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| 1 | Implication of the Hedgehog pathway in hepatocellular carcinoma显示文摘The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma(HCC)is poor because there are few treatment options.Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis,proliferation and progression of HCC.Among all of the pathways that are involved in the development of HCC,Hedgehog(HH)signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression.HH plays a physiological role in embryogenesis,through the induction of the differentiation of hepatocytes from endodermal progenitors.The re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC development.HH activation sustains the subpopulation of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC,and HH itself is a mediator of the alcohol-derived malignant transformation of liver cells.High levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical outcome.In vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth,metastasis and a mesenchymal phenotype. | Carminia Maria Della Corte Giuseppe Viscardi Federica Papaccio Giovanna Esposito Giulia Martini Davide Ciardiello Erika Martinelli Fortunato Ciardiello Floriana Morgillo | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 2 | 为 Budd-Chiari 症候群的 caval 自体移植片由于劣等的静脉 cava 阻塞显示文摘 Transjugular intrahepatic portosystemic shunt (TIPS) is the standard treatment of Budd-Chiari syndrome (BCS) non responsive to medical therapy. However, patients with inferior vena cava (IVC) obstruction proximal to the atrium do not benefit from TIPS and a surgical approach is mandatory. We report the case of BCS due to intrapericardial IVC obstruction. We describe a novel surgical approach using a fresh caval homograft. An attempt to balloon dilatation of the IVC obstruction was complicated by right atrial disruption with tamponade and ventricular fibrillation. Lately, the patient successfully underwent a reconstruction of the cavo-atrial continuity by the interposition of a fresh caval homograft, a novel surgical approach never described before for BCS. Further follow-up revealed progressive reduction and resolution of ascites, and overall clinical improvement. IVC obstruction near to the atrium can be surgically approached with a new technique consisting in inferior vena cava resection and replacement with a caval homograft. | Andrea Mancuso Luigi Martinelli Luciano De Carlis Antonio Gaetano Rampoldi Giovanni Magenta Aldo Cannata Luca Saverio Belli | 2013 | World Journal of Hepatology2013，5，5： | 9 |
| 3 | Cardiac rehabilitation and mid-term follow-up after transcatheter aortic valve implantation显示文摘跟随大动脉的阀门培植(TAVI ) 通常基于的 transcatheter 的耐心的结果的 BackgroundEvaluation 幸存和临床的改进。生活的质量上的研究被限制,并且从在过程以后的全面评价的数据是在 TAVI 经历了在里面医院和在分泌物以后以后,病人们为心脏的康复提交了的 lacking.MethodsSixty 评估临床、功能、营养的地位的多维的评价,自治的度,认知缺陷,到康复的 life.ResultsOn 承认的消沉和质量,近似,病人的一半有严重功能的缺陷和依赖为在他们的医院停留期间,三分之一个个病人承受了重要临床的复杂并发症,二不得不被转移到培植中心。尽管有这,全面结果很好。所有留下的病人在分泌物是临床上稳定的,生活的功能的地位,自治和质量在大多数被改进。在 540 天的吝啬的后续期间(变化:192-738 天) ,五个病人从 noncardiac 原因死了,三为心脏的事件被就医,并且九为非心脏的原因。功能的地位和自治在病人的多数仍然保持令人满意,大多数继续到在 TAVI 经常是很脆弱的以后,为康复提交的实时 independently.ConclusionsPatients,与功能的缺陷,其它上的依赖和临床的复杂并发症的高风险的一个高等级。在一个康复计划期间,基于一个多维的评价和干预,大多数病人在功能的地位,生活的质量,和自治显示出重要改进,它在中间的后续期间在题目的多数仍然保持稳定。 | Renzo Zanettini Gemma Gatto Ileana Mori Maria Beatrice Pozzoni Stefano Pelenghi Luigi Martinelli Silvio Klugmann | 2014 | Journal of Geriatric Cardiology2014，11，4： | 8 |
| 4 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 5 | Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis显示文摘AIM:To investigated the molecular cause of very early-onset ulcerative colitis(UC)in an 18-mo-old affected child.METHODS:We analysed the interleukin-10(IL10)receptor genes at the DNA and RNA level in the proband and his relatives.Beta catenin and tumor necrosis factor-α(TNFα)receptors were analysed in the proteins extracted from peripheral blood cells of the proband,his relatives and familial adenomatous polyposis(FAP)and PTEN hamartoma tumor syndrome(PHTS)patients.Samples were also collected from the proband’s inflamed colorectal mucosa and compared to healthy and tumour mucosa collected from a FAP patient and patients affected by sporadic colorectal cancer(CRC).Finally,we examined mesalazine and azathioprine effects on primary fibroblasts stabilised from UC and FAP patients.RESULTS:Our patient was a compound heterozygote for the IL10RB E47K polymorphism,inherited from his father,and for a novel point mutation within the IL10RA promoter(the-413G->T),inherited from his mother.Beta catenin and tumour necrosis factorαreceptors-Ⅰ(TNFRI)protein were both over-expressed in peripheral blood cells of the proband’s relatives more than the proband.However,TNFRII was over-expressed only in the proband.Finally,both TNFα-receptors were shown to be under-expressed in the inflamed colon mucosa and colorectal cancer tissue compared to healthy colon mucosa.Consistent with this observation,mesalazine and azathioprine induced,in primary fibroblasts,IL10RB and TNFRII over-expression and TNFRI and TNFαunder-expression.We suggest thatβ-catenin and TNFRI protein expression in peripheral blood cells could represent molecular markers of sub-clinical disease in apparently healthy relatives of patients with early-onset UC.CONCLUSION:A synergistic effect of several variant alleles of the IL10 receptor genes,inherited in a Mende-lian manner,is involved in UC onset in this young child. | Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De Rosa | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 6 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 7 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 8 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 9 | γ-Glutamyltransferase activity in human atherosclerotic plaques—Biochemical similarities with the circulating enzyme显示文摘 | Maria Franzini Alessandro Corti Barbara Martinelli Antonella Del Corso Michele Emdin Giuliano F. Parenti Mattia Glauber Alfonso Pompella Aldo Paolicchi | 2008 | Atherosclerosis2008，，1： | 2 |
| 10 | Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance显示文摘 | Teresa Troiani Silvia Zappavigna Erika Martinelli Santolo R. Addeo Paola Stiuso Fortunato Ciardiello Michele Caraglia | 2013 | Expert Opinion on Biological Therapy2013，，2： | 2 |
| 11 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 12 | Cerebral sinus-venous thrombosis显示文摘 | Ida Martinelli Serena Maria Passamonti Elena Rossi Valerio De Stefano | 2012 | Internal and Emergency Medicine2012，，3： | 2 |
| 13 | Hierarchical cluster analysis as a tool to manage variation in germplasm collections显示文摘 | J. P. Peeters J. A. Martinelli | 1989 | Theoretical and Applied Genetics1989，，： | 2 |
| 14 | Validation of material point method for soil fluidisation analysis显示文摘The main aim of this paper is to describe and analyse the modelling of vertical column tests that undergo fluidisation by the application of a hydraulic gradient.A recent advancement of the material point method(MPM),allows studying both stationary and non-stationary fluid flow while interacting with the solid phase.The fluidisation initiation and post-fluidisation processes of the soil will be investigated with an advanced MPM formulation(Double Point)in which the behavior of the solid and the liquid phase is evaluated separately,assigning to each of them a set of material points(MPs).The result of these simulations are compared to analytic solutions and measurements from laboratory experiments.This work is used as a benchmark test for the MPM double point formulation in the Anura3D software and to verify the feasibility of the software for possible future engineering applications. | Marco Bolognin Mario Martinelli Klaas J.Bakker Sebastiaan N.Jonkman | 2017 | Journal of Hydrodynamics2017，29，3： | 2 |
| 15 | Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian ceils via direct antioxidant activity显示文摘 | Sestili P Martinelli C Bravi G | 2006 | Free Radical Biology and Medicine2006，40，： | 1 |
| 16 | 显示文摘 | Filippi M Martinelli V | 1994 | J Neurol Sci1994，125，： | 1 |
| 17 | The Risk of Recurreny Deep Venous Thrombosis Among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin mutation显示文摘 | Martinelli I Mannuccio PM | 1999 | N Engl J Med1999，341，： | 1 |
| 18 | Simian virus 40 sequences and expression of the viral large T antigen oneoprotein in human pleomorphie adenomas of parotid glands 显示文摘 | Martinelli M Martini F Rinaldi E | 2002 | Am J Pathol2002，161，4： | 1 |
| 19 | Change in peripheral T-cell subsets and natural killer cytotoxicity in relation to colorecta cancer surgery cancer 显示文摘 | Tratter P I Martinelli G Steinberg B | 1986 | Detect Prew1986，9，： | 1 |
| 20 | Optimization of railway operations using neural net-works显示文摘 | David R Martinelli TENG Hua-liang | 1996 | Transportation Research1996，4，1： | 1 |
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