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| 1 | Rhizospheric microbial communities are driven by Panax ginseng at different growth stages and biocontrol bacteria alleviates replanting mortality显示文摘The cultivation of Panax plants is hindered by replanting problems, which may be caused by plantdriven changes in the soil microbial community. Inoculation with microbial antagonists may efficiently alleviate replanting issues. Through high-throughput sequencing, this study revealed that bacterial diversity decreased,whereas fungal diversity increased, in the rhizosphere soils of adult ginseng plants at the root growth stage under different ages. Few microbial community, such as Luteolibacter, Cytophagaceae, Luteibacter, Sphingomonas,Sphingomonadaceae, and Zygomycota, were observed; the relative abundance of microorganisms, namely,Brevundimonas, Enterobacteriaceae, Pandoraea, Cantharellales, Dendryphion, Fusarium, and Chytridiomycota,increased in the soils of adult ginseng plants compared with those in the soils of 2-year-old seedlings. Bacillus subtilis 50-1, a microbial antagonist against the pathogenic Fusarium oxysporum, was isolated through a dual culture technique. These bacteria acted with a biocontrol efficacy of 67.8%. The ginseng death rate and Fusarium abundance decreased by 63.3% and 46.1%, respectively, after inoculation with B. subtilis 50-1. Data revealed that microecological degradation could result from ginseng-driven changes in rhizospheric microbial communities;these changes are associated with the different ages and developmental stages of ginseng plants. Biocontrol using microbial antagonists alleviated the replanting problem. | Linlin Dong Jiang Xu Lianjuan Zhang Ruiyang Cheng Guangfei Wei He Su Juan Yang Jun Qian Ran Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 27 |
| 2 | Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng显示文摘Panax notoginseng is famous for its important therapeutic effects. Saponins are bioactive compounds found in different parts and developmental stages of P. notoginseng plants. Thus, it is urgently to study saponins distribution in different parts and growth ages of P. notoginseng plants. In this study,potential biomarkers were found, and their chemical characteristic differences were revealed through metabolomic analysis. High-performance liquid chromatography data indicated the higher content of saponins(i.e., Rg1, Re, Rd, and Rb1) in the underground parts than that in the aerial parts. 20(S)-Protopanaxadiol saponins were mainly distributed in the aerial parts. Additionally, the total saponin content in the 3-year-old P. notoginseng plant(188.0 mg/g) was 1.4-fold higher than that in 2-year-old plant(130.5 mg/g). The transcriptomic analysis indicated the tissue-specific transcription expression of genes, namely, PnFPS, PnSS, PnSE1, PnSE2, and PnDS, which encoded critical synthases in saponin biosyntheses. These genes showed similar expression patterns among the parts of P. notoginseng plants.The expression levels of these genes in the flowers and leaves were 5.2 fold higher than that in the roots and fibrils. These results suggested that saponins might be actively synthesized in the aerial parts and transformed to the underground parts. This study provides insights into the chemical and genetic characteristics of P. notoginseng to facilitate the synthesis of its secondary metabolites and a scientific basis for appropriate collection and rational use of this plant. | Guangfei Wei Linlin Dong Juan Yang Lianjuan Zhang Jiang Xu Feng Yang Ruiyang Cheng Ran Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 13 |
| 3 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 4 | Spatial structure optimization of mountainous abandoned mine land reuse based on system dynamics model and CLUE-S model显示文摘The mountainous abandoned mine land is often distributed in the fomi of fragmented patches. Therefore, it can greatly promote the reuse value of abandoned mine land and relieve the pressure of land demand to realize the rational reuse of abandoned mine land based on the future land use structure and spatial layout of mountainous area. In this paper, optimization of the spatial structure of mountainous abandoned mine land reuse is realized through the system dynamics model and CLUE-S model. Mentougou district, Beijing, China is selected as the research area. System dynamics model with feedback functions is constructed to simulate land use structure from 2011 to 2025, which is taken as the quanfiiative constraint on spatial structure optimization. CLUE-S model with neighborhood analysis function is applied to simulate future land use spatial structure. The simulation result layer is superimposed with the abandoned mine land distribution layer and the optimized spatial structure of abandoned mine land reuse then is determined, checked by reuse suitability evaluation. The result shows that abandoned mine land can be fully optimized as other land use types according to demand, and the reuse directions are water conservancy facilities land, urban land, rural residential land, tourism land, garden land, woodland and grassland. The trend of abandoned mine land reuse tend to be consistent with land use types of neighboring patches. This study can provide theoretical reference for the practices of mountainous abandoned mine land reuse. | Linlin Cheng Haiyuan Sun Ye Zhang Shaofeng Zhen | 2019 | International Journal of Coal Science & Technology2019，6，1： | 5 |
| 5 | A model for coupling reservoir inflow and wellbore flow in fishbone wells显示文摘A coupling model is proposed in this paper by using the Green Function and Newman's product principle, and the solution method is provided here as well. This model can be used to describe the reservoir inflow and wellbore flow for fishbone wells in an unsteady flow or pseudo-steady flow state. A case study indicates that the bottom hole pressure declines quickly in the unsteady flow period which is very short. The pressure drop per unit time remains unchanged under the pseudo-steady flow conditions. The distribution of flow rate along the main wellbore shows a wave shape under the unsteady flow condition, and the flow rate distribution in each branch is similar. The flow rate distribution along the main wellbore is irregular 'U' shaped under the pseudo-steady flow condition, and the space-symmetrical branches have the same flow distribution pattern. In the initial production period, the flow rate increases significantly as the length of branches and the angle between branches and the main wellbore increase. As the production continues, the length and angle of branches have only a slight effect on the flow in fishbone wells. | Lian Peiqing Cheng Linsong Tan Xuequn Li Linlin | 2012 | Petroleum Science2012，9，3： | 4 |
| 6 | Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling显示文摘Testosterone deficiency is common in male patients with chronic obstructive pulmonary disease (COPD) and may correlate with the deterioration of COPD. Clinical research suggests that testosterone replacement therapy may slow the COPD progression, but the specific biological pathway remains unclear. In this study, we explored the effect of testosterone on pulmonary inflammation in male COPD rats. The animals were co-treated with lipopolysaccharide (LPS) and cigarette to induce COPD. In COPD rats, nuclear respiratory factor 1 (NRF1) and NF-κB p65 were upregulated. In cigarette smoke extract (CSE)-, LPS-, or the combination of CSE and LPS-treated L132 cells, NRF1 and p65 were also upregulated. Silencing NRF1 resulted in the downregulation of p65. ChIP‒seq, ChIP‒qPCR, and luciferase results showed that NRF1 transcriptionally regulated p65. Both male and female COPD rats showed an upregulated NRF1 level and similar pulmonary morphology. But NRF1 was further upregulated in male castrated rats. Further supplementing testosterone in castrated male rats significantly reduced NRF1, pulmonary lesions, and inflammation. Supplementation of testosterone also reduced the phosphorylation of p65 and IKKβ induced by LPS or CSE in L132 cells. Our results suggest that testosterone plays a protective role in pulmonary epithelial inflammation of COPD through inhibition of NRF1-derived NF-κB signaling and the phosphorylation of p65. | Xueting Wang Linlin Huang Shan Jiang Kang Cheng Dan Wang Qianqian Luo Xiaomei Wu Li Zhu | 2021 | Journal of Molecular Cell Biology2021，13，2： | 4 |
| 7 | Comparison of international mine reclamation bonding systems with recommendations for China显示文摘 | Linlin Cheng Jeffrey G. Skousen | 2017 | International Journal of Coal Science & Technology2017，4，2： | 3 |
| 8 | Design ofL-Cysteine Functionalized Au@SiO2@Fe3O4/Nitrogen-doped Graphene Nanocomposite and Its Application in Electrochemical Detection of Pb2+显示文摘 | NIE Jing HE Bin CHENG Yanmei YIN Wei HOU Changjun HUO Danqun QIAN Linlin QIN Yunan FA Huanbao | 2017 | Chemical Research in Chinese Universities2017，33，6： | 3 |
| 9 | Comparative population genomics dissects the genetic basis of seven domestication traits in jujube显示文摘Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural traits.It was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood.Here,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×depth.Using the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in jujube.For fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription factor.Similarly,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS.In the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits.This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube. | Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia Liu Linlin Hou Hanxiao Liu Xusheng Zhao | 2020 | Horticulture Research2020，7，1： | 2 |
| 10 | The effects of circadian rhythm on catechin accumulation in tea leaves显示文摘As the major bitter-and astringent-tasting components in tea leaves,catechins play an essential role in determining flavor characteristics and health benefits of tea products.This study analyzed the circadian rhythm effects on the accumulation pattern of catechins in tender leaves of three tea cultivars,'Huangkui'(HK),'Longjing43'(LJ43)and'Fuding Dabaicha'(FD).There were two major factors involved in the catechin regulation in tea plants:genetic background of the cultivar-specific regulation,and temporal effects of the circadian rhythm.Etiolated leaves of'HK'contained lower levels of catechins than'LJ43'and'FD'.The composition of EGCG in total catechins was significantly higher in'LJ43'leaves(65%)when compared with that in'HK'and'FD'(45%).The accumulation of individual catechins increased during the daytime but decreased overnight,especially over the time period of 22:00−02:00.The correlation analysis between catechins and environmental factors indicated catechin accumulation in tea leaves potentially resulted from a combined regulation of light and temperature.These findings provide new insights into our understanding of circadian rhythm regulation on flavor-important secondary metabolites in tea leaves. | Xiaohui Wang Wenfeng Zhu Xin Cheng Zhiqiang Lu Xuyang Liu Xiaochun Wan Chuankui Song Linlin Liu | 2021 | Beverage Plant Research2021，1，1： | 2 |
| 11 | Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA显示文摘Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP protein family consisting of IGF2BP1~3 with the capacity of binding to many transcripts and regulating RNA stability, localization, and translation. In this study, we discovered that expression of IGF2BP2 was upregulated and led to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). IGF2BP2 protein was gradually elevated from normal pancreas, pancreatic intraepithelial neoplasia to PDAC in an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, we demonstrated that IGF2BP2 promoted aerobic glycolysis and PDAC cell proliferation through directly binding to and stabilizing GLUT1 mRNA. In summary, our study unveiled an important role of IGF2BP2 in PDAC development by modulating aerobic glycolysis and as a potential therapeutic target for PDAC treatment. | Shan Huang Zheng Wu Yunyun Cheng Wenzhen Wei Linlin Hao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 12 | Estimation of Fracture Geometry Parameters and Characterization of Rock Mass Structure for the Beishan Area,China显示文摘The accurate estimation of fracture geometry parameters and the characterization of rock mass structure are two important topics in the geological disposal system of high-level radioactive waste(HLW).The Beishan area,as the current preselected area for China’s HLW disposal,has three subareas considered to be the key survey area at the stage of site selection.In this paper,a comprehensive survey method conducted on the outcrop is developed to estimate fracture geometry parameters.Results show that fracture occurrence obeys a Fisher distribution,fracture trace length obeys a normal distribution,and the distribution of spacing obeys a negative exponential distribution.An evaluation index,Rock Mass Structure Rating(RMSR),is proposed to characterize rock mass structure for the three subareas.The results show that the Xinchang area is more suitable to act as China’s HLW disposal repository site.At the same time,the index can also be applied to characterize surface rock mass structure and rock mass integrity at the site selection phase of HLW disposal. | WEI Xiang GUO Ying CHENG Hanlie WEI Jianfei ZHANG Linlin HUO Liang HOU Zhenkun | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 13 | The effect of SARS-CoV-2 infection on human embryo early development:a multicenter prospective cohort study显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients. | Xiaolei Chen Huangcong Shi Cheng Li Wanxia Zhong Linlin Cui Wenjun Zhang Ling Geng Kuona Hu Mei Fang Daimin Wei Junhao Yan Yun Sun Keliang Wu Han Zhao Zi-Jiang Chen | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 14 | Expression of β-1,4-Galactosyltransferase-I in Rat during Inflammation显示文摘 | Ji Qian Chun Cheng Haiou Liu Jianping Chen Meijuan Yan Shuqiong Niu Jing Qin Linlin Sun Lei Liu Jianxin Gu Aiguo Shen | 2007 | Inflammation (-)2007，，1： | 1 |
| 15 | Geomechanics involved in gas hydrate recovery显示文摘Gas hydrate is regarded as a promising energy owing to the large carbon reserve and high energy density.However,due to the particularity of the formation and the complexity of exploitation process,the commercial exploitation of gas hydrate has not been realized.This paper reviews the physical properties of gas hydratebearing sediments and focuses on the geomechanical response during the exploitation.The exploitation of gas hydrate is a strong thermal–hydrological–mechanical–chemical(THMC)coupling process:decomposition of hydrate into water and gas produces multi-physical processes including heat transfer,multi-fluid flow and deformation in the reservoir.These physical processes lead to a potential of geomechanical issues during the production process.Frequent occurrence of sand production is the major limitation of the commercial exploitation of gas hydrate.The potential landslide and subsidence will lead to the cessation of the production and even serious accidents.Preliminary researches have been conducted to investigate the geomechanical properties of gas hydrate-bearing sediments and to assess the wellbore integrity during the exploitation.The physical properties of hydrate have been fully studied,and some models have been established to describe the physical processes during the exploitation of gas hydrate.But the reproduction of actual conditions of hydrate reservoir in the laboratory is still a huge challenge,which will inevitably lead to a bias of experiment.In addition,because of the effect of microscopic mechanisms in porous media,the coupling mechanism of the existing models should be further investigated.Great efforts,however,are still required for a comprehensive understanding of this strong coupling process that is extremely different from the geomechanics involved in the conventional reservoirs. | Zhiqiang Liu Yunxiao Lu Jiuhui Cheng Qiang Han Zunjing Hu Linlin Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 1 |
| 16 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 17 | Changes of structure and optical energy gap induced by oxygen pressure during the deposition of ZnO films显示文摘 | Sun Linlin Cheng Wenjuan | 2006 | Physical B2006，381，12： | 1 |
| 18 | Magnesium ion-implantation-based gallium nitride p-i-n photodiode for visible-blind ultraviolet detection显示文摘In this work, a GaN p-i-n diode based on Mg ion implantation for visible-blind UV detection is demonstrated.With an optimized implantation and annealing process, a p-GaN layer and corresponding GaN p-i-n photodiode are achieved via Mg implantation. As revealed in the UV detection characterizations, these diodes exhibit a sharp wavelength cutoff at 365 nm, high UV/visible rejection ratio of 1.2 × 10~4, and high photoresponsivity of 0.35 A/W, and are proved to be comparable with commercially available GaN p-n photodiodes. Additionally, a localized states-related gain mechanism is systematically investigated, and a relevant physics model of electricfield-assisted photocarrier hopping is proposed. The demonstrated Mg ion-implantation-based approach is believed to be an applicable and CMOS-process-compatible technology for GaN-based p-i-n photodiodes. | WEIZONG XU YATING SHI FANGFANG REN DONG ZHOU LINLIN SU QING LIU LIANG CHENG JIANDONG YE DUNJUN CHEN RONG ZHANG YOUDOU ZHENG HAI LU | 2019 | Photonics Research2019，7，8： | 1 |
| 19 | Attenuation of hearing loss in DBA/2J mice by anti-apoptotic treatment显示文摘 | Linlin Yang Heng Zhang Xu Han Xin Zhao Fangyuan Hu Ping Li Gang Xie Lixiang Gao Lin Cheng Xicheng Song Fengchan Han | 2015 | Hearing Research2015，，： | 1 |
| 20 | Investigation of Linarinic acid and one of its derivatives against cerebral ischemia in mice显示文摘The study aims to investigate the effects of(-)-Linarinic acid(LA) and one of its derivatives(LAd) on brain injury induced by ischemia. Malonaldehyde(MDA) is determined as an index for lipid peroxidation both in vitro and vivo. Mice were pre-treated with LA and LAd for 3 d.Thereafter, they were induced to have incomplete cerebral ischemia with both bilateral carotid artery occlusion and hypotension(BCAOH). In the first part of the in vivo experiment, mice were divided into four groups: sham(control), ischemia, ischemia + LA(200 mg/kg, i.g.) and ischemia + LAd(200 mg/kg, i.g.). In the second part, the dose-response of LAd was investigated at 100, 200 and 400 mg/kg i.g., respectively. A modified neurological severity score was developed for evaluating behavioral deficits of the mice with ischemia. Brains of the mice were excised in order to determinate MDA after ischemia for 6 h. Survival time, survival rate, neurological injury score and MDA level in brains were observed. Results were: 1) The data in vitro showed that both LA and LAd could inhibit the generation of MDA. IC50 values obtained by Probit analysis were 2.9 mM for LAd and 4.88 mM for LA;2) BCAOH could significantly shorten the survival span, reduce the survival rate and cause neurological deficits,which were associated with high level of lipid hydroperoxide production in cerebral tissues;3) LAd decreased lipid peroxidation and improved the neurological outcome more than LA.It is concluded that LAd offers a better neuroprotection than LA against brain damage caused by cerebral ischemia. | Yihan Wang Chao Zhao Qiujv Wang Huimin Wen Yaru Gu Linlin Fan Chao Ma Maosheng Cheng Yuyang Zhang | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 1 |
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