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| 1 | Numerical simulation of predicting and reducing solid particle erosion of solid-liquid two-phase flow in a choke显示文摘Chokes are one of the most important components of downhole flow-control equipment.The particle erosion mathematical model,which considers particle-particle interaction,was established and used to simulate solid particle movement as well as particle erosion characteristics of the solid-liquid two-phase flow in a choke.The corresponding erosion reduction approach by setting ribs on the inner wall of the choke was advanced.This mathematical model includes three parts:the flow field simulation of the continuous carrier fluid by an Eulerian approach,the particle interaction simulation using the discrete particle hard sphere model by a Lagrangian approach and calculation of erosion rate using semi-empirical correlations.The results show that particles accumulated in a narrow region from inlet to outlet of the choke and the dominating factor affecting particle motion is the fluid drag force.As a result,the optimization of rib geometrical parameters indicates that good anti-erosion performance can be achieved by four ribs,each of them with a height(H) of 3 mm and a width(B) of 5 mm equaling the interval between ribs(L). | Li Guomei Wang Yueshe He Renyang Cao Xuewen Lin Changzhi Meng Tao | 2009 | Petroleum Science2009，6，1： | 3 |
| 2 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 3 | Novel function of perforin in negatively regulating CD4^+ T cell activation by affecting calcium signaling显示文摘Perforin 是主要从事调停的形成毛孔的蛋白质目标 T 房间死亡并且被细胞毒素的 T 淋巴细胞(CTL ) 和自然漂亮房间采用。然而,它是否也在常规 CD4+ T 房间功能起一个作用,仍然保持不清楚。这里,我们报导那在 perforin 缺乏(PKO ) 老鼠, CD4+ T 房间是响应 T 的 hyperproliferative 房间受体(TCR ) 刺激。hyperproliferation 的这个特征被改进在房间分割并且在 IL-2 分泌物伴随。看起来, perforin 缺乏不在胸腺怒气和淋巴节点影响 T 房间开发。在 vivo, perforin 缺乏导致增加的抗原特定的 T 房间增长和抗体生产。而且, PKO 老鼠更产生试验性的自体免疫的眼色素层炎。探讨分子的机制,我们发现在 TCR 刺激以后,从 PKO 老鼠的 CD4+ T 房间显示增加的细胞内部的钙流动并且随后提高抄写因素 NFAT1 的激活。我们的结果显示 perforin 在由影响 TCR 依赖的 Ca2+ 发信号调整 CD4+ T 房间激活和有免疫力的反应起一个否定作用。 | Enguang Bi Chunjian Huang Yu Hu Xiaodong Wu Weiwen Deng Guomei Lin Zhiduo Liu Lin Tian Shuhui Sun Kairui Mao Jia Zou Yuhan Zheng Bing Sun | 2009 | Cell Research2009，19，7： | 2 |
| 4 | Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation显示文摘理解自然变应原导致的气喘的致病是重要的,它能排除人工的助手的干扰并且在疾病提供自然有免疫力的反应的卓见。在现在的学习,我们证明甚至没有明矾的帮助, Trichosanthin (TCS ) 能导致航线发炎。而且, TCS 显得能够代替明矾支持卵特定的航线发炎。TCS 在一个早阶段在腹膜导致了 IL-4-producing 嗜曙红血球的累积, TCS 的辅助功能被 IL-4 的阻塞在这个阶段消除。最后, TCS 从 WT 鼠标,然而并非从 IL-4-deficient 鼠标触发的嗜曙红血球被显示为卵特定的 Th2 回答的正式就职作为助手工作。我们的数据显示 TCS 是不仅变应原,而且一个 Th2 类型助手 modulating 切换对一条 Th2 小径的有免疫力的回答。事件的这链在整洁 TCS 的一个早阶段由嗜曙红血球源于 IL-4 生产。在结论, TCS 可能作为一个 Th2 助手有用,并且天生的有免疫力的房间例如嗜曙红血球,可以是一个好目标学习 Th2 反应的开始。 | Yuan Wang Kairui Mao Shuhui Sun Guomei Lin Xiaodong Wu Gang Yao Bing Sun | 2009 | Cell Research2009，19，8： | 1 |
| 5 | Genome-wide and transcriptome-wide identification of the APX gene family in rapeseed (Brassica napus L.) and their expression features under low temperature stress显示文摘Ascorbate peroxidase(APX)is a crucial H2O2 scavenger that utilizes ascorbic acid as an electron donor and plays a significant role in plant stress resistance.This study aims to identify and characterize the Brassica napus L.APX gene family through genome and transcriptome sequencing,while also revealing their expression profile under low-temperature stress via transcriptome and proteome analysis.The results indicate the presence of 18 genes with three different conserved domains distributed in Brassica napus L.,which can be classified into three major branches based on phylogenetic analysis.Eleven members were predicted to have the low-temperature response component(LTR).Most APX genes exhibit up-regulated transcriptional expression under low temperature stress,particularly APX2,APX4,APX12,and APX18.In terms of proteomics data,only six members(APX2,APX4,APX8,APX12,APX17,and APX18)showed temporal specificity in their expression patterns.Therefore,this study provides valuable insights into the complexity of the APX family in the functional characterization of its genes for future research. | Xuan Sun Guomei Liu Lin Yao Chunfang Du | 2023 | Oil Crop Science2023，8，4： | 0 |
| 6 | 肺腺癌实性结节肿瘤间质与多排螺旋CT早期增强间的关系研究(英文)显示文摘Objective: To evaluate correlations between proportion and distribution of tumor stroma and MDCT early phase enhancement character in solid lung adenocarcinoma, and compare with microvessel density and histological subtypes. Methods: Thirty-one patients with lung adenocarcinoma shown as solid solitary pulmonary nodules underwent routine con-trast-enhanced MDCT followed by surgical resections. CT character included net enhancement and distribution of enhance-ment. The largest cut surface of tumor specimens were stained by hematoxylin and eosin. About 25 fields of view of each specimen were scanned as digitized pictures at low magnification. Semi-auto segmentation software was used to calculate mean stroma proportion. Pearson correlation coefficient was used to represent the relationships between extent of tumor en-hancement, proportion of tumor stroma and MVD respectively. Fisher's exact test was used to analyze statistical differences in degree of CT enhancement among groups of different histological subtypes. Results: Proportion of invasive tumor stroma (13.2%-54.5%, mean 26.2 ± 8.8%) was correlated positively with net enhancement (8-60.8 HU, mean 31.2 ± 13.6 HU; r = 0.483, P = 0.006) which was more than MVD. 58.1% cases showed homogenous enhancement, 32.3% cases showed periph-eral inhomogenous enhancement, 3.2% cases showed central inhomogenous enhancement, 3.2% cases showed asymmetri-cal inhomogenous enhancement, and 3.2% cases showed no enhancement. 58.1% cases' stroma showed mixed distribution, 35.5% cases showed peripheral distribution, 3.2% cases showed central distribution, and 3.2% cases showed asymmetrical distribution. Significantly more adenocarcinomas classified with 'net enhancement > 20 HU' were found in the acinar group than in the solid with mucin subtype (P = 0.005). Conclusion: Extent of CT enhancement reflects underlying not only the tumor angiogenesis but also stroma proliferation in solid small lung adenocarcinoma. Tumor stroma proportion could reflect the histopathologic basis of small lung adenocarcinoma's CT enhancement substantially than MVD. Distribution between enhancement and tumor stroma have good correspondence. Most of acinar adenocarcinomas have higher degree of CT net enhancement than solid with mucin adenocarcinomas. | Yong Wang Xueguo Liu Yujing Lin Xianping Yi Lianju Ding Xiaohong Wang Qjngsi Zeng Jianxing He Mingzhu Liang Peixin Qin Guomei Zhong Yanli He Xiaobin Liu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，5： | 0 |
| 7 | Detection and Elimination Harmonic in Power System显示文摘This paper shows the harm of harmonic in power system,compares the measures of normal digital filter and wavelet MARto afford reference to the detection and elimination in power system harmonic control. | CHEN QISONG CHEN XlAWEI QI LIN WANG GUOMEI | 2007 | 微计算机信息2007，23，28： | 0 |
| 8 | gcCov:Linked open data for global coronavirus studies显示文摘Impact Statement We present a method of mapping data from publicly available genomics and publication resources to the Resource Description Framework(RDF)and implement a server to publish linked open data(LOD).As one of the largest and most comprehensive semantic databases about coronaviruses,the resulted gcCov database demonstrates the capability of using data in the LOD framework to promote correlations between genotypes and phenotypes.These correlations will be helpful for future research on fundamental viral mechanisms and drug and vaccine designs. | Wenyu Shi Guomei Fan Zhihong Shen Chuan Hu Juncai Ma Yuanchun Zhou Zhen Meng Songnian Hu Yuhai Bi Liang Wang Haiying Yu Siru Lin Xiuqiang Sun Xinjiao Zhang Dongmei Liu Qinlan Sun Linhuan Wu | 2022 | mLife2022，1，1： | 0 |
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