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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Expression of Livin in tissues of lung cancer and its correlation with the expression of caspase-3显示文摘Objective: To study the expressions of two isoforms of Livin in tissues of lung cancer and their relations to histological types and chemotherapy, and to study their correlations to the expression of caspase-3 as well. Methods: Ex-pressions of Livin isoforms α, β and caspase-3 were detected by reverse transcription polymerase chain reaction (RT-PCR) assay in lung cancer tissues as well as in controls. Results: Livin isoforms α and β were expressed in 12 of 27, and 19 of 27 lung cancer tissues respectively, much more than those in lung para-cancerous [both were (0/6)] or benign disease lung tissues (0/12, 1/12; P < 0.01 and P < 0.01). Moreover, they were detected in 7/14, 9 /14 lung adenocarcinomas and 4/12, 9/12 squamocellular and large cell carcinomas, respectively, and both showed expressions in one small cell carcinoma. The levels of these two isoforms in lung cancer were significantly higher than those in controls by Gel imaging system (P < 0.05 and P < 0.05), the former was higher in adenocarcinoma than that in squamocellular carcinoma (P < 0.05), while the latter was the same in both (P > 0.05). Meanwhile, the levels of caspase-3 in lung cancer were significantly lower than those in controls, and it was suggested to be negatively associated with either each of two isoforms or their sum (P < 0.05, P < 0.01 and P < 0.01). Two isoforms of Livin expression seemed to increase after chemotherapy but not related to clinical stages (P > 0.05). Conclusion: Two isoforms of Livin are differently expressed in different histological types of lung cancer and may contribute to corresponding cancerous development; the levels of Livin are negatively associated with those of caspase-3, this may be due to the fact that Livin could resist against apoptosis; high expression of Livin seems to be related to chemotherapy but not clinical stages. | Hongru Li Yusheng Chen Gang Chen Baosong Xie Lifang Lin | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，7： | 3 |
| 3 | The nonresonant perturbation theory based field measurement and tuning of a linac accelerating structure显示文摘Assisted by the bead pull technique,nonresonant perturbation theory is applied for measuring and tuning the field of the linac accelerating structure.The method is capable of making non-touching amplitude and phase measurements,real time mismatch feedback and field tuning.Some key considerations of the measurement system and of a C-band traveling-wave structure are discussed,and the bead pull measurement and the tuning of the C-band traveling-wave linac accelerating structure are presented at last. | FANG WenCheng TONG DeChun GU Qiang ZHAO ZhenTang SHENG Xing CHEN LiFang WANG Lin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 3 |
| 4 | Incidence of Macrosomia in Rural Areas—Henan Province,China,2013–2017显示文摘Introduction:Macrosomia has short-term and long-term adverse health effects and is thus an important public health concern.Recent decades have witnessed increasing incidence of macrosomia in many countries.Methods:The present study used a large population-based birth cohort study to depict incidence of macrosomia among live births in rural areas of Henan Province of China from 2013 to 2017.Results:Among the 1,262,916 births,82,353 were cases of macrosomia.The overall incidence of all types of macrosomia,of macrosomia with birth weight<4,500 g,and of macrosomia with birth weight≥4,500 g were 6.52%,5.30%,and 1.22%,respectively.From 2013 to 2017,the incidence of macrosomia decreased by 31.3%from 7.96%in 2013 to 5.47%in 2017(X^(2)_(trend)=946.96,P_(trend)<0.001).Male infants and infants≥42 gestational weeks had significantly higher incidence of macrosomia than that of female infants and infants<42 gestational weeks(P<0.001).Conclusion:Gestational weight control through nutrition management and physical activities during pregnancy are needed to reduce incidence of macrosomia. | Shiqi Lin Jian Chai Jiajia Li Xuejun Shang Lijun Pei Lifang Jiang Junxi Zhang Panpan Sun Wei Dong Yuhong Wang Dezhuan Zhou | 2021 | China CDC weekly2021，3，37： | 3 |
| 5 | Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer显示文摘Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular invasion.Here,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also proposed.Methods:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square tests.In the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion prediction.Then,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation set.Moreover,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the nomogram.Results:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training set.Then,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed to have satisfactory discrimination in the training(AUC 0.784;95%CI:0.715 to 0.853)and validation(AUC 0.743;95%CI:0.635 to 0.850)set.The decision curve analysis(DCA)indicated the clinical usefulness of our nomogram.In models comparison,using the receiver operator characteristic(ROC)analyses,the nomogram showed higher discriminatory accuracy than any variables incorporated in the nomogram alone and the DCAs also identified the nomogram as possessing the highest net benefits at wide range of threshold probabilities.Conclusion:CSP7 status was identified as an independent factor for predicting muscular invasion in BC patients and was successfully incorporated in a clinical nomogram combining the results of the FISH assay with clinical risk factors. | Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin | 2020 | Cancer Communications2020，40，4： | 3 |
| 6 | Epstein-Barr 病毒的从潜伏的膜蛋白质 2 的重叠 epitopes (LMP2 ) 的空想地熔化的抗原富人作为一支潜在的疫苗和诊断代理人显示文摘Epstein-Barr 病毒(EBV ) 在全世界是流行的并且在人与几恶意的疾病被联系。(LMP2 ) 潜伏的膜蛋白质 2 在联系 EBV 的 tumors; 的致病 EBV 起一个关键作用;因此, LMP2 被认为是一个潜在的 immunodiagnostic 和 immunotherapeutic 目标。multi-epitope-based 抗原是为治疗学的疫苗的一种有希望的选择并且如此的恶意诊断。在这研究,我们系统地屏蔽了细胞毒素的 T 淋巴细胞(CTL ) ,助手 T 房间(Th ) 和在用生物信息学的 EBV-LMP2 以内的 B 房间 epitopes。基于屏幕,在 T 房间和 B 房间的重叠 epitopes 的二个肽富人被选择构造为叫作 EBV-LMP2m 的妄想的 multi-epitope 蛋白质包含顺序的 plasmid,它 LMP2aa195~232 和 LMP2aa419~436 是镇静的。EBV-LMP2m 蛋白质在 E 被表示。在原核生物的 codon 优化以后的 coli BL21 (DE3 ) 。在 BALB/c 老鼠的净化的妄想的抗原的接种在阴道粘液而且特定的 CTL 回答在浆液和能分泌的 IgA 导致了特定的 IgG 的高水平不仅。由把净化的 EBV-LMP2m 用作抗原,在 202 鼻咽的癌(NPC ) 的浆液标本的特定的 IgG 的存在病人们有效地与 52.84 % 被检测;敏感和 95.40 %特性,基于 VCA-IgA 在传统的察觉方法上代表改进, 60.53 %敏感和 76.86 %特性) 。上述结果显示 EBV-LMP2m 可以为 NPC 病人为联系 EBV 的肿瘤而且一个诊断代理人被用作潜在的目标抗原不仅。 | Xiaoyun Lin Shao Chen Xiangyang Xue Lijun Lu Shanli Zhu Wenshu Li Xiangmin Chen Xiaozhi Zhong Pengfei Jiang Torsoo Sophia Sename Yi Zheng Lifang Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 7 | AGAMOUS AND TERMINAL FLOWER controls floral organ identity and inflorescence development in Medicago truncatula显示文摘Angiosperms integrate a multitude of endogenous and environmental signals to control floral development,thereby ensuring reproductive success.Here,we report the identification of AGAMOUS AND TERMINAL FLOWER(AGTFL),a novel regulator of floral development in Medicago truncatula.Mutation of AGTFL led to the transformation of carpels and stamens into numerous sepals and petals and altered primary inflorescence identity.AGTFL encodes a nucleus-localized proteincontaining a putative Myb/SANT-like DNA-binding domain and a PKc kinase domain.Molecular and genetic analyses revealed that AGTFL regulates the transcription of MtAGs and MtTFL1 to control floral organ identity and inflorescence development. | Butuo Zhu Hui Li Yifeng Hou Pengcheng Zhang Xiuzhi Xia Na Wang Hui Wang Kirankumar S.Mysore Jiangqi Wen Yanxi Pei Lifang Niu Hao Lin | 2019 | Journal of Integrative Plant Biology2019，61，8： | 2 |
| 8 | RcbHLH59-RcPRs module enhances salinity stress tolerance by balancing Na^(+)/K^(+) through callose deposition in rose (Rosa chinensis)显示文摘Basic helix–loop–helix(bHLH)proteins play pivotal roles in plant growth,development,and stress responses.However,the molecular and functional properties of bHLHs have not been fully characterized.In this study,a novel XI subgroup of the bHLH protein gene RcbHLH59 was isolated and identified in rose(Rosa sp.).This gene was induced by salinity stress in both rose leaves and roots,and functioned as a transactivator.Accordingly,silencing RcbHLH59 affected the antioxidant system,^(Na+/K+)balance,and photosynthetic system,thereby reducing salt tolerance,while the transient overexpression of RcbHLH59 improved salinity stress tolerance.Additionally,RcbLHLH59 was found to regulate the expression of sets of pathogenesis-related(PR)genes in RcbHLH59-silenced(TRV-RcbHLH59)and RcbHLH59-overexpressing(RcbHLH59-OE)rose plants.The RcPR4/1 and RcPR5/1 transcript levels showed opposite changes in the TRVRcbHLH59 and RcbHLH59-OE lines,suggesting that these two genes are regulated by RcbHLH59.Further analysis revealed that RcbHLH59 binds to the promoters of RcPR4/1 and RcPR5/1,and that the silencing of RcPR4/1 or RcPR5/1 led to decreased tolerance to salinity stress.Moreover,callose degradation-and deposition-related genes were impaired in RcPR4/1-or RcPR5/1-silenced plants,which displayed a salt tolerance phenotype by balancing the ^(Na+/K+)ratio through callose deposition.Collectively,our data highlight a new RcbLHLH59-RcPRs module that positively regulates salinity stress tolerance by balancing Na^(+)/K^(+)and through callose deposition in rose plants. | Lin Su Yichang Zhang Shuang Yu Lifang Geng Shang Lin Lin Ouyang Xinqiang Jiang | 2023 | Horticulture Research2023，10，3： | 2 |
| 9 | A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice显示文摘我们评估了包括主要的外部膜蛋白质(MOMP ) 的一支候选人疫苗的 immunogenicity 和功效 multi-epitopeof Chlamydia trachomatis。从包含多重 T 房间和 B 房间 epitopes 的 MOMP 导出的 multi-epitope 的短基因是人工地,包含 codon 的 synthesized.The recombinant plasmid pET32a (+) 优化了 MOMP multi-epitope 基因被构造。在 Escherichia coli 的 fusionprotein Trx-His-MOMP multi-epitope 的表示被钠 dodecyl sulfatepolyacrylamide 胶化电气泳动和西方的污点分析证实。Balb/c 老鼠是 inoculatedwith 皮下地,三与 2 星期的间隔预定的净化的熔化蛋白质。结果出现了 MOMP multi-epitopeelicited 不仅对 C 的强壮的体液的有免疫力的回答。由显著地产生特定的抗体(IgG1 和 IgG2a ) 的高水平的 trachomatis,而且由 inducingrobust 的细胞的有免疫力的回答在老鼠的细胞毒素的 T 淋巴细胞回答。而且, MOMP multi-epitope 实质地告知 IFN- 的分泌物,表明这支疫苗能导致强壮的 Th1 回答。最后,老鼠与 C 的 MOMP multi-epitope displayeda 减小种牛痘。在 chlamydial 挑战和感染的 C 的一个加速的清理之上流的 trachomatis。trachomatis。在结论, MOMP multi-epitope 疫苗可以对 C 为有效预防 andtherapeutic 疫苗的发展有潜力。trachomatis 感染。 | Jianxin Tu B ailong Hou Bingbing Wang Xiaoyun Lin Wenci Gong Haiyan Dong Shanli Zhu Shao Chen Xiangyang Xue Kong-Nan Zhao Lifang Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 1 |
| 10 | Vulnerability assessment of the coastal wetlands in the Yangtze Estuary, China to sea-level rise显示文摘 | Lifang Cui Zhenming Ge Lin Yuan Liquan Zhang | 2014 | Estuarine, Coastal and Shelf Science2014，，： | 1 |
| 11 | Crystalline-amorphous interfaces of NiO-CrO_(x)electrocatalysts for boosting the urea oxidation reaction显示文摘The overall energy efficiency of electrochemical systems is severely hindered by the traditional anodic oxygen evolution reaction(OER).Utilizing urea oxidation reaction(UOR)with lower thermodynamic potential to replace OER provides a promising strategy to enhance the energy efficiency.Amorphous and heterojunctions electrocatalysts have been aroused extensive studies owing to their unique physicochemical properties and outperformed activity.Herein,we report a simple method to construct a novel crystalline-amorphous NiO-CrO_(x)heterojunction grown on Ni foam for UOR electrocatalyst.The NiO-CrO_(x)electrocatalyst displays excellent UOR performance with an ultralow working potential of 1.32 V at 10 mA·cm^(−2)and ultra-long stability about 5 days even at 100 mA·cm^(−2).In-situ Raman analysis and temperature-programmed desorption(TPD)measurement verify that the presence of the amorphous CrO_(x)phase can boost the reconstruction from NiO to active NiOOH species and enhance adsorption ability of urea molecule.Besides,the unique crystalline-amorphous interfaces are also benefit to improving the UOR performance. | Xuejie Cao Tongzhou Wang Hongye Qin Guangliang Lin Lihua Zhao Lifang Jiao | 2023 | Nano Research2023，16，3： | 1 |
| 12 | Environmental and occupational exposure to chemicals and telomere length in human studies显示文摘 | Xiao Zhang Shao Lin William E Funk Lifang Hou | 2013 | Occupational and Environmental Medicine2013，，10： | 1 |
| 13 | Abnormal hypermethylation of promoter region downregulates chemokineCXC ligand 14 expression in gastric cancer显示文摘 | Changyuan Hu Feng Lin Guangbao Zhu Xiangyang Xue Yujie Ding Zhiguang Zhao Lifang Zhang Xian Shen | 2013 | International Journal of Oncology2013，，5： | 1 |
| 14 | Improvement of electrochemical properties of LiFePO4/C cathode materials by chlorine doping显示文摘 | Lin Yang Lifang Jiao Yanli Miao Huatang Yuan | 2009 | Journal of Solid State Electrochemistry2009，，10： | 1 |
| 15 | Research on laser welding of high-strength galvanized automobile sheets 显示文摘 | MEI Lifang CHEN Genyu LIN Xiangzhong | 2009 | Optics and Lasers in Engineering2009，，47： | 1 |
| 16 | Quantifying soil structure and preferential flow in intactsoil using x-ray computed tomography 显示文摘 | Luo Lifang Lin Henry Halleck Phil | 2008 | Soil Science Society of America Journal2008，72，4： | 1 |
| 17 | Vulnerability assessment of the coastal wetlands in the Yangtze Estuary, China to sea-level rise显示文摘 | CUI Lifang GE Zhenming YUAN Lin | 2015 | Estuarine Coastal & Shelf Science2015，156，： | 1 |
| 18 | Optimal Pricing Strategies for a Manufacturer and a Value-Adding Retailer in a Dual-Channel Environment显示文摘In this paper,we study a supply chain that consists of a manufacturer and a value-adding retailer that sell a product to customers through dual channels,i.e.a traditional channel(TC)and an online channel(OC).Observing that in practice,the manufacturer may or may not offer an OC guide price to the retailer and/or act as the leader in the supply chain,we discuss and compare two practical pricing strategies,with and without an OC guide price,under two different power configurations based on which member of the supply chain acts as the leader.Our results show that if the manufacturer does not provide a guide price,the retailer might/might not set a higher TC price than the two OC prices,depending on the level of migration effectiveness and the potential market demand.However,if the manufacturer does provide a guide price,the retailer will always charge a higher TC price than the guide price(or the two OC prices)when the retailer acts as the leader.Moreover,we show that the two players in the supply chain might or might not prefer the pricing strategies with an OC guide price.Our results also indicate that migration effectiveness harms the retailer's profit,and the manufacturer may benefit from mild competition between the two channels.Finally,we show that regardless of whether the manufacturer chooses to offer an OC guide price or not,both the manufacturer and the retailer prefer to act as the follower for high migration effectiveness and the profit of the supply chain will increase when the retailer acts as the leader for low migration effectiveness. | Yongwu Zhou Lifang Yang Bin Cao Xiaogang Lin Jinsen Guo | 2020 | Journal of Systems Science and Systems Engineering2020，29，3： | 1 |
| 19 | Quantitative relationships be- tween soil macropore characteristics and preferential flow and transport显示文摘 | Luo Lifang Lin H S Schmidt J | 2010 | Soil Science Society of America Journal2010，74，6： | 1 |
| 20 | Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation显示文摘 | Hanbei Chen Lifang Wu Yakui Li Jian Meng Ning Lin Dianqiang Yang Yemin Zhu Xiaoyong Li Minle Li Ye Xu Yuchen Wu Xuemei Tong Qing Su | 2014 | 2014 (1-2)2014，，1： | 1 |
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