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| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 3 | Evaluating the suitability of TRMM satellite rainfall data for hydrological simulation using a distributed hydrological model in the Weihe River catchment in China显示文摘这研究的目的到份量上评估热带降雨测量有雨计量器数据并且进一步的使命(TRMM ) 数据到使用驱使一个分布式的时间变体获得模型(DTVGM ) 在中国在半潮湿的 Weihe 河集水执行水文学模拟的这个 TRMM 数据。在模拟前,比较与一 10 年(20012010 ) 设置的每日的雨计量器数据表明在每日的时间步, TRMM 降雨数据擅长比降雨极端捕获雨出现和吝啬的值。在每月的时间规模上,在 TRMM 和雨计量器降雨数据之间的好线性关系被发现,与决心系数 R < 啜 class= “ a-plus-plus ” > 为个人在 0.78 和 0.89 之间变化的 2 驻扎。每日的水文学过程上的数据的七年( 20012007 )的随后的模拟结果证实 DTVGM 什么时候由雨计量器数据校准了,比什么时候由 TRMM 数据校准更好表现,但是 TRMM 数据驾驶的模拟的性能比在每月的时间规模上由计量器数据开车的好。结果因此建议 TRMM 降雨数据对在学习的每月的流速及流水量模拟更合适区域,和那当为水平衡部件的刻度和结果的效果也被考虑时, TRMM 3B42-V7 产品有潜力表现很好在类似的盆。 | ZHAO Haigen | 2015 | Journal of Geographical Sciences2015，25，2： | 12 |
| 4 | Accumulation and source of heavy metals in sediment of a reservoir near an industrial park of northwest China显示文摘 | Yuanjie ZHU Xinwei LU Linna YANG Lijun WANG | 2016 | Frontiers of Earth Science2016，10，4： | 11 |
| 5 | Fabrication of submicron barium sulfate aggregates in the presence of ethylenediaminetetraacetic acid anions显示文摘Barium sulfate aggregates with an average size of 0.5 μm were synthesized at pH 7,directed by ethylenediaminetetraacetic acid(EDTA) anions.The particle morphology,chemical composition,and size distribution of the BaSO_4 aggregates were characterized.The as-synthesized BaSO_4 particles were spherical and comprised many interconnected nanoballs,of which the surface properties were affected by the EDTA anions.The adsorption of EDTA anions reversed the charge and weakened the surface polarity of BaSO_4,instigating the formation of aggregates by a self-assembly and transformation process.The resulting BaSO_4 particles at pH 9-10 were ellipsoidal and featured smooth surfaces.Based on the zeta potential of BaSO_4,variations in the morphology induced by changes in pH were closely related to the adsorption of mono- and multi-valent anions onto the electrical double layer of BaSO_4. | Linna Hu Guangxiu Wang Chun Yang Rong Cao | 2015 | Particuology2015，13，5： | 11 |
| 6 | Purification and Characterization of a New Thermostable κ-CarrageenasefromtheMarineBacterium Pseudoalteromonas sp. QY203显示文摘A new extracellular κ-carrageenase, namely CgkP, 34.0 kDa in molecular weight, was purified from Pseudoalteromonas sp. QY203. CgkP showed relatively high activity at acidities ranging from pH6.0 to pH9.0 and temperatures ranging from 30℃ to 50℃ with the highest activity at 45℃ and pH7.2. Sodium chloride increased its activity markedly, and KCl increased its activity slightly. The divalent and trivalent metal ions including Cu2+ , Ni2+ , Zn2+ , Mn2+ , Al3+ and Fe3+ significantly inhibited its activity, while Mg2+ did not. CgkP remained 70% of original activity after being incubated at 40℃ for 48 h, and remained 80% of the activity after being incubated at 45℃ for 1 h. It exhibited endo-κ-carrageenase activity, mainly depolymerizing the κ-carrageenan into disaccharide and tetrasaccharide. CgkP was more thermostable than most of previously reported κ-carrageenases with a potential of being used in industry. | LI Shangyong JIA Panpan WANG Linna YU Wengong HAN Feng | 2013 | Journal of Ocean University of China2013，12，1： | 10 |
| 7 | Circumjacent distribution pattern of the Lungmachian graptolitic black shale(early Silurian) on the Yichang Uplift and its peripheral region显示文摘Stratigraphic hiatuses of variable time intervals within the Rhuddanian to early Aeronian(Llandovery, Silurian) are identified in the area bordering East Chongqing, West Hubei and Northwest Hunan in central China. Their distribution suggested the existence of a local uplift, traditionally named the Yichang Uplift. The diachronous nature of the basal black shale of the Lungmachi Formation crossing different belts of this Uplift signifies the various developing stages during the uplifting process.The present paper defines the temporal and spatial distribution pattern of the Yichang Uplift, which might be one of the important controlling factors for the preservation and distribution of the shale gas in this region, as it has been demonstrated that the shale gas exploration is generally less promising in the areas where more of the basal part of the Lungmachi Formation is missing.Therefore, better understanding of the circumjacent distribution pattern developed throughout the uplifting process may provide the important guidance for the shale gas exploration. The present work is a sister study to the published paper, 'Stage-progressive distribution pattern of the Lungmachian black graplolitic shales from Guizhou to Chongqing, Central China'. These two studies thus provide a complete Ordovician-Silurian black shale distribution pattern in the Middle and Upper Yangtze, a region with the major shale gas fields in China. | Xu CHEN Qing CHEN Yongyi ZHEN Hongyan WANG Linna ZHANG Junpeng ZHANG Wenhui WANG Zhaohui XIAO | 2018 | Science China Earth Sciences2018，61，9： | 9 |
| 8 | A New Algorithm for Literature Recommendation Based on a Bibliographic Heterogeneous Information Network显示文摘A literature recommendation algorithm based on a heterogeneous information network is proposed. The proposed algorithm can process different types of semantic information and implicit feedback. The experimental results show that the proposed algorithm can provide more effective recommendations than those algorithms without employing these semantic information and implicit feedback. | LI Linna WANG Lijun JIANG Xueqin HAN Hongqi ZHAI Yun | 2018 | Chinese Journal of Electronics2018，27，4： | 4 |
| 9 | Environmental conditions and genetic differentiation:what drives the divergence of coexisting Leymus chinensis ecotypes in a large-scale longitudinal gradient?显示文摘Aims The two coexisting Leymus chinensis ecotypes exhibit remarkable divergences in adaptive strategies under drought and salinity in semi-humid meadows and semi-arid steppes.In order to detect the major genetic and environmental factors dominating the intraspecific phenotype variations and ecotype formation,the questions regarding the two distinct phenotypic forms(ecotypes)in L.chin-ensis were addressed:(i)did environments drive the L.chinensis ecotype formation?(ii)was there a molecular basis for the morphological divergence between the two ecotypes?(iii)which driving force dominated the intraspecies divergence,divergent natural selection,genetic drift or stabilizing selection?Methods We applied a series experiments on demographical,morphological and physiological traits of two Leymus chinensis ecotypes with gray green(GG)and yellow green(YG)leaf color in nine wild sites along a longitudinal gradient from 114°to 124°E in northeast China.The environmental data including mean annual precipitation,mean annual temperature,elevation and soil properties were collected.We compared the differences of morphological,physiological and genetic differentiations between the two ecotypes.Important FindingsThe GG type exhibited stronger fitness than YG type from the population densities,morphological traits(e.g.shoot height,leaf area,leaf and seed weights et al.),leaf mass per area(LMA)and physiological traits[relative water content(RWC),proline,soluble sugar contents].Most of above phenotypes(e.g.total shoot densities,spike length et al.)were significantly correlated with mean annual precipitation,mean annual temperature and soil water content(SWC),rarely a correlated with soil pH and soil nutrient.Transplanted populations showed convergence trend by their leaf chlorophyll contents and osmotic adjustments(proline and soluble sugar contents)in the greenhouse,but still exhibited their divergences between two ecotypes in the outdoor transplantation,suggesting that whether L.chinensis ecotype differentiated could be largely affected by the environmental conditions.Furthermore,by the comparison result of quantitative genetic variation(Q_(ST))values from phenotypes with theoretical neutral genetic differentiation(F_(ST)),differentiation in phenotypic traits greatly surpassed neutral predictions,implying that directional natural selection played a crucial role in L.chinen-sis ecotype differentiation.In addition,microsatellite analysis from Neighbor-joining tree and Bayesian assignment generated into two groups according to ecotypes,indicating molecular genetic differentiation also propelled the two ecotypes divergence.We conclude that L.chinensis population variations were driven by combing divergent natural selection(precipitation,temperature and SWCs)along the large-scale gradient and significantly intrinsic genetic differentiation. | Shan Yuan Chengyuan Guo Linna Ma Renzhong Wang | 2016 | Journal of Plant Ecology2016，9，5： | 4 |
| 10 | Designandconstructionof athree-dimensionalelectrodewith biomass-derived carbon current collector andwater-soluble binder for high-sulfur-loading lithium-sulfur batteries显示文摘Lithium-sulfur batteries attract lots of attention due to their high specific capacity,low cost,and environmental friendliness.However,the low sulfur utilization and short cycle life extremely hinder their application.Herein,we design and fabricate a three-dimensional electrode by a simple filtration method to achieve a high-sulfur loading.Biomass porous carbon is employed as a current collector,which not only enhances the electronic transport but also effectively limits the volume expansion of the active material.Meanwhile,an optimized carboxymethyl cellulose binder is chosen.The chemical bonding restricts the shuttle effect,leading to improved electrochemical performance.Under the ultrahigh sulfur load of 28mg/cm2,the high capacity of 18mAh/cm2 is still maintained,and stable cycling performance is obtained.This study demonstrates a viable strategy to develop promising lithium-sulfur batteries with a three-dimensional electrode,which promotes sulfur loading and electrochemical performance. | Pengfei Wang Zhe Gong Ke Ye Vipin Kumar Kai Zhu Linna Sha Jun Yan Jinling Yin Kui Cheng Guiling Wang Dianxue Cao | 2020 | Carbon Energy2020，2，4： | 3 |
| 11 | The Strigolactone-Related Mutants have Enhanced Lamina Joint Inclination Phenotype at the Seedling Stage显示文摘Strigolactones(SLs)are a class of newly discovered plant hormones and play diverse roles in plant growth and development.Recently,it has been demonstrated that SLs negatively regulate shoot branching by inhibiting bud outgrowth in plants(Umehara et al.,2008).Several genes involved in SL biosynthesis or signaling had been identified in both monocots and dicots.Loss-of-function mutants corresponding to these genes exhibit enhanced shoot branching phenotype(Beveridge and Kyozuka,2010).In rice,the SL biosynthetic mutants,d17/htd1 and d10,are caused by mutation of carotenoid cleavage dioxygenase 7(CCD7)and carotenoid cleavage dioxygenase 8(CCD8),respectively(Zou et al.,2006;Arite et al,2007).The SL biosynthetic mutant,d27,is caused by a mutation of | Xiaoming Li Shiyong Sun Chengxiang Li Shenglong Qiao Tao Wang Linna Leng Hongyun Shen Xuelu Wang | 2014 | Journal of Genetics and Genomics2014，41，11： | 3 |
| 12 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 13 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 14 | Fabrication and characterization of 3D printed biocomposite scaffolds based on PCL and zirconia nanoparticles显示文摘The application of three-dimensional printed polymer scaffolds in repairing bone defects is a promising strategy.Among them,polycaprolactone(PCL)scaffolds are widely studied due to their good processability and controlled degradation rate.However,as an alternative graft for repairing bone defects,PCL materials have poor hydrophilicity,which is not conducive to cell adhesion and growth.In addition,the poor mechanical properties of PCL materials cannot meet the strength required to repair bone defects.In this paper,nano-zirconium dioxide(ZrO2)powder is embedded in PCL material through a meltmixing process,and a regular grid scaffold is constructed by 3D printing.The embedding of nanometer zirconium dioxide powder improves the hydrophilicity and water absorption of the composite scaffold,which is conducive to cell adhesion,proliferation and growth and is beneficial to the exchange of nutrients.Therefore,the PCL/ZrO2 composite scaffold showed better biological activity in vitro.At the same time,the PCL/ZrO2 composite material system significantly improves the mechanical properties of the scaffold.Among them,compared with the pure PCL scaffold,the Young’s modulus is increased by about 0.4 times,and the compressive strength is increased by about 0.5 times.In addition,the osteogenic differentiation results also showed that the PCL/ZrO2 composite scaffold group showed better ALP activity and more effective bone mineralization than the pure PCL group.We believe that the 3D printed PCL/ZrO2 composite scaffold has certain application prospects in repairing bone defects. | Qifan Wang Zhiyong Ma Ying Wang Linna Zhong Wenjia Xie | 2021 | Bio-Design and Manufacturing2021，4，1： | 2 |
| 15 | Precipitation data and their uncertainty as input for rainfallinduced shallow landslide models显示文摘Physical models used toforecast the temporal occurrence of rainfall-induced shallow landslides are based on deterministic laws.Owing to the existing measuring technology and our knowledge of the physical laws controlling landslide initiation,model uncertainties are due to an inability to accurately quantify the model input parameters and rainfall forcing data.An uncertainty analysis of slope instability prediction provides a rationale for refining the geotechnical models.The Transient Rainfall Infiltration and Grid-based Regional Slope Stability-Probabilistic(TRIGRS-P)model adopts a probabilistic approach to compute the changes in the Factor of Safety(FS)due to rainfall infiltration.Slope Infiltration Distributed Equilibrium(SLIDE)is a simplified physical model for landslide prediction.The new code(SLIDE-P)is also modified by adopting the same probabilistic approach to allow values of the SLIDE model input parameters to be sampled randomly.This study examines the relative importance of rainfall variability and the uncertainty in the other variables that determine slope stability.The precipitation data from weather stations,China Meteorological Administration Land Assimilation System 2.0(CLDAS2.0),China Meteorological Forcing Data set precipitation(CMFD),and China geological hazard bulletin are used to drive TRIGRS,SLIDE,TRIGRS-P and SLIDE-P models.The TRIGRS-P and SLIDE-P models are used to generate the input samples and to calculate the values of FS.The outputs of several model runs with varied input parameters and rainfall forcings are analyzed statistically.A comparison suggests that there are significant differences in the simulations of the TRIGRS-P and SLIDE-P models.Although different precipitation data sets are used,the simulation results of TRIGRS-P are more concentrated.This study can inform the potential use of numerical models toforecast the spatial and temporal occurrence of regional rainfall-induced shallow landslides. | Yueli CHEN Linna ZHAO Ying WANG Qingu JIANG Dan QI | 2019 | Frontiers of Earth Science2019，13，4： | 2 |
| 16 | A New κ-Carrageenase Cgk S from Marine Bacterium Shewanella sp. Kz7显示文摘A new κ-carrageenase gene cgk S was cloned from marine bacterium Shewanella sp. Kz7 by using degenerate and site-finding PCR. The gene was comprised of an open reading frame of 1224 bp, encoding 407 amino acid residues, with a signal peptide of 24 residues. Based on the deduced amino acid sequence, the κ-carrageenase Cgk S was classified into the Glycoside Hydrolase family 16. The cgk S gene was expressed in Escherichia coli, and the recombinant enzyme was purified to homogeneity with a specific activity of 716.8 U mg-1 and a yield of 69%. Recombinant Cgk S was most active at 45℃ and p H 8.0. It was stable at p H 6.0–9.0 and below 30℃. The enzyme did not require Na Cl for activity, although its activity was enhanced by Na Cl. Cgk S degraded κ-carrageenan in an endo-fashion releasing tetrasaccharides and disaccharides as main hydrolysis products. | WANG Linna LI Shangyong ZHANG Shilong LI Jiejing YU Wengong GONG Qianhong | 2015 | Journal of Ocean University of China2015，14，4： | 2 |
| 17 | Oriented CuZnAl ternary layered double hydroxide films:In situ hydrothermal growth and anticorrosion properties显示文摘 | Lei Xiaodong Wang Linna Zhao Xuhui | 2013 | Ind Eng Chem Res2013，52，17： | 1 |
| 18 | Research on the Construction of Technology Innovation Virtual Team in SMEs: Based on the Perspective of Industry-university-research Cooperative Innovation显示文摘 | WANG Linna ZHU Konglai | 2011 | Management Science and Engineering2011，5，2： | 1 |
| 19 | Near-infrared quantum cutting in Ho 3+ , Yb 3+ -codoped BaGdF 5 nanoparticles via first-and second-order energy transfers显示文摘 | Linna Guo Yuhua Wang Jia Zhang Yanzhao Wang Pengyu Dong | 2012 | Nanoscale Research Letters2012，，1： | 1 |
| 20 | New Organic Dyes Based on Biarylmethylene-Bridged Triphenylamine for Dye Sensitized Solar Cell显示文摘三新器官的染料在敏化染料的太阳能电池(DSSC ) 为应用被综合并且描绘。在这些染料,衔接 diarylmethylene 的 triphenylamine 是施主,并且不同领受人和 vinylthiophene 被设计得到 TBA-1, TBA-2 和 TBA-3。他们的 photophysical,电气化学、光电的性质被调查,并且象这些性质上的连接一样的领受人结构的效果被评估。结果证明在施主和领受人之间的 vinylthiophene 连接为改进收获 TBA-2 的能力的光是有利的。另外,电气化学的阻抗光谱学实验建议更大的 R 消遣 和 TBA-2 的更长的电子一生。因此,它超过另外的染料,展出 3.87% 的最高的力量变换效率,与 J 8.25 mA·cm −2 和 V > 666 mV 的 oc 。不幸地,有三个领受人的 TBA-3 组织 3.52% 的仅仅表演效率,显示增加领受人组的设计起提高太阳能电池效率上的很少作用。 | Fei Wu Haitao Liu Lawrence Tien Lin Lee Tao Chen Min Wang Linna Zhu | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
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