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| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | Environmental conditions and genetic differentiation:what drives the divergence of coexisting Leymus chinensis ecotypes in a large-scale longitudinal gradient?显示文摘Aims The two coexisting Leymus chinensis ecotypes exhibit remarkable divergences in adaptive strategies under drought and salinity in semi-humid meadows and semi-arid steppes.In order to detect the major genetic and environmental factors dominating the intraspecific phenotype variations and ecotype formation,the questions regarding the two distinct phenotypic forms(ecotypes)in L.chin-ensis were addressed:(i)did environments drive the L.chinensis ecotype formation?(ii)was there a molecular basis for the morphological divergence between the two ecotypes?(iii)which driving force dominated the intraspecies divergence,divergent natural selection,genetic drift or stabilizing selection?Methods We applied a series experiments on demographical,morphological and physiological traits of two Leymus chinensis ecotypes with gray green(GG)and yellow green(YG)leaf color in nine wild sites along a longitudinal gradient from 114°to 124°E in northeast China.The environmental data including mean annual precipitation,mean annual temperature,elevation and soil properties were collected.We compared the differences of morphological,physiological and genetic differentiations between the two ecotypes.Important FindingsThe GG type exhibited stronger fitness than YG type from the population densities,morphological traits(e.g.shoot height,leaf area,leaf and seed weights et al.),leaf mass per area(LMA)and physiological traits[relative water content(RWC),proline,soluble sugar contents].Most of above phenotypes(e.g.total shoot densities,spike length et al.)were significantly correlated with mean annual precipitation,mean annual temperature and soil water content(SWC),rarely a correlated with soil pH and soil nutrient.Transplanted populations showed convergence trend by their leaf chlorophyll contents and osmotic adjustments(proline and soluble sugar contents)in the greenhouse,but still exhibited their divergences between two ecotypes in the outdoor transplantation,suggesting that whether L.chinensis ecotype differentiated could be largely affected by the environmental conditions.Furthermore,by the comparison result of quantitative genetic variation(Q_(ST))values from phenotypes with theoretical neutral genetic differentiation(F_(ST)),differentiation in phenotypic traits greatly surpassed neutral predictions,implying that directional natural selection played a crucial role in L.chinen-sis ecotype differentiation.In addition,microsatellite analysis from Neighbor-joining tree and Bayesian assignment generated into two groups according to ecotypes,indicating molecular genetic differentiation also propelled the two ecotypes divergence.We conclude that L.chinensis population variations were driven by combing divergent natural selection(precipitation,temperature and SWCs)along the large-scale gradient and significantly intrinsic genetic differentiation. | Shan Yuan Chengyuan Guo Linna Ma Renzhong Wang | 2016 | Journal of Plant Ecology2016，9，5： | 4 |
| 3 | Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance显示文摘 | Yongjie Ma Yixian Huang Linna Yan Mingming Gao Dexi Liu | 2013 | Pharmaceutical Research2013，，5： | 3 |
| 4 | Fabrication and characterization of 3D printed biocomposite scaffolds based on PCL and zirconia nanoparticles显示文摘The application of three-dimensional printed polymer scaffolds in repairing bone defects is a promising strategy.Among them,polycaprolactone(PCL)scaffolds are widely studied due to their good processability and controlled degradation rate.However,as an alternative graft for repairing bone defects,PCL materials have poor hydrophilicity,which is not conducive to cell adhesion and growth.In addition,the poor mechanical properties of PCL materials cannot meet the strength required to repair bone defects.In this paper,nano-zirconium dioxide(ZrO2)powder is embedded in PCL material through a meltmixing process,and a regular grid scaffold is constructed by 3D printing.The embedding of nanometer zirconium dioxide powder improves the hydrophilicity and water absorption of the composite scaffold,which is conducive to cell adhesion,proliferation and growth and is beneficial to the exchange of nutrients.Therefore,the PCL/ZrO2 composite scaffold showed better biological activity in vitro.At the same time,the PCL/ZrO2 composite material system significantly improves the mechanical properties of the scaffold.Among them,compared with the pure PCL scaffold,the Young’s modulus is increased by about 0.4 times,and the compressive strength is increased by about 0.5 times.In addition,the osteogenic differentiation results also showed that the PCL/ZrO2 composite scaffold group showed better ALP activity and more effective bone mineralization than the pure PCL group.We believe that the 3D printed PCL/ZrO2 composite scaffold has certain application prospects in repairing bone defects. | Qifan Wang Zhiyong Ma Ying Wang Linna Zhong Wenjia Xie | 2021 | Bio-Design and Manufacturing2021，4，1： | 2 |
| 5 | Defect characterization of amorphous silicon thin film solar cell based on low frequency noise显示文摘The reliability of solar cells is the key factor todetermine the performance and lifetime of photo-voltaic products. Compared to the insensitivity oftraditional electrical detection and the limitationsof in-situ characterization methods, noise measure-ment has been widely used in semiconductor de-vice reliability characterization for its rapid, sen-sitive and nondestructive. The energy band struc-ture shows that there are two kinds of defects existin amorphous silicon solar cells. | Linna HU Liang HE Hua CHEN Xiaofei JIA Ying HU Hongmei MA DANDan GUO Yu QIN | 2018 | Science China(Information Sciences)2018，61，6： | 1 |
| 6 | Investigation of the Potential and Mechanism of Clove for Mitigating Airborne Particulate Matter Emission from Stationary Sources显示文摘植物的障碍(VB ) 有潜力减轻从区域来源射出的空气污染物质,包括喂操作(AFO ) 的集中的动物。然而,机制充分没被调查,从而在实践限制植被系统的应用程序。有可重复、可控制的条件的一个试验性的方法被开发测量微粒事(下午)集中的变化在在风中的 VB 迎风、顺风与扫描电子显微镜( SEM )在叶子掘并且观察积累的下午,因此在减轻从 AFO 射出的下午评估 VB 的能力。分支规模植被,劈开(syzygium aromaticum ) 因为它的叶子是专业之一,被选择因素影响下午分散。结果证明分支规模障碍多孔的媒介有能力防碍气流和还原剂下午,它能被风速度,粒子尺寸部分和表面区域密度影响劈开。而且,劈开元素能适应风和微结构劈开(例如叶子的层次结构) 在 PM 免职上影响了。这些结果显示在这研究开发的方法可以被用来在从静止来源减轻下午评估植被的潜力,并且植被的一些特征能是为探索减少微粒的工程申请的进一步学习的同样仿生的原型。 | Jin Tong Xin Liu Ronaldo Maghirang Kaiqi Wei Linna Liu Chun Wang Yunhai Ma Donghui Chen Hongjia Yan Li Guo | 2017 | Journal of Bionic Engineering2017，14，2： | 1 |
| 7 | Isoliquiritigenin inhibits Ishikawa endometrial carcinoma cells proliferation and promotes apoptosis显示文摘Endometrial cancer is the fourth most frequent neoplasia i women worldwide,and the molecular mechanisms involved in the etiology and pathogenesis continue to be investigated.Isoliquiritigenin(ISL),an important flavonoid isolated from Glycyrrhizae radix,possesses a wide range of pharmacological properties such as antioxidant,antiinflammatory,antitumor and immunoreg ulatory activities.This study aimed to investigate the molecular mechanisms of ISL on the proliferation and apoptosis resistance of Ishikawa endometrial carcinoma cells. | Yao Lijie Jiang Yang Ma Yong Guo Linna Jin Haifeng | 2021 | 解剖学杂志2021，44，S01： | 0 |
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