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| 1 | Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers显示文摘Cognitive impairment is a common clinical manifestation of multiple sclerosis,but its pathophysiology is not completely understood.White and grey matter injury together with synaptic dysfunction do play a role.The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment.So far,only a few studies on this topic have been published,giving interesting results that deserve further investigation.Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis.The aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune,glial and neuronal pathology with cognitive impairment in multiple sclerosis.Although preliminary,these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis,thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains. | Lorenzo Gaetani Nicola Salvadori Elena Chipi Lucia Gentili Angela Borrelli Lucilla Parnetti Massimiliano Di Filippo | 2021 | Neural Regeneration Research2021，16，1： | 2 |
| 2 | The advancements,challenges,and future implications of the CRISPR/Cas9 system in swine research显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds,thus improving yields.In addition,CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research.In this review,we present the advancements of the CRISPR/Cas9 system in swine research,such as animal breeding,vaccine development,xenotransplantation,and disease modeling.We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. | Jinfu Zhang Emmanuel M.Khazalwa Hussein M.Abkallo Yuan Zhou Xiongwei Nie Jinxue Ruan Changzhi Zhao Jieru Wang Jing Xu Xinyun Li Shuhong Zhao Erwei Zuo Lucilla Steinaa Shengsong Xie | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 3 | Moro orange juice prevents fatty liver in mice显示文摘AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced obesity.METHODS:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 wk.Liver morphology,gene expression of lipid transcription factors,and metabolic enzymes were assessed.RESULTS:Mice fed HFD displayed increased body weight,insulin resistance and dyslipidemia.Moro juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total cholesterol.Mice fed HFD showed liver steatosis associated with ballooning.Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid oxidation.Consistently,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 activity.CONCLUSION:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver. | Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano | 2012 | World Journal of Gastroenterology2012，18，29： | 2 |
| 4 | Visualization of 3D information with digital holography using laser printers显示文摘 | LUCILLA Croce Ferri | 2001 | Computers& Graphics2001，25，： | 2 |
| 5 | Diagnosing prodromal Alzheimer’s disease: Role of CSF biochemical markers显示文摘 | Lucilla Parnetti Alessia Lanari Giorgio Silvestrelli Emanuele Saggese Paolo Reboldi | 2005 | Mechanisms of Ageing and Development2005，，2： | 2 |
| 6 | Enrichment of tomato fruit with health -promoting anthocyanins by expression of select transcription factors 显示文摘 | Eugenio B Lucilla T Marco G | 2008 | Nature Biotechnology2008，26，11： | 1 |
| 7 | Effect of HLA-Matching Recipients to Donor Noninherited Maternal Antigens on Outcomes after Mismatched Umbilical Cord Blood Transplantation for Hematologic Malignancy显示文摘 | Vanderson Rocha Stephen Spellman Mei-Jie Zhang Annalisa Ruggeri Duncan Purtill Colleen Brady Lee Ann Baxter-Lowe Etienne Baudoux Paola Bergamaschi Robert Chow Brian Freed Gesine Koegler Joanne Kurtzberg Jerome Larghero Lucilla Lecchi Arnon Nagler Cristina | 2012 | Biology of Blood and Marrow Transplantation2012，，12： | 1 |
| 8 | Ecology and characterization by molecular methods of Staphylococcus species isolated from fresh sausages显示文摘 | KALLIOPI RANTSIOU LUCILLA IACUMIN CARLO CANTONI et al | 2005 | Intemat J Food Microbiol2005，97，3： | 1 |
| 9 | Attitudes towards HPV immunization of Italian mothers of adolescent girls and potential role of health professionals in the immunization program 显示文摘 | Alberto E Tozzi Lucilla R | 2009 | Vaccine2009，27，19： | 1 |
| 10 | Mild Hyperhomocyst(e)inemia: A Possible Risk Factor for Cervical Artery Dissection显示文摘 | Virgilio Gallai Valeria Caso Maurizio Paciaroni Gabriela Cardaioli Erland Arning Teodoro Bottiglieri Lucilla Parnetti | 2001 | Stroke: Journal of the American Heart Association2001，，3： | 1 |
| 11 | Characterisation of naturally fermented sausages produced in the North East of Italy显示文摘 | GIUSEPPE C ROSALINDA U LUCILLA I | | 0，，03： | 1 |
| 12 | Micronutrient-Enriched Rapeseed Oils Improve the Brain Oxidant/Antioxidant System in Rats Fed a High-Fat Diet显示文摘 | Serafina S Lucilla A Benedetto RD | 2011 | Journal of Agricultural and Food Chemistry2011，59，： | 1 |
| 13 | Low Morphine Doses in Opioid-Naive Cancer Patients with Pain显示文摘 | Sebastiano Mercadante Gianpiero Porzio Patrizia Ferrera Fabio Fulfaro Federica Aielli Corrado Ficorella Lucilla Verna Walter Tirelli Patrizia Villari Edoardo Arcuri | 2006 | Journal of Pain and Symptom Management2006，，3： | 1 |
| 14 | Standerdization and interlabo- ratory reproducibilit assessment of plused - field gel electrophoresis -generated fingerprints of Acinetobacter baumannii显示文摘 | Harald S Lucilla D Bressan R | 2005 | J Clin Mi- crobiol2005，43，： | 1 |
| 15 | Cephalic-phase insulin and glucagon release in normal subjects and in patients receiving pancreas transplantation显示文摘 | Antonio Secchi Rossana Caldara Andrea Caumo Lucilla D. Monti Doretta Bonfatti Valerio Di Carlo Guido Pozza | 1995 | Metabolism1995，，9： | 1 |
| 16 | Relationship between connective tissue cells and fibronectin in a sequential model of experimental hepatic fibrosis显示文摘 | Giovanna Cenacchi Giorgio Ballardini Lucilla Badiali Giorgi Carlo Antonio Busachi Mario Rosso Francesco Bianco Bianchi Graziella Biagini Renzo Laschi | 1983 | Virchows Archiv B Cell Pathology Including Molecular Pathology1983，，1： | 1 |
| 17 | Molecualr evolution of Metallo-p-Lactamase-Producing Pseudomonas aeruginosa in a Nosocomial Setting of High-Level Endemicity显示文摘 | Cristina L Elisabetta E Lucilla D | 2006 | J Clin Mi- crobiol2006，44，7： | 1 |
| 18 | Presence of icaA and icaD Genes and Slime Production in a Collection of Staphylococcal Strains from Catheter-Associated Infections显示文摘 | Carla RA Lucilla B and Lucio M | 2001 | J Clin Microbiol2001，39，： | 1 |
| 19 | Identification of new aminoacid amides containing the imidazo[2,1- b ]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling显示文摘 | Alessandro Furlan Francesco Colombo Andrea Kover Nathalie Issaly Cristina Tintori Lucilla Angeli Vincent Leroux Sébastien Letard Mercedes Amat Yasmine Asses Bernard Maigret Patrice Dubreuil Maurizio Botta Rosanna Dono Joan Bosch Oreste Piccolo Daniele Pas | 2011 | European Journal of Medicinal Chemistry2011，，： | 1 |
| 20 | Treatment of Alzheimer’s disease: From pharmacology to a better understanding of disease pathophysiology显示文摘 | Giorgio Silvestrelli Alessia Lanari Lucilla Parnetti Daniele Tomassoni Francesco Amenta | 2005 | Mechanisms of Ageing and Development2005，，2： | 1 |
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