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| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 3 | Purification and Characterization of a New Thermostable κ-CarrageenasefromtheMarineBacterium Pseudoalteromonas sp. QY203显示文摘A new extracellular κ-carrageenase, namely CgkP, 34.0 kDa in molecular weight, was purified from Pseudoalteromonas sp. QY203. CgkP showed relatively high activity at acidities ranging from pH6.0 to pH9.0 and temperatures ranging from 30℃ to 50℃ with the highest activity at 45℃ and pH7.2. Sodium chloride increased its activity markedly, and KCl increased its activity slightly. The divalent and trivalent metal ions including Cu2+ , Ni2+ , Zn2+ , Mn2+ , Al3+ and Fe3+ significantly inhibited its activity, while Mg2+ did not. CgkP remained 70% of original activity after being incubated at 40℃ for 48 h, and remained 80% of the activity after being incubated at 45℃ for 1 h. It exhibited endo-κ-carrageenase activity, mainly depolymerizing the κ-carrageenan into disaccharide and tetrasaccharide. CgkP was more thermostable than most of previously reported κ-carrageenases with a potential of being used in industry. | LI Shangyong JIA Panpan WANG Linna YU Wengong HAN Feng | 2013 | Journal of Ocean University of China2013，12，1： | 10 |
| 4 | Optimal Energy-Efficient Transmission for Hybrid Spectrum Sharing in Cooperative Cognitive Radio Networks显示文摘In order to improve the energy efficiency(EE)in cognitive radio(CR),this paper investigates the joint design of cooperative spectrum sensing time and the power control optimization problem for the secondary user systems to achieve the maximum energy efficiency in a cognitive network based on hybrid spectrum sharing,meanwhile considering the maximum transmit power,user quality of service(QoS)requirements,interference limitations,and primary user protection.The optimization of energy efficient sensing time and power allocation is formulated as a non-convex optimization problem.The Dinkelbach’s method is adopted to solve this problem and to transform the non-convex optimization problem in fractional form into an equivalent optimization problem in the form of subtraction.Then,an iterative power allocation algorithm is proposed to solve the optimization problem.The simulation results show the effectiveness of the proposed algorithms for energy-efficient resource allocation in the cognitive network. | Linna Hu Rui Shi Minghe Mao Zhiyu Chen Hongxi Zhou Weiliang Li | 2019 | China Communications2019，16，6： | 9 |
| 5 | Composite solid electrolyte of Na3PS4-PEO for all-solid-state SnS2/Na batteries with excellent interfacial compatibility between electrolyte and Na metal显示文摘High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS4-polyethylene oxide is synthesized by the solution-phase reaction method with an improved ionic conductivity up to 9.4 × 10-5 S/cm at room temperature. Moreover, polyethylene oxide polymer layer is wrapped homogeneously on the surface of Na3PS4 particles, which could effectively avoid the direct contact between Na3PS4 electrolyte and sodium metal, thus alleviate their side reactions. We demonstrate that all-solid-state battery SnS2/Na with the composite solid electrolyte Na3PS4-polyethylene oxide delivers an enhanced electrochemical performance with 230 m Ah/g after 40 cycles. | Xiaoyan Xu Yuanyuan Li Jun Cheng Guangmei Hou Xiangkun Nie Qing Ai Linna Dai Jinkui Feng Lijie Ci | 2020 | Journal of Energy Chemistry2020，29，2： | 7 |
| 6 | Private Car Travel Characteristics and Influencing Factors in Chinese Cities——A Case Study of Guangzhou in Guangdong,China显示文摘Taking Guangzhou as a case,this paper adopted a questionnaire survey to gather first-hand data and analyzed the characteristics and influencing factors of private car travel in Chinese cities.As the research indicated,trip purposes of private car travel are mainly commute and business affairs with a more flexible trip in the urban core area.And trip intensities are concentrated in a certain extent,with trip frequency being lower in the urban core area than the peripheral area.In addition,the trip time has two significant peaks occurring in the morning and afternoon,and one trough in the midday.And trip spatial distribution is mainly within commute with both residence and employment in urban area and inward commute with residence in suburban area while employment in urban area.Both kinds of commutes direct to the urban area.The study also shows that the characteristics of private car travel are principally influenced by two aspects:travelers' attributes and urban characteristics.The main travelers' social and economic attributes influenced it include the gender,education attainment,age,driving experience and per capita monthly household income.The urban characteristics influenced it mainly cover the land use pattern,public traffic facilities and spatial attributes of residential environment. | CAO Xiaoshu CHEN Hemei LI Linna ZHEN Feng | 2009 | Chinese Geographical Science2009，19，4： | 5 |
| 7 | A New Algorithm for Literature Recommendation Based on a Bibliographic Heterogeneous Information Network显示文摘A literature recommendation algorithm based on a heterogeneous information network is proposed. The proposed algorithm can process different types of semantic information and implicit feedback. The experimental results show that the proposed algorithm can provide more effective recommendations than those algorithms without employing these semantic information and implicit feedback. | LI Linna WANG Lijun JIANG Xueqin HAN Hongqi ZHAI Yun | 2018 | Chinese Journal of Electronics2018，27，4： | 4 |
| 8 | The Strigolactone-Related Mutants have Enhanced Lamina Joint Inclination Phenotype at the Seedling Stage显示文摘Strigolactones(SLs)are a class of newly discovered plant hormones and play diverse roles in plant growth and development.Recently,it has been demonstrated that SLs negatively regulate shoot branching by inhibiting bud outgrowth in plants(Umehara et al.,2008).Several genes involved in SL biosynthesis or signaling had been identified in both monocots and dicots.Loss-of-function mutants corresponding to these genes exhibit enhanced shoot branching phenotype(Beveridge and Kyozuka,2010).In rice,the SL biosynthetic mutants,d17/htd1 and d10,are caused by mutation of carotenoid cleavage dioxygenase 7(CCD7)and carotenoid cleavage dioxygenase 8(CCD8),respectively(Zou et al.,2006;Arite et al,2007).The SL biosynthetic mutant,d27,is caused by a mutation of | Xiaoming Li Shiyong Sun Chengxiang Li Shenglong Qiao Tao Wang Linna Leng Hongyun Shen Xuelu Wang | 2014 | Journal of Genetics and Genomics2014，41，11： | 3 |
| 9 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 10 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 11 | Direct and single-step sensing of primary ovarian cancers related glycosidases显示文摘High sensitive,accurate detection for tumor-associated overexpressed enzyme activity is highly significant for further understanding enzyme function,discovering potential drugs,and early diagnosis and prevention of diseases.In this work,we developed a facile,direct and single-step detection platform for primary ovarian cancers related glycosidase activity based on the inner filter effect(IFE)between glycosidase catalytic product and black phosphorus quantum dots(BPQDs).Highly fluorescent BPQDs were successfully synthesized from bulk black phosphorus by a simple liquid exfoliation method.Under the catalysis ofβ-galactosidase,p-nitrophenyl-β-D-galactopyranoside(PNPG)was transformed into pnitrophenol(PNP)andβ-D-galactopyranoside.Meanwhile,the absorption of catalytic product PNP greatly overlapped with the excitation and emission spectra of fluorescent BPQDs,leading to the fluorescence quenching of BPQDs with a high quenching efficiency.The proposed sensing strategy provided a low detection limit of 0.76 U/L,which was 1-2 orders of magnitude lower than most unmodified sensing platforms.D-Galactal was selected as the inhibitor forβ-galactosidase to further assess the feasibility of screening potential inhibitors.The fluorescence recovery of BPQDs suggests that the unmodified sensing platform is feasible to discover potential drugs ofβ-galactosidase.Our work paves a general way in the detection of glycosidase activity with fluorescent BPQDs,which can be promising for glycosidase-related disease diagnosis and pathophysiology elucidation. | Dan Li Ling Liang Yawei Tang Linna Fu Shehua Xiao Quan Yuan | 2019 | Chinese Chemical Letters2019，30，5： | 2 |
| 12 | Ag doped urchin-like α-MnO2 toward efficient and bifunctional electrocatalysts for Li-02 batteries显示文摘Rechargeable Li-O2 batteries (LOBs) have been receiving intensive attention because of their ultra-high theoretical energy densityclose to the gasoline. Herein, Ag modified urchin-like α-MnO2 (Ag-MnO2) material with hierarchical porous structure is obtained bya facile one-step hydrothermal method. Ag-MnO2 possesses thick nanowires and presents hierarchical porous structure of mesoporesand macropores. The unique structure can expose more active sites, and provide continuous pathways for O2 and discharge productsas well. The doping of Ag leads to the change of electronic distribution in α-MnO2 (i.e., more oxygen vacancies), which playimportant roles in improving their intrinsic catalytic activity and conductivity. As a result, LOBs with Ag-MnO2 catalysts exhibit loweroverpotential, higher discharge specific capacity and much better cycle stability compared to pure a-MnO2. LOBs with Ag-MnO2catalysts exhibit a superior discharge specific capacity of 13,131 mA·h·g^-1 at a current density of 200 mA·h·g^-1, a good cycle stabilityof 500 cycles at the capacity of 500 mA·h·g^-1. When current density is increased to 400 mA·h·g^-1, LOBs still retain a long lifespan of170 cycles at a limited capacity of 1,000 mA·h·g^-1. | Linna Dai Qing Sun Lina Chen Huanhuan Guo Xiangkun Nie Jun Cheng Jianguang Guo Jianwei Li Jun Lou Lijie Ci | 2020 | Nano Research2020，13，9： | 2 |
| 13 | A New κ-Carrageenase Cgk S from Marine Bacterium Shewanella sp. Kz7显示文摘A new κ-carrageenase gene cgk S was cloned from marine bacterium Shewanella sp. Kz7 by using degenerate and site-finding PCR. The gene was comprised of an open reading frame of 1224 bp, encoding 407 amino acid residues, with a signal peptide of 24 residues. Based on the deduced amino acid sequence, the κ-carrageenase Cgk S was classified into the Glycoside Hydrolase family 16. The cgk S gene was expressed in Escherichia coli, and the recombinant enzyme was purified to homogeneity with a specific activity of 716.8 U mg-1 and a yield of 69%. Recombinant Cgk S was most active at 45℃ and p H 8.0. It was stable at p H 6.0–9.0 and below 30℃. The enzyme did not require Na Cl for activity, although its activity was enhanced by Na Cl. Cgk S degraded κ-carrageenan in an endo-fashion releasing tetrasaccharides and disaccharides as main hydrolysis products. | WANG Linna LI Shangyong ZHANG Shilong LI Jiejing YU Wengong GONG Qianhong | 2015 | Journal of Ocean University of China2015，14，4： | 2 |
| 14 | Potential Deformation and Its Application to the Diagnosis of Heavy Precipitation in Mesoscale Convective Systems显示文摘Many observational studies have shown that deformation, like vertical vorticity and divergence, is closely related to the occurrence and distribution of strong precipitation. In this paper, to involve deformation in precipitation diagnosis, a new parameter called potential deformation(PD) is derived and then applied to precipitation detection within a simulated mesoscale convective system(MCS). It is shown that PD includes both stretching deformation and shearing deformation and shares similar characteristics with deformation insofar as it does not change with the rotating coordinate. Diagnosis of the simulated MCS reveals that PD performs well in tracing the MCS' precipitation. In terms of their distributional pattern, the large-value areas of PD are similar to the precipitation in the different development stages of the MCS. A detailed analysis of the physical processes contained within the PD shows that it can reflect the three-dimensional moisture variation,vertical wind shear and wind deformation within the MCS. These structures are usually a comprehensive reflection of the characteristics of the surface cold pool, rear inflow jet, downward cold air flow and upward warm moist flow within the precipitating convective cells. For this reason, the PD shows much stronger anomalies in the precipitating atmosphere than the non-precipitating atmosphere, which implies considerable potential for its application in detecting heavy precipitation within MCSs. | Na LI Lingkun RAN Linna ZHANG Shouting GAO | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 15 | Optimization of Wind-Marine Hybrid Power System Configuration Based on Genetic Algorithm显示文摘Multi-energy power systems can use energy generated from various sources to improve power generation reliability.This paper presents a cost-power generation model of a wind-tide-wave energy hybrid power system for use on a remote island,where the configuration is optimized using a genetic algorithm.A mixed integer programming model is used and a novel object function,including cost and power generation,is proposed to solve the boundary problem caused by existence of two goals.Using this model,the final optimized result is found to have a good fit with local resources. | SHI Hongda LI Linna ZHAO Chenyu | 2017 | Journal of Ocean University of China2017，16，4： | 1 |
| 16 | Assuring the quality of volunteered geographic information显示文摘 | Michael F. Goodchild Linna Li | 2012 | Spatial Statistics2012，，： | 1 |
| 17 | Studies on the spray dried lactose as carrier for dry powder inhalation显示文摘The purpose of this study was to investigate the spray dried lactose as carrier for dry powder inhalation(DPI).The lactose particles were prepared by spray drying,then the particle size,shape and crystal form were characterized by laser diffraction,scanning electron microscopy(SEM),X-ray diffraction(XRD)and differential scanning calorimetry(DSC).The spray dried lactose particles were spherical and amorphous,but would transfer to crystal form when storage humidity was above 32%.Thus,the humidity of the storage environment should be controlled below 30%strictly in order to maintain the amorphous nature of spray dried lactose which is a great benefit to DPI development. | Linna Wu Xu Miao Ziyun Shan Ying Huang Lu Li Xin Pan Qinghe Yao Ge Li Chuanbin Wu | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 1 |
| 18 | Research overview of regulations in the Process of Dynamic Mining 显示文摘 | Bingru Yang Wei Song Linna Li el al | 2006 | Journal of Computational Information Systems2006，2，3： | 1 |
| 19 | The mechanism discussion on the pinellia protein function to mouse's anti-pregnant early and anti-birth 显示文摘 | XIA LINNA LI CHAOJING | 1985 | The first journal of Shanghai medical school1985，12，3： | 1 |
| 20 | Effect of mechanical activation on acid-leaching of kaolin residue显示文摘 | TANG Aidong SU Linna LI Chuanchang et aI | 2010 | Appl Clay Sci2010，48，3： | 1 |
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