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| 1 | Gastric cancer:Prevention,screening and early diagnosis显示文摘Gastric cancer continues to be an important healthcare problem from a global perspective. Most of the cases in the Western world are diagnosed at late stages when the treatment is largely ineffective. Helicobacter pylori(H. pylori) infection is a well-established carcinogen for gastric cancer. While lifestyle factors are important,the efficacy of interventions in their modification,as in the use of antioxidant supplements,is unconvincing. No organized screening programs can be found outside Asia(Japan and South Korea). Although several screening approaches have been proposed,including indirect atrophy detection by measuring pepsinogen in the circulation,none of them have so far been implemented,and more study data is required to justify any implementation. Mass eradication of H. pylori in high-risk areas tends to be cost-effective,but its adverse effects and resistance remain a concern. Searches for new screening biomarkers,including microRNA and cancer-autoantibody panels,as well as detection of volatile organic compounds in the breath,are in progress. Endoscopy with a proper biopsy follow-up remains the standard for early detection of cancer and related premalignant lesions. At the same time,new advanced high-resolution endoscopic technologies are showing promising results with respect to diagnosing mucosal lesions visually and targeting each biopsy. New histological risk stratifications(classifications),including OLGA and OLGIM,have recently been developed. This review addresses the current means for gastric cancer primary and secondary prevention,the available and emerging methods for screening,and new developments in endoscopic detection of early lesions of the stomach. | Victor Pasechnikov Sergej Chukov Evgeny Fedorov Ilze Kikuste Marcis Leja | 2014 | World Journal of Gastroenterology2014，20，38： | 64 |
| 2 | Atrophic gastritis and gastric cancer tissue miRNome analysis reveals hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers显示文摘BACKGROUND Gastric cancer(GC)is one of the most frequently diagnosed tumor globally.In most cases,GC develops in a stepwise manner from chronic gastritis or atrophic gastritis(AG)to cancer.One of the major issues in clinical settings of GC is diagnosis at advanced disease stages resulting in poor prognosis.Micro RNAs(mi RNAs)are small noncoding molecules that play an essential role in a variety of fundamental biological processes.However,clinical potential of mi RNA profiling in the gastric cancerogenesis,especially in premalignant GC cases,remains unclear.AIM To evaluate the AG and GC tissue mi RNomes and identify specific mi RNAs’potential for clinical applications(e.g.,non-invasive diagnostics).METHODS Study included a total of 125 subjects:Controls(CON),AG,and GC patients.All study subjects were recruited at the Departments of Surgery or Gastroenterology,Hospital of Lithuanian University of Health Sciences and divided into the profiling(n=60)and validation(n=65)cohorts.Total RNA isolated from tissue samples was used for preparation of small RNA sequencing libraries and profiled using next-generation sequencing(NGS).Based on NGS data,deregulated mi RNAs hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p were analyzed in plasma samples of independent cohort consisting of CON,AG,and GC patients.Expression level of hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p was determined using the quantitative real-time polymerase chain reaction and 2-ΔΔCt method.RESULTS Results of tissue analysis revealed 20 differentially expressed mi RNAs in AG group compared to CON group,129 deregulated mi RNAs in GC compared to CON,and 99 altered mi RNAs comparing GC and AG groups.Only 2 mi RNAs(hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p)were identified to be step-wise deregulated in healthy-premalignant-malignant sequence.Area under the curve(AUC)-receiver operating characteristic analysis revealed that expression level of hsa-mi R-196 a-5 p is significant for discrimination of CON vs AG,CON vs GC and AG vs GC and resulted in AUCs:88.0%,93.1%and 66.3%,respectively.Comparing results in tissue and plasma samples,hsa-mi R-129-1-3 p was significantly down-regulated in GC compared to AG(P=0.0021 and P=0.024,tissue and plasma,respectively).Moreover,analysis revealed that hsa-mi R-215-3 p/5 p and hsa-mi R-934 were significantly deregulated in GC based on Helicobacter pylori(H.pylori)infection status[log2 fold change(FC)=-4.52,P-adjusted=0.02;log2 FC=-4.00,P-adjusted=0.02;log2 FC=6.09,P-adjusted=0.02,respectively].CONCLUSION Comprehensive mi RNome study provides evidence for gradual deregulation of hsa-mi R-196 a-5 p and hsa-mi R-129-1-3 p in gastric carcinogenesis and found hsami R-215-3 p/5 p and hsa-mi R-934 to be significantly deregulated in H.pylori carrying GC patients. | Greta Varkalaite Evelina Vaitkeviciute Ruta Inciuraite Violeta Salteniene Simonas Juzenas Vytenis Petkevicius Rita Gudaityte Antanas Mickevicius Alexander Link Limas Kupcinskas Marcis Leja Juozas Kupcinskas Jurgita Skieceviciene | 2022 | World Journal of Gastroenterology2022，28，6： | 2 |
| 3 | Polymorphisms of micro RNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer显示文摘AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC. | Vytenis Petkevicius Violeta Salteniene Simonas Juzenas Thomas Wex Alexander Link Marcis Leja Ruta Steponaitiene Jurgita Skieceviciene Limas Kupcinskas Laimas Jonaitis Gediminas Kiudelis Peter Malfertheiner Juozas Kupcinskas | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 4 | Antioxidative properties of bee pollen in selected plant species显示文摘 | M. Leja A. Mareczek G. Wy?golik J. Klepacz-Baniak K. Czekońska | 2005 | Food Chemistry2005，，1： | 1 |
| 5 | Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin 显示文摘 | Jaworek J Bonior J Leja - Szpa A | 2002 | J Physiol Pharmacol2002，53，1： | 1 |
| 6 | Antioxidant abil- ity of broccoli flower buds during short-term storage 显示文摘 | Leja M Mareczek A Starzynska A | 2001 | Food Chemistry2001，72，2： | 1 |
| 7 | The validity of a biomar- ker method for indirect detection of gastric mucosal atrophy versus standard histopathology 显示文摘 | Leja M Kupcinskas L Funka K | 2009 | Dig Dis Sci2009，54，11： | 1 |
| 8 | Antioxidant ability of broccoli flower buds during short-term storage显示文摘 | Leja M | 2001 | Food Chemistry2001，72，： | 1 |
| 9 | Detection of Sodium ChannelToxins: Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seaiood Extracts 显示文摘 | Manger R Leja L Lee S | 1994 | Journal of AOAC International1994，78，2： | 1 |
| 10 | Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis显示文摘 | Limas Kupcinskas Thomas Wex Juozas Kupcinskas Marcis Leja Audrius Ivanauskas Laimas Virgilijus Jonaitis Dainius Janciauskas Gediminas Kiudelis Konrads Funka Agnese Sudraba Han-Mo Chiu Jaw-Town Lin Peter Malfertheiner | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 1 |
| 11 | Systemic treatment with CAR - engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice 显示文摘 | Hillerdal V Ramachandran M Leja J | 2014 | BMC cancer2014，14，： | 1 |
| 12 | Gastritis staging: interobserver agreement by applying OLGA and OLGIM systems显示文摘 | Sergejs Isajevs Inta Liepniece-Karele Dainius Janciauskas Georgijs Moisejevs Viesturs Putnins Konrads Funka Ilze Kikuste Aigars Vanags Ivars Tolmanis Marcis Leja | 2014 | Virchows Archiv2014，，4： | 1 |
| 13 | Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas显示文摘 | Leja J Essaghir A Essand M | 2009 | Mod Pathl2009，22，2： | 1 |
| 14 | High consumption of fattyfish from the Baltic Sea is associated with changes in humanlymphocyte subset levels 显示文摘 | Hagmar L Hallberg T Leja M | 1995 | Toxicology Letters1995，77，13： | 1 |
| 15 | Detection of sodium channel toxins:directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins and seafood extracts 显示文摘 | Manger RL Leja LS Lee SY | 1995 | AOAC lnt1995，78，： | 1 |
| 16 | Antioxidative properties of bee pollen in selected plant species显示文摘 | LEJA M MARECZEK A WYZGOLIK G | 2007 | Food Chemistry2007，100，1： | 1 |
| 17 | Modifications of the intrepic responses to α-and β-adrenoceptor stimulation PE propofol in rat meocardium 显示文摘 | Lejae M Hanouz JL Lecarpantier E | 1998 | Anesth Analg1998，87，2： | 1 |
| 18 | Antioxidative properties of bee pollen in selected plant species显示文摘 | LEJA M MARECZEK A WY ZGOLIK G | 2007 | Food Chemistry2007，100，： | 1 |
| 19 | Protective effect of melatonin and its precursor L -tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion 显示文摘 | Jaworek J Leja - Szpak A Bonior J | 2003 | J Pineal Res2003，34，1： | 1 |
| 20 | Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers显示文摘 | Lars Agréus Ernst J Kuipers Limas Kupcinskas Peter Malfertheiner Francesco Di Mario Marcis Leja Varocha Mahachai Niv Yaron Martijn van Oijen Guillermo Perez Perez Massimo Rugge Jukka Ronkainen Mikko Salaspuro Pentti Sipponen Kentaro Sugano Joseph Sung | 2012 | Scandinavian Journal of Gastroenterology2012，，2： | 1 |
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