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| 1 | Use of antibiotic-loaded cement in total knee arthroplasty显示文摘Bone cement has the capacity to release antibiotic molecules if any antibiotic is included in it, and these elution properties are improved as cement porosity is increased. In vitro studies have shown high local antibiotic concentration for many hours or few days after its use. Antibiotic loaded bone cement(ALBC) is helpful when treating an infection in total knee arthroplasty(TKA) revision surgery. The purpose of this paper was to review the evidence for the routine use of ALBC in TKA in the literature, its pros and cons. Many authors have recommended the use of ALBC also in primary TKA for infection prophylaxis, but the evidence based on data from National Registries, randomized clinical trials and meta-analysis suggest a protective effect of ALBC against infection when used in hips, but not(or only mild) in knees. A possible explanation to this finding is that the duration and quantity of locally elevated antibiotic levels after surgery are smaller in TKA, due to the smaller amount of cement used for fixation in TKA-only a layer in the bone surface. There are some concerns about the routine use of ALBC in primary TKA as prophylaxis against infection: Firstly, there is a risk of hypersensivity or toxicity even when the chance is highly improbable. Secondly, there is a reduction in the mechanical properties of the cement, but this can be probably neglected if the antibiotic is used in low doses, not more than 1 g per 40 g cement package. Another significant concern is the increased economic cost, which could be overlooked if there were enough savings in treating fewer prosthetic infections. Finally, there is also a risk of selection of antibiotic-resistant strains of bacteria and this could be the main concern. If used, the choice of the antibiotic mixed in ALBC should consider microbiological aspects(broad antimicrobial spectrum and low rate of resistant bacteria), physical and chemical aspects(thermal stability, high water solubility), pharmacological characteristics(low risk to allergic reactions or toxicity) and economic aspects(not too expensive). The most commonly used antibiotics in ALBC are gentamicin, tobramycin and vancomycin. In conclusion, there is a paucity of randomized clinical trials in the use of ALBC in primary TKAs and the actual evidence of the effect of ALBC in reducing the risk of infection is insufficient. This, in addition to concerns about patient safety, risks of increase in the antibiotic resistance of microorganisms and the increase in costs in the procedure, lead us to recommend a cautious use of ALBC, perhaps only in high-risk patients(immunocompromised, morbidly obese, diabetic and patients with previous history of fracture or infection around the knee) unless the benefits of ALBC use were fully proven. Meanwhile, the rigorous use of peri-operative prophylactic systemic antibiotics and adoption of efficient antiseptic procedures and improved surgical techniques must be considered the gold standard in infection prevention in TKA surgery. | Pedro Hinarejos Pau Guirro Lluis Puig-Verdie Raul Torres-Claramunt Joan Leal-Blanquet Juan Sanchez-Soler Joan Carles Monllau | 2015 | World Journal of Orthopedics2015，6，11： | 5 |
| 2 | Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity显示文摘Memory CD8 T cells can provide long-term protection against tumors,which depends on their enhanced proliferative capacity,self-renewal and unique metabolic rewiring to sustain cellular fitness.Specifically,memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill their metabolic demands.In contrast,tumor-infiltrating lymphocytes(TILs)display severe metabolic defects,which may underlie their functional decline.Here,we show that overexpression of proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),the master regulator of mitochondrial biogenesis(MB),favors CD8 T cell central memory formation rather than resident memory generation.PGC-1α-overexpressing CD8 T cells persist and mediate more robust recall responses to bacterial infection or peptide vaccination.Importantly,CD8 T cells with enhanced PGC-1αexpression provide stronger antitumor immunity in a mouse melanoma model.Moreover,TILs overexpressing PGC-1αmaintain higher mitochondrial activity and improved expansion when rechallenged in a tumor-free host.Altogether,our findings indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation,metabolic fitness,and antitumor immunity in vivo. | Nina Dumauthioz Benjamin Tschumi Mathias Wenes Bastien Marti Haiping Wang Fabien Franco Wenhui Li Isabel CLopez-Mejia Lluis Fajas Ping-Chih Ho Alena Donda Pedro Romero Lianjun Zhang | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 3 | Linoleic acid metabolic pathway allows for an efficient increase of intramuscular fat content in pigs显示文摘Background: Intramuscular fat(IMF) content is a relevant trait for high-quality meat products such as dry-cured ham,but increasing IMF has the undesirable correlated effect of decreasing lean growth.Thus,there is a need to find selection criteria for IMF independent from lean growth.In pigs,the proportion of linoleic(C18:2) and arachidonic(C20:4) acids decline with fat deposition and therefore they can be considered as indicators of fatness.The aim of this research was to estimate the genetic variation for C18:2 and C20:4 in IMF and their genetic correlations with IMF and lean growth traits,with the objective to assess their potential as specific biomarkers of IMF.The analysis was conducted using a full-pedigreed Duroc resource line with 91,448 records of body weight and backfat thickness(BT) at 180 days of age and 1371 records of fatty acid composition in the muscle gluteus medius.Results: The heritability estimates for C18:2 and C20:4 in IMF,whether expressed in absolute(mg/g of muscle) or in relative(mg/g of fatty acid) terms,as well as for their ratio(C20:4/C18:2),were high(> 0.40),revealing that the C18:2 to C20:4 pathway is subjected to substantial genetic influence.Litter effects were not negligible,with values ranging from8% to 15% of the phenotypic variance.The genetic correlations of C18:2 and C20:4 with IMF and BT were negative(-0.75 to-0.66,for IMF,and-0.64 to-0.36,for BT),if expressed in relative values,but almost null(-0.04 to 0.07),if expressed in absolute values,except for C18:2 with IMF,which was highly positive(0.88).The ratio of C20:4 to C18:2 also displayed a stronger genetic correlation with IMF(-0.59) than with BT(-0.10).Conclusions: The amount of C18:2 in muscle can be used as an IMF-specific biomarker.Selection for the absolute amount of C18:2 is expected to deliver a similar response outcome as selection for IMF at restrained BT.Further genetic analysis of the C18:2 metabolic pathway may provide new insights into differential fat deposition among adipose tissues and on candidate genes for molecular markers targeting specifically for one of them. | Sofia Gol Rayner Gonzalez-Prendes Lluis Bosch Marc Tor Josep Reixach Ramona N.Pena Joan Estany | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 3 |
| 4 | Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells显示文摘 | Luca Pellegrinet Veronica Rodilla Zhenyi Liu Shuang Chen Ute Koch Lluis Espinosa Klaus H. Kaestner Raphael Kopan Julian Lewis Freddy Radtke | 2011 | Gastroenterology2011，，4： | 2 |
| 5 | Community responses to extreme climatic conditions显示文摘 | Frederic JIGUET Lluis BROTONS Vincent DEVICTOR | 2011 | Current Zoology2011，57，3： | 2 |
| 6 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
| 7 | The importance of diverse collaborative networks for the novelty of product innovation显示文摘 | María Jesús Nieto Lluis Santamaría | 2006 | Technovation2006，，6： | 2 |
| 8 | T cell responses and viral variability in blood donation candidates with occult hepatitis B infection显示文摘 | Marta Bes Victor Vargas Maria Piron Natalia Casamitjana Juan Ignacio Esteban Nuria Vilanova Asuncion Pinacho Josep Quer Lluis Puig Jaime Guardia Silvia Sauleda | 2011 | Journal of Hepatology2011，，4： | 2 |
| 9 | Generalized Hamming weights and equivalences of codes显示文摘It is proved that any linear isomorphism between two linear codes which preserves a generalizedHamming weight is a monomial equivalence, which is an extension of a theorem of MacWilliams. | 樊恽 刘宏伟 Lluis Puig | 2003 | Science China Mathematics2003，46，5： | 2 |
| 10 | Golf course irrigation with reclamined wastewater显示文摘 | Lluis Sala | 1991 | Wat Sci Tech1991，24，9： | 1 |
| 11 | Below What FEV1 Should Arterial Blood be Routinely Taken to Detect Chronic Respiratory Failure in COPD显示文摘 | Diego AR Lluis J Mitra BD | | 0，，07： | 1 |
| 12 | Design of a Rapid Response and High Efficiency Service by Lean Production Principles: Methodology and Evaluation of Variability of Performance显示文摘 | Lluis Cuatrecasas Arb6s | 2002 | International Journal of Production Economics2002，80，6： | 1 |
| 13 | Parallel ordinary kriging interpolation incorporating automatic variogram fitting显示文摘 | Lluis Pesquer Ana Cort6s Xavier Pons | 2011 | Corn puters Geoseiences2011，37，4： | 1 |
| 14 | Periodic Activation of Wnt/β-Catenin Signaling Enhances Somatic Cell Reprogramming Mediated by Cell Fusion显示文摘 | Frederic Lluis Elisa Pedone Stefano Pepe Maria Pia Cosma | 2008 | Cell Stem Cell2008，，5： | 1 |
| 15 | Beyond formal R&D: Taking advantage of other sources of innovation in low - and medium - technology industries 显示文摘 | LLUIS SANTAMARIAA MARIA JESUS NIETOB ANDROS BARGE -GILC | 2009 | Re- search Policy2009，38，： | 1 |
| 16 | Singlet Excited-State Dynamics of 5-Fluorocytosine and Cytosine: An Experimental and Computational Study 显示文摘 | Lluis B Boiko C Patrick M H et aI | 2005 | J Phys Chem A2005，109，20： | 1 |
| 17 | Impact of Imbalancing in the Self-splitting of Beams with Nested Vortices into Solitons in Quadratic Non-linear Crystals显示文摘 | Gabriel Molina-Terriza Juan P Torres Lluis Torner Soto-Crespo J M | 1998 | Optics Communications1998，158，： | 1 |
| 18 | Relationship between haematoma in femoral neck fractures contamination and early postoperative prosthetic joint infection 显示文摘 | Lluis FV Alonso Z Sebastidn G | 2011 | Injury2011，42，2： | 1 |
| 19 | Bone histomorphometry in 22 male patients with normocalciuric idiopathic osteoporosis显示文摘 | Manuel Cira-Recasens Lluis Perez-Edo Josep Blanch-Rubio | 2005 | Bone2005，36，： | 1 |
| 20 | E2Fs Regulate Adipocyte Differentiation显示文摘 | Lluis Fajas Rebecca L. Landsberg Yolande Huss-Garcia Claude Sardet Jacqueline A. Lees Johan Auwerx | 2002 | Developmental Cell2002，，1： | 1 |
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