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| 1 | 利用DEM提取地貌指数的方法述评显示文摘介绍了几个广泛应用于水文科学的流域地貌指数(包括地表坡度、流量分配系数、单宽集水面积、集水面积以及湿度指数)的计算方法,阐述了这些地貌指数在水文科学中所代表的物理意义和对流域水文过程空间分布的描述能力。对了解流域地貌对降雨径流的影响,揭示产汇流过程的物理机制,研制和开发分布式水文物理模型均有重要意义。 | 熊立华 郭生练 Kieran M.O Connor | 2002 | 水科学进展2002，13，6： | 30 |
| 2 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 3 | The effects of psychological contract breach and organizational cynicism: not all social exchange violations are created equal显示文摘 | Jonathan L.Johnson Anne M.O’Leary‐Kelly | 2003 | J Organiz Behav2003，，5： | 2 |
| 4 | Nonlinear model predictive control of an industrial four-stage evaporator system via simulation显示文摘 | G.P Rangaiah P Saha M.O Tadé | 2002 | Chemical Engineering Journal2002，，3： | 2 |
| 5 | Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease显示文摘 | Pamela M.O’Connor Tamia K.Lapointe Paul L.Beck Andre G.Buret | 2010 | Inflamm Bowel Dis2010，，8： | 2 |
| 6 | In situ TiB 2 reinforced Al alloy composites显示文摘 | L Lü M.O Lai Y Su H.L Teo C.F Feng | 2001 | Scripta Materialia2001，，9： | 2 |
| 7 | Role of video games in improving health-related outcomes:A systematic review显示文摘 | Primack B.A Carroll M.V MeNamara M Klem M.L King B Rich M.O Nayak S | | 0，，06： | 1 |
| 8 | 查看详情显示文摘 | Abdalla M.O Ludwick A Mitchell T | | 0，，24： | 1 |
| 9 | 查看详情显示文摘 | Haslam E Makinson G.K Naumann M.O Jill C | | 0，，： | 1 |
| 10 | Synthesis of in situ Al–TiB 2 composites using stir cast route显示文摘 | K.L Tee L Lu M.O Lai | 2000 | Composite Structures2000，，1： | 1 |
| 11 | 查看详情显示文摘 | Baldwin E.A Nisperos-Carriedo M.O Baker R.A | | 0，，： | 1 |
| 12 | An assessment of U(VI)removal from groundwater using biochar produced from hydrothermal carbonization显示文摘 | Kumar S Loganathan V.A Gupta R.B Barnett M.O | | 0，，10： | 1 |
| 13 | Intranasal delivery of PEGylated salmon calcitonins:hypocalcemic effects in rats显示文摘 | Lee K.C Park M.O Na D.H | | 0，，： | 1 |
| 14 | Biosynthetic pathway of citrinin in the filamentous Fungus Monascus ruber as revealed by 13C Nuclear Magnetic Resonance显示文摘 | Hajjaj H Klaébé A Loret M.O | | 0，，1： | 1 |
| 15 | Improvement of strength and fracture toughness of a spray-deposited AlCuMgAgMnTiZr alloy by optimized heat treatments and thermomechanical treatments显示文摘 | O Beffort C Solenthaler M.O Speidel | 1995 | Materials Science & Engineering A1995，，1： | 1 |
| 16 | 5‐HT2B receptors modulate visceral hypersensitivity in a stress‐sensitive animal model of brain‐gut axis dysfunction显示文摘 | S. M.O’mahony D. C.Bulmer A.‐m.Coelho P.Fitzgerald C.Bongiovanni K.Lee W.Winchester T. G.Dinan J. F.Cryan | 2010 | Neurogastroenterology & Motility2010，，5： | 1 |
| 17 | cclib: A library for package‐independent computational chemistry algorithms显示文摘 | Noel M.O’boyle Adam L.Tenderholt Karol M.Langner | 2008 | J. Comput. Chem2008，，5： | 1 |
| 18 | A supramodal number representation in human intraparietal cortex显示文摘 | Eger E Sterzer P Russ M.O Giraud A.L & Kleinschmidt A | | 0，，04： | 1 |
| 19 | The genesis of strategy in new ventures: escaping the constraints of founder and team knowledge显示文摘 | Michael J.Fern Laura B.Cardinal Hugh M.O’Neill | 2012 | Strat Mgmt J2012，，4： | 1 |
| 20 | Bond-talence Parameters for Solids显示文摘 | N.E.Brese M.O' keeffe | | 0，，： | 1 |
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