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| 1 | Estimation of Three-Dimensional Volumetric Errors of Numerically Controlled Machine Tools by a Tracking Interferometer显示文摘 | Soichi Ibaraki Kunitaka Takeuchi Tomoaki Yano Toshiyuki Takatsuji Sonko Osawa Osamu Sato | 2011 | Journal of Mechanics Engineering and Automation2011，1，4： | 4 |
| 2 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 3 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | Virol2012，，2： | 1 |
| 4 | Current status and challenges of the japanese paper industry显示文摘 | Kunitaka Toyofuku | 2010 | IPW2010，，3： | 1 |
| 5 | A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice显示文摘 | Emi Nakashima Akiko Oya Yuri Kubota Naomi Kanada Ryo Matsushita Kazuyoshi Takeda Fujio Ichimura Kouji Kuno Naofumi Mukaida Kunitaka Hirose Isao Nakanishi Toshimitsu Ujiie Kouji Matsushima | 1996 | Pharmaceutical Research1996，，12： | 1 |
| 6 | Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells显示文摘 | Kunitaka M Mori L | | 0，，： | 1 |
| 7 | The cobalt porphyrinlewis base system: A highly selective catalyst for alternating copolymerization of CO2 and epoxide under mild conditions显示文摘 | Hiroshi Sugimoto Kunitaka Kuroda | 2008 | Maeromolecules2008，41，： | 1 |
| 8 | In vivo absorption of porous apatite- and wollastonite-con- taining glass-ceramic显示文摘 | KUNITAKA OHSAWA MAASSHI NEO TSUYOSHI OKAMOTO | 2004 | Journal of Materials Science:Materials in Medicine2004，，8： | 1 |
| 9 | The cobalt porphyrin- lewis base system:A highly selective catalyst for ahema- ting copolymerization of CO2 and epoxide under mild con- ditions 显示文摘 | Hiroshi Sugimoto Kunitaka Kuroda | 2008 | Macromolecules2008，41，： | 1 |
| 10 | The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential显示文摘 | Kouji Kuno Kenji Bannai Michinori Hakozaki Kouji Matsushima Kunitaka Hirose | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 11 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | J. Med. Virol2012，，2： | 1 |
| 12 | Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy显示文摘AIM:To analyzed the association between inosine triphosphatase(ITPA)(rs1127354) genotypes and sustained virological response(SVR) rates in peginterferon(Peg-IFN)α + ribavirin(RBV) treatment.METHODS:Patients who underwent Peg-IFNα + RBV combination therapy were enrolled(n = 120) and they had no history of other IFN-based treatments.Variation in hemoglobin levels during therapy,cumulative reduction of RBV dose,frequency of treatment withdrawal,and SVR rates were investigated in each ITPA genotype.RESULTS:In patients with ITPA CC genotype,hemoglobin decline was significantly greater and the percentage of patients in whom total RBV dose was < 60% of standard and/or treatment was withdrawn was significantly higher compared with CA/AA genotype.However,SVR rates were equivalent between CC and CA/AA genotypes,and within a subset of patients with Interleukin 28B(IL28B)(rs8099917) TT genotype,SVR rates tended to be higher in patients with ITPA CC genotype,although the difference was not significant.CONCLUSION:ITPA CC genotype was a disadvantageous factor for Peg-IFNα + RBV treatment in relation to completion rates and RBV dose.However,CC genotype was not inferior to CA/AA genotype for SVR rates.When full-length treatment is accomplished,it is plausible that more SVR is achieved in patients with ITPA CC variant,especially in a background of IL28B TT genotype. | Tatsuya Fujino Yoko Aoyagi Mariko Takahashi Ryoko Yada Naoko Yamamoto Yuki Ohishi Akihiko Nishiura Motoyuki Kohjima Tsuyoshi Yoshimoto Kunitaka Fukuizumi Manabu Nakashima Masaki Kato Kazuhiro Kotoh Makoto Nakamuta Munechika Enjoji | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 1 |
| 13 | Peptides of type II collagen can induce the cleavage of type II collagen and aggre- can in articular cartilage显示文摘 | Tadashi Yasuda Elena Tchetina Kunitaka Ohsawa | 2006 | Matrix Biology2006，25，7： | 1 |
| 14 | A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice显示文摘 | Emi Nakashima Akiko Oya Yuri Kubota Naomi Kanada Ryo Matsushita Kazuyoshi Takeda Fujio Ichimura Kouji Kuno Naofumi Mukaida Kunitaka Hirose Isao Nakanishi Toshimitsu Ujiie Kouji Matsushima | 1996 | Pharmaceutical Research1996，，12： | 1 |
| 15 | Superparamagnetic iron oxide–enhanced magnetic resonance images of hepatocellular carcinoma: Correlation with histological grading显示文摘 | Yasuharu Imai Takamichi Murakami Shigeyuki Yoshida Masahiro Nishikawa Masahiko Ohsawa Koh Tokunaga Masaru Murata Kunitaka Shibata Shinichiro Zushi Masanori Kurokawa Takeshi Yonezawa Sumio Kawata Manabu Takamura Hiroaki Nagano Masato Sakon Morito Monden Ke | 2000 | Hepatology2000，，2： | 1 |
| 16 | The cobah porphyrin lewis base system: a highly selective catalyst for alternating copolymerization of CO2 and epoxide under mild conditions显示文摘 | SUC IM()TO H KUNITAKA K | 2008 | Macromolecules2008，41，： | 1 |
| 17 | Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth显示文摘 | Nomiyama Takashi Kawanami Takako Irie Shinichiro Hamaguchi Yuriko Terawaki Yuichi Murase Kunitaka Tsutsumi Yoko Nagaishi Ryoko Tanabe Makito Morinaga Hidetaka Tanaka Tomoko Mizoguchi Makio Nabeshima Kazuki Tanaka Masatoshi Yanase Toshihiko | 2014 | Diabetes2014，，11： | 1 |
| 18 | 碳氢吸附过滤器的开发显示文摘LEVII法规的燃油蒸发排放(EVAP)部分中对降低发动机进气系统每日蒸发的燃油损失特别重视。为此,作者开发了一种空气净化器,它利用一个活性炭吸附器来吸附从发动机进气系统蒸发的碳氢排放物,可满足LEVII和PZEV排放法规对其15年有效使用期的要求。这种净化器的特点是具有很强的吸附性和很低的流动阻力。 | Kunitaka Maeda | 2005 | 国外内燃机2005，37，4： | 0 |
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