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| 1 | Orthogonal analysis of water model study on the optimization of flow control devices in a six-strand tundish显示文摘Improper flow control devices in a multi-strand tundish can cause some problems, for example, liquid steel cannot reach every nozzle at the same time and the liquid steel in nozzles far away from the entry zone has a lower temperature. The water model experiment of a six-strand tundish of Tianjin Iron & Steel Co. Ltd. was performed, a new 'U' type baffle was obtained, and its parameters were defined by perpendicular analysis. The 'U' baffle can not only improve those imperfections, but also prolong the residence time of nonmetallic inclusions, which is good for their flotation and separation. | Zhengyan Wei Yanping Bao Jianhua Liu Wenxu Gong Baoming Wang | 2007 | Journal of University of Science and Technology Beijing2007，14，2： | 18 |
| 2 | RVFL-Based Optical Fiber Intrusion Signal Recognition With Multi-Level Wavelet Decomposition as Feature显示文摘光纤维警告前系统(OFPS ) 逐渐地为监视的管道安全被看作了重要工具之一。侵入信号类型正确地被识别它能减少解决和管道的维护的费用。大多数在 OFPS 的以前的特征抽取方法通常从时间领域的看法被寻找。在一些情况中,然而,在时间领域没有区分的特征。在第一,侵入信号跑展示的纸,挖,并且精选鹤嘴锄被多水平小浪分解在频率领域提取,也就是说,侵入信号被分解成五个乐队。第二,不同频率乐队的平均精力比率被获得,它被看作每种侵入类型的特征。最后,特征样品被送到随机的向量功能连接(RVFL ) 为训练完成信号的分类和鉴定联网。试验性的结果证明算法罐头正确地区分不同侵入信号并且完成更高的识别率。 | Yanping WANG Dianjun GONG Liping PANG Dan YANG | 2018 | Photonic Sensors2018，8，3： | 11 |
| 3 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 4 | Preliminary assessment of heavy metal contamination in surface water and sediments from Honghu Lake, East Central China显示文摘表面水和沉积里的重金属集中在湖北省从洪胡·莱克收集了,中国被分析,并且生态的风险根据沉积质量指南被评估。结果证明表面水里的重金属的平均集中是被评价:作为 > Zn > Cu > Cr > Pb > Ni > Cd > Hg。与在另外的河和背景价值里报导的结果比较,洪胡·莱克被弄脏由作为, Cr, Pb, Cu 和 Ni。大多数金属可能主要从在湖附近的化肥,工业自河和国内废水。重金属集中比在另外的区域在入口区域是相对更高的。当重要积极关联在 Zn, Cd 和 Pb 之间是在场的时,否定关联在很重的金属和 pH 之间被观察。在沉积核心,当时, Cu, Zn, Cr 和 Ni 显示出一个减少的趋势在场的 Cd 一个增加的趋势。减少作为,在由于在 1998 的洪水事件的 1990 年代力量的 Cu, Zn, Cr 和 Ni。生态的风险评价的分析基于沉积质量指南建议在从洪胡·莱克的大多数沉积的重金属有中等毒性,与 Cr being 最高的优先级污染物质[出版摘要] | Ying HU Shihua QI Chenxi WU Yanping KE Jing CHEN Wei CHEN Xiangyi GONG | 2012 | Frontiers of Earth Science2012，6，1： | 7 |
| 5 | Groundwater contributions in water-salt balances of the lakes in the Badain Jaran Desert,China显示文摘Groundwater-fed lakes are essential for the ecology in arid and semiarid regions.As a typical arid region,the Badain Jaran Desert (BJD) is famous in the world for the presence of a large number of groundwater-fed saline lakes among the mega dunes.Based on the up to date geological surveys and observations,this study analyzed the groundwater contributions in water-salt balances of the lakes in the desert.We found different types of springs,including the sublacustrine springs that indicate an upward flow of groundwater under the lakebed.A simplified water balance model was developed to analyze the seasonal variations of water level in the Sumu Barun Jaran Lake,which revealed an approximately steady groundwater discharge in the lake and explained why the amplitude of seasonal changes in lake level is less than 0.5 m.In addition,a salt balance model was developed to evaluate the salt accumulations in the groundwater-fed lakes.The relative salt accumulation time is 800–7,000 years in typical saline lakes,which were estimated from the concentration of Cl-,indicating a long history evolution for the lakes in the BJD.Further researches are recommended to provide comprehensive investigations on the interactions between the lakes and groundwater in the BJD. | GONG Yanping WANG Xusheng HU B Xiao ZHOU Yangxiao HAO Chunbo WAN Li | 2016 | Journal of Arid Land2016，8，5： | 7 |
| 6 | Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system显示文摘Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution.However,there have not been any similar sys-tems developed for Clostridium,an important bacterial genus.Here we report a novel two-step strategy for de-veloping controllable hypermutable cells of Clostridium acetobutylicum,an important and representative indus-trial strain.Firstly,the mutS/L operon essential for methyl-directed mismatch repair(MMR)activity was inactivated from the genome of C.acetobutylicum to generate hy-permutable cells with over 250-fold increased mutation rates.Secondly,a proofreading control system carrying an inducibly expressed mutS/L operon was constructed.The hypermutable cells and the proofreading control system were integrated to form a controllable hypermut-able system SMBMutC,of which the mutation rates can be regulated by the concentration of anhydrotetracycline(aTc).Duplication of the miniPthl-tetR module of the proof-reading control system further signifi cantly expanded the regulatory space of the mutation rates,demonstrating hypermutable Clostridium cells with controllable mutation rates are generated.The developed C.acetobutylicum strain SMBMutC2 showed higher survival capacities than the control strain facing butanol-stress,indicating greatly increased evolvability and adaptability of the controllable hypermutable cells under environmental challenges. | Guodong Luan Zhen Cai Fuyu Gong Hongjun Dong Zhao Lin Yanping Zhang Yin Li | 2013 | Protein & Cell2013，4，11： | 4 |
| 7 | The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages显示文摘The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the 'eat me' signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the 'don’t eat me' signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment. | Yanping Wu Xiang Luo Qingqing Zhou Haibiao Gong Huaying Gao Tongzheng Liu Jiaxu Chen Lei Liang Hiroshi Kurihara Yi-Fang Li Rong-Rong He | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 8 | C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42显示文摘CCAAT/enhancer 有约束力的蛋白质α(C/EBP α) 是 transcriptional 禁止细胞增殖的规章的因素,和其他的翻译开始生产二多肽, C/EBP α p 30 并且 C/EBP α p 42。由表示介绍, C/EBP α p 30specifically 禁止了基因的一个唯一的集合,这被揭示,包括 MPP11, p84N5 和 SMYD2,它没被 C/EBP α p 影响 42 在两根 QSG-7701 hepatocyte 房间线和 QGY-7703 hepatoma, cells.Semi 量的 RT-PCR 分析独立地证实了这些结果。Chromatinimmunoprecipitation 试金显示出 30 比 C/EBP α p 更强烈绑了在这些基因的倡导者的那 C/EBP α p 42。在 C/EBP α是调整的 down 的临床的 hepatoma 在样品,所有三基因明确地由 30 在上面的 C/EBP α p 禁止了调整。然而, MPP11, p84N5 和 SMYD2genes 的压抑可能直接不涉及 C/EBP α p 30-mediated 生长抑制。我们的数据建议 30 调整的那 C/EBP α p 目标基因的一个唯一的集合并且多于 C/EBP α p 的 dominant-negativeregulator 42。 | Chunxi Wang~1 Xiaotao Chen~1 Yanping Wang~1 Jialei Gong~1 Gengxi Hu ~1State Key Laboratory of Molecular Biology institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China | 2007 | Cell Research2007，17，4： | 2 |
| 9 | Correction: The NAC transcription factor ClNAC68 positively regulates sugar content and seed development in watermelon by repressing ClINV and ClGH3.6显示文摘In this article 1,author name Yanping Wang was incorrectly tagged as corresponding author.Prof.Wang should be the co-first author,instead of the corresponding author.The original article has been corrected. | Jinfang Wang Yanping Wang Jie Zhang Yi Ren Maoying Li Shaowei Tian Yongtao Yu Yi Zuo Guoyi Gong Haiying Zhang Shaogui Guo Yong Xu | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | The Role of Groundwater in the Salt Lakes in the Badain Jaran Desert,China显示文摘The Badain Jaran Desert is the second largest desert in China with tallest sand dunes on the earth.In contrast to the extremely dry climate,there are about 100 lakes spreading regularly over the depressions among | GONG Yanping WANG Xusheng CHEN Tianfei LU Huiting | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 2 |
| 11 | Cloning, identification, and expression analysis at the stage of gonadal sex differentiation of chicken miR-363 and 363显示文摘miRNAs (microRNAs ) 是小的,功能的、非编码的 RNA 并且被证明了在从房间区别到有机体开发的多样的生物过程的规定含有。以达到在鸡胚胎上探索 miRNAs 的角色性决心和 gonadal 区别,我们克隆并且识别茎环先锋结构( GenBank 同意没有 GU597370 )鸡肉, miR-363 和363*由在 E3.56.5 d 的阶段在鸡胚胎学习他们的时间、空间的表示模式列在后面(胚胎的天 3.56.5 )由半量的 RT-PCR 和愿望(在 situ 杂交整个山)在这研究。结果显示出那 miR-363 * 根据 miRNAs 的结构的特征在 miR-363 和 363* 的鸡染色体,和 flanking 顺序在未知片断的克隆的顺序定位了先锋。显著地微分的表示(P < 0.05 ) 在雌、雄的鸡肉之间的 gga-miR-363,胚胎的性腺被发现在 E4.5 和 6.5 d,而是 gga-miR-363 的微分表示 * 从 E3.5,到 6.5,在两性之间的 d 达不到重要水平。那个表达式 gga-miR-363 表明的显示的愿望的结果主要在 E6.5 出现在手足芽,脊索,外胚层,在 E4.5 d 鸡胚胎的大脑,和尿生殖的系统(UGS ) d,和 E6.5 d 的表达式水平在男性比那在女性是更高的。gga-miR-363 将在 gonadal 发展和 gga-miR-363 包含,这能被推测 * 可能在鸡胚胎开发的早阶段期间有短暂规章的功能。 | Pan Huang Yanzhang Gong Xiuli Peng ShijunLi Yu Yang Yanping Feng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 2 |
| 12 | A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms显示文摘OBJECTIVE:To provide a basis for the clinical identification of true and false reflux,integrated traditional Chinese and Western medicine,and psychosomatic treatment,we conducted a retrospective study of the etiology and epidemiological and Traditional Chinese Medicine(TCM) syndrome characteristics of patients with reflux/heartburn symptoms.METHODS:The 210 10 patients with reflux/heartburn treated at Tianjin Nankai Hospital from January 1,2016,to December 31,2019,were divided into four groups according to their pathogenesis.Sex,age,course of disease,incidence rate,gastroscopy,24-h p Himpedance,esophageal manometry,Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD) score,8-week proton pump inhibitor(PPI) treatment effect,and TCM syndrome characteristics were statistically analyzed.RESULTS:A total of 21010 patients(8864 men and 12146 women),with reflux/heartburn symptoms were screened,including 6284(29.9%) patients with reflux esophagitis(RE),10427(49.6%) patients with nonerosive reflux esophagitis(NERD),2430(11.6%) patients with reflux hypersensitivity(RH),and 1870(8.9%) patients with functional heartburn(FH).The incidence of the disease was higher in women than in men(P <0.0001).The ranking of the incidence of anxiety and depression in these four groups was FH > RH > NERD > RE(P < 0.0001).There were more women than men in the groups with anxiety and more men than women in the groups with depression(P < 0.0001),and there was no significant difference in the distribution of anxiety and depression between men and women(P = 0.5689).There were significant differences in TCM syndrome characteristics between NERD,RE,and functional esophageal diseases(P < 0.01).The highest proportion of functional esophageal disease TCM symptoms was Qi stagnation and phlegm obstruction syndrome(36.16%),and there was no significant difference between RH and FH.The effective rates of PPI treatment at 8 weeks in patients in the RE,NERD,RH,and FH groups were 89%,72%,54%,and 0%,respectively.RE was classified into grades A,B,C,and D according to the Los Angeles grading system.The ranking of the incidence of these four grades was A > B > C > D(P < 0.0001).The effective rates of PPI treatment at 8 weeks were 91%,81%,69%,and 63% in patients with grade A,B,C,and D RE,respectively(P < 0.0001).The highest proportion of TCM syndrome types of NERD and RE was the stagnated heat syndrome in the liver and stomach syndrome,38.99% and 33.90%,respectively.CONCLUSION:Reflux/heartburn symptoms are relatively common in middle-aged women,and NERD is the most common etiology,followed by RE,RH,and FH.The most common TCM syndrome characteristics in NERD and RE were stagnated heat syndrome in the liver and stomach syndrome,and Qi stagnation and phlegm obstruction syndrome in functional esophageal diseases.Most patients with reflux/heartburn symptoms also experienced anxiety and depression. | TANG Yanping LI Peicai LIU Xi LIU Lei GONG Yanxia WEI Xiaodong LIU Lina YANG Li | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 13 | Isolation and characterization of sexual dimorphism genes expressed in chicken embryonic gonads显示文摘在鸡肉,胚胎的性腺区分进一双睾丸或一个卵巢的 bipotential,而是位于 gonadal 性区别下面被识别了的很少基因和性决心基因仍然是未知的。为了识别更多的基因,在鸡性区别包含了,我们采用了孤立差别的减少性的杂交表示了的抑制在从鸡性腺的性之间的基因在 E3.5E6 的一个时期期间。相应于 88 基因的 152 cDNA 克隆的一个总数(41 从 F-M 图书馆并且 47 从 M-F 图书馆) 用点污点分析被屏蔽。这些基因在性染色体与五主要位于宏染色体(15 )( 在 W 的并且四在 Z ) ,编码四统治属于酶, DNA 协会, RNA 协会,和结构的蛋白质的分子的范畴。在鸡 EST 数据库把获得的 cDNA 序列与那些作比较,它从 F-M 图书馆显示出 32 基因的那 cDNAs 并且 16 从 M-F 图书馆,在二的相当或相同的事物报导了胚胎的性腺 cDNA 图书馆。涉及 epigenetic 和抄写规定的八基因的量的即时 PCR 分析证明在 CDK2AP1, SMARCE1, SAP18, SUDS3,和 PQBP1 的性之间的显著地不同的表示在性腺开发(E4 ) 出现在早阶段。把表示基因基于性差别的功能的比较,包括 ATP5A1W 的一些通常认为地重要的基因的角色, CDK2AP1, mitochondrial 抄本,等等被分析了。在结论,孤立的基因的描述将提供珍贵线索识别涉及鸡性区别和性腺开发的基因机制的潜在的候选人。 | Yanping Feng Xiuli Peng Shijun Li Yanzhang Gong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，4： | 2 |
| 14 | Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma显示文摘 | Jin Cheng Ling Tian Jingjing Ma Yanping Gong Zhengxiang Zhang Zhiwei Chen Bing Xu Hui Xiong Chuanyuan Li Qian Huang | 2014 | Molecular Oncology2014，，： | 1 |
| 15 | CRISPR/Cas9-mediated mutagenesis of CiBG1 decreased seed size and promoted seed germination in watermelon显示文摘Abscisic acid(ABA)is a critical regulator of seed development and germination.β-glucosidases(BGs)have been suggested to be contributors to increased ABA content because they catalyze the hydrolysis of ABA-glucose ester to release free ABA.However,whether BGs are involved in seed development is unclear.In this study,a candidate gene,CiBG1,in watermelon was selected for targeted mutagenesis via the CRISPR/Cas9 system.Seed size and weight were significantly reduced in the Clbg1-mutant watermelon lines,which was mainly attributed to decreased cell number resulting from decreased ABA levels.A transcriptome analysis showed that the expression of 1015 and 1429 unique genes was changed 10 and 18 days after pollination(DAP),respectively.Cytoskeleton-and cell cycle-related genes were enriched in the differentially expressed genes of wild type and Clbg1-mutant lines during seed development.Moreover,the expression of genes in the major signaling pathways of seed size control was also changed.In addition,seed germination was promoted in the Cibg1-mutant lines due to decreased ABA content.These results indicate that ClBG1 may be critical for watermelon seed size regulation and germination mainly through the modulation of ABA content and thereby the transcriptional regulation of cytoskeleton-,cell cycle-and signaling-related genes.Our results lay a foundation for dissecting the molecular mechanisms of controlling watermelon seed size,a key agricultural trait of significant economic importance. | Yanping Wang Jinfang Wang Shaogui Guo Shouwei Tian Jie Zhang Yi Ren Maoying Li Guoyi Gong Haiying Zhang Yong Xu | 2021 | Horticulture Research2021，8，1： | 1 |
| 16 | A recognition system of China-style license plates based on mathematical morphology and neural network显示文摘 | Yanping Bai Hongping Hu Fei Li Wei Shuang Lixia Gong | 2010 | International Journal of Mathematical Models and Methods in Applied Sciences2010，4，1： | 1 |
| 17 | Multiplicity and uniqueness for a class of discrete fractional boundary value problems显示文摘 | Lv Zhanmei Gong Yanping Chen Yi | 2014 | Appl Math2014，59，6： | 1 |
| 18 | Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils显示文摘Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune responses.However,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune diseases.Here,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species production.However,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil viability.Dysregulated neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive lymphocytes.Interestingly,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease activity.Taken together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies. | Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C.Tsokos Minghong Jiang Xuan Zhan | 2023 | Cellular & Molecular Immunology2023，20，11： | 1 |
| 19 | A national survey on pediatric critical values used in clinical laboratories across Canada显示文摘 | Yanping Gong Khosrow Adeli | 2009 | Clinical Biochemistry2009，，16： | 1 |
| 20 | Effect of aging on islet beta-cell function and its mechanisms in Wistar rats显示文摘 | Zhaoyan Gu Yingzhen Du Yu Liu Lichao Ma Lin Li Yanping Gong Hui Tian Chunlin Li | 2012 | AGE2012，，6： | 1 |
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