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| 1 | Fabrication of submicron barium sulfate aggregates in the presence of ethylenediaminetetraacetic acid anions显示文摘Barium sulfate aggregates with an average size of 0.5 μm were synthesized at pH 7,directed by ethylenediaminetetraacetic acid(EDTA) anions.The particle morphology,chemical composition,and size distribution of the BaSO_4 aggregates were characterized.The as-synthesized BaSO_4 particles were spherical and comprised many interconnected nanoballs,of which the surface properties were affected by the EDTA anions.The adsorption of EDTA anions reversed the charge and weakened the surface polarity of BaSO_4,instigating the formation of aggregates by a self-assembly and transformation process.The resulting BaSO_4 particles at pH 9-10 were ellipsoidal and featured smooth surfaces.Based on the zeta potential of BaSO_4,variations in the morphology induced by changes in pH were closely related to the adsorption of mono- and multi-valent anions onto the electrical double layer of BaSO_4. | Linna Hu Guangxiu Wang Chun Yang Rong Cao | 2015 | Particuology2015，13，5： | 11 |
| 2 | Optimal Energy-Efficient Transmission for Hybrid Spectrum Sharing in Cooperative Cognitive Radio Networks显示文摘In order to improve the energy efficiency(EE)in cognitive radio(CR),this paper investigates the joint design of cooperative spectrum sensing time and the power control optimization problem for the secondary user systems to achieve the maximum energy efficiency in a cognitive network based on hybrid spectrum sharing,meanwhile considering the maximum transmit power,user quality of service(QoS)requirements,interference limitations,and primary user protection.The optimization of energy efficient sensing time and power allocation is formulated as a non-convex optimization problem.The Dinkelbach’s method is adopted to solve this problem and to transform the non-convex optimization problem in fractional form into an equivalent optimization problem in the form of subtraction.Then,an iterative power allocation algorithm is proposed to solve the optimization problem.The simulation results show the effectiveness of the proposed algorithms for energy-efficient resource allocation in the cognitive network. | Linna Hu Rui Shi Minghe Mao Zhiyu Chen Hongxi Zhou Weiliang Li | 2019 | China Communications2019，16，6： | 9 |
| 3 | Viscoelasticity of Asphalt Modified With Packaging Waste Expended Polystyrene显示文摘In view of environmental and economic aspect,asphalt was modified with recycled packaging waste expended polystyrene(WEPS)instead of common polymer.The differential scanning calorimetry(DSC),rotational viscometer and dynamic shear rheology(DSR)were used to analyze and evaluate the viscoelasticity of modified asphalt.Results indicate that the sensitivity of modified asphalt to temperature is decreased while the rut resistance of asphalt is increased.In addition,the viscoelasticity of asphalt is improved after the modification with WEPS.Besides,the modified asphalt has high viscosity at low temperature and low viscosity at high temperature,which is favorable for construction. | Changqing Fang Linna Jiao Jingbo Hu Qian Yu Dagang Guo Xing Zhou Ruien Yu | 2014 | Journal of Materials Science & Technology2014，30，9： | 3 |
| 4 | Request Merging Based Cross-User Deduplication for Cloud Storage with Resistance Against Appending Chunks Attack显示文摘Cross-user deduplication is an emerging technique to eliminate redundant uploading in cloud storage.Its deterministic response indicating the existence of data creates a side channel to attackers,which makes the privacy in the cloud at risk.Such kind of attack as well as further appending chunks attack,still cannot be well resisted in current solutions,thus is becoming a big obstacle in using this technique.We propose a secure cross-user deduplication,called Request merging based deduplication scheme(RMDS),which takes the lead to consider resistance against appending chunks attack in a lightweight way,let alone side channel attack.We utilize the proposed XOR based chunk-level server-side storage structure together with a request merging strategy to obfuscate attackers in minimized communication overhead.The experiment results show that,with security guaranteed,the proposed scheme is more efficient comparing with the state of the art. | TANG Xin ZHANG Yi ZHOU Linna LIU Dan HU Bingwei | 2021 | Chinese Journal of Electronics2021，30，2： | 3 |
| 5 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 6 | Preparation of active CaCO3 nanoparticles and mechanical properties of the composite materials显示文摘 | Linna Hu Pengfei Dong Guanwei Zhen | 2009 | Materials Letters2009，63，3： | 1 |
| 7 | Defect characterization of amorphous silicon thin film solar cell based on low frequency noise显示文摘The reliability of solar cells is the key factor todetermine the performance and lifetime of photo-voltaic products. Compared to the insensitivity oftraditional electrical detection and the limitationsof in-situ characterization methods, noise measure-ment has been widely used in semiconductor de-vice reliability characterization for its rapid, sen-sitive and nondestructive. The energy band struc-ture shows that there are two kinds of defects existin amorphous silicon solar cells. | Linna HU Liang HE Hua CHEN Xiaofei JIA Ying HU Hongmei MA DANDan GUO Yu QIN | 2018 | Science China(Information Sciences)2018，61，6： | 1 |
| 8 | Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis显示文摘Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. | Hongxia Liang Zhenhua Li Zhigang Ren Qiaodi Jia Linna Guo Shasha Li Hongyu Zhang Shiqi Hu Dashuai Zhu Deliang Shen Zujiang Yu Ke Cheng | 2020 | Nano Research2020，13，8： | 1 |
| 9 | The sawtooth space filling curve coupling compressed sensing color gray scale realtime encryption algorithm显示文摘 | HU Yi WANG Linna ZHU Gongsheng | 2015 | Laser Journal2015，36，2： | 1 |
| 10 | Preparation of active CaCO3 nanoparticles and mechanical properties of the composite materials显示文摘 | Hu Linna Dong Pengfei Zhen Guanwei | 2009 | Materials Letters2009，63，34： | 1 |
| 11 | Electrospinning of antibacterial and anti-inflammatory Ag@hesperidin core-shell nanoparticles into nanofibers used for promoting infected wound healing显示文摘Bacterial infection and excessive inflammation are still the main obstacles to wound repair.Thus,antibacterial and antiinflammation nanomaterials are always attracting for infected wound healing.In this work,ultra-uniform(-20 nm)and colloidally stable Ag nanoparticles(Ag-Hes NPs)with core-shell structure were prepared by using hesperidin as reducing and capping agent.The obtained Ag-Hes NPs present effective antibacterial properties on both Staphylococcus aureus and Escherichia coli.Ag-Hes NPs also got high 1,1-diphenyl-1-picrylhydrazyl scavenging capability of 69%.Under the package of polyvinyl alcohol and sodium alginate,Ag-Hes NPs were encapsulated into electro spun nanofibers to form hydrogel(Ag-Hes@H).This strategy provides a moisture environment which could enrich and release Ag-Hes NPs gradually.Cell experiments and animal wound healing investigation proved that Ag-Hes@H could promote the proliferation and migration of human umbilical vein endothelial cells and accelerate infected wound healing.Meanwhile,Ag-Hes@H significantly reduced the expression of inflammatory cytokines,including IL-6,MMP9 and TNF-α.Immunohistochemistry data further suggested that Ag-Hes@H accelerated wound closure by promoting collagen deposition and skin cell proliferation.The designed antibacterial and anti-inflammatory Ag-Hes@H has great potential for promoting infected wound healing. | Xiuli Ren Yanan Hu Linna Chang Shibo Xu Xifan Mei Zhenhua Chen | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 12 | cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors显示文摘cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net. | Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu | 2021 | Neuroscience Bulletin2021，37，10： | 0 |
| 13 | Optimal Energy Efficiency Resource Allocation Strategy for Cognitive Clustering Network under PUEA Attack显示文摘5G has pushed the use of radio spectrum to a new level,and cognitive clustering network can effectively improve the utilization of radio spectrum,which is a feasible way to solve the growing demand for wireless communications.However,cognitive clustering network is vulnerable to PUEA attack,which will lead to the degradation of system detection performance,thereby reducing the energy efficiency.Aiming at these problems,this paper investigates the optimal energy efficiency resource allocation scheme for cognitive clustering network under PUEA attack.A cooperative user selection algorithm based on selection factor is proposed to effectively resist PUEA user attack and improve detection performance.We construct the energy efficiency optimization problem under multi-constraint conditions and transform the nonlinear programming problem into parametric programming problem,which is solved by Lagrangian function and Karush-Kuhn-Tucker condition.Then the sub-gradient iterative algorithm based on optimal energy efficiency under PUEA attack is proposed and its complexity is analyzed.Simulation results indicate that proposed method is effective when subjected to PUEA attacks,and the impact of different parameters on energy efficiency is analyzed. | Linna Hu Ning Cao Rui Shi Xue Cai Minghe Mao Zhiyu Chen | 2020 | China Communications2020，17，10： | 0 |
| 14 | H3K4me2/3 modulate the stability of RNA polymerase II pausing显示文摘Dear Editor,Modifications of histones are intricately linked with the regulation of gene expression,having demonstrated roles in various physiological processes and pathogenesis.Methylation of histone H3 lysine 4(H3K4)implemented by the COMPASS family is enriched at promoters and associated cis-regulatory elements,with H3K4 trimethylation(H3K4me3)being a hallmark of active gene promoters.1 However,the relative contributions of the deposition and removal of H3K4 methylation to transcriptional control remain unclear.We found that rapid depletion of core COMPASS subunits led to a dynamic turnover of H3K4me2 and H3K4me3 that is mediated by KDM5 demethylases.Depleting H3K4me2 and H3K4me3 did not affect TFIID recruitment or initiating RNA polymerase II(Pol II)but instead reduced levels of paused Pol II,which could be attributed to increased enrichment of the Integrator-PP2A complex(INTAC). | Shibin Hu Aixia Song Linna Peng Nan Tang Zhibin Qiao Zhenning Wang Fei Lan Fei Xavier Chen | 2023 | Cell Research2023，33，5： | 0 |
| 15 | Photoresponsive Biomimetic Protocells for Near-Infrared-Light- Regulated Phototheranostics显示文摘Nature has created complex living systems with outstanding structure and remarkable function.Constructing biomimetic systems that rival living organisms has attracted considerable research inter-est in research fields of self-assembly and bionic sci-ence. | Ling Liang Yawei Tang Xiaoxiao Hu Jie Wang Shehua Xiao Dan Li Linna Fu Zhihao Li Quan Yuan | 2019 | CCS Chemistry2019，1，4： | 0 |
| 16 | Modulating surface cation vacancies of nickel-cobalt oxides as efficient catalysts for lithium-oxygen batteries显示文摘Rechargeable lithium-oxygen batteries(LOBs)have received incremental attention owing to their high energy density and applicability to mobile devices and electric vehicles.However,the lack of robust,low-cost,and environmentally benign bifunctional catalysts is a major impediment to the commercial application.The introduction of vacancies is one of the effective strategies to enhance the performance of cathode catalysts for lithium-oxygen batteries,but the preparation is complicated.In this work,needle-like microsphere cathode catalysts of nickel-cobalt oxide containing cationic vacancies are constructed by controlling the annealing temperature.It is demonstrated that the presence of cationic vacancies can modulate the electronic structure of the catalyst,reduce the energy barrier for the oxygen electrode re-action,meanwhile enhance the bifunctional catalytic activity.Impressively,the nickel-cobalt oxide-based LOB with cationic vacancies exhibits large specific capacity(12,205 mAh g^(-1)at 200 mA g^(-1))and good durability.This work provides worthwhile insight into the formation and catalytic enhancement mech-anism of transition metal oxide catalysts with cationic vacancies,and to some extent,the creation of efficient and low-cost oxygen electrocatalysts for LOBs. | Yuan Yang Linna Dai Jianwei Qiu Zhibiao Hu Peng Wang Yongtao Zhao Huanhuan Guo Pengchao Si Rui Song | 2023 | Journal of Materials Science & Technology2023，，8： | 0 |
| 17 | An asymmetric catalytic multi-component reaction enabled the green synthesis of isoserine derivatives and semi-synthesis of paclitaxel显示文摘Paclitaxel(Taxol^(@))as a cornerstone of chemotherapy remains in high demand.The semi-synthesis of paclitaxel via coupling of Taxus leaf-produced baccatin III and manually synthesized isoserine(C-13 side chain)is one of the solutions to avoid environmental damage caused by the sacrifice of the whole Taxus brevifolia.A green synthesis of the C-13 side chain is pivotal to the green production of paclitaxel.We herein report a green synthesis of isoserine derivatives and the semi-synthesis of paclitaxel via a straightforward assembly of isoserines based on an Rh2(TPA)3(OAc)/CPA1 co-catalyzed asymmetric multi-component reaction of ethyl diazoacetate,triethyl silanol and N-(anthrancen-9-ylmethyl)benzaldimine.The method is featured by improved atom economy,effective mass yield,and environmental factors compared to our previous racemic method and BMS company's semi-synthesis method.And the method allows for rapid access to paclitaxel derivatives with varied C-13 side chains. | Taoda Shi Xinglin Li Yukai Li Xiang Fu Linna Wu Dengqing Wu Wenhao Hu | 2023 | Green Synthesis and Catalysis2023，4，1： | 0 |
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