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| 1 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 2 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 3 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 4 | Effects of nitrogen ion implantation on Ca^(2+) concentration and membrane potential of pollen cell显示文摘The effects of low energy nitrogen ion implantation on Ca2+ concentration and membrane potential of illy (Mum davidii Duch) pollen cell have been studied. The results showed that the Ca2+ concentration was increased when pollen grain was implanted by nitrogen ion with energy 100 keV and dose 1013 ions/cm2. However, the increase of Ca2+ concentration was partly inhibited by the addition of Ca2+ channel inhibitor depending on dose. And nitrogen ion implantation caused depolarization of pollen cell membrane potential. In other words, membrane potential was increased, but the effect decreased by adding Ca2+ channel inhibitor. However, it was still significantly higher than the membrane potential of control cells. It was indicated that the depolarization of cell membrane potential opened the calcium channel on the membrane that caused the increasing of intracel-lular calcium concentration. This might be an earlier step of the effect of low energy nitrogen ion implantation on pollen germination. | HUANG Zhonglian, JING Yanping, ZHU Guoli, LU Ting, ZHOU Hongyu & REN Haiyun1. Key Laboratory of Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Beijing 100875, China 2. Key Laboratory of Plant Physiology and Biochemistry of the Ministry of Agriculture, China Agriculture University, Beijing 100094, China 3. Institution of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China | 2001 | Chinese Science Bulletin2001，46，20： | 5 |
| 5 | Higher Order Triangular Mixed Finite Element Methods for Semilinear Quadratic Optimal Control Problems显示文摘In this paper,we investigate a priori error estimates for the quadratic optimal control problems governed by semilinear elliptic partial differential equations using higher order triangular mixed finite element methods.The state and the co-state are approximated by the order k Raviart-Thomas mixed finite element spaces and the control is approximated by piecewise polynomials of order k(k≥0).A priori error estimates for the mixed finite element approximation of semilinear control problems are obtained.Finally,we present some numerical examples which confirm our theoretical results. | Kang Deng Yanping Chen Zuliang Lu | 2011 | Numerical Mathematics(Theory,Methods and Applications)2011，4，2： | 4 |
| 6 | Influence of filler morphology on percolation threshold of isotropical conductive adhesives (ICA)显示文摘Different aspect ratio silver nano-structured materials including nanocubes,nanorods and nanowires were prepared by micro-waved assisted glycol reduction method.Different characterization methods including SEM and XRD were processed on these nanomaterials.Isotropical conductive adhesives(ICA) were developed by using these Ag nanomaterials as conductive fillers.It was found that the conductivity and thermal conductivity percolation threshold of the ICA depended on the morphologies of the fillers,lower percolation threshold could be obtained by using higher aspect ratio filler.A modified percolation threshold theory was put forward to explain and simulate the experiment results,the simulated results could match the experiment results very well. | TAO Yu YANG ZhenGuo LU XiaoLu TAO GuoLiang XIA YanPing WU HaiPing | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 7 | Optically stimulated luminescence dosimeter based on CaS:Eu,Sm显示文摘Alkaline earth sulfides (MgS,CaS and BaS) crystal doped with rare-earth ions is an optically stimulated luminescence dosimeter with very high sensitivity,short time constant of the optically stimulated luminescence (OSL) separated perfectly from the stimulation.In this paper,an OSL dosimeter is described.It has linear dose response from 0.01 to 1000 Gy.The equipment,relatively simple and small in size is promising for applications in space exploration and for high dose irradiation and dangerous irradiation conditions. | LIU Yanping CHEN Zhaoyang BA Weizhen FAN Yanwei GUO Qi YU Xuefeng CHANG Aiming LU Wu DU Yanzhao | 2008 | Nuclear Science and Techniques2008，19，2： | 4 |
| 8 | Effect of the Oxidation Time on Properties of Ceramic Coatings Produced on Ti-6Al-4V by Micro-Arc Oxidation显示文摘Ceramic coatings were prepared on Ti-6AI-4V alloy using ac micro-arc oxidation (MAO) in silicate-hypophosphate solution. Growth regularity and formation mechanism of ceramic coatings were discussed. It was found that during the first stage the growth rate of coatings toward the external surface was larger than that toward substrate and then the coating began to grow mainly towards Ti alloy. When the total coating thickness reaches a certain value, it would no longer increase. In addition, the variations of the composition and microstructure of ceramic coatings according to the depositing time were also investigated with X-ray diffraction (XRD) and scanning electron microscope (SEM).The amount of rutile TiO2 gradually increased, whereas the amounts of the anatase TiO2 and amorphous phases first increased and then decreased slightly. | Zhaohua JIANG, Xuetong SUN, Yanping LI, Fuping WANG and Yandong LU Department of Applied Chemistry, Harbin Institute of Technology, Harbin 150001, China | 2005 | Journal of Materials Science & Technology2005，21，2： | 3 |
| 9 | A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus显示文摘To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus(IBDV), a pair of viruses, namely the moderately virulent IBDV(rG x-F9VP2) and the attenuated strain(rGt), were used. Residue mutations A222P(P_(BC)) and S330R(PHI), selected by sequence comparison, were introduced individually into r Gx-F9VP2 by using a reverse genetics system. In addition, the reverse mutation of either P222 A or R330 S was introduced into r Gt. The four modified viruses were then rescued and evaluated in vitro(CEF cells) and in vivo(SPF chickens). Results showed that A222 P elevated the replication efficiency of rG x-F9VP2 while P222 A reduced that of rG t in CEF cells. A mutation at residue 330 did not alter IBDV replication. In addition, animal experiments showed that a single mutation at either residue 222 or 330 did not significantly influence the virulence of IBDV. In conclusion, residue 222 in PBC of VP2 is involved in the replication efficiency of IBDV in vitro but does not affect its virulence in vivo, further facilitating our understanding of the gene-function of IBDV. | Xiaole Qi Xiang Gao Zhen Lu Lizhou Zhang Yongqiang Wang Li Gao Yulong Gao Kai Li Honglei Gao Changjun Liu Hongyu Cui Yanping Zhanga Xiaomei Wang | 2016 | Science China(Life Sciences)2016，59，7： | 2 |
| 10 | The Role of Groundwater in the Salt Lakes in the Badain Jaran Desert,China显示文摘The Badain Jaran Desert is the second largest desert in China with tallest sand dunes on the earth.In contrast to the extremely dry climate,there are about 100 lakes spreading regularly over the depressions among | GONG Yanping WANG Xusheng CHEN Tianfei LU Huiting | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 2 |
| 11 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 12 | Influence of electroplating conditions on magnetic properties of Fe-36wt.% Ni alloy film显示文摘A Fe-Ni soft magnetic film was prepared in sulphate solution by electroplating. The influences of the molar ratio of n[Fe2+]/n[Ni2+], current density, bath temperature, pH and L-ascorbic acid concentration on magnetic properties of Fe-Ni alloy film were investigated. The results show that the saturated flux density(BS) of the film increases initially and decreases after it reaches the specific value with the increase of n[Fe2+]/n[Ni2+] molar ratio, current density, bath temperature and pH. However, the relationship between L-ascorbic acid concentration and BS keeps linear. It is observed that the coercive force(Hc) is enhanced with the increase of n[Fe2+]/n[Ni2+] molar ratio, current density and pH. By comparison, when the bath temperature increases, Hc always decreases. With the increase of L-ascorbic acid concentration, the coercive force increases initially and then decreases. | LIU Tiancheng LU Zhichao LI Deren LI Peng LU Yanping SUN Ke ZHOU Shaoxiong | 2006 | Rare Metals2006，25，z1： | 2 |
| 13 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 14 | Identification of two novel missense WFS1 mutations,H696Y and R703H,in patients with non-syndromic low-frequency sensorineural hearing loss显示文摘Non-syndromic 低频率的 sensorineural 听觉损失(LFSNHL ) 是听见在频率, 2000 Hz 主要被影响的损失的一种不平常的类型。迄今为止,在二基因, DIAPH1 和 WFS1 的不同变化,被发现了与 LFSNHL 被联系。这里,我们与 postlingual 和进步 LFSNHL 报导一个五产生的中国家庭。我们在在标记 SNP_A-2167174 和 D4S431 之间的染色体 4p16 上印射疾病地点到 2.5 Mb 区域,与 DFNA6/14/38 地点重叠。候选人基因定序揭示了异质接合的 c.2086C > 在 exon 的 T 替换 8 WFS1,在 Wolframin (WFS1 ) 的 C 终点导致 p.H696Y 替换。另外,我们执行了在 37 个分散的病人, WFS1 屏蔽的 mutational 750 岁,与 LFSNHL。我们检测了异质接合的 c.2108G > 在 exon 的替换 8 WFS1,在一个病人导致 p.R703H 替换。在 WFS1 的 H696 和 R703 高度越过种类被保存,包括人,猩猩,老鼠,老鼠,和青蛙(Xenopus ) 。顺序分析表明了 c.2086C 的缺席 > T 或 c.2108G > 在在中国背景的 200 个无关的控制题目之中的 WFS1 基因的 A 替换,支持他们代表的假设原因的变化,和不稀罕的多型性。我们的数据为为 LFSNHL 建立更好的 genotypephenotype 关联提供另外的分子、临床的信息。 | Yi Sun Jing Cheng Yanping Lu Jianzhong Li Yu Lu Zhanguo Jin Pu Dai Rongguang Wang Huijun Yuan | 2011 | Journal of Genetics and Genomics2011，38，2： | 2 |
| 15 | How Do China's Importing Firms Respond to Non-taritf Measures?显示文摘After the formation of the World Trade Organization(WTO)in 1995,most countries gradually reduced their import tariffs to a fairly low level.However,the reduced tariffs could not he simply read as a reduction in trade barriers.Indeed,many suspect that countries tend to use more non-tariff measures(NTMs),substituting them for tariff barriers,to protect their domestic economies.This paper uses newly compiled and detailed Chinese NTM data,together with highly disaggregated firm import data and manufacturing firm operational data,to investigate the impact of China s import-related NTMs on firm imports.The main empirical results show that,as in the case of tariff barriers,China s trade policy NTMs mainly inhibit firms'intermediate imports.In contrast,China s public policy NTMs significantly improve the intensive and extensive margins of firm s intermediate imports and raise the prices and quality of imported inputs.The greater the extent to which a firm engages in processing trade,the larger is the promoting effect of public policy NTMs on the firm s import margins far intermediate inputs,and the greater is the restricting ejfect on the prices and the quality of the firm's imported inputs. | Xiaodan Hu Yunhua Tian Yanping Zhou Lu Feng | 2021 | China & World Economy2021，29，4： | 1 |
| 16 | Phase unwrapping algorithms for radar interferometry: residue-cut, least-squares, and synthesis algorithms显示文摘 | ZEBKER Howard A LU Yanping | 1998 | Opt Soc Am A1998，15，3： | 1 |
| 17 | An approach to application for LiNi 0.6 Co 0.2 Mn 0.2 O 2 cathode material at high cutoff voltage by TiO 2 coating显示文摘 | Yanping Chen Yun Zhang Baojun Chen Zongyi Wang Chao Lu | 2014 | Journal of Power Sources2014，，： | 1 |
| 18 | Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival显示文摘 | Xiaolan Zhou Jin Lin Wang John Lu Yanping Song Keith S. Kwak Qingsheng Jiao Robert Rosenfeld Qing Chen Thomas Boone W. Scott Simonet David L. Lacey Alfred L. Goldberg H.Q. Han | 2010 | Cell2010，，4： | 1 |
| 19 | Electrochemical behaviors of graphene–ZnO and graphene–SnO 2 composite films for supercapacitors显示文摘 | Ting Lu Yanping Zhang Haibo Li Likun Pan Yinlun Li Zhuo Sun | 2010 | Electrochimica Acta2010，，13： | 1 |
| 20 | Ethical Leadership and Subordinates’ Occupational Well-Being: A Multi-level Examination in China显示文摘 | Yanping Li Jia Xu Yidong Tu Xinxin Lu | 2014 | Social Indicators Research2014，，3： | 1 |
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