individuals: does social support play a mediating or moderating role? 显示文摘 | Breet E Kagee A Seedat S | 2014 | AIDS Care2014，26，8： | 1 |
| 11 | Histopathology of membranous obstruction of the in ferior vena cave in the Budd - Chiari syndrome显示文摘 | Kage M Arakawa M Kojiro M | 1992 | Castroenterology1992，102，6： | 1 |
| 12 | Identification by Proteomic Analysis of Calreticulin as a Marker for Bladder Cancer and Evaluation of the Diagnostic Accuracy of Its Detection in Urine显示文摘 | Kage Y Iwa K Wakaba Y | 2004 | Clin Chem2004，50，： | 1 |
| 13 | Numerical Study of Interaction of Propagated Shock with Boundary Layer Behind Contact Surface in Ducts显示文摘The interactions of the shock with the boundary layer of the cold gas behind the contact in many different conditions.i.e. three kinds of test gases and three kinds of sound speed ratios across the contact,were explored by numerical study.The trajectories of the transmitted shock in cold gas flow and the development of shock bifurcation in the process of interaction with boundary layer are illustrated by many kinds of figures(e.g.the time-distance diagrams of the acoustic impedance contours on the axis,the pressure and density contours and the static pressure distributions on the axis.). | Kazuyuki Kage Katsuya Ishimatsu Toyoyasu Okubayashi | 2003 | Journal of Thermal Science2003，12，1： | 1 |
| 14 | Image analysis of irrqularity of cluster shape in cytological diagnosis of breast tumors : cluste analysis with 2D-fractar dimension 显示文摘 | Yokoyama T Kawhara A Kage M | 2005 | Diagn Ctopathol2005，33，2： | 1 |
| 15 | Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat显示文摘 | Karen Kage Wende Niforatos Chang Z. Zhu Kevin J. Lynch Prisca Honore Michael F. Jarvis | 2002 | Experimental Brain Research2002，，4： | 1 |
| 16 | Role of Cys-603 in dimmer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2显示文摘 | Kage K Fujita T Sugimoto Y | 2005 | Cancer Sci2005，96，12： | 1 |
| 17 | Proposal of a new nomenclature for Budd-Chiari syndrome:hepatic vein thrombosis versus thrombosis of the inferior vena cava at its hepatic portion显示文摘 | Okuda K Kage M Shrestha S M | 1998 | Hepatology1998，28，5： | 1 |
| 18 | Pathomorhologie characteristics of small hepatocellular carcinoma:a special referenee to small hepatocellular carcinoma with indistinct margins显示文摘 | Nakashima O Sugihara S Kage M | 1995 | Hepatolugy1995，22，1： | 1 |
| 19 | A Study on Characteristic of Pressure Reduction of Compressed Air in a Long Pipe 显示文摘 | Hiroshi TANAKA lzumi HASEGAWA Kazuyuki KAGE etal | 1988 | Nippon Kikai Gakkai Rombunshu B Hen1988，52，481： | 1 |
| 20 | Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimeriza-tion 显示文摘 | Kage K Tsukahara S Sugiyama T | 2002 | Int J Cancer2002，97，： | 1 |
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