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| 1 | Ridge subduction and porphyry copper-gold mineralization:An overview显示文摘Many large porphyry Cu-Au deposits are connected to adakitic rocks known to be closely associated with ridge subduction. For example, there are several subducting ridges along the east Pacific margin, e.g., in Chile, Peru, and South America, most of which are associated with large porphyry Cu-Au deposits. In contrast, there are much fewer ridge subductions on the west Pacific margin and porphyry Cu-Au deposits are much less there, both in terms of tonnage and the number of deposits. Given that Cu and Au are moderately incompatible elements, oceanic crust has much higher Cu-Au concentrations than the mantle and the continental crust, and thus slab melts with their diagnostic adakitic chemistry have systematically higher Cu and Au, which is favorable for mineralization. Considering the geotherm of subducting slabs in the Phanerozoic, ridge subduction is the most favorable tectonic setting for this. Therefore, slab melting is the likely link in the spatial association between ridge subduction and Cu-Au deposits. Geochemical signatures of slab melting and hence maybe ridge subduction in less eroded regions in eastern China, the central Asian orogenic belt etc. may indicate important exploration targets for large porphyry Cu-Au deposits. | SUN WeiDong LING MingXing YANG XiaoYong FAN WeiMing DING Xing LIANG HuaYing | 2010 | Science China Earth Sciences2010，53，4： | 97 |
| 2 | The Genome of Dendrobium officinale Illuminates the Biology of the Important Traditional Chinese Orchid Herb显示文摘 | Liang Yan Xiao Wang Hui Liu Yang Tian Jinmin Lian Ruijuan Yang ShumeiHao Xuanjun Wang Shengchao Yang Qiye Li Shuai Qi Ling Kui Moses Okpekum Xiao Ma Jiajin Zhang Zhaoli Ding Guojie Zhang Wen Wang Yang Dong Jun Sheng | 2015 | Molecular Plant2015，8，6： | 64 |
| 3 | Expression of nuclear factor-KB in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus显示文摘AIM In this study we investigated therelationship of the X protein of HBV and nuclearfactor-KB (NF-κB) and the expression of NF-KB inhuman hepatocellular carcinoma tissues.METHODS Immunohistochemistry SP methodwas used to detect the expression of NF-κB and the X protein of HBV in human hepatocellularcarcinoma tissues of 52 cases. Gene transfectionmediated by lipofectamine was used to transfectthe eukaryotic expression vector pCDNA3. 1-HBXof HBV x gene into human hepatocellularcarcinoma cell line HCC-9204 and NF-κB wasdetected.RESULTS NF-κB was widely expressed inhuman hepatocellular carcinoma tissues in atotal of 52 cases and its expression was relatedto the X protein of HBV. NF-KB was localizedboth in the cytoplasm and . The nuclei ofhepatocellular carcinoma cells in 11 cases whichwere positive for the X protein of HBV while in 41cases negative for the X protein of HBV, NF-Kbwas only localized in the cytoplasm ofhepatocellular carcinoma cells but translocatedto the nuclei of hepatocellular carcinoma cellsafter the eukaryotic expression vectorpCDNA3.1-HBX was transfected into HCC-9204cells.CONCLUSION This study strongly suggeststhat the nuclear factor NF-KB is widely expressedin hepatocellular carcinoma tissues in differentstyles according to the expression of the Xprotein of HBV. NF-κB is abnormally activated inhepatocellular carcinoma, which is probablyrelated to the X protein of HBV. The X protein ofHBV can activate NF-κB to translocate into nucleiof hepatocellular carcinoma cells. | Shuang Ping Guo~1 Wen Liang Wang~1 Yu Qiang Zhai~2 Yi Ling Zhao~1 ~1Department of Pathology,Xijing Hospital of the Fourth Military Medical University,Xi’an,China ~2Department of Urology,the Central Hospital of Xi’an,China | 2001 | World Journal of Gastroenterology2001，7，3： | 55 |
| 4 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 5 | De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis显示文摘AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver cirrhosis.METHODS:A total of 120 na ve patients with HBVrelated decompensated cirrhosis participated in this study.Sixty patients were treated with combined LAM and ADV therapy(LAM+ADV group),while the other60 were treated with ETV monotherapy(ETV group)for two years.Tests for liver and kidney function,alpha-fetoprotein,HBV serum markers,HBV DNA load,prothrombin time(PT),and ultrasonography or computed tomography scan of the liver were performed every1 to 3 mo.Repeated measure ANOVA and theχ2test were performed to compare the efficacy,side effects,and the cumulative survival rates at 48 and 96 wk.RESULTS:Forty-five patients in each group were observed for 96 wk.No significant differences in HBV DNA negative rates and alanine aminotransferase(ALT)normalization rates at weeks 48(χ2=2.12 and 2.88)and96(χ2=3.21 and 3.24)between the two groups were observed.Hepatitis B e antigen seroconversion rate in the LAM+ADV group at week 96 was significantly higher in the ETV group(43.5%vs 36.4%,χ2=4.09,P<0.05).Viral breakthrough occurred in 2 cases(4.4%)by week 48 and in 3 cases(6.7%)by week 96 in the LAM+ADV group,and no viral mutation was detected.In the ETV group,viral breakthrough occurred in 1 case(2.2%)at the end of week 96.An increase in albumin(F=18.9 and 17.3),decrease in total bilirubin and in ALT(F=16.5,17.1 and 23.7,24.8),reduced PT(F=22.7 and 24.5),and improved Child-Turcotte-Pugh and the model for end-stage liver disease scores(F=18.5,17.8,and 24.2,23.8)were observed in both groups.The cumulative rates of mortality and liver transplantation were 16.7%(10/60)and 18.3%(11/60)in the LAM+ADV and ETV groups,respectively.CONCLUSION:Both LAM+ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication,improve liver function,and decrease mortality. | Jiang-Shan Lian Lin-Yan Zeng Jian-Yang Chen Hong-Yu Jia Yi-Min Zhang Dai-Rong Xiang Liang Yu Jian-Hua Hu Ying-Feng Lu Ling Zheng Lan-Juan Li Yi-Da Yang | 2013 | World Journal of Gastroenterology2013，19，37： | 36 |
| 6 | PVT v2:Improved baselines with Pyramid Vision Transformer显示文摘Transformers have recently lead to encouraging progress in computer vision.In this work,we present new baselines by improving the original Pyramid Vision Transformer(PVT v1)by adding three designs:(i)a linear complexity attention layer,(ii)an overlapping patch embedding,and(iii)a convolutional feed-forward network.With these modifications,PVT v2 reduces the computational complexity of PVT v1 to linearity and provides significant improvements on fundamental vision tasks such as classification,detection,and segmentation.In particular,PVT v2 achieves comparable or better performance than recent work such as the Swin transformer.We hope this work will facilitate state-ofthe-art transformer research in computer vision.Code is available at http://gffzz188fe103f8f1460as5kqbww6nufc06fwx.ffgz.tsg.suse.edu.cn/whai362/PVT. | Wenhai Wang Enze Xie Xiang Li Deng-Ping Fan Kaitao Song Ding Liang Tong Lu Ping Luo Ling Shao | 2022 | Computational Visual Media2022，8，3： | 30 |
| 7 | Possible early Neoproterozoic magmatism associated with slab window in the Pingshui segment of the Jiangshan-Shaoxing suture zone: Evidence from zircon LA-ICP-MS U-Pb geochronology and geochemistry显示文摘We report here geochemical data, U-Pb zircon ages, and Hf isotopes for the high-Mg diorites (HMDs), Nb-enriched basaltic porphyrys (NEBPs) and plagiogranites (PLAGs) in the Pingshui segment of the Jiangshan-Shaoxing suture zone. The HMDs are characterized by high Mg# (>60), high Na and LREE contents, depletion of HREE and HFSE, and pronounced positive εNd(t) values of 7.0 to 7.7, similar to some adakitic high-Mg andesites. The NEBPs are relatively Na-rich (Na2O/K2O>6) and display high abundances of P2O5 (~1.00%), TiO2 (~3.08%) and HFSE (e.g., Nb=9.53-10.27 ppm). Their Nd isotopic compositions (εNd(t)=6.8-8.0) are comparable to those of the HMDs. The PLAGs are metaluminous (A/CNK=0.84-0.89) and sodic (Na2O/K2O>10). Their depletion in HFSE (e.g., Nb, Ta) is consistent with 'SSZ-type' plagiogranite. Zircon LA-ICP-MS U-Pb dating yields an age of 932±7 Ma for the HMD, 916±6 Ma for the NEBP, and 902±5 Ma for the PLAG, respectively, indicating that they were products of early Neoproterozoic magmatism. The PLAGs exhibit relatively high zircon Hf isotopes and positive εHf(t) values of 11.0 to 16.2, consistent with their Nd isotopic data (εNd(t)=7.5-8.4). Such features are similar to those of oceanic plagiogranites in ophiolites and distinct from those of crust-derived granites. The PLAGs were most likely derived from partial melting of subducted oceanic crust in an active continental margin. Considering these results in the context of the regional geology, we suggest that a slab window in the subducting oceanic crust between the Yangtze Block and Cathaysia Block was possibly the principal cause for the unique arc magmatism in the area. The upwelling asthenosphere below the slab window may have provided significant thermodynamic conditions. | CHEN ZhiHong GUO KunYi DONG YongGuan CHEN Rong LI LongMing LIANG YiHong LI ChunHai YU XiMing ZHAO Ling XING GuangFu | 2009 | Science China Earth Sciences2009，52，7： | 26 |
| 8 | Hf isotopic composition of zircons from the Huashan-Guposhan intrusive complex and their mafic enclaves in northeastern Guangxi:Implication for petrogenesis显示文摘High precision zircon U-Pb dating indicates that main intrusive bodies (Tong'an,Niumiao,Huashan,Lisong),and a mafic microgranular enclave in the Huashan-Guposhan complex were formed at 160-163 Ma.The εHf(t) values of zircons from the Huashan granite vary from -2.8 to +0.3 and those from the Lisong granite vary from -2.3 to +0.3,which are obviously different with those values (+2.6 to +7.4) of the mafic enclaves from the Lisong granite.These Hf isotopic data indicate that the mafic enclaves and host granites were crystallized from different sources of magmas,providing evidence for mafic-felsic magma mixing processes.The highest εHf(t) value of zircons from the mafic enclaves is up to +7.4,indicating that the mafic magma was originated from a relatively depleted mantle source.Studies on regional geology and the contemporaneous mafic and alkaline rocks in this area indicate that the mafic magma was not originated from reworking of basaltic juvenile crust,but from partial melting of the mantle.However,it remains to be resolved whether the mafic magma was derived from partial melting of the asthenosphere or the lithospheric mantle.The Huashan granite and the Lisong granite were formed from hybrid magma of mantle-derived and crust-derived magmas,and the mafic enclaves are considered as remains of mantle-derived magma during mixing processes.The εHf(t) values of zircons from the Niumiao diorite vary from -1.1 to +2.1,and those from the Tong'an quartz monzonite vary from -1.7 to +1.7.These values are lower than those from the mafic enclaves,suggesting that the diorite and monzonite were formed from different source-derived magmas with the mafic enclaves.The εHf(t) values for the Niumiao diorite and the Tong'an monzonite are only slightly higher than those for the Hushan granite and the Lisong granite.Abundant mafic enclaves also occur in the Niumiao diorite and in the Tong'an monzonite.Thus,we suggest that the Niumiao diorite and the Tong'an monzonite were probably also formed from the same hybrid magma as the granites but come through less degree of fractional crystallization and crustal contamination.The strong mantle-derived and crust-derived magma mixing caused by an intense crustal extension and thinning in the Mid-Late Jurassic may be the major mechanism for generating the diorites and granites in southeastern Hunan and northeastern Guangxi belt in South China. | ZHAO KuiDong JIANG ShaoYong ZHU JinChu LI Liang DAI BaoZhang JIANG YaoHui LING HongFei | 2010 | Chinese Science Bulletin2010，55，6： | 24 |
| 9 | Charlson comorbidity index helps predict the risk of mortality for patients with type 2 diabetic nephropathy显示文摘研究目的:探讨Charlson合并症指数(CCI)对2型糖尿病肾病死亡率的预测作用。研究方法:建立2型糖尿病肾病研究队列,根据CCI评分将患者合并症的严重程度分为三度:轻度(CCI1–2分)、中度(CCI 3–4分)、重度(CCI≥5分)。将影响死亡率的因素及按CCI分层后的组间差异指标进行Logistic回归分析及方差分析(ANOVA)。Kaplan-Meier生存曲线分析CCI指数对生存时间及死亡率的影响。重要结论:533例2型糖尿病肾病患者纳入研究。所有患者的CCI评分均大于1,44.7%(238/533)的患者死亡。患者的死亡率随CCI评分增加而增加,CCI 1–2分患者的死亡率为21.0%(50/238),CCI 3–4分患者的死亡率为56.7%(135/238),CCI≥5分患者的死亡率为22.3%(53/238)。Logistic回归分析显示CCI评分、血红蛋白和血浆白蛋白水平是患者死亡率的预测因子(P<0.05)。方差分析结果显示,与CCI评分相对较低的患者相比,CCI评分越高的患者其血红蛋白水平较低,而血清肌酐较高,死亡率也更高。Kaplan-Meier生存曲线显示CCI评分越高的患者生存时间越短。CCI评分是一种简单易行且实用的评估疾病合并症的方法,可用于预测2型糖尿病肾病患者的死亡率。关注2型糖尿病肾病患者的合并症将有利于早期、有效治疗及改善预后。 | You-qun HUANG Rong GOU Yong-shu DIAO Qing-hua YIN Wen-xing FAN Ya-ping LIANG Yi CHEN Min WU Li ZANG Ling LI Jing ZANG Lu CHENG Ping FU Fang LIU | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，1： | 23 |
| 10 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway显示文摘This study aimed to verify the effects of berberine(BBR)on the fat metabolism proteins involved in the sirtuin 3(SIRT3)/adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)/acetyl-CoA carboxylase(ACC)pathway in the liver tissues of rats with high-fat diet(HFD)-induced non-alcoholic fatty liver disease(NAFLD).Forty-eight rats were randomly divided into the normal control(NC)group,HFD group or BBR group,with 16 rats in each group.After 8 and 16 weeks of treatment,serum and liver samples were collected.Subsequently,body parameters,biochemical parameters and liver pathology were examined.The expression levels of proteins involved in the SIRT3/AMPK/ACC pathway in the liver were detected by Western blotting.After 8 and 16 weeks of a HFD,the successful establishment of rat models with different degrees of NAFLD was confirmed by hematoxylin and eosin(H&E)and Oil Red O staining.NAFLD rat models exhibited obesity and hyperlipidemia,and the protein expression levels of SIRT3,p-AMPK.p-ACC,and CPT-1A in the liver were significantly decreased compared to those in the NC group.The concurrent administration of BBR with the HFD effectively improved serum and liver lipid profiles and ameliorated liver injury.Furthermore,the protein expression levels of SIRT3,p-AMPK,p-ACC,and CPT-1 A in the liver were significantly increased in the BBR group as compared with those in the HFD group.In conclusion,our data suggest that the mechanism by which BBR ameliorates HFD-induced hepatic steatosis may be related to the activation of the SIRT3/AMPK/ACC pathway in the liver. | Yu-pei ZHANG Yuan-jun DENG Kai-rui TANG Run-sen CHEN Shu LIANG Yin-ji LIANG Li HAN Ling JIN Zi-en LIANG Yan-ning CHEN Qin-he YANG | 2019 | Current Medical Science2019，39，1： | 21 |
| 11 | Cyclical one-way continental rupture-drift in the Tethyan evolution: Subduction-driven plate tectonics显示文摘Numerous continents have rifted and drifted away from Gondwana to repeatedly open ocean basins over the past-500 millionyears.These Gondwana-derived continents drifted towards and collided with components of the Eurasian continent to successively close the preexisting oceans between the two.Plate tectonics satisfactorily describes the continental drift from Gondwana to Eurasia but does not define the geodynamic mechanism of continuously rifting to collisions of continents in the Tethy an Realm.After reappraisal of geological records of the rift,collision and subduction initiation from the surface and various geophysical observations from depth,we propose that Eurasia-directed subducting oceanic slabs would have driven Tethyan system in the Phanerozoic.The Eurasia-directed subduction would have dragged the passive Gondwana margin to rift and drift northwards,giving birth to new oceans since the Paleozoic.The closure of preexisting oceans between the Gondwana-derived continents and Eurasia led to continental collisions,which would have induced the initiation of oceanic subduction in the Tethyan Realm.Multiple episodic switches between collision-subduction-rift repeatedly led to the separation of continental fragments from Gondwana and dragged them to drift towards Eurasia.The final disappearance of Neo-Tethy s would have induced collision of the Gondwana-derived continents with the Eurasian continent,giving rise to the Cenozoic Alpine-Zagros-Himalayan collisional system.Therefore,the Eurasia-directed oceanic subduction would have acted as a’one-way train’that successively transferred the ruptured Gondwana continental fragments in the south,into the terminal in the north.In this regard,the engine of this'Tethyan one-way train'is the negative buoyancy of subducting oceanic slabs. | Bo WAN Fuyuan WU Ling CHEN Liang ZHAO Xiaofeng LIANG Wenjiao XIAO Rixiang ZHU | 2019 | Science China Earth Sciences2019，62，12： | 21 |
| 12 | Lithofacies and sedimentary characteristics of the Silurian Longmaxi Shale in the southeastern Sichuan Basin,China显示文摘The Silurian Longmaxi Shale (SLS) is the target for shale gas exploration and exploitation in the southeastern Sichuan Basin.Based on detailed description of cores and outcrops,analysis of Gamma Ray (GR) logs,thin sections and mineralogical data,the SLS can be subdivided into six lithofacies:(1) clayey shale,(2) siliceous calcareous shale,(3) siliceous dolomitic shale,(4) silty-clayey interlaminated shale,(5) muddy siltstone,and (6) graptolite shale.Three facies associations are recognized in the study area,i.e.,inner shelf,outer shelf,and bathyal plain (including turbidite) facies.Outer shelf and bathyal plain facies dominate the lower interval of the SLS,while inner shelf facies dominates the upper part of the SLS.The thickness of the black shale in the northern part of the study area is the greatest,where siliceous calcareous shale,siliceous dolomitic shale,and graptolite shale are predominant.These three kinds of shale are rich in total organic carbon (TOC) content and brittle minerals,which is favourable for the accumulation of shale gas and its future exploitation. | Jiang Zaixing Guo Ling Liang Chao | 2013 | Journal of Palaeogeography2013，2，3： | 21 |
| 13 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 14 | Portosplenomesenteric vein thrombosis in patients with early-stage severe acute pancreatitis显示文摘AIM To investigate the incidence and risk factors of portosplenomesenteric vein thrombosis(PSMVT) in the early stage of severe acute pancreatitis(SAP).METHODS Patients with SAP in a tertiary care setting from January 2014 to December 2016 were retrospectively reviewed. All contrast-enhanced computed tomography(CT) studies were reassessed and reviewed. Clinical outcome measures were compared between SAP patients with and without PSMVT in the early stage of the disease. Univariate and multivariate logistic regression analyses were sequentially performed to assess potential risk factors for the development of PSMVT in SAP patients. A receiver operating characteristic(ROC) curve was generated for the qualifying independent risk factors.RESULTS Twenty-five of the one hundred and forty(17.86%) SAP patients developed PSMVT 6.19 ± 2.43 d after acute pancreatitis(AP) onset. PSMVT was confirmed by contrast-enhanced CT. Multivariate stepwise logistic regression analyses showed that Balthazar's CT severity index(CTSI) scores [odds ratio(OR): 2.742; 95% confidence interval(CI): 1.664-4.519; P = 0.000], hypoalbuminemia(serum albumin level < 25 g/L)(OR: 32.573; 95%CI: 2.711-391.353; P = 0.006) and gastrointestinal wall thickening(OR: 4.367, 95%CI: 1.218-15.658; P = 0.024) were independent risk factors for PSMVT developed in patients with SAP. The area under the ROC curve for Balthazar's CTSI scores was 0.777(P = 0.000), the sensitivity was 52%, and the specificity was 93% at a cut-off value of 5.5.CONCLUSION High Balthazar's CTSI scores, hypoalbuminemia and gastrointestinal wall thickening are independent risk factors for PSMVT developed in the early stage of SAP. | Ling Ding Feng Deng Chen Yu Wen-Hua He Liang Xia Mi Zhou Xin Huang Yu-Peng Lei Xiao-Jiang Zhou Yin Zhu Nong-Hua Lu | 2018 | World Journal of Gastroenterology2018，24，35： | 20 |
| 15 | Severity of acute gastrointestinal injury grade is a good predictor of mortality in critically ill patients with acute pancreatitis显示文摘BACKGROUND Gastrointestinal(GI)dysfunction is a common and important complication of acute pancreatitis(AP),especially in patients with severe AP.Despite this,there is no consensus means of obtaining a precise assessment of GI function.AIM To determine the association between acute gastrointestinal injury(AGI)grade and clinical outcomes in critically ill patients with AP.METHODS Patients with AP admitted to our pancreatic intensive care unit from May 2017 to May 2019 were enrolled.GI function was assessed according to the AGI grade proposed by the European Society of Intensive Care Medicine in 2012,which is mainly based on GI symptoms,intra-abdominal pressure,and feeding intolerance in the first week of admission to the intensive care unit.Multivariate logistic regression analysis was performed to assess the association between AGI grade and clinical outcomes in critically ill patients with AP.RESULTS Among the 286 patients included,the distribution of patients with various AGI grades was 34.62%with grade I,22.03%with grade II,32.52%with grade III,and 10.84%with grade IV.The distribution of mortality was 0%among those with grade I,6.35%among those with grade II,30.11%among those with grade III,and 61.29%among those with grade IV,and AGI grade was positively correlated with mortality(χ2=31.511,P<0.0001).Multivariate logistic regression analysis showed that age,serum calcium level,AGI grade,persistent renal failure,and persistent circulatory failure were independently associated with mortality.Compared with the Acute Physiology and Chronic Health Evaluation II score(area under the curve:0.739 vs 0.854;P<0.05)and Ranson score(area under the curve:0.72 vs 0.854;P<0.01),the AGI grade was more useful for predicting mortality.CONCLUSION AGI grade is useful for identifying the severity of GI dysfunction and can be used as a predictor of mortality in critically ill patients with AP. | Ling Ding Hong-Yan Chen Jin-Yun Wang Hui-Fang Xiong Wen-Hua He Liang Xia Nong-Hua Lu Yin Zhu | 2020 | World Journal of Gastroenterology2020，26，5： | 20 |
| 16 | M@MIL-100(Fe) (M = Au, Pd, Pt) nanocomposites fabricated by a facile photodeposition process: Efficient visible-light photocatalysts for redox reactions in water显示文摘高效、稳定的双功能的 photocatalytic 材料的合适的设计和准备仍然是研究的一个重要目的。在这个工作,高度驱散高贵金属的 nanoparticles (Au, Pd,磅) 用一种灵巧的房间温度 photodeposition 技术在 MIL-100 (Fe )( 表示 M@MIL-100 (Fe )) 上被使不能调动。nanocomposites 展出了的产生 M@MIL-100 (Fe )(M = Au, Pd,和磅) 与 blank-MIL-100 (Fe ) 相比在可见光的照耀(420 nm ) 下面向甲基橘子(瞬间) 和重金属的 Cr (VI ) 离子的减小的 photocatalytic 降级提高了 photoactivities。把这些结果与 photoelectrochemical 分析相结合表明那高贵金属的免职能有效地在可见光的照耀下面改进 MIL-100 (Fe ) 的费用分离效率。这现象接着向 photocatalytic 氧化还原作用反应导致 M@MIL-100 (Fe ) 的 visible-light-driven photoactivity 的改进。特别地,有显著地展出的 2 nm 的一种平均的磅粒子尺寸的 Pt@MIL-100 ( Fe ) M@MIL-100 ( Fe )( M = Au 和 Pd )与那些相比提高了 photoactivities ,它能被归因于提高的轻吸收紧张和 photogenerated 费用搬运人的更有效的分离的综合效果。另外,可能的 photocatalytic 反应机制也被建议。 | Ruowen Liang Fenfen Jing Lijuan Shen Na Qin Ling Wu | 2015 | Nano Research2015，8，10： | 19 |
| 17 | Gefitinib inhibits M2-1ike polarization of tumor- associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway显示文摘 | Muhammad TARIQ Jie-qiong ZHANG Gui-kai LIANG Qiao-jun HE Ling DING Bo YANG | 2017 | Acta Pharmacologica Sinica2017，38，11： | 18 |
| 18 | Expression of phosphatidylinositol-3 kinase and effects of inhibitor Wortmannin on expression of tumor necrosis factor-α in severe acute pancreatitis associated with acute lung injury显示文摘BACKGROUND: Acute lung injury(ALI) is a common and serious complication of severe acute pancreatitis(SAP). The study aimed to investigate the protective effect and mechanism of phosphatidylinositol-3 kinase(PI3K) inhibitor Wortmannin in SAP associated with ALI.METHODS: Ninety rats were randomly divided into three groups: sham operation(SO) group(n=30), SAP group(n=30), and SAP+Wortmannin(SAP+W) group(n=30). SAP model was induced by retrograde injection of 4% sodium taurocholate into the biliopancreatic duct of rats. The rate of lung water content, myeloperoxidase(MPO), matrix metalloproteinase 9(MMP-9), protein kinase B(PKB), abdphosphorylation of protein kinase B(P-PKB) activity in the lung tissue were evaluated.RESULTS: In the SAP group, the p-PKB expression in the lung tissue began to rise at 3 hours after modeling, and peaked at 12 hours(P<0.05); the rate of lung water content, MPO and TNF-α activity were also gradually increased, and the degree of lung lesion gradually increased(P<0.05). In the SAP+Wortmannin group, the p-PKB expression in the lung tissue began to rise at 3 hours after modeling, and peaked at 12 hours; it was higher than that in the SO group(P<0.05), but significantly lower than that in the SAP group(P<0.05). The rest indicators in the SAP+Wortmannin group were also significantly decreased as compared with the SAP group(P<0.05).CONCLUSIONS: The expression of phosphatidylinositol-3 kinase/protein kinase B was elevated in severe pancreatitis rats with lung injury. This suggested that PI3 K signal transduction pathway is involved in the control and release of proinfl ammatory cytokines TNF-α, which may play an important role in the pathogenesis of severe acute pancreatitis associated with lung injury. This finding indicated that Wortmannin can block the PI3 K signal transduction pathway, and inhibit the release of infl ammatory factor TNF-α. | Ming Wei Yan-jie Gong Ling Tu Jia Li Ying-hong Liang Yi-hua Zhang | 2015 | World Journal of Emergency Medicine2015，6，4： | 18 |
| 19 | The Dayingzi detachment fault system in Liaodong Peninsula and its regional tectonic significance显示文摘Large scale lithosphere thinning is an important characteristic of the destruction of the North China Craton (NCC) during the late Mesozoic. A series of extensional structures were developed under extensional setting, among which is the Dayingzi detachment fault system (DFS). The DFS is constituted by three parts, volcano-sedimentary basins at the hanging wall, the Dayingzi-Huanghuadian detachment fault zone, and Paleoproterozoic metamorphic rock series and Mesozoic plutons at the foot-wall. In the section across the detachment fault zone, there is a sequence of tectonites including fault gouge, microbreccia, cataclastic-mylonites, mylonites, and gneissic biotite monzonite granite. Microstructural characteristics of tectonites and electron backscatter diffraction (EBSD) patterns of quartz indicate that the rocks from the footwall experienced a process from upper greenschist facies to lower greenschist facies. SHRIMP and LA-ICP MS U-Pb dating of zircons from the volcanic rocks in the basins, the tectonic evolution of the DFS is summarized as follows: 1) regional extension started at 135.0±1.2 Ma ago, when the detachment fault cut through the middle crust. Faulting induced the upwelling of magma and eruption of volcanic rocks and deformed a series of medium-acid volcanic rocks; 2) after 135.0±1.2 Ma, a large scale detachment faulting was active cross-cutting the mid-upper crust. The western margin of Jurassic and Triassic granite was ductilly and brittly sheared; besides, the Cretaceous volcano-sedimentary rocks were tilted when the master fault approached the surface; 3) at around 127±1 Ma, the detachment fault stopped its activity and was intruded by the unsheared Cretaceous granite near Chaoyang. Comparison with the Liaonan metamorphic core complex (MCC) and other extensional structures in Liaodong Peninsula led to a general trend of including three zones in the Peninsula: MCC zone, detachment fault systems (DFS) zone, and half graben zone. MCC commonly cuts through the mid-lower crust, DFS through the mid-upper crust, and half graben through the upper crust. Therefore, development of the extensional structures in Liaodong Peninsula indicates that they are the results of crustal extension and thinning at different crustal levels. They may provide a deep insight into the dynamic mechanism, history of destruction and lithosphere thinning of the North China Craton (NCC). | SHEN Liang LIU JunLai HU Ling JI Mo GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，10： | 17 |
| 20 | Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition显示文摘 | Yue Shi Xiao-chun Liang Hong Zhang Qun-li Wu Ling Qu Qing Sun | 2013 | Acta Pharmacologica Sinica2013，34，9： | 16 |
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