|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 3 | Vulnerability assessment of the coastal wetlands in the Yangtze Estuary, China to sea-level rise显示文摘 | Lifang Cui Zhenming Ge Lin Yuan Liquan Zhang | 2014 | Estuarine, Coastal and Shelf Science2014，，： | 1 |
| 4 | First Serologic Study for Influenza A (H7N9) Virus among Veterinarians in Guangdong,China显示文摘 | Han Zhou Xinliang Fu Lifang Wang Jin Cui Yun Zheng Shuyi He Lingshuang Sun Kun Jia Pei Zhou Weanbao Qi Guihong Zhang | 2014 | Journal of Clinical Virology2014，，： | 1 |
| 5 | Vulnerability assessment of the coastal wetlands in the Yangtze Estuary, China to sea-level rise显示文摘 | CUI Lifang GE Zhenming YUAN Lin | 2015 | Estuarine Coastal & Shelf Science2015，156，： | 1 |
| 6 | A study on the fabrication of porous chitosan/gelatin network scaffold for tissue engineering显示文摘 | Shen Feng Cui Yuanlu Yang Lifang | 2000 | Polymer International2000，49，12： | 1 |
| 7 | Adoptive immunotherapy of lung cancer with immobilized anti-TCRγδ antibody-expanded human γδ T Cells in peripheral blood显示文摘 | Ning Kang Jianhua Zhou Tie Zhang Lifang Wang Fang Lu Ying Cui Lianxian Cui Wei He | 2009 | Cancer Biology & Therapy2009，，16： | 1 |
| 8 | Advanced duodenal carcinoma:Chemotherapy efficacy and analysis of prognostic factors显示文摘Objective This study aimed to determine the efficacy of chemotherapy and to identify potential chemotherapy agents to treat advanced primary duodenal carcinoma(PDC). Methods Seventy-three patients with advanced PDC were included in the study. Response rate(RR), disease control rate(DCR), progression-free survival(PFS), overall survival(OS) and prognosis were compared among patients using the Cox proportional hazards model. Results The overall RR and DCR of 52 patients were 21.15% and 69.23%, respectively. The median PFS and OS times were 4.51 and 11.47 months, respectively. Palliative chemotherapy improved the OS of patients with advanced PDC compared with patients who did not receive chemotherapy(14.28 months vs. 5.20 months, HR = 0.205, 95% CI: 0.077 to 0.547, P = 0.0016). Multivariate analysis indicated mucinous histology and liver metastasis as factors predictive of poor prognosis in patients with advanced PDC. Conclusion Palliative chemotherapy may improve the OS of patients with advanced PDC. Mucinous histology and liver metastasis were the main prognostic factors in patients with advanced PDC. | Junbao Liu Chengxu Cui Lifang Yuan Jinwan Wang Shuping Shi Zhujun Shao Haijian Tang Tingting Yang Chunhui Gao Nan Wang Wei Liu | 2016 | Oncology and Translational Medicine2016，2，1： | 1 |
| 9 | Synthesis, crystal structures and magnetic properties of cyanide-bridged macrocyclic complexes显示文摘Three cyanide-bridged dodecanuclear macrocyclic wheel-like complexes [Cr(bpmb)(CN)2]6[Mn(5-Brsalpn)]6-12H2O (1), [Co(bpmb)(CN)2]6[Mn(5-Brsalpn)]6-12H2O (2) and [Co(bpmb)(CN)2]6[Mn(5-Clsalpn)]6-24H2O-8CH3CN (3) [bpmb2- = 1,2-bis(pyridine-2-carboxamido)-4-methylbenzenate dianion; 5-Brsalpn2-= N,N’-propylenebis(5-bromosalicylideneaminato) dianion; 5-Clsalpn2-= N,N’-propylenebis(5-chlorosalicylideneaminato) dianion] have been synthesized and their crystal structures and magnetic properties have been investigated. The three compounds are structurally isomorphous and consist of alternating Mn( Ⅲ )-Schiff base cations and [M(bpmb)(CN)2]- anions, generating cyanide-bridged nanosized dodecanuclear macrocyclic structures with an approximate diameter of 2 nm. The study of the magnetic properties of complex 1 reveals an antiferromagnetic interaction between the Cr(Ⅲ) and Mn(Ⅲ) ions through the cyanide bridges. A best-fit to the magnetic susceptibility of the complex leads to a magnetic coupling constant of JCrMn = -2.65(6) cm-1 on the basis of a one-dimensional alternating chain model with the Hamiltonian H =-JCrMn∑N to 1=0 Si·Si+1. | NI ZhongHai ZHANG LiFang CUI AiLi KOU HuiZhong | 2009 | Science China Chemistry2009，52，9： | 0 |
| 10 | Construction and verification of an infectious cDNA clone of coxsackievirus B5显示文摘Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses genomes represent a single open reading frame flanked by 5’-and 3’-untranslated terminal regions(UTRs). | Lifang Song Bopei Cui Jinghuan Yang Xiaotian Hao Xujia Yan Jialu Zhang Dong Liu Ziyang Song Qian Wang Qunying Mao Zhenglun Liang | 2022 | Virologica Sinica2022，37，3： | 0 |
| 11 | Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors显示文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses. | Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 12 | Application Effect of Sludge Extract in the Planting of Zinnia elegans显示文摘[Objectives] The research aimed to study the effect of sludge extract on the growth of Zinnia elegans, and evaluate its possibility of application. [Methods] Z. elegans was taken as research object, and the effect of sludge extract on the growth indicators of Z. elegans was studied. [Results] The sludge extract can obviously promote the growth of Z. elegans, and the growth indicators were significantly improved when compared with the control group. The application effect was close to that of foliar fertilizer purchased in the market. In each treatment group, the low concentration of sludge extract did not significantly promote the growth of Z. elegans, while too high concentration could inhibit its growth, and the optimal dilution ratio was 600 times. [Conclusions] Further preparation of amino acid foliar fertilizer from sludge extract and its application in planting garden plants can realize the resource utilization of sludge and has a good development and application prospect. | Yu FU Cheng YANG Lifang CUI Fanfei MENG Aiai YANG Guangneng ZENG | 2022 | Asian Agricultural Research2022，14，9： | 0 |
| 13 | Hyperbranched magnetic polymer:highly efficient removal of Cr(Ⅵ)and application in electroplating wastewater显示文摘By using a two-step hydrothermal method and trithiocyanuric acid(TTCA),2,4,6-trihydrazino-1,3,5-triazine(THT),and Fe_(3)O_(4)as raw materials,a spherical magnetic adsorbent polymer(TTCA/THT@Fe_(3)O_(4))was synthesized to achieve the efficient removal of Cr(VI)from wastewater.Under optimal adsorption conditions,the maximum adsorption capacity of TTCA/THT@Fe_(3)O_(4)for Cr(VI)can reach 1340 mg∙g‒1.Notably,the removal efficiency can approach 98.9%,even at the lower concentration of 20 mg∙L^(‒1)Cr(VI).For actual wastewater containing Cr(VI),the Cr(VI)concentration was reduced from 25.8 to 0.4 mg∙L^(‒1),a remarkable 20%lower than the current industry discharge standard value.A mechanism for the high adsorption performance of Cr(VI)on TTCA/THT@Fe_(3)O_(4)was investigated using Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,and density functional theory.It can be plausibly attributed to the formation of Cr/N and Cr/S coordination bonds.Additionally,surface electrostatic adsorption,reduction effects,and the spherical polymer structure increase the contact area with Cr(VI),maximizing adsorption.The synergistic effect of adsorption and reduction enhances the adsorption performance of TTCA/THT@Fe_(3)O_(4)for Cr(VI)and total chromium in water.The resultant polymer has a simple preparation process,excellent adsorption performance,easy magnetic separation,and promising application for actual wastewater. | Nan Sun Qing Wu Lifang Jin Zichen Zhu Jianhui Sun Shuying Dong Haijiao Xie Chunyan Zhang Yanrui Cui | 2023 | Frontiers of Chemical Science and Engineering2023，17，10： | 0 |
| 14 | The Method of Spatially Smoothed Seismicity Parameters in Consideration of Seismotectonic Background and Its Application to Seismic Hazard Estimation显示文摘In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids, and some parameters (e.g. b-value, M0, Mu, azimuth and M-L relationship) for each seismotectonic model were assigned. Secondly, using elliptical smoothing based on a seismotectonic background model, the statistical earthquake incidence rate in each grid is successively calculated. Lastly, the relevant ground motion attenuation relationship is chosen to assess seismic hazard of general sites. The maps for the distribution of horizontal peak ground acceleration with 10% probability of exceedance in 50 years were obtained by using the seismic hazard analysis method based on grid source. This seismicity model simplifies the methodology of probabilistic seismic hazard analysis, especially appropriate for those places where seismic tectonics is not yet clearly known. This method can provide valuable references for seismic zonation and seismic safety assessment for significant engineering projects. | Zhang Lifang Lv Yuejun Peng Yanju Ma Xiaoling Cui Manfeng | 2013 | Earthquake Research in China2013，27，1： | 0 |
| 15 | Suitable carrier protein and linker peptide significantly increase the secretory expression of human lysozyme in Aspergillus niger显示文摘Lysozyme(LYZ)is an oval-shaped antimicrobial agent with good bacterial lytic properties and is widely distributed in human,animal,plant,and even some microbial tissues.It can destroy the walls of bacterial cells by cleaving the chemical bond linking Nacetylglucosamine and N-acetyl carbamate in the peptidoglycan layer. | Qi Wu Can Xu Wei Shi Lifang Li Hui Zhang Tianqi Liu Junbo Fan Lingmeng Cui Jie Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 16 | Combined application of organic fertilizer and chemical fertilizer alleviates the kernel position effect in summer maize by promoting post-silking nitrogen uptake and dry matter accumulation显示文摘Adjusting agronomic measures to alleviate the kernel position effect in maize is important for ensuring high yields.In order to clarify whether the combined application of organic fertilizer and chemical fertilizer(CAOFCF)can alleviate the kernel position effect of summer maize,field experiments were conducted during the 2019 and 2020 growing seasons,and five treatments were assessed:CF,100%chemical fertilizer;OFCF1,15%organic fertilizer+85%chemical fertilizer;OFCF2,30%organic fertilizer+70%chemical fertilizer;OFCF3,45%organic fertilizer+55%chemical fertilizer;and OFCF4,60%organic fertilizer+40%chemical fertilizer.Compared with the CF treatment,the OFCF1 and OFCF2 treatments significantly alleviated the kernel position effect by increasing the weight ratio of inferior kernels to superior kernels and reducing the weight gap between the superior and inferior kernels.These effects were largely due to the improved filling and starch accumulation of inferior kernels.However,there were no obvious differences in the kernel position effect among plants treated with CF,OFCF3,or OFCF4 in most cases.Leaf area indexes,post-silking photosynthetic rates,and net assimilation rates were higher in plants treated with OFCF1 or OFCF2 than in those treated with CF,reflecting an enhanced photosynthetic capacity and improved postsilking dry matter accumulation(DMA)in the plants treated with OFCF1 or OFCF2.Compared with the CF treatment,the OFCF1 and OFCF2 treatments increased post-silking N uptake by 66.3 and 75.5%,respectively,which was the major factor driving post-silking photosynthetic capacity and DMA.Moreover,the increases in root DMA and zeatin riboside content observed following the OFCF1 and OFCF2 treatments resulted in reduced root senescence,which is associated with an increased post-silking N uptake.Analyses showed that post-silking N uptake,DMA,and grain yield in summer maize were negatively correlated with the kernel position effect.In conclusion,the combined application of 15-30%organic fertilizer and 70-85%chemical fertilizer alleviated the kernel position effect in summer maize by improving post-silking N uptake and DMA.These results provide new insights into how CAOFCF can be used to improve maize productivity. | Lichao Zhai Lihua Zhang Yongzeng Cui Lifang Zhai Mengjing Zheng Yanrong Yao Jingting Zhang Wanbin Hou Liyong Wu Xiuling Jia | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 17 | VIS Atlas:A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns显示文摘Integration of oncogenic DNA viruses into the human genome is a key step in most virusinduced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an extensive collection of integration breakpoints for three most prevalent oncoviruses,human papillomavirus,hepatitis B virus,and Epstein-Barr virus based on the next-generation sequencing(NGS)data,literature,and experimental data.There are 63,179 breakpoints and 47,411 junctional sequences with full annotations deposited in the VIS Atlas database,comprising 47 virus genotypes and 17 disease types.The VIS Atlas database provides(1)a genome browser for NGS breakpoint quality check,visualization of VISs,and the local genomic context;(2)a novel platform to discover integration patterns;and(3)a statistics interface for a comprehensive investigation of genotypespecific integration features.Data collected in the VIS Atlas aid to provide insights into virus pathogenic mechanisms and the development of novel antitumor drugs. | Ye Chen Yuyan Wang Ping Zhou Hao Huang Rui Li Zhen Zeng Zifeng Cui Rui Tian Zhuang Jin Jiashuo Liu Zhaoyue Huang Lifang Li Zheying Huang Xun Tian Meiying Yu Zheng Hu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员