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| 1 | Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity显示文摘Memory CD8 T cells can provide long-term protection against tumors,which depends on their enhanced proliferative capacity,self-renewal and unique metabolic rewiring to sustain cellular fitness.Specifically,memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill their metabolic demands.In contrast,tumor-infiltrating lymphocytes(TILs)display severe metabolic defects,which may underlie their functional decline.Here,we show that overexpression of proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),the master regulator of mitochondrial biogenesis(MB),favors CD8 T cell central memory formation rather than resident memory generation.PGC-1α-overexpressing CD8 T cells persist and mediate more robust recall responses to bacterial infection or peptide vaccination.Importantly,CD8 T cells with enhanced PGC-1αexpression provide stronger antitumor immunity in a mouse melanoma model.Moreover,TILs overexpressing PGC-1αmaintain higher mitochondrial activity and improved expansion when rechallenged in a tumor-free host.Altogether,our findings indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation,metabolic fitness,and antitumor immunity in vivo. | Nina Dumauthioz Benjamin Tschumi Mathias Wenes Bastien Marti Haiping Wang Fabien Franco Wenhui Li Isabel CLopez-Mejia Lluis Fajas Ping-Chih Ho Alena Donda Pedro Romero Lianjun Zhang | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 2 | A Prol2Ala substitation in PPARg2 associated with decreased receptor activity lower body mass index and improved insulin sensitivity 显示文摘 | Deeb SS Fajas L Nemoto M | 1998 | Nat Gonet1998，20，： | 2 |
| 3 | Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-or in humans显示文摘 | Auboeuf D Rieusset J Fajas L | 1997 | Diabetes1997，46，8： | 1 |
| 4 | The organization promoter analusis and expression of the human PPAR-gamma gene显示文摘 | Fajas L Auboerf D Raspe E | 1997 | J Biol Chem1997，272，18： | 1 |
| 5 | A Pro12Ala substitution in PPART2 associated with decreased receptor activity ,lower body mass index and impaired insulin sensitivity 显示文摘 | Deeb S S Fajas L Nemoto M | 1998 | Nat genet1998，20，： | 1 |
| 6 | The pleiotropic functions of peroxisome proliferator-activated receptor gamma显示文摘 | Debril MB Renaud JP Fajas L | 2001 | J Mol Med2001，79，1： | 1 |
| 7 | PPARgamma controls cell proliferation and apoptosis in an RB -dependent manner显示文摘 | FAJAS L EGLER V REITER R | 2003 | Oncogene2003，22，27： | 1 |
| 8 | E2Fs regulate adipocyte differentiation 显示文摘 | Fajas L Landsberg RL Huss-Garcia Y | 2002 | Dev Cell2002，3，1： | 1 |
| 9 | The retinoblastoma- histone deacetylase 3 complex inhibits PPARgarnma and adipocyte differentiation显示文摘 | Fajas L Egler V Reiter R | 2002 | Dev Cell2002，3，： | 1 |
| 10 | The organization,promoter analysis,and expression of the human PPARgamma gene显示文摘 | Fajas L Auboeuf D Raspe E | 1997 | J Biol Chem1997，272，18： | 1 |
| 11 | Transcriptional control of adipo- genesis显示文摘 | Fajas L Fruchart JC Auwerx J | 1998 | Current Opinion in Cell Bio11998，10，2： | 1 |
| 12 | Transcriptional Control of Adipogenesis显示文摘 | FAJAS L FRUCHART J C AUWERX | 1998 | Curr Opin Cell Biol1998，10，2： | 1 |
| 13 | The organization, promoter analysis, and expression of the human PPARgamma gene显示文摘 | Fajas L Auboeuf D Raspe E | 1997 | J Biol Chem1997，272，18： | 1 |
| 14 | PPARgamma3 mRNA:a distinct PPARgamma mRNA subtype transcribed from an independent promoter显示文摘 | Fajas L Fruchart J C Auwerx J | 1998 | FEBS Lett1998，438，： | 1 |
| 15 | Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferators aetivated receptors and liver X receptorain humans:no alteration in adipose tissue of obese and NIDDM patients显示文摘 | Auboeuf D Rieusset J Fajas L | 1997 | Diabetes1997，48，： | 1 |
| 16 | CXCL5 drives obesity to diabetes, and further 显示文摘 | Chavey C Fajas L | 2009 | Aging July2009，1，7： | 1 |
| 17 | Differential regulation of peroxisome proliferator activated receptor gamma (PPAR-gamma) and PPAR-gamma 2 messenger RNA expression in the early stages of adipogenesis显示文摘 | Saladin R Fajas L Dana S | 1999 | Cell Growth Differ1999，10，： | 1 |
| 18 | Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis显示文摘 | Saladin R Fajas L Dana S | 1999 | Cell Growth Differ1999，10，1： | 1 |
| 19 | E2Fs Regulate Adipocyte Differentiation显示文摘 | Lluis Fajas Rebecca L. Landsberg Yolande Huss-Garcia Claude Sardet Jacqueline A. Lees Johan Auwerx | 2002 | Developmental Cell2002，，1： | 1 |
| 20 | A Pro12Ala substitution in body mass index and improved insulin sensitivity显示文摘 | Deeb SS Fajas L Nemoto M | 1998 | Nat Genet1998，20，： | 1 |
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