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| 1 | High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa显示文摘It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-n Cov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas(TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression(FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. | Hao Xu Liang Zhong Jiaxin Deng Jiakuan Peng Hongxia Dan Xin Zeng Taiwen Li Qianming Chen | 2020 | International Journal of Oral Science2020，12，1： | 69 |
| 2 | Crustal evolution of the Shiwandashan area in South China:Zircon U-Pb-Hf isotopic records from granulite enclaves in Indo-Sinian granites显示文摘标明日期的 U-Pb 在东南的 Guangxi 省从 Shiwandashan 区域在 Jiuzhou peraluminous 花岗石从 metasedimentary granulite 被外国领地包围的土地在锆石上结合了 Hf 同位素分析,华南在这份报纸被介绍。结果证明这些 granulite 被外国领地包围的土地的 protoliths 主要由有一座山峰的碎屑状的材料在 822 妈变老的 Neo-Mesoproterozoic (5641061 妈) 组成。这些材料可能从在 Rodinian Supercontinent 的 Neoproterozoic 决裂期间是 emplaced 的火的岩石被导出。辅助沉积包括 Paleoproterozoic (17782227 妈) ,有最旧的 U-Pb 的甚至 Meso-Paleoarchean 材料在 3551 | ZHAO Liang GUO Feng FAN WeiMing LI ChaoWen QIN XiaoFeng LI HongXia | 2010 | Chinese Science Bulletin2010，55，19： | 18 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | The deep-lake deposit in the Upper Triassic Yanchang Formation in Ordos Basin, China and its significance for oil-gas accumulation显示文摘The deep-lake facies of the Yanchang Formation represents a large outflowing lake basin in the Ordos area. Its deposition can be divided into four stages: lake genetic and expanding stage, peak stage, inversion stage and dying stage. All the stages are obviously consistent with the evolution of depositional environment and the paleoclimate in the region. The study indicates that the lake basin has evolution fluctuations from highstand to lowstand for four times in its evolution history, and the deposition center of the lake has not obviously moved, staying along the Huachi-Yijun belt. The deep lake sedimentary system mainly consists of deep water deltas and turbidite fans during the entire evolution course of the lake basin in the Late Triassic. The former mainly developed on the slope of steep shore of the delta in the early period of the deep-water expansion and gradually experienced a big shift from deep-water deltas to shallow-water platform delta. And the latter appeared almost in all the above stages and had two types of turbidite fans, slope-moving turbidite fans and slump turbidite fans. The slope-moving turbidite fans have relatively complete facies belts overlapping one another vertically and consist of the slope channel of inter fans, the turbidite channel, inter turbidite channel and turbidite channel front of middle fans and outer fans (or lakebottom plain). However, the slide-moving turbidity fans are formed in the deep lake with their microfacies difficult to be distinguished, and only the center microfacies and edge microfacies can be determined. The two types of the turbidity fans are similarly distributing in the near-root-slope and far-root-slope regions. The deep-lake deposition governs the distribution of the hydrocarbon and reservoir, while the slope-moving turbidite fans are excellent reservoirs for oil-gas exploration due to their great thickness, widespread distribution and accumulation properties. | CHEN QuanHong LI WenHou GAO YongXiang GUO YanQin FENG JuanPing ZHANG DaoFeng CAO HongXia LIANG JiWei | 2007 | Science China Earth Sciences2007，50，z2： | 12 |
| 5 | Effect of pre-homogenizing treatment on microstructure and mechanical properties of hot-rolled AZ91 magnesium alloys显示文摘To improve the homogeneity and rolling formability of as-cast AZ91 magnesium,the effects of pre-homogenizing treatment on microstructure evolution,deformation mechanism,mechanical properties and tensile fracture morphology of hot-rolled AZ91 magnesium alloy were studied.The results showed that the amount of coarseβ-Mg17Al12 phase decreases dramatically,being distributed along the grain boundaries as small strips after homogenizing.Twining plays a dominant role in the deformation mechanism of AZ91 alloys in the experimental condition,while dynamic recrystallization(DRX)considerably occurred in homogenized-rolled alloys,contributed to microstructure uniformity andβ-Mg17Al12 phase precipitated refinement.The tensile strength of homogenized-rolled AZ91 alloys increases dramatically with elongation declining slightly in contrast to homogenized alloys.The fracture surface of homogenized-rolled specimen exhibits more ductile fracture with the manifestation of a large amount of dimples distributing higher density in matrix,while the micro cracks are prone to initiate around the Mg/Mg17Al12 phase interface and grain boundaries owing to the fragile interface bonding of two phases. | Liuwei Zheng Huihui Nie Wei Liang Hongxia Wang Yide Wang | 2016 | Journal of Magnesium and Alloys2016，4，2： | 5 |
| 6 | Extraordinary hydro-climatic events during the period AD 200?300 recorded by slackwater deposits in the upper Hanjiang River valley, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Shuyan Yin Hongxia Su Liang Zhou Jianchao Yang | 2013 | Palaeogeography Palaeoclimatology Palaeoecology2013，，： | 4 |
| 7 | Dissipative particle dynamics thermostat: a novel thermostat for molecular dynamics simulation of liquid crystals with Gay–Berne potential显示文摘The Gay–Berne(GB) model has been proved to be highly successful in the simulation of liquid crystal phases via both molecular dynamics(MD) and nonequilibrium molecular dynamics(NEMD). However, the conventional thermostats used in the simulations of GB systems, such as Nosé–Hoover and Langevin thermostats, have serious shortcomings especially in NEMD simulations. Recently, dissipative particle dynamics(DPD) has established itself as a useful thermostat for soft matter simulations, whereas the application of DPD thermostat in(NE)MD simulations is limited to the spherically isotropic potential models, such as the Lennard–Jones model. Considering the virtues of the DPD thermostat, that is, local, momentum conserved, and Galilean invariant, we extend the DPD thermostat to the non-spherical GB model. It is interesting to find that the translational DPD and rotational DPD thermostats can be used in the GB system independently and both can achieve the thermostatting effects. Also, we compared the performance of the DPD thermostat with other commonly used thermostats in NEMD simulations by investigating the streaming velocity profiles and the dynamics of phase separation in a typical but simple binary GB mixture under shear field. It is revealed that the known virtues of DPD thermostats, such as Galilean invariant, shear velocity profile-unbiased, and unscreened hydrodynamic interactions, are still intact when applying to GB systems. Finally, the appropriate parameters for the DPD thermostat in the GB system are identified for future investigations. | Yuting Ouyang Liang Hao Yanping Ma Hongxia Guo | 2015 | Science China Chemistry2015，58，4： | 3 |
| 8 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 9 | Microstructure and mechanical properties of cast Mg-15Al-xNd alloy by permanent mold显示文摘To improve the comprehensive mechanical properties of Mg-15Al magnesium alloy,different amounts(from 0 to 4.0wt.%)of Nd were added to the alloy and six Mg-15Al-xNd alloys were prepared by metal mould casting.The effect of Nd content on microstructure of the alloys was investigated by means of OM,SEM,EDS,TEM,and XRD.The tensile properties were tested at room temperature(RT)and high temperature(473 K).The results indicate that the primaryα-Mg dendrite is significantly refined with the addition of Nd.The best refinement is reached at 1.0wt.%Nd content and the average dendrite arm spacing decreases from 80-100μm(without Nd addition)to^20μm.A further increase in Nd content leads to the coarsening of the primaryα-Mg dendrite.The addition of Nd improves the tensile properties of Mg-15Al both at RT and 473 K.The Mg-15Al alloy containing 1.0wt.%Nd exhibits the best tensile properties.Compared with the alloy without Nd,the yield and ultimate tensile strength of the Mg-15Al-1.0Nd alloy at RT increase from 132.3 to 148.6 MPa and 152.3 to 189.6MPa,increase by 12.3%and 24.5%,respectively;and the elongation at RT increases from 0.05%to 1.24%.The yield and tensile strength of the alloy at 473 K increase from 97.9 to 115.3 MPa and 121.6 to 140.1 MPa,increase by 15.2%and 20%,respectively.Further increment of Nd content to 1.5wt.%degrades the tensile properties,which is ascribed to grain coarsening and growth of the Al-Nd phase. | Zhou Kangkang Wang Hongxia Liang Wei Zhang Jinshan Zhang Hongxia | 2013 | China Foundry2013，10，5： | 2 |
| 10 | TiO2-incorporated polyelectrolyte composite membrane with transformable hydrophilicity/hydrophobicity for nanofiltration separation显示文摘The wettability of the membrane surface has shown obvious influent on the separation performance of the membrane.In this work,a hydrophilic PDA-[PDDA/TiO2]+Cl-membrane was prepared by a one-step codeposition of poly(diallyldimethylammonium chloride)(PDDA)polyelectrolyte solution containing positively charged TiO2@PDDA nanoparticles with the assistance of dopamine(DA).Such positively charged membrane can be transformed into a hydrophobic membrane PDA-[PDDA/TiO2]+PFO-via the counterion exchange between Cl-and PFO-(perfluorooctanoate).The transformation between hydrophilicity and hydrophobicity is reversible.For both hydrophilic and hydrophobic membranes,the nanofiltration performances were respectively investigated by the aqueous solution and ethanol solution of dyes including methyl blue(MB),Congo red(CR)and Evans blue(EB),and as well metal salt aqueous solution.The consecutive running stability and anti-fouling performance of both hydrophilic and hydrophobic membranes were explored.The results revealed that both membranes showed high nanofiltration performances for retention of dyes in(non)aqueous solution.For the hydrophilic membrane,the rejection of salts in a sequence is MgSO4>Na2SO4>MgCl2>NaCl.Moreover,both of the hydrophilic and hydrophobic membranes showed high stability and antifouling property. | Yahua Lu Zhenping Qin Naixin Wang Hongxia Guo Quanfu An Yucang Liang | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 2 |
| 11 | The creep behavior of Mg-9Al-1Si-1SiC composite at elevated temperature显示文摘The creep properties of as-cast Mg-9Al-1Si alloy and Mg-9Al-1Si-1SiC composite were compared.The results show that Mg-9A1-lSi-lSiC composite performs a better creep resistance than that of Mg-9Al-1Si alloy at constant temperature and stress(473 K,70MPa).Besides,the creep behavior of Mg-9Al-1 Si-1SiC composite at various temperature from 448 K to 498 K and under stresses of 70-90 MPa were systematically investigated.The Mg-9Al-1 Si-1SiC composite exhibited a stress exponent from 5.5 to 6.9 and the creep activation energy fell within the range of 86-111 kJ/mol.The results showed that the creep mechanism of Mg-9Al-1Si-1SiC composite was mainly attributed to the effects of secondary phase strengthening mechanism and dislocation climb mechanism. | Pengwen Zhou Shaoxiong Zhang Ming Li Hongxia Wang Weili Cheng Lifei Wang Hang Li Wei Liang Yiming Liu | 2020 | Journal of Magnesium and Alloys2020，8，3： | 2 |
| 12 | Recent advances in the synthesis of nanoscale hierarchically porous metal–organic frameworks显示文摘Nanoscale hierarchically porous metal–organic frameworks(NHP-MOFs)have received unprecedented attention in many fields owing to their integration of the strengths of nanoscale size(<1μm)and hierarchical porous structure(micro-,meso-and/or macro-pores)of MOFs.This review focuses on recent advances in the main synthetic strategies for NHP-MOFs based on different metal ions(e.g.,Cu,Fe,Co,Zn,Al,Zr,and Cr),including the template method,composite technology,post-synthetic modification,in situ growth and the grind method.In addition,the mechanisms of synthesis,regulation techniques and the advantages and disadvantages of various methods are discussed.Finally,the challenges and prospects of the commercialisation of promising NHP-MOFs are also presented.The purpose of this review is to provide a road map for future design and development of NHP-MOFs for practical application. | Chongxiong Duan Kuan Liang Zena Zhang Jingjing Li Ting Chen Daofei Lv Libo Li Le Kang Kai Wang Han Hu Hongxia Xi | 2022 | Nano Materials Science2022，4，4： | 2 |
| 13 | Experimental study of the mass transfer behavior of carbon dioxide absorption into ternary phase change solution in a packed tower显示文摘Phase change absorbents for CO_(2)are of great interest because they are expected to greatly reduce the heat energy consumption during the regeneration process.Compared with other phase change absorbents,monoethanolamine(MEA)-sulfolane-water is inexpensive and has a fast absorption rate.It is one of the most promising solvents for large-scale industrial applications.Therefore,this study investigates the mass transfer performance of this phase change system in the process of CO_(2)absorption in a packed tower.By comparing the phase change absorbent and the ordinary absorbent,it is concluded that the use of MEA/sulfolane phase change absorbent has significantly improved mass transfer efficiency compared to a single MEA absorbent at the same concentration.In the 4 mol·L^(-1)MEA/5 mol·L^(-1)sulfolane system,the CO_(2)loading of the upper liquid phase after phase separation is almost zero,while the volume of the lower liquid phase sent to the desorption operation is about half of the total volume of the absorbent,which greatly reduces the energy consumption.This study also investigates the influence of operating parameters such as lean CO_(2)loading,gas and liquid flow rates,CO_(2)partial pressure,and temperature on the volumetric mass transfer coefficient(K_(G)α_(V)).The research shows that K_(G)α_(V) increases with increasing liquid flow rate and decreases with the increase of lean CO_(2)loading and CO_(2)partial pressure,while the inert gas flow rate and temperature have little effect on K_(G)α_(V).In addition,based on the principle of phase change absorption,a predictive equation for the K_(G)α_(V) of MEA-sulfolane in the packed tower was established.The K_(G)α_(V) obtained from the experiment is consistent with the model prediction,and the absolute average deviation(AAD)is 7.8%. | Yihan Yin Aoqian Qiu Hongxia Gao Yanqing Na Zhiwu Liang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 14 | Value of qualitative research in polycystic ovary syndrome显示文摘 | Ma Hongxia Liang Huiling Gao Jingshu Ma Hongli Liu Jianping Ng Hungyu Ernest Billhult Annika Stener-Victorin Elisabet Mu Xin Wu Xiaoke | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 15 | Photoreduction of CO_(2) in the presence of CH_(4) over g-C_(3)N_(4) modified with TiO_(2) nanoparticles at room temperature显示文摘CO_(2)reduction under simulated sunlight over photocatalysts has become an attractive researcher area recently.In this work,carbon nitride compounds modified by TiO_(2)nanoparticles(TNPs)have been used for the photoreduction of CO_(2)in the presence of CH_(4)at room temperature.Briefly,a series of noble-metal-free TNP-graphitic-carbon nitride(g-C_(3)N_(4),also abbreviated CN)photocatalysts with different TNPs loadings and calcination temperatures have been synthesized by a wet-chemical method.The characterization results of XRD,FTIR,SEM,TEM,BET,XPS,CO_(2)Adsorption,UV-vis,and PL demonstrate that the BET surface area and CO_(2)adsorption capacity have been improved after the calcination.Besides,the g-C_(3)N_(4)has been successfully coupled with the TNPs and a heterojunction has formed at their interface.These characters contribute to increase the photocatalytic activity of TNPs-CN toward reducing CO_(2)in the presence of CH_(4),and its'performance is better than bare g-C_(3)N_(4),Titania(P_(25))-CN,MgO-CN,or Cu_(2)O-CN.Orthogonal experiments are then carried out to investigate the sensitivity factors and optimum conditions.The sensitivity results show that the reaction pressure makes little difference on the photocatalysis results,which verifies the photoinduced CO_(2)-CH_(4)reaction has a tiny change in gas volume.In addition,under the optimum conditions,the turnover frequency(TOF)of CO after 4 h reaction can reach 9.98μmol g-cat.^(-1)h^(-1),and traces of ethane and ethylene have been detected during the reactions.In addition,surface acetate and carbonaceous deposit are found on the(20)TNPs-CN/450 surface after continuous 24 h irradiation under the optimum conditions,which resulting in the inactivation of the catalyst.Finally,possible reaction mechanisms have been proposed based on the results. | Ming Chen Jiachen Wu Chongchong Lu Xiao Luo Yangqiang Huang Bo Jin Hongxia Gao Xiaowen Zhang Morris Argyle Zhiwu Liang | 2021 | Green Energy & Environment2021，6，6： | 2 |
| 16 | Thermal and mechanical evaluation of cyanate ester resin modified with bismaleimide and diallyl phthalate显示文摘 | He Shaobo Liang Guozheng Yan Hongxia | | 0，，9： | 1 |
| 17 | Overex pression of TiERF1 enhances resistance to sharp eyespot in transgenic wheat显示文摘 | Chen Liang Zhang Zengyan Liang Hongxia | 2008 | Journal of Experimental Botany2008，59，15： | 1 |
| 18 | Effect of doping cerium in the support of catalyst pd-Co/Cu-Co-Mn mixed oxides on the oxidative carbonylation of phenol显示文摘 | LIANG Yinghua GUO Hongxia CHEN Hongping | 2009 | CIESC Journal2009，17，3： | 1 |
| 19 | The effect of silane coupling agent on the sliding wear behavior of nanometer ZrO2/bismaleimide composites显示文摘 | Hongxia Yan Rongchang Ning Guozheng Liang Ying Huang Tingli Lu | 2007 | Journal of Materials Science2007，，3： | 1 |
| 20 | Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis显示文摘Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. | Hongxia Liang Zhenhua Li Zhigang Ren Qiaodi Jia Linna Guo Shasha Li Hongyu Zhang Shiqi Hu Dashuai Zhu Deliang Shen Zujiang Yu Ke Cheng | 2020 | Nano Research2020，13，8： | 1 |
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