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| 1 | Distribution characteristics of seamount cobalt-rich ferromanganese crusts and the determination of the size of areas for exploration and exploitation显示文摘In 2001,the International Seabed Authority (ISBA) initiated the consideration relating to the Regulations for Prospecting and Exploration for Hydrothermal Polymetallic Sulphides and Cobalt-rich Ferromanganese Crusts in the Area at its 7th session.Since then,the consideration of the Regulations has been mainly focused on the size of areas to be allocated for exploration and exploitation of the crusts.This paper,based on the investigation data and the analysis of the distribution characteristics of the crusts,suggests a model for determining the size of areas for exploration and exploitation of the crusts,taking into account various factors such as production scale,crust thickness and grade,mineable area proportion,recovery efficiency,exploration venture,and so on.Through the modeling, the paper suggests that the exploration area (the area covered by each application for approval of a plan of work for exploration of cobalt-rich crusts) shall be 4 856 km 2 and the exploitation area (the mine site area) shall be 1 214 km 2,for 20 years of 1 million wet tonnes annual production. | HE Gaowen MA Weilin SONG Chengbing YANG Shengxiong ZHU Benduo YAO Huiqiang JIANG Xunxiong CHENG Yongshou | 2011 | Acta Oceanologica Sinica2011,30,3: | 9 |
| 2 | New index of ferromanganese crusts reflecting oceanic environmental oxidation显示文摘Ferromanganese crusts (hereinafter crusts) form in aerobic environment and the environmental oxida-tion degree is recorded by the redox sensitive element Co in the crusts. The ages of the layers from the surface to bottom of the crusts are determined, and main element contents at high resolution along the depth sections of three crusts from the Pacific Ocean are analyzed by an electron microprobe. Thus the variations of Co/(Fe+Mn) and Co/(Ni+Cu) with age/depth of the crust layers are obtained. By comparing the ratios of Co/(Fe+Mn) and Co/(Ni+Cu) with the δ 18O curves of the Pacific benthic foraminifera, we find that these two ratios can reflect the variation of the environmental oxidation state under which the crust layers deposit. The evolution of the oxidation degree reflected by the two indexes resembles the evo-lution of temperature since the Oligocene reflected by the δ 18O curves of the Pacific benthic foraminif-era. This suggests that the crust-forming environment after the Oligocene is controlled mainly by the oxygen-rich bottom water originated from the Antarctic bottom water (AABW). However it is not the case prior to the Oligocene. Furthermore it suggests that the environmental oxidation degree controls the formation of the crusts and the Co contents in the crusts. This explains why the Co contents in the crusts increase with time up to now. | WU GuangHai ZHOU HuaiYang ZHANG HaiSheng LING HongFei MA WeiLin ZHAO HongQiao CHEN JianLin LIU JieHong | 2007 | Science China Earth Sciences2007,50,3: | 7 |
| 3 | Classification of seamount morphology and its evaluating significance of ferromanganese crust in the central Pacific Ocean显示文摘Using the SeaBeam technology, the morphology of seamount and its relation to the formation of cobalt-rich crust in the central Pacific Ocean were surveyed during the cruise in 2003 for marine mineral resources. The result shows that seamounts can be divided morphologically into the spire seamount and the flat topped seamount. These two types of seamount bear great differences in their landform, lithology and cobalt-rich crust. On the upper portion of the flat topped seamount, the flat top and the sharp escarpments are unfavorable to the growth of crust, and, consequently, the crusts here are mostly laminar or gravelly, their thicknesses generally show great variations, and the consecutive ore body often develops in its deep water region. On the spire topped seamount, however, the flat area is small, and its gradient is constant without large variation from the top to the bottom. This favors the growth of cobalt-rich crust and often leads to consecutive tabular ore body of medium thickness, occurring on the spire topped seamount from the shallow water region to the deep water region. The cobalt-rich crust on the spire topped seamount is much better than that on the flat topped seamount for the crust abundance, crust coverage and number of ore-occurrences within unit area. Furthermore, the crust on the spire topped seamount is rich in cobalt, nickel, manganese elements of high economic value. Because the crust with high quality ore often occurs in the shallow water region on the spire topped seamount, it can be mined and use more easily in the future. | CHU Fengyou SUN Guosheng MA Weilin LI Shoujun QIAN Xinyan ZHAO Hongqiao | 2006 | Acta Oceanologica Sinica2006,25,2: | 6 |
| 4 | Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy显示文摘Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)therapy.Recently,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA effectively.In this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of MOF.The collagen II-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser irritation.Briefly,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain extent.Meanwhile,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte protection.RB@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling pathway.Additionally,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS imaging.More significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat model.Overall,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy. | Song Xue Xiaojun Zhou Weilin Sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma | 2021 | Bioactive Materials2021,6,8: | 5 |
| 5 | Nonlinear Contact Between Inner Walls of Deep Sea Pipelines in Buckling Process显示文摘In order to study buckling propagation mechanism in deep sea pipelines, the contact between pipeline's inner walls in buckling process was studied. A two-dimensional ring model was used to represent the pipeline and a nonlinear spring model was adopted to simulate the contact between inner walls. Based on the elastoplastic constitutive relationship and the principle of virtual work theory, the coupling effect of pipeline's nonlinear large deformation and wall contact was included in the theoretical analysis with the aid of MATLAB, and the application scope of the theoretical model was also discussed. The calculated results show that during the loading process, the change in external pressure is closely related to the distribution of section stress, and once the walls are contacting each other, the external pressure increases and then remains stable after it reaches a specific value. Without fracture, the pipeline section will stop showing deformation. The results of theoretical calculations agree well with those of numerical simulations. Finally, in order to ensure reliability and accuracy of the theoretical results, the collapse pressure and propagation pressure were both verified by numerical simulations and experiments. Therefore, the theoretical model can be used to analyze pipeline's buckling deformation and contact between pipeline's inner walls, which forms the basis for further research on three-dimensional buckling propagation. | MA Weilin YU Jianxing ZHOU Qingji XIE Bin CAO Jing LI Zhibo | 2015 | Journal of Ocean University of China2015,14,1: | 4 |
| 6 | Nanocluster PtNiP supported on graphene as an efficient electrocatalyst for methanol oxidation reaction显示文摘In this study,phosphorus doped graphene supported PtNiP nanocluster electrocatalyst(PtNiP/P-graphene)was successfully prepared via a simple hypophosphite-assisted co-reduction method.The improved anchoring force and increased anchoring sites of graphene support result from phosphorus doping as well as size-confined growth effect of NaH_(2)PO_(2) leads to uniform dispersion of ultrafine PtNiP nanoclusters.Doped P also promotes the removal of CO-like intermediate by adjusting Pt electronic structure combining with alloyed Ni via electronic effects.As a result,the as-prepared PtNiP/P-graphene catalyst with more exposed active sites and optimized electronic structure of Pt alloy shows excellent electrocatalytic performances for methanol oxidation reaction(MOR)both in activity and durability in an acidic medium. | Long Yang Guoqiang Li Rongpeng Ma Shuai Hou Jinfa Chang Mingbo Ruan Wenbin Cai Zhao Jin Weilin Xu Guiling Wang Junjie Ge Changpeng Liu Wei Xing | 2021 | Nano Research2021,14,8: | 4 |
| 7 | The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016). | Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin | 2021 | Journal of Genetics and Genomics2021,48,11: | 2 |
| 8 | Resources calculation of cobalt-rich crusts with the grid subdivision and integral method显示文摘On the basis of three geological models and several orebody boundaries,a method of grid subdivision and integral has been proposed to calculate and evaluate the resources of cobalt-rich crusts on the seamounts in the central Pacific Ocean.The formulas of this method are deduced and the interface of program module is designed.The method is carried out in the software 'Auto mapping system of submarine topography and geomorphology MBChart'.This method and program will possibly become a potential tool to calculate the resources of seamounts and determine the target diggings for China's next Five-year Plan. | WU Ziyin CHU Fengyou MA Weilin LI Shoujun SHANG Jlhong | 2007 | Acta Oceanologica Sinica2007,26,5: | 2 |
| 9 | Geochemical characteristics of platinum-group elements in polymetallic nodules from the Northwest Pacific Ocean显示文摘Polymetallic nodules and cobalt (Co)-rich crusts are enriched in platinum-group elements (PGEs),especially platinum (Pt) and may be important sinks of PGEs.At present,little information is available on PGEs in polymetallic nodules,and their geochemical characteristics and the causes of PGEs enrichment are unclear.Here PGEs of polymetallic nodules from abyssal basin in the Marcus-Wake Seamount area of the Northwest Pacific Ocean are reported and compared with the published PGEs data of polymetallic nodules and Co-rich crusts in the Pacific.The total PGEs (ΣPGE) content of polymetallic nodules in study area is 258×10^–9) in average,markedly higher than that of Clarion-Clipperton Zone (CCZ) nodules (ΣPGE=127×10^–9) and lower than that of Co-rich crusts in the Marcus-Wake Seamount (ΣPGE=653×10^–9),similar to that of Co-rich crusts in the South China Sea(ΣPGE=252×10^~–9).The CI chondrite-normalized PGEs patterns in different regions of polymetallic nodules and cobalt-rich crusts are highly consistent,with all being characterized by positive Pt and negative Pd anomalies These results,together with those of previous studies,indicate that PGEs in polymetallic nodules and Co-rich crusts are mainly derived directly from seawater.Pt contents of polymetallic nodules from the study area are negatively correlated with water depth,and Pt/ΣPGE ratios in nodules there are also lower than those of the Corich crusts in the adjacent area,indicating that sedimentary water depth and oxygen fugacity of ambient seawater are the possible important controlling factors for Pt accumulation in crusts and nodules. | Zhongrong Qiu Yanhui Dong Weilin Ma Weiyan Zhang Kehong Yang Hongqiao Zhao | 2020 | Acta Oceanologica Sinica2020,39,8: | 2 |
| 10 | Characteristics and distributions of humic acids in two soil profiles of the southwest China Karst area显示文摘Characteristics and distributions of humic acid(HA) and soil organic matter(SOM) in a yellow soil profile and a limestone soil profile of the southwest China Karst area were systematically investigated to reveal their evolutions in different soils of the study area. The results showed that characteristics and distribution of SOM along the two soil profiles were notably different. Total organic carbon(TOC) contents of soil samples decreased just slightly along the limestone soil profile but sharply along the yellow soil profile. TOCs of the limestone soils were significantly higher than those of the corresponding yellow soils, and C/N ratios of SOMs showed a similar variation trend to that of TOCs, indicating that SOM can be better conserved in the limestone soil than in the yellow soil. The soil humic acids were exhaustively extracted and further fractionated according to their apparent molecular weights using ultrafiltration techniques to explore underlying conservation mechanisms. The result showed that C/N ratios of HAs from different limestone soil layers were relatively stable and that large molecular HA fractions predominated the bulk HA of the top soil, indicating that HA in the limestone profile was protected while bio and chemical degradations were retarded. Combined with organic elements contents and mineral contents of two soils, weconcluded that high calcium contents in limestone soils may play a key role in SOM conservation by forming complexation compounds with HAs or/and enclosing SOMs with hypergene CaCO_3 precipitation. | Liangang Ma Baohua Xiao Xinyue Di Weilin Huang Shijie Wang | 2016 | Acta Geochimica2016,35,1: | 2 |
| 11 | Geochemistry and age of seamounts in the West Pacific: mantle processes and petrogenetic implications显示文摘Research on seamounts provides some of the best constraints for understanding intraplate volcanism, and samples from seamounts reveal crucial evidence about the geochemical makeup of the oceanic mantle. There are still many seamounts in the West Pacific Seamount Province(WPSP) that have not been studied, meaning their ages and geochemistry remain unknown. A better understanding of these seamount trails and their evolutionary history, investigated with age and geochemistry data, will enable better understanding of the geological processes operating underneath the Pacific Ocean Plate. Here, new ^(40)Ar/^(39) Ar ages and trace element and Sr-Nd-Pb isotopic data for seven basalt rocks from four seamounts in the WPSP are provided. Chemically, these rocks are all Oceanic Island Alkali basalt(OIA type); analysis of olivine phenocrysts shows that the magmas experienced strong olivine fractionation and changed from olivine + plagioclase to olivine + plagioclase + clinopyroxene cotectic during their evolution. Rare earth element(REE) patterns and a spider diagram of the samples in this study show OIB(Ocean Island Basalt) like behavior. The range of ^(87)Sr/^(86) Sr values is from 0.704 60 to 0.706 24, the range of ^(206)Pb/^(204) Pb values is from 18.241 to 18.599, and the range of ^(143)Nd/^(144) Nd values is from 0.512 646 to 0.512 826; together, these values indicate magma sources ranging from EMI to EMII. Finally, new ^(40)Ar/^(39) Ar age data show that these seamounts formed at ~97 and ~106 Ma, indicating that some may have undergone the same formation processes as seamounts in the eastern part of the Magellan Seamount Trail, but other seamounts likely have different origins. | Limei Tang Yanhui Dong Fengyou Chu Ling Chen Weilin Ma Yonggang Liu | 2019 | Acta Oceanologica Sinica2019,38,1: | 2 |
| 12 | Correlation of DNA methylation patterns to the phenotypic features of Tibetan elite alpinists in extreme hypoxia显示文摘High altitude is an extreme environment that imposes hypoxic pressure on physiological processes,and natives living at high altitudes are more adaptive in certain physiological processes.So far,epigenetic modifications under extreme changes in hypoxic pressures are relatively less understood.Here,we recruit 32 Tibetan elite alpinists(TEAs),who have successfully mounted Everest(8848 m)at least five times.Blood samples and physiological phenotypes of TEAs and 32 matched non-alpinist Tibetan volunteers(non-TEAs)are collected for analysis.Genome-wide DNA methylation analysis identifies 23,202 differentially methylated CpGs(P_(adj)<0.05,|β|>0.1)between the two groups.Some differentially methylated CpGs are in hypoxia-related genes such as PPP1R13L,MAP3K7CL,SEPTI-9,and CUL2.In addition,Gene ontology enrichment analysis reveals several inflammation-related pathways.Phenotypic analysis indicates that 12 phenotypes are significantly different between the two groups.In particular,TEAs exhibit higher blood oxygen saturation levels and lower neutrophil count,platelet count,and heart rate.For DNA methylation association analysis,we find that two CpGs(cg16687447,cg06947206)upstream of PTEN were associated with platelet count.In conclusion,extreme hypoxia exposure leads to epigenetic modifications and phenotypic alterations of TEA,providing us clues for exploring the molecular mechanism underlying changes under extreme hypoxia conditions. | Zhuoma Basang Shixuan Zhang La Yang Deji Quzong Yi Li Yanyun Ma Meng Hao WeiLin Pu Xiaoyu Liu Hongjun Xie Meng Liang Jiucun Wang Qiangba Danzeng | 2021 | Journal of Genetics and Genomics2021,48,10: | 2 |
| 13 | Influence of temperature on corona discharge treatment of cotton fibers显示文摘 | Pibo Ma Juan Huang Genyang Cao Weilin Xu | 2010 | Fibers and Polymers2010,,6: | 1 |
| 14 | Selective removal of polycyclic aromatic hydrocarbons (PAHs) from soil washing effluents using biochars produced at different pyrolytic temperatures显示文摘 | Helian Li Ronghui Qu Chao Li Weilin Guo Xuemei Han Fang He Yibing Ma Baoshan Xing | 2014 | Bioresource Technology2014,,: | 1 |
| 15 | Resistance of strains producing extended-spectrum β-lactamases and genotype distribution in China显示文摘 | Yunsong Yu Shujuan Ji Yagang Chen Weilin Zhou Zeqing Wei Lanjuan Li Yilin Ma | 2006 | Journal of Infection2006,,1: | 1 |
| 16 | Application of corona discharge on desizing of polyvinyl alcohol on cotton fabrics显示文摘 | MA Pibo WANG Xin XU Weilin | | 0,,: | 1 |
| 17 | A comparative study of two methods for treating type III tibial emi- nence avulsion fracture in adults 显示文摘 | Weilin Sang Libo Zhu Jinzhong Ma | 2012 | Knee Surg Sports Traumatol Arthrosc Arthrosc2012,20,8: | 1 |
| 18 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021,2,1: | 1 |
| 19 | Performance Improvement of a Centrifugal Compressor for the Fuel Cell Vehicle by Tip Leakage Vortex Control显示文摘Heightened interests have been laid at the preliminary design and optimization of the centrifugal compressor for the fuel cell vehicle.The centrifugal compressor for fuel cell vehicle is driven by a high-speed motor;however,the limit of the motor speed makes the flow passage of the impeller long and narrow,which leads to a serious tip leakage loss.Serious tip leakage loss deteriorates the compressor performance.In this paper,3-D numerical simulations were carried out with the aim of investigating the tip leakage loss in a prototype centrifugal compressor for a 100 kW fuel cell stack.The results revealed that the mixing loss caused by the interaction between the tip leakage vortex and the downstream tip leakage flow contributed to the major part of the tip leakage loss.The path of the tip leakage vortex almost followed the streamwise direction,while the downstream tip leakage flow exhibited strong circumferential momentum,which referred to the fact that they were nearly orthogonal.Therefore,a flow control approach,which was realized by enhancing the blade loading around the leading edge of blade tips in this paper,was proposed to decrease the interaction angle between the tip leakage vortex and the downstream tip leakage flow and then mitigate mixing loss by changing the flow direction of the tip leakage vortex.The results showed a smaller interaction angle was achieved in the optimized impeller compared with the baseline one.Meanwhile,the efficiency was also improved by 1.30%at design condition and the maximum efficiency improvement could be up to 10%at large mass flow condition of 92000 r/min.Being manufactured and tested,the optimized compressor was proved to achieve an isentropic efficiency of 75.84%at design condition. | CHEN Haoxiang ZHUGE Weilin ZHANG Yangjun MA Xuelong TAO Lin | 2021 | Journal of Thermal Science2021,30,6: | 0 |
| 20 | Exploration on learning molecular docking with deep learning models显示文摘Background:Molecular docking-based virtual screening(VS)aims to choose ligands with potential pharmacological activities from millions or even billions of molecules.This process could significantly cut down the number of compounds that need to be experimentally tested.However,during the docking calculation,many molecules have low affinity for a particular protein target,which waste a lot of computational resources.Methods:We implemented a fast and practical molecular screening approach called DL-DockVS(deep learning dock virtual screening)by using deep learning models(regression and classification models)to learn the outcomes of pipelined docking programs step-by-step.Results:In this study,we showed that this approach could successfully weed out compounds with poor docking scores while keeping compounds with potentially high docking scores against 10 DUD-E protein targets.A self-built dataset of about 1.9 million molecules was used to further verify DL-DockVS,yielding good results in terms of recall rate,active compounds enrichment factor and runtime speed.Conclusions:We comprehensively evaluate the practicality and effectiveness of DL-DockVS against 10 protein targets.Due to the improvements of runtime and maintained success rate,it would be a useful and promising approach to screen ultra-large compound libraries in the age of big data.It is also very convenient for researchers to make a well-trained model of one specific target for predicting other chemical libraries and high docking-score molecules without docking computation again. | Qin Xie Wei Ma Jianhang Zhang Shiliang Li Xiaobing Deng Youjun Xu Weilin Zhang | 2023 | Quantitative Biology2023,11,3: | 0 |