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| 1 | Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients显示文摘AIM: To identify prognostic factors of patients with hepatocellular carcinoma (HCC), who were treated by orthotopic liver transplantation (OLT). METHODS: From January 2000 to October 2006, 165 patients with HCC underwent OLT. Various clinicopathological risk factors for actuarial and recurrence-free survival were identified using the Kaplan-Meier method with the log-rank test. The Cox proportional hazards model was used to identify independently predictive factors for actuarial and recurrence-free survival, which were used to propose new selection criteria. We compared the outcome of the subgroup patients meeting different criteria. Survival analysis was performed using the Kaplan-Meier method with the log-rank test. RESULTS: The median follow-up was 13.0 mo (2.8-69.5 mo). Overall, 1-, 2-, 3-and 5-year actuarial survival was 73.3%, 45.6%, 35.4% and 32.1%, respectively. One-, 2-, 3-and 5-year overall recurrencefree survival was 67.0%, 44.3%, 34.5% and 34.5%, respectively. In univariate analysis, number of tumors, total tumor size, lobar distribution, differentiation, macrovascular invasion, microvascular invasion, capsulationof the tumor, and lymph node metastasis were found to be associated significantly with actuarial and tumor-free survival. By means of using the multivariate Cox proportional hazards model, total tumor size and macrovas-cular invasion were found to be independent predictors of actuarial and tumor-free survival. When the selection criteria were expanded into the proposed criteria, there was no significant difference in 1-, 2-, 3-and 5-year actuarial and tumor-free survival of the 49 patients who met the proposed criteria (97.6%, 82.8%, 82.8% and 82.8%, and 90.7%, 82.8%, 68.8% and 68.8%, respectively) compared with that of patients who met the Milan or University of California, San Francisco (UCSF) criteria. CONCLUSION: Macrovascular invasion and total tumor diameter are the strongest prognostic factors. The proposed criteria do not adversely affect the outcome of liver transplantation for HCC, compared with the Milan or UCSF criteria. | Jin Li Lu-Nan Yan Jan Yang Zhe-Yu Chen Bo Li Yong Zeng Tian-Fu Wen Ji-Chun Zhao Wen-Tao Wang Jia-Yin Yang Ming-Qing Xu Yu-Kui Ma | 2009 | World Journal of Gastroenterology2009，15，33： | 37 |
| 2 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 3 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 4 | Transcriptional landscape of rice roots at the single-cell resolution显示文摘There are two main types of root systems in flowering plants,namely taproot systems of dicots and fibrous root systems found in monocots.Despite this fundamental split,our current knowledge of cellular and molecular mechanism driving root development is mainly based on studies of the dicot model Arabidopsis.However,the world major crops are monocots and little is known about the transcriptional programs underlying cell-type specification in this clade.Here,we report the transcriptomes of more than 20000 single cells derived from root tips of two agronomically important rice cultivars.Using combined computational and experimental analyses we were able to robustly identify most of the major cell types and define novel cell-type-specific marker genes for both cultivars.Importantly,we found divergent cell types associated with specific regulatory programs,including phytohormone biosynthesis,signaling,and response,which were well conserved between the two rice cultivars.In addition,we detected substantial differences between the cell-type transcript profiles of Arabidopsis and rice.These species-specific features emphasize the importance of analyzing tissues across diverse model species,including rice.Taken together,our study provides insight into the transcriptomic landscape of major cell types of rice root tip at single-cell resolution and opens new avenues to study cell-type specification,function,and evolution in plants. | Qing Liu Zhe Liang Dan Feng Sanjie Jiang Yifan Wang Zhuoying Du Ruoxi Li Guihua Hu Pingxian Zhang Yanfei Ma Jan ULohmann Xiaofeng Gu | 2021 | Molecular Plant2021，14，3： | 9 |
| 5 | Housing characteristics and indoor environment in relation to children's asthma, allergic diseases and pneumonia in Urumqi, China显示文摘In order to evaluate the prevalence of childhood asthma,allergic diseases and pneumonia in Urumqi City,China,as well as its associations with housing and home characteristics,a cross-sectional study was performed in 4618 children(81.7%response rate,average age 4.7±0.9 year,boys accounting for 53.7%).Questions on children’s asthma and allergic diseases were from the International Study on Asthma and Allergies in Childhood(ISAAC)and were integrated with questions on the home environment from the Dampness in Buildings and Health(DBH)study,slightly modified to account for Chinese building characteristics and life habits.The prevalences of physician diagnosed asthma,allergic rhinitis(AR)and pneumonia were 3.6%,8.7%and 40.9%,respectively.One fourth of children reported wheezing and more than 40%AR symptoms in the last 12 months.Controlling for confounding factors,positive associations were found for home mold/dampness and wheezing(adjusted odds ratio,aOR 1.33,95%CI 1.07 1.66),AR symptoms(1.34,1.09 1.64)last 12 months and physician diagnosed pneumonia(1.33,1.09 1.62).Floor material by wood,PVC or carpeting;and walls by wallpaper,painting or wood material,were positively associated with AR symptoms.Home environmental tobacco smoke(ETS)was positively associated with wheezing(1.23,1.04 1.46)and pneumonia(1.25,1.07 1.45).In conclusion,there was a relatively high prevalence of asthmatic and AR symptoms and diagnosed pneumonia in preschool children in Urumqi.Home signs of mold growth or dampness,windowpane condensation,as well as ETS and interior surface materials emitting chemicals were risk factors for allergic symptoms and pneumonia. | WANG TingTing ZHAO ZhuoHui YAO Hua WANG ShuLan NORBACK Dan CHEN Jie MA JinFeng JI XiaoLi WANG Li SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 9 |
| 6 | A review of soil heavy metal pollution from mines in China: Pollution and health risk assessment显示文摘 | Zhiyuan Li Zongwei Ma Tsering Jan van der Kuijp Zengwei Yuan Lei Huang | 2014 | Science of the Total Environment2014，，： | 7 |
| 7 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 8 | Infrastructure for China's Ecologically Balanced Civilization显示文摘 | Chris Kennedy Ma Zhong Jan Corfee-Morlot | 2016 | Engineering2016，2，4： | 5 |
| 9 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 10 | Glucagon-like peptide-1 receptor imaging with [Lys 40 (Ahx-HYNIC- 99m Tc/EDDA)NH 2 ]-exendin-4 for the detection of insulinoma显示文摘 | Anna Sowa-Staszczak Dorota Pach Renata Miko?ajczak Helmut M?cke Agata Jabrocka-Hybel Agnieszka Stefańska Monika Tomaszuk Barbara Janota Aleksandra Gilis-Januszewska Maciej Ma?ecki Grzegorz Kamiński Aldona Kowalska Jan Kulig Andrzej Matyja Czes?aw Osuch Al | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，4： | 2 |
| 11 | Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid,superoxide anion, and NF-kappa B are sequentially involved显示文摘 | Jan JT Chen BH Ma SH | 2000 | Virol2000，74，： | 1 |
| 12 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 13 | China's Fiscal Reform显示文摘 | Ma Jan | 1997 | An Overview Asian Economic Review1997，，4： | 1 |
| 14 | Mushroom poisoning in children: clinical presentation and outcome 显示文摘 | Jan MA Siddiqui TS Ahmed N | 2008 | J Ayub Med Coll Abbottabad2008，20，2： | 1 |
| 15 | Personality factors and breast cancer risk: a 13 - year follow - up 显示文摘 | Eveline MA Bleiker Jan HCL Hendriks Johannes DM Otten | 2008 | J Natl Cancer Inst2008，100，157： | 1 |
| 16 | Effect of wheelchair tilt- in-space and recline angles on skin perfusion over the ischial tuberosity in people with spinal cord injury 显示文摘 | Jan YK Jones MA Rabadi MH | 2010 | Arch Phys Med Rehabil2010，91，11： | 1 |
| 17 | Ultrafine manganese dioxide nanowire network for high-performance supercapacitors显示文摘 | JIANG Hao ZHAO Ting MA Jan | 2011 | Chemical Communications2011，47，： | 1 |
| 18 | A review of soil heavy metal pollution from mines in China: Pollu tion and health risk assessment显示文摘 | Li Zhi yuan Ma Zong-wei Tsering Jan van der Kuijp | 2014 | Science of the Total Envi ronment2014，，： | 1 |
| 19 | Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘 | Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold | 2015 | Int. J. Cancer2015，，1： | 1 |
| 20 | Structural characterization of Brachypodium genome and its syntenic relationship with rice and wheat显示文摘 | Naxin Huo John P. Vogel Gerard R. Lazo Frank M. You Yaqin Ma Stephanie McMahon Jan Dvorak Olin D. Anderson Ming-Cheng Luo Yong Q. Gu | | 0，2009，： | 1 |
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