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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | 颈总动脉内径与心血管事件及死亡风险研究:4项队列研究的汇总分析显示文摘颈动脉内径增加是动脉重构的表现,且可能是心血管病的危险因素。研究者评估颈动脉内径与脑卒中、冠状动脉性心脏病、心血管病及全因死亡的关系,并探讨与血压有关的中膜增厚、动脉僵硬、动脉壁应力及动脉硬化等动脉重构过程能否解释此关系。 | Sedaghat S van Sloten TT Laurent S London GM Pannier Kavousi M Mattace-Raso F Franco OH Boutouyrie P Ikram MA Stehouwer CDA 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 3 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 4 | Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study显示文摘 | Roger K. Schindhelm Jacqueline M. Dekker Giel Nijpels Lex M. Bouter Coen D.A. Stehouwer Robert J. Heine Michaela Diamant | 2006 | Atherosclerosis2006，，2： | 3 |
| 5 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 6 | 血压变异性加大与认知功能减退相关显示文摘由于预期寿命增加,越来越多的人将面临与增龄相关的认知困难。因此,确定认知障碍的可改变的风险因素非常重要。极短期到中期的血压变异性(blood pressure variability,BPV)可能就是这样一个因素,因为它可能导致脑缺血。 | Zhou TL Kroon AA van Sloten TT van Boxtel MPJ Verhey FRJ Schram MT Kohler S Stehouwer CDA Henry RMA 刘莉(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 7 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 8 | Microalbuminuria and risk for car- diovascular disease: Analysis o{ potential mechanisms显示文摘 | Stehouwer CD Smulders YM | 2006 | J Am Soc Nephrol2006，17，8： | 1 |
| 9 | Endothelial dysfunction and pathogenesis of diabetic angiopathy显示文摘 | Stehouwer CD Lambert J Donker AJ | 1997 | Cardiovasc Res1997，34，1： | 1 |
| 10 | C-reactive protein in healthy subjects:associations with obesity,insulin resistance and endothelial dysfunction:Potential role for cytokines originating from adipose tissue显示文摘 | Yudkin JS Stehouwer CDA Emeis JJ | 1999 | Arterioscler Thromb Vase Biol1999，19，4： | 1 |
| 11 | Inflammatory mark- ers, adiponectin, and risk of type 2 diabetes in the Pima Indian显示文摘 | Krakoff J Funahashi T Stehouwer CD | 2003 | Diabetes Care2003，26，6： | 1 |
| 12 | Increased urinary albu- min excretion,endothelial dysfunction, and chronic low-grade in- flammation in type 2 diabetes: progressive, interrelated, and inde- pendently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 13 | Total homocys-teine and vascular disease in diabetes; a double hit显示文摘 | Huijberts MS Becker A and Stehouwer CD | 2005 | ClinChem Lab Med2005，43，10： | 1 |
| 14 | Homocysteine and blood pressure显示文摘 | Van Guldener C Nanayakkara PW Stehouwer CD | 2003 | Curr Hypertens Rep2003，5，1： | 1 |
| 15 | Increased urinary albumin excretion,endothelial dysfunction,and chronic low-grade inflammation in type 2 diabetes:progressive,interrelated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 16 | Endothelial dysfunction precedes development of microalbuminuria in IDDM显示文摘 | Stehouwer CD Fischer HR van Kuijk AW | 1995 | Diabetes1995，44，5： | 1 |
| 17 | Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease? 显示文摘 | Honing MLH Stehouwer CDA | 2004 | Clin Sci2004，106，4： | 1 |
| 18 | Urinary albumin excretion, cardiovascular disease, and endothelial dys function in non-insulin-dependent diabetes mellitus 显示文摘 | Stehouwer CD Nauta J J Zeldenrust GC | 1992 | Lancet1992，340，8815： | 1 |
| 19 | Increased urinary albumin excretion,endothelial dvsfunction and chronic low-grade inflammation in type-2 diabetes:progressive,interre-lated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 20 | Association of C- eactive protein with obesity, insulin resistance, and subclinical atherosclerosis in healthy middle-aged women显示文摘 | Hak AE Stehouwer DA Bots ML | 1999 | Arterioscler Thromb Vasc Biol1999，19，1： | 1 |
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