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| 1 | Small bowel tumors detected and missed during capsule endoscopy: Single center experience显示文摘AIM:To characterize small bowel(SB)tumors detected by capsule endoscopy(CE),and identify missed tumors.METHODS:The study included 145 consecutive patients in whom 150 CEs were performed.Following CE,the medical records of the study population were reviewed.Results of double-or single-balloon enteroscopy performed after CE and the results of surgery in all patients operated on were retrieved.The patients were contacted through telephone interviews or postal mail.In addition,the national cancer registry and the polish clinical gastrointestinal stromal tumor(GIST)Registry were searched to identify missed neoplasms.RESULTS:Indications for CE included overt and occult obscure gastrointestinal bleeding(n=81,53.7%),anemia(n=19,12.7%),malabsorption(n=18,12%),abnormal CB follow through(n=9,6%),abdominal pain(n=7,5%),celiac disease(n=5,3%),neuroendocrine tumor(n=3,2%),Crohn’s disease(n=2,<2%),Peutz-Jeghers syndrome(n=2,<2%),other polyposes(n=2,<2%),and diarrhea(n=2,<2%).The capsule reached the colon in 115(76.6%)examinations.In 150 investigations,CE identified 15SB tumors(10%),14 of which were operated on or treated endoscopically.Malignancies included metastatic melanoma(n=1),adenocarcinoma(n=2),and GIST(n=3).Benign neoplasms included dysplastic Peutz-Jeghers polyps(n=4).Non-neoplastic masses included venous malformation(n=1),inflammatory tumors(n=2),and a mass of unknown histology(n=1).During the follow-up period,three additional SB tumors were found(2 GISTs and one mesenteric tumor of undefined nature).The National Cancer Registry and Polish Clinical GIST Registry revealed no additional SB neoplasms in the post-examination period(follow-up:range 4.2-102.5 mo,median 39 mo).The sensitivity of CE for tumor detection was 83.3%,and the negative predictive value was 97.6%.The specificity and positive predictive value were both 100%.CONCLUSION:Neoplasms may be missed by CE,especially in the proximal SB.In overt obscure gastrointestinal bleeding,complementary endoscopic and/or radiologic diagnostic tests are indicated. | Edyta S Zagorowicz Anna M Pietrzak Ewa Wronska Jacek Pachlewski Piotr Rutkowski Ewa Kraszewska Jaroslaw Regula | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 2 | Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease显示文摘AIM: To determine the features of Enterococcus that contribute to the development and maintenance of the inflammatory process in patients with inflammatory bowel disease (IBD). METHODS: Multiplex polymerase chain reaction (PCR) was applied to assess the presence of genes that encode virulence factors [surface aggregating protein (asa1), gelatinase (gelE), cytolysin (cylA), extracellular surface protein (esp) and hyaluronidase (hyl)] in the genomic DNA of 28 strains of Enterococcus isolated from the intestinal tissues of children with IBD (n =16) and of children without IBD (controls; n = 12). Additionally, strains with confirmed presence of the gelE gene were tested by PCR for the presence of quorum sensing genes (fsrA, fsrB, fsrC) that control the gelatinase production. Gelatinase activity was tested on agar plates containing 1.6% gelatin. We also analysed the ability of Enterococcus strains to release and decompose hydrogen peroxide (using Analytical Merckoquant peroxide test strips) and tested their ability to adhere to Caco-2 human gut epithelium cells and form biofilms in vitro. RESULTS: A comparison of the genomes of Enterococcus strains isolated from the inflamed mucosa of patients with IBD with those of the control group showed statistically significant differences in the frequency of theasa1 gene and thegelE gene. Furthermore, the cumulative occurrence of different virulence genes in the genome of a single strain ofEnterococcus isolated from the IBD patient group is greater than in a strain from the control group, although no significant difference was found. Statistically significant differences in the decomposition of hydrogen peroxide and adherence to the Caco-2 epithelial cell line between the strains from the patient group and control group were demonstrated. The results also showed that profuse biofilm production was more frequent amongEnterococcus strains isolated from children with IBD than in control strains. CONCLUSION: Enterococcus strains that adhere strongly to the intestinal epithelium, form biofilms and possess antioxidant defence mechanisms seem to have the greatest influence on the inflammatory process. | Edyta Golińska Anna Tomusiak Tomasz Gosiewski Gra yna Wiecek Agnieszka Machul Diana Mikoajczyk Magorzata Bulanda Piotr B Heczko Magdalena Strus | 2013 | World Journal of Gastroenterology2013，19，23： | 8 |
| 3 | Comprehensive Approach for Porous Materials Analysis Using a Dedicated Preprocessing Tool for Mass and Heat Transfer Modeling显示文摘The paper presents a comprehensive, newly developed software – poROSE(poROus materials examination SoftwarE) for the qualitative and quantitative assessment of porous materials and analysis methodologies developed by the authors as a solution for emerging challenges. A low porosity rock sample was analyzed and thanks to the developed and implemented methodologies in poROSE software, the main geometrical properties were calculated. A tool was also used in preprocessing part of the computational analysis to prepare a geometrical representation of the porous material. The basic functions as elimination of blind pores in the geometrical model were completed and the geometrical model was exported for CFD software. As a result, it was possible to carry out calculations of the basic properties of the analyzed porous material sample. The developed tool allows to carry out quantitative and qualitative analysis to determine the most important properties characterized porous materials. In presented tool the input data can be images from X-ray computed tomography(CT), scanning electron microscope(SEM) or focused ion beam with scanning electron microscope(FIB-SEM) in grey level. A geometric model developed in the proper format can be used as an input to modeling mass, momentum and heat transfer, as well as, in strength or thermo-strength analysis of any porous materials. In this example, thermal analysis was carried out on the skeleton of rock sample. Moreover, thermal conductivity was estimated using empirical equations. | MADEJSKI Pawel KRAKOWSKA Paulina HABRAT Magdalena PUSKARCZYK Edyta JEDRYCHOWSKI Mariusz | 2018 | Journal of Thermal Science2018，27，5： | 7 |
| 4 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 5 | A dopamine and noradrenaline reuptake inhibitor (bupropion) does not alter exercise performance of bank voles显示文摘 | Ewa JAROMIN Edyta Teresa SADOWSKA Pawet KOTEJA | 2016 | Current Zoology2016，62，3： | 3 |
| 6 | Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer显示文摘Advances in genomics,molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value.Epidemiological and biological studies suggest a role for adiposity,dyslipidaemia,hyperinsulinemia,altered glucose homeostasis,and elevated expression of insulin-like growth factor(IGF)axis members in the risk and prognosis of cancer.This review discusses some recent past and current approaches being taken by researches in obesity and metabolic disorders.The authors describe three main systems as the most studied metabolic candidates of carcinogenesis:dyslipidemias,adipokines and insulin/IGF axis.However,each of these components is unsuccessful in defining the diseases risk and progression,while their co-occurrence increases cancer incidence and mortality in both men and women. | Magorzata Muc-Wierzgoń Ewa Nowakowska-Zajdel Sylwia Dziegielewska-Gesiak Teresa Kokot Katarzyna Klakla Edyta Fatyga Elzbieta Grochowska-Niedworok Dariusz Waniczek Janusz Wierzgoń | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 7 | Genetic Variation in Bank Vole Populations in Natural and Metal-Contaminated Areas 显示文摘 | Magdalena Mikowska Aneta Gaura Edyta Sadowska | 2014 | Archives of EnvironmentalContamination Toxicology2014，67，： | 1 |
| 8 | Determination of dopamine by flow - injection analysis coupled with luminol- hexacyanoferrate(Ⅲ) chemiluminescence detection 显示文摘 | Edyta N R Rosa B Anatol K | 2004 | J Pharma and Biomed Anal2004，36，1： | 1 |
| 9 | Polymorphism in CTSB exon 7 as associated with activity of the lysosomal proteases in longissimus dorsi muscle of growing Friesian bulls显示文摘 | Edyta J K Stanislaw J Rosochacki | 2007 | Animal Science Papers and Reports2007，25，4： | 1 |
| 10 | Microbial transfomlation of baicalin and baicalein显示文摘 | Edyta Kostrzewa-Sustow Jadwiga Dmochowska-CAadysz Jan Oszmi- aflski | 2007 | J Mol Catal B Enzy2007，49，1： | 1 |
| 11 | Restoration of the Cooling Conditions in a Three-dimensional Continuous Casting Process Using Artificial In-telligence Algorithms 显示文摘 | EDYTA H | 2015 | Applied Mathematical Modelling2015，39，8： | 1 |
| 12 | Short-dayand melatonin effects on milking parameters, prolactin profilesand growth-hormone secretion in lactating sheep 显示文摘 | EDYTA M TOMASZ M KATARZYNA R | 2013 | SmallRuminant Research*2013，109，： | 1 |
| 13 | Short-day and me- latonin effects on milking parameters, prolactin profiles and growth-hormone secretion in lactating sheep显示文摘 | Edyta M Tomasz M Katatxyna R | 2013 | Small Rumi- nant Research2013，109，： | 1 |
| 14 | Microbial transformation of baicalin and baicalein显示文摘 | Edyta Kostrzewa-Suslow Jadwiga Dmochowska-Gladysz Jan Oszmia'nski | 2007 | J Mol Catal B-Enzym2007，49，： | 1 |
| 15 | Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘 | Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold | 2015 | Int. J. Cancer2015，，1： | 1 |
| 16 | Effect of an aliphatic spacer group on the adsorption mechanism on the colloidal silver surface of L proline phosphonodipeptides显示文摘 | EDYTA P PAWEL K LEONARD M P | 2008 | J Raman Spectroscopy2008，39，12： | 1 |
| 17 | Application of multiplex FISH, CGH and MSSCP techniques for cytogenetic and molecular a- nalysis of transitional cell carcinoma ( TCC ) cells in voided urine specimens显示文摘 | Maria C Aleksandra B K Edyta B | 2006 | J Appl Genet2006，47，3： | 1 |
| 18 | Analysis of the lirst Polish BIM-Based cost estimation application显示文摘 | Edyta P Krzysztof Z and Miroslaw S | 2015 | Procedia Engineering2015，123，： | 1 |
| 19 | New Method for the Antibacte- rial and Antifungal Modification of Silver Finished Tex- tiles 显示文摘 | Barbara Filipowska Edward Rybicki Anetta Walawska Edyta Matyjas-Zgondek | 2011 | FIBRES & TEXTILES in Eastern Europe2011，194，87： | 1 |
| 20 | The importance of Notch signaling in peripheral T-cell lymphomas显示文摘 | Maria R? rb? k Kamstrup Edyta Biskup Lise Mette Rahbek Gjerdrum Elizabeth Ralfkiaer Omid Niazi Robert Gniadecki | 2014 | Leukemia & Lymphoma2014，，3： | 1 |
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