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| 1 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 2 | 三种南方典型水稻土长期试验下有机碳积累机制研究 Ⅲ.两种水稻土颗粒有机质结构特征的变化显示文摘采用固体交叉极化魔角自旋^(13)C核磁共振(CPMAS^(13)C-NMR)波谱技术对长期不同施肥处理下红壤性水稻土和太湖地区黄泥土本体土壤以及水稳性团聚体中颗粒有机质(POM)的化学结构特征进行了研究。结果表明,不同施肥处理下本体土壤和不同粒径水稳性团聚体中POM的结构组成相似,主要由烷氧C、烷基C和芳香C组成,其中以烷氧C含量最高。施肥改变了本体土壤POM中各类C原子的相对百分含量,有机肥以及化肥配施有机肥条件下烷氧C含量明显降低,芳香C和酚基C含量有不同程度的增加,表明POM的稳定性增强;单施化肥下烷氧C含量最高,而烷基C、芳香C和芳香度均最低,POM的稳定性减弱,不利于POM的积累。施肥改变了黄泥土不同粒径水稳性团聚体中POM各类C原子的相对百分含量,从而使得不同粒径中POM对其团聚体的稳定性作用发生变化;而红壤性水稻土不同粒径水稳性团聚体POM各类C原子的相对百分含量并未明显受到施肥措施的影响。 | 周萍 Alessandro Piccolo 潘根兴 Daniela Smejkalova | 2009 | 土壤学报2009，46，3： | 29 |
| 3 | Utility of fluorescent cholangiography during laparoscopic cholecystectomy: A systematic review显示文摘AIM: To verify the utility of fluorescent cholangiography for more rigorous identification of the extrahepatic biliary system.METHODS: MEDLINE and Pub Med searches were performed using the key words 'fluorescent cholangiography', 'fluorescent angiography', 'intraoperative fluorescent imaging', and 'laparoscopic cholecystectomy' in order to identify relevant articles published in English, French, German, and Italian during the years of 2009 to 2014. Reference lists from the articles were reviewed to identify additional pertinent articles. For studies published in languages other than those mentioned above, all available information was collected from their English abstracts. Retrieved manuscripts(case reports, reviews, and abstracts) concerning the application of fluorescent cholangiography were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. In contrast to classic meta-analyses, statistical analysis was performed where the outcome was calculated as the percentages of an event(without comparison) in pseudo-cohorts of observed patients.RESULTS: A total of 16 studies were found that involved fluorescent cholangiography during standard laparoscopic cholecystectomies(n = 11), singleincision robotic cholecystectomies(n = 3), multiport robotic cholecystectomy(n = 1), and single-incision laparoscopic cholecystectomy(n = 1). Overall, these preliminary studies indicated that this novel technique was highly sensitive for the detection of important biliary anatomy and could facilitate the prevention of bile duct injuries. The structures effectively identified before dissection of Calot's triangle included the cystic duct(CD), the common hepatic duct(CHD), the common bile duct(CBD), and the CD-CHD junction. A review of the literature revealed that the frequenciesof detection of the extrahepatic biliary system ranged from 71.4% to 100% for the CD, 33.3% to 100% for the CHD, 50% to 100% for the CBD, and 25% to 100% for the CD-CHD junction. However, the frequency of visualization of the CD and the CBD were reduced in patients with a body mass index > 35 kg/m2 relative to those with a body mass index < 35 kg/m2(91.0% and 64.0% vs 92.3% and 71.8%, respectively).CONCLUSION: Fluorescent cholangiography is a safe procedure enabling real-time visualization of bile duct anatomy and may become standard practice to prevent bile duct injury during laparoscopic cholecystectomy. | Antonio Pesce Gaetano Piccolo Gaetano La Greca Stefano Puleo | 2015 | World Journal of Gastroenterology2015，21，25： | 21 |
| 4 | 南方典型水稻土长期试验下有机碳积累机制研究 Ⅳ.颗粒有机质热裂解-气相-质谱法分子结构初步表征显示文摘采用热裂解-气相-质谱(Pyr-TMAH-GC/MS)技术对长期不同施肥处理下太湖地区黄泥土本体土壤及水稳性团聚体中颗粒有机碳(POC)的化学组分进行了研究。结果表明,POC的热裂解产物主要来源于脂肪族化合物和木质素类化合物。木质素类化合物主要以愈疮木基丙烷(G)和p-羟苯基(P)两种木质素单体为主,从而揭示黄泥土POC积累中草本植物(水稻、油菜的残茬和秸秆)的输入贡献。脂肪族化合物主要为C8-C30脂肪酸甲基酯(FAMEs),且大多为偶数碳结构。施肥改变了各裂解产物在本体土壤和水稳性团聚体中的分布,从而使得不同施肥处理下各类化合物对POC稳定性的贡献出现了差异。化肥配施猪粪下木质素类化合物以及微生物源的脂肪族化合物均贡献于本体土壤POC的积累与稳定,而化肥配施秸秆下本体土壤POC的化学稳定性主要归因于高等植物源化合物的贡献,其次为微生物源脂肪族化合物。化肥配施有机肥下水稳性团聚体中较高的POC主要归因于植物源有机物质的分解贡献。本研究揭示了合理施肥下水稻土中有机碳的化学抗性组分在土壤有机碳积累中的促进作用,各组分的相对分布差异可指示有机碳积累的不同来源。 | 周萍 潘根兴 Alessandro Piccolo Riccardo Spaccini | 2011 | 土壤学报2011，48，1： | 14 |
| 5 | 有关正畸初始弓丝就位后的疼痛感——热激活弓丝和超弹弓丝的随机对照研究显示文摘目的:正畸热激活弓丝能够产生比超弹弓丝更轻、更符合生物学的力量.从而能够降低正畸初次就诊所产生的疼痛感。然而.该说法的证据却较少。本研究的目的即比较使用热激活弓丝(HANT)和超弹弓丝(SE)作为正畸初始弓丝就位后患者的疼痛感的差别。方法和材料:共纳入30例患者(男11例,女19例,年龄11~26岁)。上颌或下颌粘接金属托槽.随机使用0.016英寸热激活弓丝和0016英寸超弹弓丝,橡皮圈结扎入槽。要求患者使用视觉模拟量表(VAS)记录7d内不同时刻(8:00.12:00.16:00,2000.2400)的疼痛指数。结果:两组结果均显示疼痛程度最重的为第2天,疼痛程度最轻的为第7天:热激活弓丝组第2.3,4天的VAS评分均显著低于超弹弓丝组(P〈0.005)。针对服用止痛药、体育锻炼、合并其他来源的疼痛和伴随压力性事件等情况做出调整后.结果仍然相同。超弹弓丝组在第3天服用止痛药的频率明显高于热激活组(P〈0.05)。不同时间点间疼痛感未发现明显差异,牙列拥挤与疼痛程度未发现相关性.上下颔的疼痛感也无明显差异。结论:使用热激活弓丝能够降低正畸初诊疼痛感。 | Iacopo Cioffi Antonclla Piccolo Renato Tagliaferri Sergio Paduano Angela Galeotti Roberto Martina 邓金荣 高雪梅 | 2012 | 中国口腔医学继续教育杂志2012，15，6： | 8 |
| 6 | 土壤修复:腐植酸作为天然表面活性剂淋洗高度污染土壤显示文摘修复位于意大利北部的前ACNA化工厂(萨沃纳)附近的高污染场地是意大利的当务之急。文章目的是致力于寻找环境友好型的新技术用于修复ACNA污染场地的土壤。从ACNA场地获取质地和有机污染物数量和类型都不同的两种土壤样本A和B,采用多种洗涤剂对两种土壤样本进行淋洗,比较这些洗涤剂去除土壤污染物的效率。实验采用的洗涤剂包括:水,两种合成表面活性剂:十二烷基硫酸钠(SDS)和Triton X-100(TX100)和腐殖酸(HA)作为临界胶束浓度的天然表面活性剂溶液。在土壤样本淋洗前后分别采用超声处理和索氏法提取污染物。土壤A富含多环芳烃,而土壤B含有大量噻吩。处理细质土壤B时,超声处理具有更高的分析效率,处理粗质土壤A,索氏法的处理效率处于正常水平。采用清水洗涤土壤不能完全从土壤中除去污染物,而用后几种方法除去污染物时,所有有机表面活性剂的效率基本相同(高达90%)。因此,使用含天然腐殖酸的溶液淋洗高度污染的土壤似乎是一个更好的选择,因为含天然腐殖酸的溶液能够促进土壤中微生物的活性,而合成表面活性剂则相反,会使被淋洗过的土壤出现进一步的自然衰减。 | Pellegrino Conte Anna Agretto Riccardo Spaccini Alessandro Piccolo | 2014 | 中国洗涤用品工业2014，，1： | 3 |
| 7 | Fluorescent cholangiography: An up-to-date overview twelve years after the first clinical application显示文摘Laparoscopic cholecystectomy(LC)is one of the most frequently performed gastrointestinal surgeries worldwide.Bile duct injury(BDI)represents the most serious complication of LC,with an incidence of 0.3%-0.7%,resulting in significant perioperative morbidity and mortality,impaired quality of life,and high rates of subsequent medico-legal litigation.In most cases,the primary cause of BDI is the misinterpretation of biliary anatomy,leading to unexpected biliary lesions.Near-infrared fluorescent cholangiography is widely spreading in clinical practice to delineate biliary anatomy during LC in elective and emergency settings.The primary aim of this article was to perform an up-to-date overview of the evolution of this method 12 years after the first clinical application in 2009 and to highlight all advantages and current limitations according to the available scientific evidence. | Antonio Pesce Gaetano Piccolo Francesca Lecchi NicolòFabbri Michele Diana Carlo Vittorio Feo | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 8 | Decomposition of maize straw in three European soils as revealed by DRIFT spectra of soil particle fractions显示文摘 | R Spaccini A Piccolo G Haberhauer M Stemmer M.H Gerzabek | 2001 | Geoderma2001，，3： | 2 |
| 9 | Subclinical hypothyroidism in young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters显示文摘 | Cristina Laguna Benetti-Pinto Vanessa Ribeiro Santana Berini Piccolo Heraldo Mendes Garmes Cássia Raquel Teatin Juliato | 2012 | Fertility and Sterility2012，，： | 2 |
| 10 | Adsorption and desorption of glyphosate in some European soils显示文摘 | Piccolo A Celano G Arienzo M Mirabella A | 1994 | Journal of Environmental Science and Health Part B: Pesticides Food Contaminants and Agricultural Wastes1994，29，6： | 2 |
| 11 | Corn bined effects of waves and plants on a mud deposition event at a mudflat-saltmarsh edge in the Bahia Blanca estuary显示文摘 | Paula D Pratolongo Gerardo M E Perillo M Cintia Piccolo | 2010 | Estuarine Coastal and Shelf Science2010，87，： | 1 |
| 12 | Intracoronary versus intravenous bolus abciximab administration in patients undergoing primary percutaneous coronary intervention with acute ST-elevation myocardial infarction:a pooled analysis of individual patient data from five randomised controlled trials显示文摘 | Piccolo R Eitel I Iversen A Z | 2014 | Eurolntervention2014，9，9： | 1 |
| 13 | Giant gastrointestinal stromal tumor(GIST) of the stomach cause of high bowel obstruction: surgical management 显示文摘 | Cappellani A Piccolo G Cardi F | 2013 | World J Surg Onco12013，11，： | 1 |
| 14 | Stable coronary artery disease: revascularisation and invasive strategies 显示文摘 | Piccolo R Giustino G Mehran R | 2015 | Lancet2015，386，： | 1 |
| 15 | Zinc salt catalyzed rearrangement of acetals of optically active aryl 1-chloroethyl ketones:synthesis of optically active 2-arylpropionic acids and esters显示文摘 | Piccolo O Sfreafico F Visentin G | 1987 | J Org Chem1987，52，： | 1 |
| 16 | Potential availability of heavy metals to phytoextraction from contaminated soils induced by exogenous humic sub- stances 显示文摘 | HALIM M CONTE P PICCOLO A | 2003 | Chemosphere2003，52，： | 1 |
| 17 | Molecular characteris-tics of humic acids extracted from compost at increasing maturity stages显示文摘 | RICCARDO SPACCINI ALESSANDRO PICCOLO | 2009 | Soil Biology&Biochemistry2009，41，： | 1 |
| 18 | Nitrogen sta- ble isotopic composition of leaves and soil: Tropical versus tem- perate forests显示文摘 | Martinelli L A Piccolo M C Townsend A R | 1999 | Biogeochemistry1999，46，： | 1 |
| 19 | Clinical and molecular models of glioblastoma multiforme survival显示文摘 | Piccolo SR Frew L1 | 2013 | Inr J Data Min Bioirfform2013，7，： | 1 |
| 20 | Review on the use of insects in the diet of farmed fish:Past and future显示文摘 | Henry M Gasco L Piccolo G et d | 2015 | Animal Feed Sci- ence and Technology2015，203，： | 1 |
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