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| 1 | Phosphorus fractions and its release in the sediments of Haihe River,China显示文摘The amounts and forms of phosphorus(P) in surface sediments of Haihe River,Tianjin,North China,were examined using a sequential chemical extraction procedure.Five fractions of sedimentary P,including loosely sorbed P(NH4Cl-P),redox-sensitive P(BD-P),metal oxide bound P(NaOH-P),calcium bound P(HCl-P),and residual P(Res-P)(organic and refractory P),were separately quantified.The results indicated that the contents of different P fractions in the sediments varied greatly.The total P(TP) contents ranged from 968 to 2017 mg/kg.Phosphorus contents in NH4Cl-P,BD-P,NaOH-P,and HCl-P ranged from 6.7 to 26.6 mg/kg,54.5 to 90.2 mg/kg,185.2 to 382.5 mg/kg,and 252.3 to 425.5 mg/kg,respectively,which represented 1.2%-3.2%,7.7%-13%,33.3%-48.9%,and 36.2%-54.2% of the sedimentary inorganic P,respectively.For all the sediment samples,the rank order of P-fractions was Res-P > HCl-P > NaOH-P > BD-P > NH4Cl-P.The highly positive relationship between the amounts of P released from the sediments and those in the NH4Cl-P and BD-P fractions,indicated that NH4Cl-P and BD-P were the main fractions that can release P easily. | SUN Shujuan HUANG Suiliang SUN Xueming WEN Wei | 2009 | Journal of Environmental Sciences2009，21，3： | 53 |
| 2 | Recent developments in high-strength Mg-RE-based alloys:Focusing on Mg-Gd and Mg-Y systems显示文摘Higher strength is always the goal pursued by researchers for the structural materials,especially for the lightweight magnesium(Mg)alloys which generally have relatively low strength at present.From this aspect,the present paper reviews the recent reports of a kind of Mg alloys,i.e.Mg-RE(RE:rare earths,mainly Gd or Y)casting and wrought alloys,which have been able to achieve high strength compared with common or commercial Mg alloys,from the viewpoint and content of the alloy system,alloying constitution,preparation process,tensile strength and each of the main strengthening mechanisms.This review of recent research and developments in high-strength Mg-RE alloys is beneficial for the further design of Mg alloys with higher strength as well as excellent comprehensive performance. | Jinghuai Zhang Shujuan Liu Ruizhi Wu Legan Hou Milin Zhang | 2018 | Journal of Magnesium and Alloys2018，6，3： | 60 |
| 3 | Recent Advances in Synthesis of Waterborne Polyurethane and Their Application in Water-based Ink:A Review显示文摘Over the last few years,waterborne polyurethane(WPU) was applied to various fibers,adhesives,primers for metals,caulking materials,emulsion polymerization media,paint additives,defoamers,associate thickeners,pigment pastes,textile dyes and biomaterials,resulting in the increasing enthusiasm of researchers to design and synthesize novel WPU with unique properties.Thus,various processes and raw materials have been developed to prepare WPU.This review gives an overview on the developments of WPU mainly derived from novel polyols,analyzes the potential application in water-based inks and presents the probable future research area about water-based inks.Notably,the poly(ε-caprolactone) and poly(lactic acid) are the versatile materials used in WPU synthesis and supply the potential special performance for preparing WPU.Meanwhile,addition-fragmentation chain transfer(RAFT) polymerization and atom transfer radical polymerization(ATRP) processes provide an opportunity to control the chain sequence of WPU and obtain products with the desired performance. | Xing Zhou Yan Li Changqing Fang Shujuan Li Youliang Cheng Wanqing Lei Xiangjie Meng | 2015 | Journal of Materials Science & Technology2015，31，7： | 47 |
| 4 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 5 | Autophagy in bone homeostasis and the onset of osteoporosis显示文摘Autophagy is an evolutionarily conserved intracellular process,in which domestic cellular components are selectively digested for the recycling of nutrients and energy.This process is indispensable for cell homeostasis maintenance and stress responses.Both genetic and functional studies have demonstrated that multiple proteins involved in autophagic activities are critical to the survival,differentiation,and functioning of bone cells,including osteoblasts,osteocytes,and osteoclasts.Dysregulation at the level of autophagic activity consequently disturbs the balance between bone formation and bone resorption and mediates the onset and progression of multiple bone diseases,including osteoporosis.This review aims to introduce the topic of autophagy,summarize the understanding of its relevance in bone physiology,and discuss its role in the onset of osteoporosis and therapeutic potential. | Xing Yin Chenchen Zhou Jingtao Li Renkai Liu Bing Shi Quan Yuan Shujuan Zou | 2019 | Bone Research2019，7，4： | 25 |
| 6 | Towards developing Mg alloys with simultaneously improved strength and corrosion resistance via RE alloying显示文摘Magnesium(Mg)alloys have received an increasing interest in the past two decades for their tremendous application potential.The strength and corrosion resistance levels of common Mg alloys are still relativity low,and especially they are to be improved simultaneously.The addition of rare earth(RE)to Mg alloys is believed to be beneficial for both the strength and corrosion resistance,and some RE-modified traditional Mg alloys have been studied and some new RE-containing Mg alloys have been developed by now.However,further simultaneous improvements in both strength and anti-corrosion require a better understanding of the behavior and mechanism of RE in Mg alloys.In this review,the common influence mechanisms of RE on mechanical and anti-corrosion properties of Mg alloys are summarized,and the latest research progress of RE-containing Mg alloys with simultaneously improved strength and corrosion resistance are introduced.It is demonstrated that the research on high-strength and high corrosion resistant RE-containing Mg alloys is still immature,and some opinions and suggestions are put forward for the synergetic improvement of the strength and corrosion resistance of Mg alloys,so as to contribute to the further development of Mg alloys with higher performance. | Jinshu Xie Jinghuai Zhang Zihao You Shujuan Liu Kai Guan Ruizhi Wu Jun Wang Jing Feng | 2021 | Journal of Magnesium and Alloys2021，9，1： | 25 |
| 7 | Temporal variations and source apportionment of volatile organic compounds at an urban site in Shijiazhuang, China显示文摘Shijiazhuang,the city with the worst air quality in China,is suffering from severe ozone pollution in summer.As the key precursors of ozone generation,it is necessary to control the Volatile Organic Compounds(VOCs)pollution.To have a better understanding of the pollution status and source contribution,the concentrations of 117 ambient VOCs were analyzed from April to August 2018 in an urban site in Shijiazhuang.Results showed that the monthly average concentration of total VOCs was 66.27 ppbv,in which,the oxygenated VOCs(37.89%),alkanes(33.89%),and halogenated hydrocarbons(13.31%)were the main composite on.Eight major sources were identified using Positive Matrix Factorization modeling with an accurate VOCs emission inventory as inter-complementary methods revealed that the petrochemical industry(26.24%),other industrial sources(15.19%),and traffic source(12.24%)were the major sources for ambient VOCs in Shijiazhuang.The spatial distributions of major industrial activities emissions were identified by using geographic information statistics system,which illustrated the VOCs was mainly from the north and southeast of Shijiazhuang.The inverse trajectory analysis using Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)and Potential Source Contribution Function(PSCF)clearly demonstrated the features of pollutant transport to Shijiazhuang.These findings can provide references for local governments regarding control strategies to reduce VOCs emissions. | Yanan Guan Lei Wang Shujuan Wang Yihao Zhang Jieying Xiao Xiaoli Wang Erhong Duan Li'an Hou | 2020 | Journal of Environmental Sciences2020，32，11： | 19 |
| 8 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 9 | Development and application of a water pollution emergency response system for the Three Gorges Reservoir in the Yangtze River, China显示文摘There are many watercraft and production accidents in the Three Gorges Reservoir Area (TGRA) of the Yangtze River in China every year. Accidents threaten the water quality of the 1085 km 2 surface area of the TGRA and millions of local people if oil and chemical leakage were to occur. A water pollution management system for emergency response (WPMS ER) was therefore designed for the management of pollution in this area. An integrated geographic information system (GIS)-based water pollution management information system for the TGRA, called WPMS ER TGRA, was developed in this study. ArcGIS engine was used as the system development platform, and Visual Basic as the programming language. The models for hydraulic and water quality simulation and the generation of body-fitted coordinates were developed and programmed as a dynamically linked library file using Visual Basic, and they can be launched by other computer programs. Subsequently, the GIS-based information system was applied to the emergency water pollution management of a shipwreck releasing 10 tons of phenol into the Yangtze River during two hours. The results showed that WPMS ER TGRA can assist with emergency water pollution management and simulate the transfer and diffusion of accidental pollutants in the river. Furthermore, it can quickly identify the affected area and how it will change over time within a few minutes of an accident occurring. | Qiang He Shujuan Peng Jun Zhai Haiwen Xiao | 2011 | Journal of Environmental Sciences2011，23，4： | 16 |
| 10 | Application potential of carbon nanotubes in water treatment:A review显示文摘Water treatment is the key to coping with the conflict between people's increasing demand for water and the world-wide water shortage. Owing to their unique and tunable structural, physical, and chemical properties, carbon nanotubes (CNTs) have exhibited great potentials in water treatment. This review makes an attempt to provide an overview of potential solutions to various environmental challenges by using CNTs as adsorbents, catalysts or catalyst support, membranes, and electrodes. The merits of incorporating CNT to conventional water-treatment material are emphasized, and the remaining challenges are discussed. | Xitong Liu Mengshu Wang Shujuan Zhang Bingcai Pan | 2013 | Journal of Environmental Sciences2013，25，7： | 15 |
| 11 | Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production显示文摘L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of L-serine to pyruvate and glycine, releasing the feedback inhibition by L-serine to 3-phosphoglycerate dehydrogenase (PGDH), in combination with the co-expression of 3-phosphoglycerate kinase (PGK) and feedback-resistant PGDH (PGDHr). The resulting strain, SER-8, exhibited a lower specific growth rate and significant differences in L-serine levels from Phase I to Phase V as determined for fed-batch fermentation. The intracellular L-serine pool reached (14.22±1.41) μmol gCDM 1, which was higher than glycine pool, contrary to fermentation with the wild-type strain. Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDHr improved the L-serine biosynthesis pathway. In addition, the flux from L-serine to glycine dropped by 24%, indicating that the deletion of the activator GlyR resulted in down-regulation of serine hydroxymethyltransferase (SHMT) expression. Taken together, our findings imply that L-serine pool management is fundamental for sustaining the viability of C. glutamicum, and improvement of C1 units generation by introducing the glycine cleavage system (GCV) to degrade the excessive glycine is a promising target for L-serine production in C. glutamicum. | LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi | 2012 | Science China(Life Sciences)2012，55，4： | 15 |
| 12 | Temperature and precipitation trends in Minqin Desert during the period of 1961-2007显示文摘This paper analyzed the data of temperature and precipitation in Minqin,typical desert area in north-west China,during the period of 1961 2007 by linear regression.The result indicated that the increasing rate of the mean annual temperature in Minqin was higher than that of the average of China;and the temperature in February increased by 3.01oC averagely in the past 47 years.The climate in Minqin displayed an evident warming trend.However,there was no evidently increasing trend of precipitation in the past 47 years,and drought occurred during the whole growing season. | ShuJuan ZHU1,2,3,ZhaoFeng CHANG1,2,3 1 Gansu Minqin National Field Observation & Research Station on Ecosystem of Desertified Rangeland,Minqin 733300,China 2 Key Laboratory of Desertification Combating of Gansu Province,Lanzhou 733070,China 3 Gansu Desert Control Research Institute,Lanzhou 733070,China | 2011 | Journal of Arid Land2011，3，3： | 14 |
| 13 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 14 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 15 | Germafluorene conjugated copolymer——synthesis and applications in blue-light-emitting diodes and host materials显示文摘A germafluorene-fluorene copolymer was successfully obtained via Suzuki polymerization.The ger-manium containing copolymer has an efficient blue light emission under the ultraviolet irradiation and its single layer EL device showed the highest brightness of 2630 cd/m2 at 7.8 V and the highest effi-ciency of 0.301 lm/W at 6.2 V.The copolymer can also serve as the host material for phosphorescent metal complexes with the maximum brightness of 15600 cd/m2 and the quantum efficiency of 8.5%.The results are quite promising and promise that as its analogs of fluorene and silafluorene,germafluorene is an excellent building block for blue light-emitting polymers and host materials. | CHEN RunFeng ZHU Rui ZHENG Chao LIU ShuJuan FAN QuLi HUANG Wei | 2009 | Science China Chemistry2009，52，2： | 12 |
| 16 | Experimental study on the performance of bowl-tray rice precision seeder显示文摘In order to optimize the parameters of bowl-tray rice precision seeder and improve its performance,three major factors respectively at five levels,including shaped hole diameter,vertical displacement of rice seeds and rotating speed of cam,were tested,the quadratic orthogonal rotational regression experiments were conducted,and the effects on seeding rate,leakage sowing rate and the injury rate were investigated.The test results show that factors affecting rice seeding rate are in the order of shaped hole diameter,rotating speed of cam and vertical displacement of rice seeds.The factors affecting rice planting leakage rate are in the order of shaped hole diameter,vertical displacement of rice seeds and rotating speed of cam,and the factors affecting rice injury rate are in the order of rotating speed of cam,vertical displacement of rice seeds and shaped hole diameter.Optimal parameters(shaped hole diameter:10 mm,vertical displacement of rice seeds:27 mm,rotating speed of cam:13 r/min)and performance index(seeding rate:95.43%,leakage sowing rate:0.37%,injury rate:0.58%)provided the basis for design and performance improvement of the bowl-tray rice precision seeder. | Yi Shujuan Liu Yongfen Wang Chun Tao Guixiang Liu Haiyan Wang Ruihan | 2014 | International Journal of Agricultural and Biological Engineering2014，7，1： | 10 |
| 17 | Protein microarrays for systems biology显示文摘系统生物学为在系统水平上理解生物系统拿钥匙。它最后为象癌症,糖尿病,肥胖,心理混乱,和许多其它那样的复杂疾病的治疗和痊愈拿钥匙。-omics' 技术例如 genomics, transcriptomics, proteomics,和 metabonomics,在系统生物学的主要驱动力之中。是展示了高产量,使小型化,并且能够平行分析,蛋白质 microarrays 已经为系统成为了一个重要技术平台生物学。在这评论,我们将用蛋白质 microarrays 集中于系统水平或生物系统的全球分析。蛋白质 microarrays 的四种主要类型将被讨论:proteome microarrays,抗体 microarrays,反向阶段的蛋白质数组,和 lectin microarrays。我们将也为系统生物学讨论挑战和蛋白质 microarray 技术和他们的应用的未来方向。我们强烈相信蛋白质 microarrays 将很快为系统生物学成为一个不可缺少、无价的工具。 | Lina Yang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 9 |
| 18 | An update: Epstein-Barr virus and immune evasion via microRNA regulation显示文摘Epstein-Barr virus(EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that micro RNAs(mi RNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes mi RNAs for immune evasion. EBV encodes mi RNAs targeting both viral and host genes involved in the immune response. The mi RNAs are found in two gene clusters, and recent studies have demonstrated that lack of these clusters increases the CD4^+ and CD8^+ T cell response of infected cells. These reports strongly indicate that EBV mi RNAs are critical for immune evasion. In addition, EBV is able to dysregulate the expression of a variety of host mi RNAs, which influence multiple immune-related molecules and signaling pathways. The transport via exosomes of EBV-regulated mi RNAs and viral proteins contributes to the construction and modification of the inflammatory tumor microenvironment.During EBV immune evasion, viral proteins, immune cells, chemokines, pro-inflammatory cytokines, and pro-apoptosis molecules are involved. Our increasing knowledge of the role of mi RNAs in immune evasion will improve the understanding of EBV persistence and help to develop new treatments for EBV-associated cancers and other diseases. | Lielian Zuo Wenxin Yue Shujuan Du Shuyu Xin Jing Zhang Lingzhi Liu Guiyuan Li Jianhong Lu | 2017 | Virologica Sinica2017，32，3： | 9 |
| 19 | Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight显示文摘The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness. | Linjie Wang Zhili Li Cheng Tan Shujuan Liu Jianfeng Zhang Siyang He Peng Zou Weibo Liu Yinghui Li | 2019 | Frontiers of Medicine2019，13，2： | 9 |
| 20 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
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