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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 4 | Real-time PCR versus conventional PCR for malaria parasite detection in low-grade parasitemia显示文摘 | Bianca E. Gama Felipe do E.S. Silva-Pires Mauro N’Kruman R. Lopes Maria Angélica B. Cardoso Constan?a Britto Kátia L. Torres Leila de Mendon?a Lima José Maria de Souza Cláudio T. Daniel-Ribeiro Maria de Fátima Ferreira-da-Cruz | 2007 | Experimental Parasitology2007，，4： | 1 |
| 5 | Mapping QTL for Grain Yield and Plant Traits in a Tropical Maize Population显示文摘 | Milena de Luna Alves Lima Cláudio Lopes Souza Dyeme Antonio Vieira Bento Anete Pereira Souza Luciana Aparecida Carlini-Garcia | 2006 | Molecular Breeding2006，，3： | 1 |
| 6 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 7 | The significance of the sleep pressure score显示文摘 | Lopes MC Marcus CL | | 0，，6： | 1 |
| 8 | The effect of pelvic organ prolapse severity on improvemem in overactive bladder symptoms after pelvic reconstructive surgery显示文摘 | Miranne JM Lopes V Carberry CL | 2013 | Int Urogynecol J2013，24，8： | 1 |
| 9 | In vitro tests ofsuitability of bacteriocin - producing lactic acid bacteria aspotential biopreservation cultures in vacuum -packaged cold -smoked salmon显示文摘 | Tome E Pereira VL Lopes Cl | 2008 | Food Control2008，19，5： | 1 |
| 10 | Effect of preinjury large bowel emptying on the inhibition of upper gastrointestinal motility after spinal cord injury in rats 显示文摘 | Gondim FA Rodrigues CL Lopes AC Jr | 2003 | Dig Dis Sci2003，48，9： | 1 |
| 11 | Defining control strategies for microgrids islanded operation 显示文摘 | Lopes JAP Moreira CL Madureira AG | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 12 | Mapping QTL for Grain Yield and Plant Traits in a Tropical Maize Population显示文摘 | Milena de Luna Alves Lima Cláudio Lopes Souza Dyeme Antonio Vieira Bento Anete Pereira Souza Luciana Aparecida Carlini-Garcia | 2006 | Molecular Breeding2006，，3： | 1 |
| 13 | Prediction of the induced gas flow rate from a self-inducing impeller with CFD 显示文摘 | Cláudio P Fonte Bruno S Pinho Vania Santos-Moreau José Carlos B Lopes | 2014 | Chemical Engineering Technology2014，37，4： | 1 |
| 14 | Prevalence of hepatitis B virus infection among tuberculosis patients with or without HIV in Goiania City,Brazil显示文摘 | Aires RS Matos MA Lopes CL | 2012 | J Clin Virol2012，54，4： | 1 |
| 15 | High prevalence of intestinal infections and ectoparasites in dogs, Minas Gerais State (southeast Brazil)显示文摘 | J?rg Heukelbach Raphael Frank Liana Ariza íris de Sousa Lopes Alcides de Assis e Silva Ana Cláudia Borges Jean Ezequiel Limongi Carlos Henrique Morais Alencar Sven Klimpel | 2012 | Parasitology Research2012，，5： | 1 |
| 16 | Adaptive Thermal Comfort in Brazilian Schools by Building Performance Simulation (BPS)显示文摘Building performance simulation (BPS) is a crucial tool towards the design of projects better adapted its climatic context. In this sense, the objective of this research is to evaluate a method of thermal comfort analysis of schools in three Brazilian cities using BPS. The methodological procedures involved a literature review, in which the simulation tool and analysis method were chosen. Following simulations with the software DesignBuilder were performed using as study case a standard school typology designed by the General Coordination of Educational Infrastructure (CODIN/FNDE). This article evaluates its percentage occupied comfort hours in 3 reference cities: Cuiabá-MT, Brasília-DF, and Curitiba-PR. The results show respectively, for the cities of Curitiba, Brasília and Cuiabá, percentages of comfort hours of 76%, 70%, and 23%. The research states that the project must have different strategies for different climates. Finally, this article recommends this method should be applied to other cities and buildings. | Caio Frederico e Silva Adriano Felipe Oliveira Lopes Thiago Montenegro Góes Cláudia Naves David Amorim | 2020 | Journal of Civil Engineering and Architecture2020，14，3： | 0 |
| 17 | Accuracy of gestalt perception of acute chest pain in predicting coronary artery disease显示文摘AIM To test accuracy and reproducibility of gestalt to predict obstructive coronary artery disease(CAD)in patients with acute chest pain.METHODS We studied individuals who were consecutively admitted to our Chest Pain Unit.At admission,investigators performed a standardized interview and recorded14 chest pain features.Based on these features,a cardiologist who was blind to other clinical characteristics made unstructured judgment of CAD probability,both numerically and categorically.As the reference standard for testing the accuracy of gestalt,angiography was required to rule-in CAD,while either angiography or non-invasive test could be used to rule-out.In order to assess reproducibility,a second cardiologist did the same procedure.RESULTS In a sample of 330 patients,the prevalence of obstructive CAD was 48%.Gestalt’s numerical probability was associated with CAD,but the area under the curve of0.61(95%CI:0.55-0.67)indicated low level of accuracy.Accordingly,categorical definition of typical chest pain had a sensitivity of 48%(95%CI:40%-55%)and specificity of 66%(95%CI:59%-73%),yielding a negligible positive likelihood ratio of 1.4(95%CI:0.65-2.0)and negative likelihood ratio of 0.79(95%CI:0.62-1.02).Agreement between the two cardiologists was poor in the numerical classification(95%limits of agreement=-71%to 51%)and categorical definition of typical pain(Kappa=0.29;95%CI:0.21-0.37).CONCLUSION Clinical judgment based on a combination of chest pain features is neither accurate nor reproducible in predicting obstructive CAD in the acute setting. | Cláudio Marcelo Bittencourt das Virgens Laudenor Lemos Jr Márcia Noya-Rabelo Manuela Campelo Carvalhal Antonio Maurício dos Santos Cerqueira Junior Fernanda Oliveira de Andrade Lopes Nicole Cruz de Sá Jéssica Gonzalez Suerdieck Thiago Menezes Barbosa de Souza Vitor Calixto de Almeida Correia Gabriella Sant’Ana Sodré AndréBarcelos da Silva Felipe Kalil Beirao Alexandre Felipe Rodrigues Marques Ferreira Luís Cláudio Lemos Correia | 2017 | World Journal of Cardiology2017，9，3： | 0 |
| 18 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
| 19 | Cardiopulmonary changes in patients with sickle cell anemia:A systematic review显示文摘BACKGROUND Given the high prevalence of cardiovascular and pulmonary abnormalities associated with sickle cell anemia(SCA),the clinical impact caused in addition to compromising the quality of life of patients and the overcharge that it represents to the public health system,this study systematized and evaluated scientific publications on pulmonary complications and cardiovascular diseases in sickle cell patients from 1920 to 2020.This compilation aims to provide knowledge for health professionals and managers in order to draw attention to the importance of chronic diseases in SCA patients and in addition to providing elements that provide improvements in management of useful resources that contribute to improve the quality and increase the life expectancy of these patients.AIM To systematically compile information about cardiopulmonary changes in patients with SCA.METHODS A systematic literature review was performed based on the PRISMA recommendation including scientific articles indexed in the Scientific Electronic Library Online databases of the United States National Library of Medicine and Biblioteca Virtual de Saúde.The search period was delimited between 1990 and 2020 and selected in Portuguese,English and Spanish.Three sets of descriptors were used for each database including research carried out with human beings.After reading the articles,those useful for this review were extracted using a collection instrument designed for this purpose.RESULTS The final selection included 27 studies.The year with the highest number of publications was 2016 with 5 studies(18.51%),followed by 2017 with 4(14.81%).The type of study most carried out in the period was cohort 10(37.03%)followed by cross-sectional and case-control with 8 studies in each(29.62%).Regarding the language of publication,the distribution was as follows:25(92.59%)in English,1(3.70%)in Spanish and 1(3.70%)in Portuguese.CONCLUSION The findings of the present study suggest that cardiopulmonary alterations represent a serious clinical repercussion of SCA.Of the analyzed studies,the high occurrence of pulmonary hypertension,ventricular hypertrophy and diastolic dysfunction stands out as the main cardiopulmonary complications.In view of the increased survival in SCA,there is a need for surveillance and the development of strategies aimed at preserving the cardiopulmonary function and consequently improving the quality of life of these patients. | Jamile Silva Lopes Ícaro Garcia Viana Maria Luísa Cordeiro Santos Fabrício Freire de Melo Márcio Vasconcelos Oliveira Cláudio Lima Souza | 2022 | World Journal of Hematology2022，9，3： | 0 |
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