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| 1 | Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer显示文摘 | Daniel R. Gomez Susan L. Tucker Mary K. Martel Radhe Mohan Peter A. Balter Jose Luis Lopez Guerra Hongmei Liu Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 2 |
| 2 | High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula显示文摘to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice Age.These proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface wetness.Analysis:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[cal.yr BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier conditions.The Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet phases.The LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification index.However,four different climate phases were differentiated in this period.High-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global models.The study provides new information and a detailed chronology of climatic events that will help to refine local modulation of the climate evolution model in the still quite unexplored region of the NW Iberian Peninsula,a key area for understanding the paleoclimatic dynamics in SW Europe. | Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja Sebastian Perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal | 2020 | Geoscience Frontiers2020，11，5： | 2 |
| 3 | A micromirror array with annular partitioning for high-speed random-access axial focusing显示文摘Dynamic axial focusing functionality has recently experienced widespread incorporation in microscopy,augmented/virtual reality(AR/VR),adaptive optics and material processing.However,the limitations of existing varifocal tools continue to beset the performance capabilities and operating overhead of the optical systems that mobilize such functionality.The varifocal tools that are the least burdensome to operate(e.g.liquid crystal,elastomeric or optofluidic lenses)suffer from low(≈100 Hz)refresh rates.Conversely,the fastest devices sacrifice either critical capabilities such as their dwelling capacity(e.g.acoustic gradient lenses or monolithic micromechanical mirrors)or low operating overhead(e.g.deformable mirrors).Here,we present a general-purpose random-access axial focusing device that bridges these previously conflicting features of high speed,dwelling capacity and lightweight drive by employing lowrigidity micromirrors that exploit the robustness of defocusing phase profiles.Geometrically,the device consists of an 8.2mm diameter array of piston-motion and 48-μm-pitch micromirror pixels that provide 2πphase shifting for wavelengths shorter than 1100 nm with 10-90% settling in 64.8μs(i.e.,15.44 kHz refresh rate).The pixels are electrically partitioned into 32 rings for a driving scheme that enables phase-wrapped operation with circular symmetry and requires<30 V per channel.Optical experiments demonstrated the array’s wide focusing range with a measured ability to target 29 distinct resolvable depth planes.Overall,the features of the proposed array offer the potential for compact,straightforward methods of tackling bottlenecked applications,including high-throughput single-cell targeting in neurobiology and the delivery of dense 3D visual information in AR/VR. | Nathan Tessema Ersumo Cem Yalcin Nick Antipa Nicolas Pegard Laura Waller Daniel Lopez Rikky Muller | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 4 | Laboratory evaluation of the GreenSeeker^(TM) handheld optical sensor to variations in orientation and height above canopy显示文摘Handheld optical sensors recently have been introduced to the agricultural market.These handheld sensors are able to provide operators with Normalized Difference Vegetative Index(NDVI)data when cloud cover prevents acquisition of satellite or aerial images.This research addressed the sensitivity of the GreenSeeker handheld optical sensor to changes in orientation and height above a ryegrass canopy.Planter boxes were oriented both parallel and perpendicular to the light beam from the sensor head and heights of 30.5 cm(12”),61.0 cm(24”),91.5 cm(36”),122 cm(48”)and 152 cm(60”)were tested.Results indicated that the sensor was highly sensitive(P<0.0001)to both height above canopy and orientation of the sensor relative to the target.Operators should follow manufacturer’s recommendations on operating height range of 81-122 cm and orient the sensor head in-line with the target to obtain maximum signal response. | Daniel E Martin Juan D Lopez Jr Yubin Lan | 2012 | International Journal of Agricultural and Biological Engineering2012，5，1： | 2 |
| 5 | Management of genitourinary syndrome of menopause in breast cancer survivors:An update显示文摘There is increasing attention about managing the adverse effects of adjuvant therapy(Chemotherapy and anti-estrogen treatment)for breast cancer survivors(BCSs).Vulvovaginal atrophy(VVA),caused by decreased levels of circulating estrogen to urogenital receptors,is commonly experienced by this patients.Women receiving antiestrogen therapy,specifically aromatase inhibitors,often suffer from vaginal dryness,itching,irritation,dyspareunia,and dysuria,collectively known as genitourinary syndrome of menopause(GSM),that it can in turn lead to pain,discomfort,impairment of sexual function and negatively impact on multiple domains of quality of life(QoL).The worsening of QoL in these patients due to GSM symptoms can lead to discontinuation of hormone adjuvant therapies and therefore must be addressed properly.The diagnosis of VVA is confirmed through patient-reported symptoms and gynecological examination of external structures,introitus,and vaginal mucosa.Systemic estrogen treatment is contraindicated in BCSs.In these patients,GSM may be prevented,reduced and managed in most cases but this requires early recognition and appropriate treatment,but it is normally undertreated by oncologists because of fear of cancer recurrence,specifically when considering treatment with vaginal estrogen therapy(VET)because of unknown levels of systemic absorption of estradiol.Lifestyle modifications and nonhormonal treatments(vaginal moisturizers,lubricants,and gels)are the first-line treatment for GSM both in healthy women as BCSs,but when these are not effective for symptom relief,other options can be considered,such as VET,ospemifene,local androgens,intravaginal dehydroepiandrosterone(prasterone),or laser therapy(erbium or CO2 Laser).The present data suggest that these therapies are effective for VVA in BCSs;however,safety remains controversial and a there is a major concern with all of these treatments.We review current evidence for various nonpharmacologic and pharmacologic therapeutic modalities for GSM in BCSs and highlight the substantial gaps in the evidence for safe and effective therapies and the need for future research.We include recommendations for an approach to the management of GSM in women at high risk for breast cancer,women with estrogen-receptor positive breast cancers,women with triplenegative breast cancers,and women with metastatic disease. | Daniel Maria Lubian Lopez | 2022 | World Journal of Clinical Oncology2022，13，2： | 2 |
| 6 | Pacemaker activity recorded in interstitial cells of Cajal of the gastrointestinal tract显示文摘 | Barajas- Lopez C Berezin I Daniel EE | 1989 | Am J Physiol1989，257，41： | 1 |
| 7 | Appearance of hepatocellular adenomas on gadoxetic acid-enhanced MRI显示文摘 | Timm Denecke Ingo G. Steffen Sheela Agarwal Daniel Seehofer Thomas Kr?ncke Enrique Lopez H?nninen Incken-Birthe Kramme Peter Neuhaus Sanjay Saini Bernd Hamm Christian Grieser | 2012 | European Radiology2012，，8： | 1 |
| 8 | Treating prehypertension 显示文摘 | Daniel G Yaiza Lopez - plasencia Marcus Baumann | 2006 | NEJM2006，355，4： | 1 |
| 9 | Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells显示文摘 | Liqing Jin Erwin M. Lee Hayley S. Ramshaw Samantha J. Busfield Armando G. Peoppl Lucy Wilkinson Mark A. Guthridge Daniel Thomas Emma F. Barry Andrew Boyd David P. Gearing Gino Vairo Angel F. Lopez John E. Dick Richard B. Lock | 2009 | Cell Stem Cell2009，，1： | 1 |
| 10 | Changes in Pulmonary Function After Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, or Proton Beam Therapy for Non-Small-Cell Lung Cancer显示文摘 | Jose L. Lopez Guerra Daniel R. Gomez Yan Zhuang Lawrence B. Levy George Eapen Hongmei Liu Radhe Mohan Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 11 | Preparation and Characterization of Polystyrene-based Magnetic Nanoeomposites显示文摘 | Lopez Daniel Cendoya Ione Torres Francesc | 2001 | Polymer Engineering and Science2001，41，11： | 1 |
| 12 | Category-based induction显示文摘 | Daniel N Osherson Smith E E Ormond Wilkie Alejandro Lopez Eldar Shafir | 1990 | Psycho- logical Review1990，，97： | 1 |
| 13 | Low - Noise Cryogenic X - Band Amplifier Using Wet - Etched Hydrogen Passivated InP HEMT Devices 显示文摘 | Isaac Lopez -Fernhndez Juan Daniel Gallego Puyol | 1999 | rEEE Microwave And Wireless Components Letters1999，9，10： | 1 |
| 14 | Assessment of gelatin-chitosan interactions in films by a che- mometrics approach Evaluacion de las interacciones gelatina- quitosano mediante un enfoque de quimiometria显示文摘 | Cristian A Acevedo Paulo Diaz-Calderon Daniel Lopez | 2015 | CyTA - Journal of Food2015，，13： | 1 |
| 15 | Innovation and Productivity in Devel-oping Countries: A Study of Argentine Manufacturing Firms' Behavior (1992-2001)显示文摘 | Daniel Chudnovsky Andres Lopez German Pupato | 2006 | Research Policy2006，35，2： | 1 |
| 16 | Comparison of dobutamine versus milrinone therapy in hospitalized patients awaiting cardiac transplantation: A prospective, randomized trial显示文摘 | Juan M. Aranda Richard S. Schofield Daniel F. Pauly Timothy S. Cleeton Tracy C. Walker V.Steven Monroe Dana Leach Larry M. Lopez James A. Hill | 2003 | American Heart Journal2003，，： | 1 |
| 17 | Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the hepatic manifestation of the metabolic syndrome(MetS)and is characterized by steatosis in the absence of significant alcohol consumption.However,MetS and significant alcohol intake coexist in certain individuals which may lead to the development of BAFLD.AIM To assess the clinical characteristics of patients with both alcoholic and NAFLD(BAFLD)in a large cohort in the United States.METHODS Adults from the National Health and Nutrition Examination Survey between 2003-2014 were included.NAFLD was diagnosed based on elevated alanine aminotransferase(ALT)and being overweight or obese in the absence of other liver diseases.BAFLD patients met the criteria for NAFLD but also had either MetS or type 2 diabetes and consumed excessive amounts of alcohol.Univariable and multivariable analysis were performed to assess differences between NAFLD and BAFLD and to compare severity based on a validated fibrosis score(FIB4 index).RESULTS The prevalence of NAFLD was at 25.9%(95%CI;25.1-26.8)and that of BAFLD was 0.84%(0.67,1.02)which corresponds to an estimated 1.24 million Americans affected by BAFLD.Compared to NAFLD,patients with BAFLD were more likely to be male,smokers,have higher ALT,aspartate aminotransferase,triglycerides,and lower platelets;P<0.01 for all.More importantly,after adjusting for MetS components,BAFLD patients were significantly more likely to have advanced fibrosis[adjusted OR(95%CI)based on FIB4 index>2.67 was 3.2(1.4,7.0),P=0.004].CONCLUSION A significant percentage of the American general population is afflicted by BAFLD and these patients tend to have more advanced liver fibrosis. | George Khoudari Amandeep Singh Mazen Noureddin Danielle Fritze Rocio Lopez Imad Asaad Eric Lawitz Fred Poordad Kris V Kowdley Naim Alkhouri | 2019 | World Journal of Hepatology2019，11，10： | 1 |
| 18 | Assessment of left atrial appendage function by biplane transesopbageal echocardiography in patients with nonrheumatic atrial fibrillation: identification of a subgroup of patients at increased embolic risk显示文摘 | Mugge A Kuhn H Nikutta P Grote J Lopez J A Daniel W G | 1994 | J Am Coll Cardiol1994，23，： | 1 |
| 19 | Cermet and hard metal coatings for advanced large diesel engines with reduced pollutant emissions 显示文摘 | Candel Antonio Gadow Rainer Lopez Daniel | 2005 | Ceramic Engineering and Science Pro- ceedings2005，26，3： | 1 |
| 20 | Single Versus Combined Blood Pressure Components and Risk for Cardiovascular Disease: The Framingham Heart Study显示文摘 | Stanley S. Franklin Victor A. Lopez Nathan D. Wong Gary F. Mitchell Martin G. Larson Ramachandran S. Vasan Daniel Levy | 2009 | Circulation2009，，2： | 1 |
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