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| 1 | Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia显示文摘DNA methylation is associated with malignant transformation, but limitations imposed by genetic variability, tumor heterogeneity, availability of paired normal tissues and methodologies for global assessment of DNA methylation have limited progress in understanding the extent of epigenetic events in the initiation and progression of human cancer and in identifying genes that undergo methylation during cancer. We developed a mouse model of T/natural killer acute lymphoblastic leukemia that is always preceded by polyclonal lymphocyte expansion to determine how aberrant promoter DNA methylation and consequent gene silencing might be contributing to leukemic transformation. We used restriction landmark genomic scanning with this mouse model of preleukemia reproducibly progressing to leukemia to show that specific genomic methylation is associated with only the leukemic phase and is not random. We also identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of other human cancers. | LiYu ChunhuiLiu JeffVandeusen BrianBecknell ZunyanDai Yue-ZhongWu AparnaRaval Te-HuiLiu WeiDing CharleneMao ShujunLiu LauraTSmith StephenLee LauraRassenti GuidoMarcucci JohnByrd MichaelACaligiuri ChristophPlass | 2005 | 中国生物学文摘2005，19，4： | 80 |
| 2 | Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors显示文摘Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2),one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis. Results: CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.Conclusion: CysLT2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells. | HuaHU GaoCHEN Jian-minZHANG Wei-pingZHANG LeiZHANG Qiu-fuGE Hong-tianYAO WeiDING ZhongCHEN Er-qingWEI | 2005 | Acta Pharmacologica Sinica2005，26，6： | 9 |
| 3 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 4 | Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration显示文摘 | Wolfram Goessling Trista E. North Sabine Loewer Allegra M. Lord Sang Lee Cristi L. Stoick-Cooper Gilbert Weidinger Mark Puder George Q. Daley Randall T. Moon Leonard I. Zon | 2009 | Cell2009，，6： | 2 |
| 5 | 受温度或草花粉影响而症状严重的季节性:儿童湿疹专项研究结果 | Krmer amer U. Weidinger S. Darsow U. 张宪旗 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，8： | 2 |
| 6 | Estimation of net nitrogen flux between the atmosphere and a semi-natural grassland ecosystem in Hungary显示文摘 | Machon A Horvath L Weidinger T | 2010 | European Journd of Soil Science2010，61，： | 1 |
| 7 | Monocyte-de- rived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to toll-like re- ceptor ligands 显示文摘 | Terhorst D Kalali BN Weidinger S | 2007 | Clin Exp Allergy2007，37，3： | 1 |
| 8 | Endothelial function: a surrogate endpoint in eardiovascular studies显示文摘 | Frick M Weidinger F | 2007 | Curr Pharm Des2007，13，17： | 1 |
| 9 | Prostate specific antigen as allergen in human seminal plasma allergy显示文摘 | Weidinger S Mayerhofer A Raemsch R | 2006 | J Allergy Clin Immunol2006，117，： | 1 |
| 10 | Cellular repressor of ElA-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis 显示文摘 | Schahs P Weidinger P Probst OC | 2008 | Exp Cell Res2008，314，16： | 1 |
| 11 | Association between plasrain activation system and intravascular ultrasound signs of plaque instability in patients with unstable angina and non-st-segment elevation myocardial infarction显示文摘 | Gyongyosi M Glogar D Weidinger F | 2004 | Am Heart J2004，147，1： | 1 |
| 12 | Predictors of hospital mortality in the elderly undergoing percutaneous coronary intervention for acute coronary syndromes and stable angina显示文摘 | Bauer T Mollmann H Weidinger F | 2011 | Int J Cardiol2011，151，2： | 1 |
| 13 | Association of a STAT 6 haplotype with elevated serum IgE levels in a population based co- hort of white adults显示文摘 | Weidinger S Klopp N Wagenpfeil S | 2004 | J Med Genet2004，41，9： | 1 |
| 14 | The CCN family member Wisp3, mutant in progressive pseu- dorheumatoid dysplasia, modulates BMP and Wnt signal- ing显示文摘 | Nakamura Y Weidinger G Liang JO | 2007 | J Clin Invest2007，117，10： | 1 |
| 15 | The breeding performance of Blackcap Sylvia atricapilla in two types of forest habitat 显示文摘 | WEIDINGER K | 2000 | Ardea2000，88，： | 1 |
| 16 | Atopic dermatitis显示文摘 | Weidinger S Novak N | 2015 | Lancet2015，，： | 1 |
| 17 | Endothelial function : a Surrogate endpoint in cardiovascular studies显示文摘 | Frick M Weidinger F | 2007 | Curr Pharm Des2007，13，17： | 1 |
| 18 | Seasonality in symptom severity influenced by temperature or grass pollen:results of a panel study in children with eczema显示文摘 | Kramer L Weidinger S Darsow U | 2005 | J Invest Dermatol2005，124，： | 1 |
| 19 | The role of inflamma- tion in the pathophysiology of acute coronary syndromes 显示文摘 | Alber HF Suessenbacher A Weidinger F | 2005 | Wien Kiln Wochenschr2005，117，1314： | 1 |
| 20 | The Investigation on the Value of Repeat and Combination Test of ACA and Anti‐β<sub>2</sub>‐GPI Antibody in Women with Recurrent Spontaneous Abortion显示文摘 | Shi HuaBao Xi PengWang Qi DeLin WenDi LiangXu Chuan WeiDing | 2008 | American Journal of Reproductive Immunology2008，，4： | 1 |
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