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| 1 | Phage therapy: An alternative to antibiotics in the age of multi-drug resistance显示文摘The practice of phage therapy, which uses bacterial viruses(phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins. Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. Antibacterial therapies, whether phage-or antibiotic-based, each have relative advantages and disadvantages; accordingly, many considerations must be taken into account when designing novel therapeutic approaches for preventing and treating bacterial infection. Although much about phages and human health is still being discovered, the time to take phage therapy serious again seems to be rapidly approaching. | Derek M Lin Britt Koskella Henry C Lin | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，3： | 20 |
| 2 | 黄土高原关键带土壤水分空间分异特征显示文摘地球关键带是人类生存和发展的关键区域。关键带发生的一系列物理、化学和生物过程与人类活动密切相关。土壤水分是黄土高原关键带的关键要素,同时又是黄土高原植被恢复与生态环境重建的决定因子。为揭示黄土高原关键带土壤水分的空间分异特征,采用网格(50m×50m)布点,雨季结束后采集0~500cm深度土壤样品,结合室内分析,结果表明:黄土高原小流域中73个样点0~500cm的土壤含水量分布范围介于1%~23%之间,降水对0~100cm土层的土壤水分补充明显;土壤水分在水平和垂直方向都表现出明显的空间异质性,在不同方向上的水分控制过程有所不同,是对土地利用方式、植被类型、地形要素、土壤质地等多因素综合响应的结果。充分理解关键带土壤水分空间的分异规律及其主控因素有助于该区小流域综合治理中的植被建造与布局,也有助于对该区土壤水文和生物地球化学过程的理解。 | 王云强 邵明安 胡伟 Henry Lin 黄辉 | 2016 | 地球与环境2016，44，4： | 16 |
| 3 | Subsurface Flow Processes in Sloping Cropland of Purple Soil显示文摘Subsurface flow is a prominent runoff process in sloping lands of purple soil in the upper Yangtze River basin.However,it remains difficult to identify and quantify.In this study,in situ runoff experimental plots were used to measure soil moisture dynamics using an array of time domain reflectometry(TDR) together with overland flow and subsurface flow using isolated collecting troughs.Frequency of preferential flow during rainfall events and the controls of subsurface flow processes were investigated through combined analysis of soil properties,topography,rainfall intensity,initial wetness,and tillage.Results showed that subsurface flow was ubiquitous in purple soil profiles due to welldeveloped macropores,especially in surface soils while frequency of preferential flow occurrence was very low(only 2 cases in plot C) during all 22 rainfall events.Dry antecedent moisture conditions promoted the occurrence of preferential flow.However,consecutive real-time monitoring of soil moisture at different depths and various slope positions implied the possible occurrence of multiple subsurface lateral flows during intensive storms.Rainfall intensity,tillage operation,and soil properties were recognized as main controls of subsurface flow in the study area,which allows the optimization of management practices for alleviating adverse environmental effects of subsurface flow in the region. | TANG Jialilang ZHU Bo WANG Tao CHENG Xunqiang GAO Meirong LIN Henry | 2012 | Journal of Mountain Science2012，9，1： | 7 |
| 4 | 1975~2015年董志塬土地利用/覆被变化及人类活动影响显示文摘结合遥感、地理信息系统和数学方法,通过解译不同时间段(1975年、1995年和2015年)的土地利用数据,从土地利用变化速度、转移方向和土地利用程度3个方面分析了近40年来董志塬土地利用变化特征,揭示了1975年以来董志塬人类活动影响下土地利用时空变化规律。研究结果表明:1)1975~2015年期间,董志塬建设用地、林地、水域及水利设施用地的面积呈现总体上升的趋势;建设用地面积增加幅度最大,增加236.25 km2;其次是林地面积,增加158.68 km2;水域及水利设施用地面积增加幅度最小,增加2.06 km2。近40年来,耕地、草地和未利用地面积呈总体减少趋势。耕地面积与草地面积变化趋势相反,耕地面积呈现出'先增后减'的变化特点,共减少218.01 km2;草地面积则呈现'先减后增'的特点,共减少166.93 km2;未利用地面积呈现总体减少的趋势,共减少12.02 km2。2)近40年来,土地利用变迁主要集中在耕地、草地、建设用地和林地之间,草地和耕地之间变换频繁,是董志塬主要的土地利用变化类型。3)董志塬综合土地利用动态度从前20年(1975~1995年)的0.03增加到后20年(1995~2015年)的0.11,说明土地转化强度显著增强;但对于土地利用程度,董志塬前20年为正(0.051),后20年为负(-0.012),表明1995~2015年期间人类活动对土地资源起到正面保护的作用。 | 杨思齐 金钊 余云龙 Henry Lin | 2019 | 第四纪研究2019，39，6： | 6 |
| 5 | Study on cosmogenic activation in germanium detectors for future tonne-scale CDEX experiment显示文摘A study on cosmogenic activation in germanium was carried out to evaluate the cosmogenic background level of natural and ^(70)Ge depleted germanium detectors. The production rates of long-lived radionuclides were calculated with Geant4 and CRY.Results were validated by comparing the simulated and experimental spectra of CDEX-1B detector. Based on the validated codes, the cosmogenic background level was predicted for further tonne-scale CDEX experiment. The suppression of cosmogenic background level could be achieved by underground germanium crystal growth and high-purity germanium detector fabrication to reach the sensitivity requirement for direct detection of dark matter. With the low cosmogenic background, new physics channels,such as solar neutrino research and neutrinoless double-beta decay experiments, were opened and the corresponding simulations and evaluations were carried out. | JingLu Ma Qian Yue ShinTed Lin Henry Tsz-King Wong JinWei Hu LiPing Jia Hao Jiang Jin Li ShuKui Liu ZhongZhi Liu Hao Ma WeiYou Tang Yang Tian Li Wang Qing Wang Yi Wang LiTao Yang Zhi Zeng | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 5 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 8 | What drives corporate liquidity? An international survey of cash holdings and lines of credit显示文摘 | Karl V. Lins Henri Servaes Peter Tufano | 2010 | Journal of Financial Economics2010，，1： | 3 |
| 9 | Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome显示文摘 | Mark Pimentel Evelyn J Chow Henry C Lin | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 10 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 11 | Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration显示文摘 | Dongsu Park Joel A. Spencer Bong Ihn Koh Tatsuya Kobayashi Joji Fujisaki Thomas L. Clemens Charles P. Lin Henry M. Kronenberg David T. Scadden | 2012 | Cell Stem Cell2012，，3： | 2 |
| 12 | Measurement of Trace Potassium Contaminations With Accelerator Mass SpectrometryMeasurement of Trace Potassium Contaminations With Accelerator Mass SpectrometryMeasurement of Trace Potassium Contaminations With Accelerator Mass Spectrometry显示文摘 | DONG Ke-jun HE Ming JIANG Shan WONG Henry Tsz-king QIU Jiu-zi GUAN Yong-jing WU Shao-yong LI Shi-hong LIN Min ZHOU Duo YIN Xin-yi PENG Bo DING Yan-qiu JU Zhi-ping YUAN Jian | 2005 | Annual Report of China Institute of Atomic Energy2005，，1： | 2 |
| 13 | A2-DMicrocanitlever Arrrayfor Multiplexed Biomolecural Analysis显示文摘 | Min Yue Henry Lin Daniel Eecta1 | | 0，，02： | 1 |
| 14 | The shunt-restricted arterialized venous flap for hand/digit reconstruction: enhanced perfusion, de-creased congestion, and improved reliability 显示文摘 | Lin YT Henry SL Lin CH | 2010 | J Trauma2010，69，2： | 1 |
| 15 | The shunt restricted arterialized venous flap for hand/digit reconstruction: enhanced perfusion, decreased congestion, and improved reliability显示文摘 | Lin YT Henry SL Lin CH | 2010 | The Journal of Trauma2010，69，2： | 1 |
| 16 | The shunt restricted arterialized venous flap for hand/digit reconstruc- tion: enhanced perfusion, decreased congestion, and improved reliability显示文摘 | Lin YT Henry SL Lin CH | 2010 | J Trauma2010，69，4： | 1 |
| 17 | High-throughput physical phenotyping of cell differentiation显示文摘In this report,we present multiparameter deformability cytometry(m-DC),in which we explore a large set of parameters describing the physical phenotypes of pluripotent cells and their derivatives.m-DC utilizes microfluidic inertial focusing and hydrodynamic stretching of single cells in conjunction with high-speed video recording to realize high-throughput characterization of over 20 different cell motion and morphology-derived parameters.Parameters extracted from videos include size,deformability,deformation kinetics,and morphology.We train support vector machines that provide evidence that these additional physical measurements improve classification of induced pluripotent stem cells,mesenchymal stem cells,neural stem cells,and their derivatives compared to size and deformability alone.In addition,we utilize visual interactive stochastic neighbor embedding to visually map the high-dimensional physical phenotypic spaces occupied by these stem cells and their progeny and the pathways traversed during differentiation.This report demonstrates the potential of m-DC for improving understanding of physical differences that arise as cells differentiate and identifying cell subpopulations in a label-free manner.Ultimately,such approaches could broaden our understanding of subtle changes in cell phenotypes and their roles in human biology. | Jonathan Lin Donghyuk Kim Henry T.Tse Peter Tseng Lillian Peng Manjima Dhar Saravanan Karumbayaram Dino Di Carlo | 2017 | Microsystems & Nanoengineering2017，3，1： | 1 |
| 18 | Luteolin induced DNA damage leading to human lung squamous carcinoma CH27 cell apoptosis显示文摘 | Henry Wing-Cheung Leung Chun-Hsiung Wu Chia-Hsien Lin Hong-Zin Lee | 2004 | European Journal of Pharmacology2004，，1： | 1 |
| 19 | Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration显示文摘 | Dongsu Park Joel A. Spencer Bong Ihn Koh Tatsuya Kobayashi Joji Fujisaki Thomas L. Clemens Charles P. Lin Henry M. Kronenberg David T. Scadden | 2012 | Cell Stem Cell2012，，3： | 1 |
| 20 | Aqueous Shunts in Glaucoma显示文摘 | Don S. Minckler Brian A. Francis Elizabeth A. Hodapp Henry D. Jampel Shan C. Lin John R. Samples Scott D. Smith Kuldev Singh | 2008 | Ophthalmology2008，，6： | 1 |
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