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| 1 | Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis显示文摘瞄准:在有人半胱氨酸(HCY ) 和 haemostatic 系统的各种各样的部件的 PBC 和它的关系估计 hypercoagulability。方法:我们调查了 51 个 PBC 病人(43F/8M;意味着年龄:63+/-13.9 年) 并且 102 个健康题目(86 个 women/16 人;63+/-13 年) ,并且由 PFA-100 由 Sonoclot 分析和血小板功能在全血评估了 haemostatic 过程设备。我们然后测量了 HCY (禁食并且在蛋氨酸装载以后) ,织物因素(TF ) , thrombin-antithrombin 建筑群(梭织) , D 暗淡(D-D ) , thrombomodulin (TM ) , folic,维生素 B6 和 B12 血浆铺平。C677T 5,10-methylenetetrahydrofolate 还原酶(MTHFR ) 多型性被分析。结果:病人的 Sonoclot 率值是显著地(P<0.001 ) 比那些高控制。山峰价值的 Sonoclot 时间和 PFA-100 闭合时间在病人和控制是可比较的。梭织, TF 和 HCY 层次,两个在禁食并且蛋氨酸以后的装载,显著地(P<0.001 ) 在病人更高与比在控制。维生素缺乏在 45/51 病人(88.2%) 被检测。同型结合的 TT677 MTHFR 遗传型的流行比在控制(17.5%)(P<0.05 ) 在病人(31.4%) 是显著地更高的。Sonoclot 率价值与 HCY 层次和 TF 显著地相关。结论:在 PBC, hyper-HCY 与维生素缺少和基因预先安排因素有关。内皮激活的增加的 TF 和 HCY 层次和符号与 hypercoagulability 被联系并且可以在血凝固激活有一个重要角色。 | Maria Rosa Biagini Alessandro Tozzi Rossella Marcucci Rita Paniccia Sandra Fedi Stefano Milani Andrea Galli Elisabetta Ceni Marco Capanni Raffaele Manta Rosanna Abbate Calogero Surrenti | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 2 | Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study显示文摘The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity.This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation.Although in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was preserved.Structural changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of corrosion.However,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs. | Roxane Bonithon Colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn Frank Witte Gianluca Tozzi | 2023 | Bioactive Materials2023，，1： | 2 |
| 3 | Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment显示文摘BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)involvement.The NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 LNs.This threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate staging.The reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on Cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal number.Furthermore,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of gastriccancer.AIM To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal evaluation.METHODS Eligible patients were identified from the Surveillance,Epidemiology,and End Results database.Those with stage II-III gastric cancer were considered for inclusion.Three groups were compared based on the number of analyzed LNs.They were inadequate LN assessment(ILA,<16 LNs),adequate LN assessment(ALA,16-29 LNs),and optimal LN assessment(OLA,≥30 LNs).The main outcomes were overall survival(OS)and cancer-specific survival.Data were analyzed by the Kaplan-Meier product-limit method,log-rank test,hazard risk,and Cox proportional univariate and multivariate models.Propensity score matching(PSM)was used to compare the ALA and OLA groups.RESULTS The analysis included 11607 patients.Most had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%confidence interval(CI):0.79-0.88,P<0.001 and OLA HR=0.73,95%CI:0.68-0.79,P<0.001].The OS outcome was confirmed by multivariate analysis(ALA HR=0.68,95%CI:0.64-0.71,P<0.001 and OLA:HR=0.48,95%CI:0.44-0.52,P<0.001).A 1:1 PSM analysis in 3428 patients found that the OLA group had better survival than the ALA group(OS:OLA median=34 mo vs ALA median=26 mo,P<0.001,which was confirmed by univariate analysis(HR=0.81,95%CI:0.75-0.89,P<0.001)and multivariate analysis:(HR=0.71,95%CI:0.65-0.78,P<0.001).CONCLUSION Proper nodal staging is a critical issue in gastric cancer.Assessment of an inadequate number of LNs places patients at high risk of adverse long-term survival outcomes. | Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo Stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo Sergio Bracarda Amilcare Parisi | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 4 | Pulmonary vascular endothelial cells modulate stretch-induced DNA and connective tissue synthesis in rat pulmonary artery segments显示文摘 | Tozzi CA Poiani GJ Harangozo AM | 1988 | Chest1988，93，： | 1 |
| 5 | Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells显示文摘 | Zhou Y Tozzi F Chen J | 2012 | Cancer Res2012，72，1： | 1 |
| 6 | Collagen and elastin metabolism in hypertensive pulmonary arteries of rats显示文摘 | Poiani GJ Tozzi CA Yohn SE | 1990 | Circulation research1990，66，4： | 1 |
| 7 | Long-term follow-up of lumbar fusion patients显示文摘 | LEHMANN TR SPRATT KF TOZZI JE | 1987 | Spine1987，12，2： | 1 |
| 8 | Mid-term results of endovascular reconstruction for aorto-iliac obstructive disease 显示文摘 | Piffaretti G Tozzi M Lomazzi C | 2007 | Int Angiol2007，26，1： | 1 |
| 9 | Explorative laparoscopy prior to exenterative surgery 显示文摘 | Kohler C Tozzi R Possover M | 2002 | Gynecol Oncol2002，86，3： | 1 |
| 10 | Purine and pyrimidine salvage in whole rat brain显示文摘 | Barsotti C Tozzi MG Ipata PL | 2002 | J Biol Chem2002，277，912： | 1 |
| 11 | Waterborne outbreak of Norwalk-like virus gastroenteritis at a tourist resort,Italy显示文摘 | BOCCIA D TOZZI A COTTER B | | 0，，06： | 1 |
| 12 | Predictive factors of complications after surgical repair of iatrogenic femoral pseudoaneurysms显示文摘 | Piffaretti G Mariscalco G Tozzi M | | 0，，： | 1 |
| 13 | Pediatric neurological syndromes and inborn errors of purine metabolism显示文摘 | Marcella Camici Vanna Micheli Piero Luigi Ipata Maria Grazia Tozzi | 2009 | Neurochemistry International2009，，3： | 1 |
| 14 | Managemem of pulmonary embolism during acrylic vertebroplasty显示文摘 | Tozzi P Abdelmoumene Y Como AF | 2002 | The Annals of Thoraecic Surgery2002，74，5： | 1 |
| 15 | Splenic artery aneurysrns postembolization syndrome and surgical complications显示文摘 | Piffaretti G Tozzi M lomazzi C | 2007 | Am j Surg2007，193，： | 1 |
| 16 | PD detection in extruded power cables:an approximate propagation model显示文摘 | TOZZI M CAVALLINI A MONTANARI G C | 2008 | IEEE Transactions on Dielectrics and Electrical Insulation2008，15，3： | 1 |
| 17 | Surgically induced unilateral pulmonary hypertension:time-related analysis of a new experimental model显示文摘 | Corno AF Tozzi P Genton CY | 2003 | Eur J Cardiothorac Surg2003，23，4： | 1 |
| 18 | Neural 171-estradiol facilitates long-term potentiation in the hippocampal CA1 region 显示文摘 | Grassi S Tozzi A Costa C | 2011 | Neuro- science2011，192，： | 1 |
| 19 | Development of a non-competitive immunoassay for monitoring DDT,its metabolites and analogues in water samples 显示文摘 | Anfossi L Giraudi G Tozzi C Giovannoli C Baggiani C Vanni A | 2004 | Anal Chim Acta2004，506，1： | 1 |
| 20 | Hepatic and mesenteric sar- coidosis without thoracic involvement : a case of severe noncirrhotic por- tal hypertension and successful pregnancy 显示文摘 | Vannozzi G Tozzi A Chibbaro G | 2008 | Eur J Gastroenterol Hepatol2008，20，10： | 1 |
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